1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. nAChR

Cytisine (Synonyms: (-)-Cytisine; Sophorine; Baptitoxine)

Cat. No.: HY-N0175 Purity: >98.0%
Handling Instructions

Cytisine is an alkaloid that occurs naturally in several plant genera, such as Laburnum and Cytisus. Cytisine is a partial agonist of α4β2 nAChRs, and partial to full agonist at β4 containing receptors and α7 receptors. has been used medically to help with smoking cessation.

For research use only. We do not sell to patients.

Cytisine Chemical Structure

Cytisine Chemical Structure

CAS No. : 485-35-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
25 mg USD 50 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Cytisine is an alkaloid that occurs naturally in several plant genera, such as Laburnum and Cytisus. Cytisine is a partial agonist of α4β2 nAChRs[1], and partial to full agonist at β4 containing receptors and α7 receptors[2]. has been used medically to help with smoking cessation[3].

IC50 & Target

α4β2 nAChRs[1].

In Vitro

Cytisine (2.5, 5 and 10 mM) is capable of inducing apoptosis in HepG2 cells[4].
Treatment with Cytisine increases the percentage of cells in the sub-G1 phase (P<0.01). The preincubation of HepG2 cells with Cytisine (2.5, 5 and 10 mM) significantly increases the sub-G1 cell population[4].

In Vivo

Cytisine (5 mg/kg, i.p.) eat less and gain less weight than those that receive the vehicle[2].
Total pellet intake increases during Cytisine substitution relative to nicotine and animals self-administered Cytisine significantly less than nicotine[2].

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (657.06 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.2565 mL 26.2826 mL 52.5652 mL
5 mM 1.0513 mL 5.2565 mL 10.5130 mL
10 mM 0.5257 mL 2.6283 mL 5.2565 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (10.93 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (10.93 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (10.93 mM); Clear solution

References
Molecular Weight

190.24

Formula

C₁₁H₁₄N₂O

CAS No.

485-35-8

SMILES

O=C1N(C[[email protected]@]2([H])C[[email protected]]3([H])CNC2)C3=CC=C1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
Cytisine
Cat. No.:
HY-N0175
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Cytisine

Cat. No.: HY-N0175