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Cat. No.: HY-N1120

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Triptoquinone B

(Synonyms: (+)-Triptoquinone B)

Triptoquinone B ((+)-Triptoquinone B), a sesquiterpene alkaloid, is an interleukin-1 inhibitor. Triptoquinone B shows potent inhibitory activities against interleukin 1α and β releases for human peripheral mononuclear cells.

For research use only. We do not sell to patients.

CAS No.: 142937-50-6
Formula: C₂₀H₂₆O₄
Molecular Weight:330.42

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Triptoquinone B Chemical Structure

CAS No.: 142937-50-6

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Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

IL-1

All Interleukin Related Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	19.91 μM Compound: 9	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 27133593]
Bcap37	IC₅₀	13.29 μM Compound: 9	Cytotoxicity against human Bcap37 cells after 48 hrs by MTT assay Cytotoxicity against human Bcap37 cells after 48 hrs by MTT assay	[PMID: 27133593]
Hep 3B2	IC₅₀	25.98 μM Compound: 9	Cytotoxicity against human Hep3B cells after 48 hrs by MTT assay Cytotoxicity against human Hep3B cells after 48 hrs by MTT assay	[PMID: 27133593]
HepG2	IC₅₀	26.3 μM Compound: 9	Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 27133593]
MCF7	IC₅₀	16.69 μM Compound: 9	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 27133593]
U-251	IC₅₀	>100 μM Compound: 9	Cytotoxicity against human U251 cells after 48 hrs by MTT assay Cytotoxicity against human U251 cells after 48 hrs by MTT assay	[PMID: 27133593]

Chemical Information

CAS No. 142937-50-6
Molecular Weight 330.42
Formula C₂₀H₂₆O₄
SMILES

O=C1C(C(C)C)=CC(C([C@@]2(C)CC3)=C1CC[C@@]2([H])[C@@](C)(CO)C3=O)=O
Synonyms

(+)-Triptoquinone B
Structure Classification
- Terpenoids
- Sesquiterpenes
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Takaishi Y, et, al. Triptoquinone A and B novel interleukin-1 inhibitors from Tripterygium wilfordii var Regeli. Tetrahedron Letters. 1992 Nov; 33(47): 7177-7180.

[2]. Wang XD, et, al. Terpene alkaloids from Tripterygium wilfordii. J Asian Nat Prod Res. 2005 Oct;7(5):755-9. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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