2. GPCR/G Protein
  3. Adenosine Receptor
  4. 8-Chloro caffeine

8-Chloro caffeine binds to adenosine receptors (Ki = 30 µM). 8-Chloro caffeine potentiates UV-induced chromosomal aberrations in Cl-I Chinese hamster embryonic lung cells. 8-Chloro caffeine is a derivative of the methylxanthine alkaloid caffeine.

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8-Chloro caffeine

8-Chloro caffeine Chemical Structure

CAS No. : 4921-49-7

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
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50 mg In-stock
100 mg In-stock
500 mg In-stock
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Based on 1 publication(s) in Google Scholar

8-Chloro caffeine Related Antibodies

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Adenosine A1 receptor (A1R) Adenosine A2A receptor (A2AR) Adenosine A2B receptor (A2BR) Adenosine A3 receptor (A3R)

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Description

8-Chloro caffeine binds to adenosine receptors (Ki = 30 µM). 8-Chloro caffeine potentiates UV-induced chromosomal aberrations in Cl-I Chinese hamster embryonic lung cells. 8-Chloro caffeine is a derivative of the methylxanthine alkaloid caffeine[1][2].

Molecular Weight

228.64

Formula

C8H9ClN4O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1C2=C(N(C)C(N1C)=O)N=C(N2C)Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 8.33 mg/mL (36.43 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.3737 mL 21.8684 mL 43.7369 mL
5 mM 0.8747 mL 4.3737 mL 8.7474 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.3737 mL 21.8684 mL 43.7369 mL 109.3422 mL
5 mM 0.8747 mL 4.3737 mL 8.7474 mL 21.8684 mL
10 mM 0.4374 mL 2.1868 mL 4.3737 mL 10.9342 mL
15 mM 0.2916 mL 1.4579 mL 2.9158 mL 7.2895 mL
20 mM 0.2187 mL 1.0934 mL 2.1868 mL 5.4671 mL
25 mM 0.1749 mL 0.8747 mL 1.7495 mL 4.3737 mL
30 mM 0.1458 mL 0.7289 mL 1.4579 mL 3.6447 mL
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8-Chloro caffeine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

8-Chloro caffeine4921-49-7Adenosine ReceptorP1 receptormethylxanthine alkaloid caffeineadenosine receptorshamster embryonic lung cellsInhibitorinhibitorinhibit

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