Conophylline 

Conophylline is a vinca alkaloid extracted from leaves of a tropical plant Ervatamia microphylla. Conophylline is a differentiation inducer of for pancreatic cells. Conophylline suppresses HSC and induces apoptosis^[1][2].

Conophylline (100 ng/ml; 48 hours) reproduces differentiationinducing activity but not apoptosis-inducing activity of activin^[1].
? Conophylline (100 ng/ml; 72 hours) exhibits the differentiation-inducing activity in AR42J cells and converts these cells to endocrine cells^[1].
? Conophylline increases the expression of neurogenin-3 by activating p38 mitogen-activated protein kinase to induce differentiation of AR42J cells^[1].
? Conophylline reduces the expression of α-SMA and collagen-1 in rat HSC and Lx-2 cells^[2].
? Conophylline inhibits DNA synthesis induced by serum^[2].
? Conophylline also promots activation of caspase-3 and induces apoptosis in Lx-2 Cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Conophylline (0.9 mg/kg; p.o.; daily; for 12 weeks) attenuates formation of the liver fibrosis induced by TAA in vivo^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

794.89

C₄₄H₅₀N₄O₁₀

142741-24-0

Solid

Off-white to light yellow

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Room temperature in continental US; may vary elsewhere.

• [1]. Kojima I, et al. Conophylline: a novel differentiation inducer for pancreatic beta cells. Int J Biochem Cell Biol. 2006;38(5-6):923-30.  [Content Brief]

  [2]. Kubo N, et al. Conophylline suppresses hepatic stellate cells and attenuates thioacetamide-induced liver fibrosis in rats. Liver Int. 2014 Aug;34(7):1057-67.  [Content Brief]