Dauricumine
Dauricumine is a chlorinated alkaloid that inhibits NF-κB ligand-induced differentiation of mouse bone marrow-derived macrophages into multinucleated osteoclasts.
For research use only. We do not sell to patients.
- CAS No.: 345641-00-1
- Formula: C19H24ClNO6
- Molecular Weight:397.85
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 2.2.15 | CC50 |
2.193 mM
Compound: 6
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Cytotoxicity against human Hep G2.2.15 cells
Cytotoxicity against human Hep G2.2.15 cells
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[PMID: 17723297] |
| HepG2 2.2.15 | IC50 |
>3.291 mM
Compound: 6
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Antiviral activity against HBV transfected Hep G2.2.15 cells assessed as inhibition of e antigen HBsAg secretion
Antiviral activity against HBV transfected Hep G2.2.15 cells assessed as inhibition of e antigen HBsAg secretion
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[PMID: 17723297] |
| HepG2 2.2.15 | IC50 |
1.312 mM
Compound: 6
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Antiviral activity against HBV transfected Hep G2.2.15 cells assessed as inhibition of surface antigen HBsAg secretion
Antiviral activity against HBV transfected Hep G2.2.15 cells assessed as inhibition of surface antigen HBsAg secretion
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[PMID: 17723297] |
Chemical Information
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CAS No. 345641-00-1
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Molecular Weight 397.85
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Formula C19H24ClNO6
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SMILES
COC([C@@]12[C@](C3)(CCN2C)[C@@]4([C@H](C1)Cl)[C@H](C(OC)=CC4=O)O)=C(OC)C3=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Sugimoto Y, et, al. Chlorinated alkaloids in Menispermum dauricum DC: root culture. J Org Chem. 2001 May 18;66(10):3299-302. [Content Brief]
[2]. Lee JY, et, al. Anti-osteoclastogenic effects of isoquinoline alkaloids from the rhizome extract of Sinomenium acutum. Arch Pharm Res. 2016 May;39(5):713-20. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Dauricumine Related Classifications
HY-N11494 Related Classifications
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