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Cat. No.: HY-N10323

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Corysamine chloride

Corysamine is an alkaloid derived from Stylophorum lasiocarpum. Corysamine has antimalarial activity (IC₅₀ = 0.26 µM).

For research use only. We do not sell to patients.

CAS No.: 11028-77-6
Formula: C₂₀H₁₆ClNO₄
Molecular Weight:369.80

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Corysamine chloride Chemical Structure

CAS No.: 11028-77-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Corysamine is an alkaloid derived from Stylophorum lasiocarpum^[1]. Corysamine has antimalarial activity (IC₅₀ = 0.26 µM)^[2].

IC₅₀ & Target

Plasmodium falciparum sporozoites

0.26 μM (IC₅₀)

All Parasite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	>5 μg/mL Compound: 4a	Cytotoxicity against human A549 cells assessed as growth inhibition rate after 96 hrs by MTT assay Cytotoxicity against human A549 cells assessed as growth inhibition rate after 96 hrs by MTT assay	[PMID: 25203783]
Bel-7402	IC₅₀	>5 μg/mL Compound: 4a	Cytotoxicity against human Bel7402 cells assessed as growth inhibition rate after 96 hrs by MTT assay Cytotoxicity against human Bel7402 cells assessed as growth inhibition rate after 96 hrs by MTT assay	[PMID: 25203783]
C-33-A	IC₅₀	>5 μg/mL Compound: 4a	Cytotoxicity against human C33A cells assessed as growth inhibition rate after 96 hrs by MTT assay Cytotoxicity against human C33A cells assessed as growth inhibition rate after 96 hrs by MTT assay	[PMID: 25203783]
HCT-8	IC₅₀	>5 μg/mL Compound: 4a	Cytotoxicity against human HCT8 cells assessed as growth inhibition rate after 96 hrs by MTT assay Cytotoxicity against human HCT8 cells assessed as growth inhibition rate after 96 hrs by MTT assay	[PMID: 25203783]

Chemical Information

CAS No. 11028-77-6
Molecular Weight 369.80
Formula C₂₀H₁₆ClNO₄
SMILES

CC1=C2C=CC(OCO3)=C3C2=C[N+]4=C1C5=CC6=C(C=C5CC4)OCO6.[Cl-]
Structure Classification
- Alkaloids
- Quinoline Alkaloids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Slavík, et al. Alkaloids from Stylophorum lasiocarpum (OLIV.) FEDDE. Collection of Czechoslovak Chemical Communications. 1991;56(5):1116–1122.

[2]. Iwasa, Kinuko., et al. Structure-activity relationships of quaternary protoberberine alkaloids having an antimalarial activity. European Journal of Medicinal Chemistry (1999), 34(12), 1077-1083.

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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