4921-49-7
4921-49-7
Chemical Structure
8-Chloro caffeine
- CAS. Nr.: 4921-49-7
- Formula:C8H9ClN4O2
- Molecular Weight:228.64
IUPAC Name: 8-chloro-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
InChIKey: HGKPGBJNNATDRR-UHFFFAOYSA-N
SMILES: O=C1C2=C(N(C)C(N1C)=O)N=C(N2C)Cl
Biological Activity: 8-Chloro caffeine binds to adenosine receptors (Ki = 30 µM). 8-Chloro caffeine potentiates UV-induced chromosomal aberrations in Cl-I Chinese hamster embryonic lung cells. 8-Chloro caffeine is a derivative of the methylxanthine alkaloid caffeine[1][2].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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8-Chloro caffeine | 99.86% | 8-Chloro caffeine binds to adenosine receptors (Ki = 30 µM). 8-Chloro caffeine potentiates UV-induced chromosomal aberrations in Cl-I Chinese hamster embryonic lung cells. 8-Chloro caffeine is a derivative of the methylxanthine alkaloid caffeine. | ||||||||||||||||||||
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References
- [1]. Nilsson K, et al. The effect of methylated oxypurines on the size of newly-synthesized DNA and on the production of chromosome aberrations after UV irradiation in Chinese hamster cells. Mutat Res. 1975 Nov;30(2):255-66. [Content Brief]
- [2]. Bruns RF. Adenosine antagonism by purines, pteridines and benzopteridines in human fibroblasts. Biochem Pharmacol. 1981 Feb 15;30(4):325-33. [Content Brief]
