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Cat. No.: HY-N17527

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7-Demethoxytylophorine N-oxide

7-Demethoxytylophorine N-oxide is an alkaloid inhibitor of Tobacco Mosaic Virus. 7-Demethoxytylophorine N-oxide can be isolated from the aerial parts of Cynanchum komarovii. 7-Demethoxytylophorine N-oxide is applicable to research related to Tobacco Mosaic Virus infection.

For research use only. We do not sell to patients.

CAS No.: 128922-80-5
Formula: C₂₃H₂₅NO₄
Molecular Weight:379.45

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

7-Demethoxytylophorine N-oxide Chemical Structure

CAS No.: 128922-80-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
KB 3-1	IC₅₀	0.11 μM Compound: 1	Cytotoxicity against drug-resistant human KB31 cells after 72 hrs by MTS reduction assay Cytotoxicity against drug-resistant human KB31 cells after 72 hrs by MTS reduction assay	[PMID: 11087617]

In Vivo

7-Demethoxytylophorine N-oxide (500 μg/mL; immersion; 2 seconds) shows 60% inhibition of tobacco mosaic virus infection in Nicotiana chinensis leaves^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Tobacco plant^[1]
Dosage:

500 μg/mL
Administration:

immersion; 2 seconds
Result:

Inhibited tobacco mosaic virus-induced inflammations by 60%.

Chemical Information

CAS No. 128922-80-5
Molecular Weight 379.45
Formula C₂₃H₂₅NO₄
SMILES

[O-][N+]12CC3=C(C=CC(OC)=C4)C4=C(C=C(C(OC)=C5)OC)C5=C3C[C@@]1([H])CCC2
Structure Classification
- Alkaloids
- Other Alkaloids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. An T, et al. Alkaloids from Cynanchum komarovii with inhibitory activity against the tobacco mosaic virus. Phytochemistry. 2001;58(8):1267-1269. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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