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  2. Disease Research Fields Plants Alkaloids
  3. Ranunculaceae Cancer Isoquinoline Alkaloids
  4. Coptis chinensis Franch.
  5. 8-Oxocoptisine

8-Oxocoptisine is a natural protoberberine alkaloid with anti-cancer activity.

For research use only. We do not sell to patients.

8-Oxocoptisine Chemical Structure

8-Oxocoptisine Chemical Structure

CAS No. : 19716-61-1

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Based on 1 publication(s) in Google Scholar

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Description

8-Oxocoptisine is a natural protoberberine alkaloid with anti-cancer activity[1].

In Vitro

8-Oxocoptisine has cytotoxicity against NCI-N87 (IC50=20.31 μM) and has no cytotoxicity against Caco-2 (IC50>100 μM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

335.31

Formula

C19H13NO5

CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1N2C(C3=CC(OCO4)=C4C=C3CC2)=CC5=CC=C6C(OCO6)=C15

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 2.08 mg/mL (6.20 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9823 mL 14.9116 mL 29.8231 mL
5 mM 0.5965 mL 2.9823 mL 5.9646 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9823 mL 14.9116 mL 29.8231 mL 74.5579 mL
5 mM 0.5965 mL 2.9823 mL 5.9646 mL 14.9116 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
8-Oxocoptisine
Cat. No.:
HY-N8346
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