Acutumidine
Based on 1 Customer Validation
Acutumidine is a chlorinated alkaloid present in the cultured roots of Menispermum dauricum and Hypserpa nitida Miers. Acutumidine exhibits anti-HBV activity, with an IC50 value of 2.023 mM against hepatitis B virus surface antigen. Acutumidine can be used in studies related to hepatitis B.
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- Pureté : 98.0%
- CAS No.: 18145-26-1
- Formule: C18H22ClNO6
- Masse moléculaire:383.82
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Stockage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 2.2.15 | CC50 |
>2.888 mM
Compound: 4
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Cytotoxicity against human Hep G2.2.15 cells
Cytotoxicity against human Hep G2.2.15 cells
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[PMID: 17723297] |
| HepG2 2.2.15 | IC50 |
>2.888 mM
Compound: 4
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Antiviral activity against HBV transfected Hep G2.2.15 cells assessed as inhibition of e antigen HBsAg secretion
Antiviral activity against HBV transfected Hep G2.2.15 cells assessed as inhibition of e antigen HBsAg secretion
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[PMID: 17723297] |
| HepG2 2.2.15 | IC50 |
2.023 mM
Compound: 4
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Antiviral activity against HBV transfected Hep G2.2.15 cells assessed as inhibition of surface antigen HBsAg secretion
Antiviral activity against HBV transfected Hep G2.2.15 cells assessed as inhibition of surface antigen HBsAg secretion
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[PMID: 17723297] |
In Vitro
Acutumidine (compound 4) inhibits HBsAg secretion in Hep G2.2.15 cells with an IC50 of 2.023 mM, has no activity against HBeAg at concentrations greater than 2.888 mM, and exhibits a selectivity index greater than 1.31[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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CAS No. 18145-26-1
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Appearance Solid
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Masse moléculaire 383.82
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Formule C18H22ClNO6
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Color White to off-white
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SMILES
COC([C@@]12[C@](C3)(CCN2)[C@]4([C@@H](C(OC)=CC4=O)O)[C@H](C1)Cl)=C(OC)C3=O
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Pureté et documentation
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Fiche technique (294 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Acutumidine Related Classifications
HY-N15419 Related Classifications
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