1. Neuronal Signaling
  2. Amyloid-β
  3. (-)Clausenamide

(-)Clausenamide 

Cat. No.: HY-116753
Handling Instructions

(-)Clausenamide is an active alkaloid isolated from the leaves of Clausena lansium (Lour.) Skeels, and improves cognitive function in both normal physiological and pathological conditions. (-)Clausenamide inhibits β-amyloid (Aβ) toxicity, blocking neurofibrillary tangle formation by inhibiting the phosphorylation of tau protein. (-)Clausenamide exerts a significant neuroprotective activity against Aβ25-35. (-)Clausenamide can be used for researching Alzheimer's disease (AD).

For research use only. We do not sell to patients.

(-)Clausenamide Chemical Structure

(-)Clausenamide Chemical Structure

CAS No. : 201529-58-0

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Description

(-)Clausenamide is an active alkaloid isolated from the leaves of Clausena lansium (Lour.) Skeels, and improves cognitive function in both normal physiological and pathological conditions. (-)Clausenamide inhibits β-amyloid (Aβ) toxicity, blocking neurofibrillary tangle formation by inhibiting the phosphorylation of tau protein. (-)Clausenamide exerts a significant neuroprotective activity against Aβ25-35. (-)Clausenamide can be used for researching Alzheimer's disease (AD)[1][2][3].

In Vitro

(-)Clausenamide (10 and 100 μM) reverses the overload in [Ca2+]i level stimulated by Aβ25-35, and reduces Aβ-mediated cell apoptosis in PC12 cells[3].
(-)Clausenamide (10 and 100 μM) inhibits the phosphorylation of p38 MAPK, down-regulates the expression of P53 and cleaved Caspase-3 and the ratio of Bax/Bcl-2, in Aβ25-35-treated PC12 cells[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

297.35

Formula

C18H19NO3

CAS No.
SMILES

O[[email protected]@H](C1=CC=CC=C1)[[email protected]@](N2C)([H])[[email protected]](C3=CC=CC=C3)([H])[[email protected]@H](C2=O)O

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
(-)Clausenamide
Cat. No.:
HY-116753
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