201529-58-0
Chemical Structure
(-)Clausenamide
- CAS No.: 201529-58-0
- Formula:C18H19NO3
- Molecular Weight:297.35
IUPAC Name: (3S,4R,5R)-3-hydroxy-5-((S)-hydroxy(phenyl)methyl)-1-methyl-4-phenylpyrrolidin-2-one
InChIKey: WGYGSZOQGYRGIP-NCOADZHNSA-N
SMILES: O[C@@H](C1=CC=CC=C1)[C@@](N2C)([H])[C@](C3=CC=CC=C3)([H])[C@@H](C2=O)O
Biological Activity: (-)Clausenamide is an active alkaloid isolated from the leaves of Clausena lansium (Lour.) Skeels, and improves cognitive function in both normal physiological and pathological conditions. (-)Clausenamide inhibits β-amyloid (Aβ) toxicity, blocking neurofibrillary tangle formation by inhibiting the phosphorylation of tau protein. (-)Clausenamide exerts a significant neuroprotective activity against Aβ25-35. (-)Clausenamide can be used for researching Alzheimer's disease (AD)[1][2][3].
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(-)Clausenamide | 99.92% | (-)Clausenamide is an active alkaloid isolated from the leaves of Clausena lansium (Lour.) Skeels, and improves cognitive function in both normal physiological and pathological conditions. (-)Clausenamide inhibits β-amyloid (Aβ) toxicity, blocking neurofibrillary tangle formation by inhibiting the phosphorylation of tau protein. (-)Clausenamide exerts a significant neuroprotective activity against Aβ25-35. (-)Clausenamide can be used for researching Alzheimer's disease (AD). | ||||||||||||||||||||
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- [1]. Chu S, Liu S, Duan W, et al. The anti-dementia drug candidate, (-)-clausenamide, improves memory impairment through its multi-target effect. Pharmacol Ther. 2016;162:179-187. [Content Brief]
- [2]. Chu SF, Zhang JT. Recent advances in the study of (-)clausenamide: chemistry, biological activities and mechanism of action. Acta Pharm Sin B. 2014;4(6):417-423. [Content Brief]
- [3]. Hu JF, et al. Protective effect of (-)clausenamide against Abeta-induced neurotoxicity in differentiated PC12 cells. Neurosci Lett. 2010 Oct 8;483(1):78-82. [Content Brief]
Keywords
