1. GPCR/G Protein Membrane Transporter/Ion Channel Neuronal Signaling
  2. mAChR nAChR
  3. Anagyrine hydrochloride

Anagyrine hydrochloride  (Synonyms: (-)-Anagyrine hydrochloride; Monolupine hydrochloride; Rhombinine hydrochloride)

Cat. No.: HY-121027A
Handling Instructions

Anagyrine ((-)-Anagyrine) hydrochloride is a quinolizidine alkaloid that has been found in Lupinus albus. Anagyrine hydrochloride binds to muscarinic and nicotinic acetylcholine receptors with IC50 values of 132 and 2096 µM respectively. Anagyrine hydrochloride is a potent and effective desensitizer of nAChR, and Anagyrine hydrochloride can directly, without metabolism, desensitize nAChR.

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Anagyrine hydrochloride Chemical Structure

Anagyrine hydrochloride Chemical Structure

CAS No. : 74195-83-8

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Description

Anagyrine ((-)-Anagyrine) hydrochloride is a quinolizidine alkaloid that has been found in Lupinus albus. Anagyrine hydrochloride binds to muscarinic and nicotinic acetylcholine receptors with IC50 values of 132 and 2096 µM respectively. Anagyrine hydrochloride is a potent and effective desensitizer of nAChR, and Anagyrine hydrochloride can directly, without metabolism, desensitize nAChR[1][2][3].

In Vitro

Anagyrine acts as a partial agonist in both cell lines with EC50 values of 4.2 and 231 μM in SH-SY5Y and TE-671 cells, respectively. Anagyrine is a desensitizer of nAChR with DC50 values of 6.9 and 139 μM in SH-SY5Y and TE-671 cells, respectively[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

280.79

Formula

C15H21ClN2O

CAS No.
SMILES

O=C1N2C([C@]3([H])C[C@]([C@]4([H])N(CCCC4)C3)([H])C2)=CC=C1.Cl

Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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Anagyrine hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Anagyrine hydrochloride
Cat. No.:
HY-121027A
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