345641-00-1
345641-00-1
Chemical Structure
Dauricumine
- CAS No.: 345641-00-1
- Formula:C19H24ClNO6
- Molecular Weight:397.85
IUPAC Name: (1R,2R,2'S,3a'S,7a'S)-2'-chloro-2-hydroxy-3,4',5'-trimethoxy-10'-methyl-2',3'-dihydrospiro[cyclopentane-1,1'-[3a,7a](epiminoethano)inden]-3-ene-5,6'(7'H)-dione
InChIKey: FSXRARBVZZKCGJ-WPLONRSQSA-N
SMILES: COC([C@@]12[C@](C3)(CCN2C)[C@@]4([C@H](C1)Cl)[C@H](C(OC)=CC4=O)O)=C(OC)C3=O
Biological Activity: Dauricumine is a chlorinated alkaloid that inhibits NF-κB ligand-induced differentiation of mouse bone marrow-derived macrophages into multinucleated osteoclasts[1][2].
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Dauricumine | Dauricumine is a chlorinated alkaloid that inhibits NF-κB ligand-induced differentiation of mouse bone marrow-derived macrophages into multinucleated osteoclasts. | |||||||||||||||||||||
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References
- [1]. Sugimoto Y, et, al. Chlorinated alkaloids in Menispermum dauricum DC: root culture. J Org Chem. 2001 May 18;66(10):3299-302. [Content Brief]
- [2]. Lee JY, et, al. Anti-osteoclastogenic effects of isoquinoline alkaloids from the rhizome extract of Sinomenium acutum. Arch Pharm Res. 2016 May;39(5):713-20. [Content Brief]
