Daurisoline-d₁₁ (Synonyms: (R,R)-Daurisoline-d₁₁)

Cat. No.: HY-N0221S2: FAQs
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Daurisoline-d₁₁ is the deuterium labeled Daurisoline (HY-N0221). Daurisoline is a bis-benzylisoquinoline alkaloid that can be isolated from Menispermum dauricum and Rhizoma Menispermi. Daurisoline exerts a blocking effect on hERG and has antiarrhythmic effects. Daurisoline is a potent autophagy blocker that can be used for the research of cancer.

For research use only. We do not sell to patients.

Daurisoline-d<sub>11</sub> Chemical Structure

Daurisoline-d₁₁ Chemical Structure

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Description	Daurisoline-d₁₁ is the deuterium labeled Daurisoline (HY-N0221). Daurisoline is a bis-benzylisoquinoline alkaloid that can be isolated from Menispermum dauricum and Rhizoma Menispermi. Daurisoline exerts a blocking effect on hERG and has antiarrhythmic effects. Daurisoline is a potent autophagy blocker that can be used for the research of cancer^[1]^[2].
Molecular Weight	621.81
Formula	C₃₇H₃₁D₁₁N₂O₆
SMILES	OC1=C(C2=C(CCN([C@@H]2CC3=C(C([2H])=C(C(OC4=C(C([2H])=C(C([2H])=C4[2H])C[C@H]5N(CCC6=C5C([2H])=C(C(OC)=C6[2H])OC)C)[2H])=C3[2H])O)[2H])C)C([2H])=C1OC)[2H]
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (273 KB) Handling Instructions (2659 KB)
References	[1]. Liu Q, et al. Effect of daurisoline on HERG channel electrophysiological function and protein expression. J Nat Prod. 2012 Sep 28;75(9):1539-45. [Content Brief] [2]. Wu MY, et al. Natural autophagy blockers, dauricine (DAC) and daurisoline (DAS), sensitize cancer cells to camptothecin-induced toxicity. Oncotarget. 2017 Sep 8;8(44):77673-77684. [Content Brief]

Daurisoline-d₁₁ Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Daurisoline-d₁₁(R,R)-Daurisoline-d₁₁Isotope-Labeled CompoundsPotassium ChannelAutophagyKcsAantiarrhythmicalkaloidMenispermum dauricumRhizoma MenispermiInhibitorinhibitorinhibit

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Daurisoline-d11 (Synonyms: (R,R)-Daurisoline-d11)

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