Senecionine N-oxide

Name: Senecionine N-oxide
Brand: MedChemExpress
SKU: HY-N6637
Rating: 4.5 (1 reviews)

Cat. No.: HY-N6637 Purity: 98.73%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Senecionine n-oxide is the primary product of pyrrolizidine alkaloid biosynthesis in root cultures of Senecio vulgaris. Senecionine N-oxide has anti-cancer activity.

For research use only. We do not sell to patients.

Senecionine N-oxide Chemical Structure

CAS No. : 13268-67-2

Size	Price	Stock	Quantity
1 mg	USD 135	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 400	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Senecionine N-oxide:

Senecionine N-oxide-d₃ Get quote

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Biological Activity
Purity & Documentation
References
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Description

Senecionine n-oxide is the primary product of pyrrolizidine alkaloid biosynthesis in root cultures of Senecio vulgaris. Senecionine N-oxide has anti-cancer activity^[1]^[2].

Molecular Weight

351.39

Formula

C₁₈H₂₅NO₆

CAS No.

13268-67-2

Appearance

Solid

Color

White to off-white

SMILES

O=C(O[C@]1([H])CC[N+]2([O-])[C@]1([H])C(COC([C@](C)(O)[C@H](C)C/3)=O)=CC2)C3=C/C

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (142.29 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8458 mL	14.2292 mL	28.4584 mL
5 mM	0.5692 mL	2.8458 mL	5.6917 mL
10 mM	0.2846 mL	1.4229 mL	2.8458 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.73%

Select Batch:

Data Sheet (279 KB) SDS (251 KB)

COA (261 KB) RP-HPLC (206 KB) MS (181 KB)

Handling Instructions (2659 KB)

References

[1]. Thomas Hartmann, et al. Senecionine n-oxide, the primary product of pyrrolizidine alkaloid biosynthesis in root cultures of Senecio vulgaris. Phytochemistry, Volume 26, Issue 6, 1987, Pages 1639-1643

[2]. Kupchan SM, et al. Tumor inhibitors. XXII. Senecionine and senecionine N-oxide, the active principles of Senecio triangularis. J Pharm Sci. 1967 Apr;56(4):541-3. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	2.8458 mL	14.2292 mL	28.4584 mL	71.1460 mL
	5 mM	0.5692 mL	2.8458 mL	5.6917 mL	14.2292 mL
	10 mM	0.2846 mL	1.4229 mL	2.8458 mL	7.1146 mL
	15 mM	0.1897 mL	0.9486 mL	1.8972 mL	4.7431 mL
	20 mM	0.1423 mL	0.7115 mL	1.4229 mL	3.5573 mL
	25 mM	0.1138 mL	0.5692 mL	1.1383 mL	2.8458 mL
	30 mM	0.0949 mL	0.4743 mL	0.9486 mL	2.3715 mL
	40 mM	0.0711 mL	0.3557 mL	0.7115 mL	1.7787 mL
	50 mM	0.0569 mL	0.2846 mL	0.5692 mL	1.4229 mL
	60 mM	0.0474 mL	0.2372 mL	0.4743 mL	1.1858 mL
	80 mM	0.0356 mL	0.1779 mL	0.3557 mL	0.8893 mL
	100 mM	0.0285 mL	0.1423 mL	0.2846 mL	0.7115 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Senecionine N-oxide13268-67-2OthersPyrrolizidinealkaloidbiosynthesisSeneciovulgarisanti-cancerInhibitorinhibitorinhibit

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Senecionine N-oxide

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Other Forms of Senecionine N-oxide: