Sampangine
Sampangine is an alkaloid that induces apoptosis by inducing cell cycle arrest in the G0/G1 phase. Sampangine can inhibit the biosynthesis of heme.
For research use only. We do not sell to patients.
- CAS No.: 116664-93-8
- Formula: C15H8N2O
- Molecular Weight:232.24
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A2780 | IC50 |
0.6 μM
Compound: 6
|
Antiproliferative activity against human A2780 cells after 2 days by Alamar Blue assay
Antiproliferative activity against human A2780 cells after 2 days by Alamar Blue assay
|
[PMID: 21504145] |
| BT-549 | IC50 |
6.4 μg/mL
Compound: 4
|
Cytotoxicity against human BT549 cells after 2 to 7 days by neutral red assay
Cytotoxicity against human BT549 cells after 2 to 7 days by neutral red assay
|
[PMID: 11374943] |
| HeLa | IC50 |
>10 μg/mL
Compound: 4
|
Inhibition of LFA1/ICAM1-mediated CFSE-labeled TPA-stimulated human HL60 cell adhesion to ICAM1 expressing human HeLa cells after 45 mins by fluorescence analysis
Inhibition of LFA1/ICAM1-mediated CFSE-labeled TPA-stimulated human HL60 cell adhesion to ICAM1 expressing human HeLa cells after 45 mins by fluorescence analysis
|
[PMID: 11374943] |
| HL-60 | IC50 |
2 μg/mL
Compound: 4
|
Cytotoxicity against human HL60 cells after 7 days by XTT/PMS assay
Cytotoxicity against human HL60 cells after 7 days by XTT/PMS assay
|
[PMID: 11374943] |
| KB | IC50 |
5.3 μg/mL
Compound: 4
|
Cytotoxicity against human KB cells after 2 to 7 days by neutral red assay
Cytotoxicity against human KB cells after 2 to 7 days by neutral red assay
|
[PMID: 11374943] |
| NCI-H460 | IC50 |
0.58 μM
Compound: 6
|
Antiproliferative activity against human H460 cells after 96 hrs by Cell Titre-Glo luminescent assay
Antiproliferative activity against human H460 cells after 96 hrs by Cell Titre-Glo luminescent assay
|
[PMID: 21504145] |
| SK-MEL | IC50 |
0.37 μg/mL
Compound: 4
|
Cytotoxicity against human SK-MEL cells after 2 to 7 days by neutral red assay
Cytotoxicity against human SK-MEL cells after 2 to 7 days by neutral red assay
|
[PMID: 11374943] |
| SK-OV-3 | IC50 |
4.1 μg/mL
Compound: 4
|
Cytotoxicity against human SKOV3 cells after 2 to 7 days by neutral red assay
Cytotoxicity against human SKOV3 cells after 2 to 7 days by neutral red assay
|
[PMID: 11374943] |
Chemical Information
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CAS No. 116664-93-8
-
Molecular Weight 232.24
-
Formula C15H8N2O
-
SMILES
O=C1C2=NC=CC3=CC=NC(C4=C1C=CC=C4)=C32
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)