2. GPCR/G Protein Neuronal Signaling Membrane Transporter/Ion Channel
  3. mAChR nAChR
  4. Arecoline hydrochloride

Arecoline hydrochloride, a naturally brain-penetrant and orally active occurring psychoactive alkaloid, is a partial agonist of nicotinic and muscarinic acetylcholine receptor. Arecoline hydrochloride exhibits stimulation, alertness, anxiolysis and anti-parasitic effects. Arecoline hydrochloride also can induce oxidative stress.

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CAS No. : 61-94-9

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Arecoline hydrochloride Related Antibodies

Top Publications Citing Use of Products

    Arecoline hydrochloride purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2025 Mar 26:294:118108.  [Abstract]

    Arecoline exhibited a relatively strong binding affinity to PTGS2 in vitro, with a KD value of 10.47 μM.

    Arecoline hydrochloride purchased from MedChemExpress. Usage Cited in: Vet Microbiol. 2025 Dec 15:312:110818.  [Abstract]

    Arecoline (i.p.; single dose) stimulation led to a significant decrease in hepatic and intestinal GSH, SOD, and CAT activities and a significant increase in the MDA content, which were reversed by eFT508 (i.g.; 12 h) administration in BALB/c mice.

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    Description

    Arecoline hydrochloride, a naturally brain-penetrant and orally active occurring psychoactive alkaloid, is a partial agonist of nicotinic and muscarinic acetylcholine receptor. Arecoline hydrochloride exhibits stimulation, alertness, anxiolysis and anti-parasitic effects. Arecoline hydrochloride also can induce oxidative stress[1][2][3][4][5].

    IC50 & Target

    nAChR/mAChR[3]
    In Vitro

    Arecoline hydrochloride induces the generation of reactive oxygen species and cell cycle arrest at the G1/G0 phase in HaCaT cells without affecting the expression of p21/Cip1. Arecoline hydrochloride-induced epithelial cell death at higher concentrations is caused by oxidative trauma without eliciting apoptosis. Arecoline hydrochloride upregulates the expression of the following stress-responsive genes: hemeoxygenase-1; ferritin light chain; glucose-6-phosphate dehydrogenase; glutamatecysteine ligase catalytic subunit; and glutathione reductase[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Arecoline hydrochloride Related Antibodies
    In Vivo

    Arecoline (0.2% in water; p.o., 2 weeks) hydrochloride alleviates the anxiety and depression in CFA (HY-153808)-induced mice[5].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Molecular Weight

    191.66

    Formula

    C8H14ClNO2
    CAS No.
    SMILES

    O=C(OC)C1=CCCN(C1)C.[H]Cl
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    Arecoline hydrochloride Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Arecoline61-94-9mAChRnAChRMuscarinic acetylcholine receptorNicotinic acetylcholine receptorsalkaloidnicotinicmuscarinicacetylcholinestimulationalertnessanxiolysisparasiticoxidativestressInhibitorinhibitorinhibit

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