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Cat. No.: HY-B0489A

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Arecoline hydrochloride

Name: Arecoline hydrochloride
Brand: MedChemExpress
SKU: HY-B0489A
Availability: PreOrder

7 Cited Publications

Customer Review

Based on 7 publication(s) in Google Scholar

Arecoline hydrochloride, a naturally brain-penetrant and orally active occurring psychoactive alkaloid, is a partial agonist of nicotinic and muscarinic acetylcholine receptor. Arecoline hydrochloride exhibits stimulation, alertness, anxiolysis and anti-parasitic effects. Arecoline hydrochloride also can induce oxidative stress.

For research use only. We do not sell to patients.

CAS No.: 61-94-9
Formula: C₈H₁₄ClNO₂
Molecular Weight:191.66

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Arecoline hydrochloride Chemical Structure

CAS No.: 61-94-9

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (7)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

nAChR/mAChR^[3]

All mAChR Isoforms :

In Vitro

Arecoline hydrochloride induces the generation of reactive oxygen species and cell cycle arrest at the G1/G0 phase in HaCaT cells without affecting the expression of p21/Cip1. Arecoline hydrochloride-induced epithelial cell death at higher concentrations is caused by oxidative trauma without eliciting apoptosis. Arecoline hydrochloride upregulates the expression of the following stress-responsive genes: hemeoxygenase-1; ferritin light chain; glucose-6-phosphate dehydrogenase; glutamatecysteine ligase catalytic subunit; and glutathione reductase^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Arecoline (0.2% in water; p.o., 2 weeks) hydrochloride alleviates the anxiety and depression in CFA (HY-153808)-induced mice^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 61-94-9
Molecular Weight 191.66
Formula C₈H₁₄ClNO₂
SMILES

O=C(OC)C1=CCCN(C1)C.[H]Cl
Structure Classification
- Alkaloids
- Other Alkaloids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (7)

All Bio/Physico-chemical AssayCell Imaging/StainingWBIF

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Journal Impact Factor

Cardiovasc Diabetol

2026 Jan 14;25(1):38. PMID: 41535924
Ecotoxicol Environ Saf

Assessing the carcinogenic potential and molecular mechanisms of arecoline in human lungs: from in silico methods to in vitro validation. [Abstract]

2025 Apr 1:294:118108. PMID: 40147173

Arecoline hydrochloride purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2025 Apr 1:294:118108. [Abstract]

Arecoline exhibited a relatively strong binding affinity to PTGS2 in vitro, with a K_D value of 10.47 μM.
Int J Mol Sci

Oxidative Stress and Endoplasmic Reticulum Stress Contributes to Arecoline and Its Secondary Metabolites-Induced Dyskinesia in Zebrafish Embryos. [Abstract]

2023 Mar 28;24(7):6327. PMID: 37047326
Sci Rep

Pomolic acid alleviates CCl4‑induced liver fibrosis in mice by suppressing β-arrestin 2-mediated pro-fibrotic macrophage polarization. [Abstract]

2026 Mar 31. PMID: 41917130
Vet Microbiol

Mechanistic link between eIF4E phosphorylation and viral pathogenesis: Therapeutic insights from a porcine model. [Abstract]

2026 Jan:312:110818. PMID: 41418357

Arecoline hydrochloride purchased from MedChemExpress. Usage Cited in: Vet Microbiol. 2026 Jan:312:110818. [Abstract]

Arecoline (i.p.; single dose) stimulation led to a significant decrease in hepatic and intestinal GSH, SOD, and CAT activities and a significant increase in the MDA content, which were reversed by eFT508 (i.g.; 12 h) administration in BALB/c mice.
J Oral Pathol Med

Overexpression of DEC1 in the epithelium of OSF promotes mesenchymal transition via activating FAK/Akt signal axis. [Abstract]

2022 Oct;51(9):780-790. PMID: 36053880

Arecoline hydrochloride purchased from MedChemExpress. Usage Cited in: J Oral Pathol Med. 2022 Oct;51(9):780-790. [Abstract]

Cell morphological images of HOKs after treatment with Arecoline (Arecoline hydrobromide; 150 μM; 24 h) and/or hypoxia (scale bar = 100 μm). Several HOKs treated with Arecoline (150 μM) and/or hypoxia (24 h) presented morphological alterations similar to mesenchymal cells, and were most pronounced with combination treatment.

