Cytotoxic indole alkaloids from Tabernaemontana divaricata

  • J Nat Prod. 2013 Aug 23;76(8):1406-12. doi: 10.1021/np400130y.
Mei-Fen Bao  1 ,  Ju-Ming Yan ,  Gui-Guang Cheng ,  Xing-Yao Li ,  Ya-Ping Liu ,  Yan Li ,  Xiang-Hai Cai ,  Xiao-Dong Luo
Affiliations
  • 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
PMID: 23944995 DOI: 10.1021/np400130y
Abstract

Five new vobasinyl-ibogan-type bisindole Alkaloids, tabernaricatines A-E (1-5), two new monomers, tabernaricatines F and G (6 and 7), and 24 known Indole Alkaloids were isolated from the aerial parts of Tabernaemontana divaricata. Alkaloids 1 and 2 are the first vobasinyl-ibogan-type Alkaloids possessing a six-membered ring via an ether linkage between C-17 and C-21. All compounds except for 3 were evaluated for their cytotoxicity against five human Cancer cell lines; conophylline showed significant bioactivity against HL-60, SMMC-7721, A-549, MCF-7, and SW480 cells with IC₅₀ values of 0.17, 0.35, 0.21, 1.02, and 1.49 μM, respectively.