1. Natural Products
  2. Plants Alkaloids
  3. Loganiaceae Indole Alkaloids
  4. Gelsemium eleganis (Gardn. et Champ.) Benth.
  5. Gelsevirine

Gelsevirine is the major alkaloid in Gelsemium elegans with potent anxiolytic effects. The anxiolytic mechanism of Gelsevirine may be involved in the agonist action of the glycine receptor in the brain. Gelsevirine has anti-proliferation activity with IC50 values of 1.41 mM and 1.22 mM for SW480 cells and MGC80-3 cells, respectively.

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Gelsevirine Chemical Structure

Gelsevirine Chemical Structure

CAS No. : 38990-03-3

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Description

Gelsevirine is the major alkaloid in Gelsemium elegans with potent anxiolytic effects. The anxiolytic mechanism of Gelsevirine may be involved in the agonist action of the glycine receptor in the brain. Gelsevirine has anti-proliferation activity with IC50 values of 1.41 mM and 1.22 mM for SW480 cells and MGC80-3 cells, respectively[1][2][3].

Molecular Weight

352.43

Formula

C21H24N2O3

CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C1[C@]([C@H](OC2)C[C@@H]3[C@@]2([H])[C@@]4([H])N5C)(C6=CC=CC=C6N1OC)[C@]4([H])[C@]3(C5)C=C

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

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Gelsevirine
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HY-N3940
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