Arecoline hydrochloride purchased from MedChemExpress. Usage Cited in: J Oral Pathol Med. 2022 Oct;51(9):780-790. [Abstract]

Western blot analysis of DEC1 expression in HOKs after treatment with Arecoline (Arecoline hydrobromide; 0-150 μM; 24 h). Arecoline dose-dependently increased DEC1 expression.

Arecoline hydrochloride purchased from MedChemExpress. Usage Cited in: J Oral Pathol Med. 2022 Oct;51(9):780-790. [Abstract]

Fluorescence triple staining of DEC1 (red), phosphorylated FAK (Y397; green), and phosphorylated Akt (Ser473; magenta) in the oral mucosal epithelium of mice after local buccal mucosal injection of Arecoline (Arecoline hydrobromide; 10 mg/kg; once daily) for 2 weeks. Arecoline-induced OSF tissues showed higher DEC1, phosphorylated FAK, and phosphorylated Akt expression than normal oral mucosa.
SSRN

2026 Jul 6.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Thangjam GS, et, al. Regulation of oxidative-stress responsive genes by arecoline in human keratinocytes. J Periodontal Res. 2009 Oct;44(5):673-82. [Content Brief]

[2]. Liu YJ, et, al. The pharmacology, toxicology and potential applications of arecoline: a review. Pharm Biol. 2016 Nov;54(11):2753-2760. [Content Brief]

[3]. Volgin AD, et, al. DARK Classics in Chemical Neuroscience: Arecoline. ACS Chem Neurosci. 2019 May 15;10(5):2176-2185. [Content Brief]

[4]. Kuo TM, et, al. Arecoline induces TNF-alpha production and Zonula Occludens-1 redistribution in mouse Sertoli TM4 cells. J Biomed Sci. 2014 Sep 9;21(1):93. [Content Brief]

[5]. Chen QY, et al. Inhibition of cortical synaptic transmission, behavioral nociceptive, and anxiodepressive-like responses by arecoline in adult mice. Mol Brain. 2024 Jun 17;17(1):39. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

Arecoline hydrochloride

7 Cited Publications

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (7)
Purity & Documentation
References

1/16
1/16

Arecoline hydrochloride purchased from MedChemExpress. Usage Cited in: Vet Microbiol. 2026 Jan:312:110818. [Abstract]

Customer Validation
Arecoline (i.p.; single dose) stimulation led to a significant decrease in hepatic and intestinal GSH, SOD, and CAT activities and a significant increase in the MDA content, which were reversed by eFT508 (i.g.; 12 h) administration in BALB/c mice.
1/16

Arecoline hydrochloride purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2025 Apr 1:294:118108. [Abstract]

Customer Validation
Arecoline exhibited a relatively strong binding affinity to PTGS2 in vitro, with a K_D value of 10.47 μM.
1/16

Arecoline hydrochloride purchased from MedChemExpress. Usage Cited in: J Oral Pathol Med. 2022 Oct;51(9):780-790. [Abstract]

Customer Validation
Cell morphological images of HOKs after treatment with Arecoline (Arecoline hydrobromide; 150 μM; 24 h) and/or hypoxia (scale bar = 100 μm). Several HOKs treated with Arecoline (150 μM) and/or hypoxia (24 h) presented morphological alterations similar to mesenchymal cells, and were most pronounced with combination treatment.
1/16

Arecoline hydrochloride purchased from MedChemExpress. Usage Cited in: J Oral Pathol Med. 2022 Oct;51(9):780-790. [Abstract]

Customer Validation
Western blot analysis of DEC1 expression in HOKs after treatment with Arecoline (Arecoline hydrobromide; 0-150 μM; 24 h). Arecoline dose-dependently increased DEC1 expression.
1/16

Arecoline hydrochloride purchased from MedChemExpress. Usage Cited in: J Oral Pathol Med. 2022 Oct;51(9):780-790. [Abstract]

Customer Validation
Fluorescence triple staining of DEC1 (red), phosphorylated FAK (Y397; green), and phosphorylated Akt (Ser473; magenta) in the oral mucosal epithelium of mice after local buccal mucosal injection of Arecoline (Arecoline hydrobromide; 10 mg/kg; once daily) for 2 weeks. Arecoline-induced OSF tissues showed higher DEC1, phosphorylated FAK, and phosphorylated Akt expression than normal oral mucosa.

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Arecoline hydrochloride

Publications Citing Use of MedChemExpress (MCE) Arecoline hydrochloride

All mAChR Isoforms