L-Hyoscyamine-d3
Based on 1 Customer Validation
L-Hyoscyamine-d3 is the deuterium labeled L-Hyoscyamine. L-Hyoscyamine (Daturine), a natural plant tropane alkaloid, is a potent and competitive muscarinic receptor (MR) antagonist. L-Hyoscyamine is a levo-isomer to Atropine (HY-B1205).
For research use only. We do not sell to patients.
- Purity: 98.87%
- CAS No.: 3032205-96-9
- Formula: C17H20D3NO3
- Molecular Weight:292.39
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 3032205-96-9
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Unlabeled Cas 101-31-5
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Appearance Solid
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Molecular Weight 292.39
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Formula C17H20D3NO3
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Color White to off-white
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SMILES
O=C([C@@H](C1=CC=CC=C1)CO)O[C@H]2C[C@H]3CC[C@H](N3C([2H])([2H])[2H])C2
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Synonyms
Daturine-d3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (342.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Lars Göran Axelsson, et al. Regulatory role of 5-HT and muscarinic receptor antagonists on the migrating myoelectric complex in rats. Eur J Pharmacol. 2003 Apr 25;467(1-3):211-8. [Content Brief]
[3]. Harald John, et al. Application of an enantioselective LC-ESI MS/MS procedure to determine R- and S-hyoscyamine following intravenous atropine administration in swine. Drug Test Anal. Mar-Apr 2012;4(3-4):194-8. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.4201 mL | 17.1004 mL | 34.2009 mL | 85.5022 mL |
| 5 mM | 0.6840 mL | 3.4201 mL | 6.8402 mL | 17.1004 mL | |
| 10 mM | 0.3420 mL | 1.7100 mL | 3.4201 mL | 8.5502 mL | |
| 15 mM | 0.2280 mL | 1.1400 mL | 2.2801 mL | 5.7001 mL | |
| 20 mM | 0.1710 mL | 0.8550 mL | 1.7100 mL | 4.2751 mL | |
| 25 mM | 0.1368 mL | 0.6840 mL | 1.3680 mL | 3.4201 mL | |
| 30 mM | 0.1140 mL | 0.5700 mL | 1.1400 mL | 2.8501 mL | |
| 40 mM | 0.0855 mL | 0.4275 mL | 0.8550 mL | 2.1376 mL | |
| 50 mM | 0.0684 mL | 0.3420 mL | 0.6840 mL | 1.7100 mL | |
| 60 mM | 0.0570 mL | 0.2850 mL | 0.5700 mL | 1.4250 mL | |
| 80 mM | 0.0428 mL | 0.2138 mL | 0.4275 mL | 1.0688 mL | |
| 100 mM | 0.0342 mL | 0.1710 mL | 0.3420 mL | 0.8550 mL |
L-Hyoscyamine-d3 Related Classifications
HY-N0471S Related Classifications
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