1. Apoptosis
  2. Apoptosis
  3. Conophylline

Conophylline 

Cat. No.: HY-N3619 Purity: >98.0%
Handling Instructions

Conophylline is a vinca alkaloid extracted from leaves of a tropical plant Ervatamia microphylla. Conophylline is a differentiation inducer of for pancreatic cells. Conophylline suppresses HSC and induces apoptosis.

For research use only. We do not sell to patients.

Conophylline Chemical Structure

Conophylline Chemical Structure

CAS No. : 142741-24-0

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Description

Conophylline is a vinca alkaloid extracted from leaves of a tropical plant Ervatamia microphylla. Conophylline is a differentiation inducer of for pancreatic cells. Conophylline suppresses HSC and induces apoptosis[1][2].

In Vitro

Conophylline (100 ng/ml; 48 hours) reproduces differentiationinducing activity but not apoptosis-inducing activity of activin[1].
Conophylline (100 ng/ml; 72 hours) exhibits the differentiation-inducing activity in AR42J cells and converts these cells to endocrine cells[1].
Conophylline increases the expression of neurogenin-3 by activating p38 mitogen-activated protein kinase to induce differentiation of AR42J cells[1].
Conophylline reduces the expression of α-SMA and collagen-1 in rat HSC and Lx-2 cells[2].
Conophylline inhibits DNA synthesis induced by serum[2].
Conophylline also promots activation of caspase-3 and induces apoptosis in Lx-2 Cells[2].

Apoptosis Analysis[2]

Cell Line: Lx-2 Cells
Concentration: 12 hours
Incubation Time: 0.1 μg/ml
Result: Induced apoptosis

Western Blot Analysis[2]

Cell Line: Lx-2 cells
Concentration: 0.1 μg/ml
Incubation Time: 15 minutes, 30 minutes, 60 minutes, 120 minutes
Result: Increased phospho-JNK.
In Vivo

Conophylline (0.9 mg/kg; p.o.; daily; for 12 weeks) attenuates formation of the liver fibrosis induced by TAA in vivo[2].

Animal Model: Sprague-Dawley rats (70-80 g)[2]
Dosage: 0.9 mg/kg
Administration: Oral administration; daily; for 12 weeks
Result: Attenuated formation of the liver fibrosis induced by TAA.
Molecular Weight

794.89

Formula

C₄₄H₅₀N₄O₁₀

CAS No.

142741-24-0

SMILES

CCC12C3C4(C(NC5=C(C(OC)=C(C=C45)O)OC)=C(C2)C(OC)=O)CCN3C6C(C1O)OC7=CC8=C(C=C67)C9(CCN%10CC%11C%12O%11)C%10C%12(CC)CC(C(OC)=O)=C9N8

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
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Keywords:

ConophyllineApoptosisDifferentiationinducerpancreaticHSCInhibitorinhibitorinhibit

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