1. Autophagy
  2. Autophagy
  3. Corynoxine B

Corynoxine B 

Cat. No.: HY-N0901A Purity: 99.76%
Handling Instructions

Corynoxine B is an oxindole alkaloid isolated from Uncaria rhynchophylla (Miq.) Jacks (Gouteng in Chinese); a Beclin-1-dependent autophagy inducer.

For research use only. We do not sell to patients.

Corynoxine B Chemical Structure

Corynoxine B Chemical Structure

CAS No. : 17391-18-3

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 246 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 246 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 224 In-stock
Estimated Time of Arrival: December 31
10 mg USD 368 In-stock
Estimated Time of Arrival: December 31
25 mg USD 736 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 5 publication(s) in Google Scholar

Other Forms of Corynoxine B:

Top Publications Citing Use of Products

    Corynoxine B purchased from MCE. Usage Cited in: Food Chem Toxicol. 2019 Feb;124:336-348.

    The expression levels of Beclin1, LC3II/I, and p62 are determined by western blotting in the control, 200 μM Mn treatment, and Cory B pretreatment groups.

    Corynoxine B purchased from MCE. Usage Cited in: Food Chem Toxicol. 2019 Feb;124:336-348.

    Expression levels of α-SYN and Bcl2 in the whole-cell lysates are determined by western blotting in the control, 200 μM Mn treatment, and Cory B pretreatment groups.

    Corynoxine B purchased from MCE. Usage Cited in: Food Chem Toxicol. 2019 Feb;124:336-348.

    The colocalization of HMGB1 (red) and Beclin1 (green), and Bcl2 (red) and Beclin1 (green) in the control, 200 μM Mn treatment, and 100 μM Cory B pretreatment groups.
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    Description

    Corynoxine B is an oxindole alkaloid isolated from Uncaria rhynchophylla (Miq.) Jacks (Gouteng in Chinese); a Beclin-1-dependent autophagy inducer. IC50 value: Target: Autophagy inducer in vitro: Corynoxine B, a natural autophagy inducer, restores the deficient cytosolic translocation of HMGB1 and autophagy in cells overexpressing SNCA, which may be attributed to its ability to block SNCA-HMGB1 interaction [1]. in vivo: Corynoxine B exhibited prolongation of the thiopental-induced hypnosis on oral administration in mice [2].

    Molecular Weight

    384.47

    Formula

    C22H28N2O4

    CAS No.
    SMILES

    O=C(NC1=C2C=CC=C1)[[email protected]]32[[email protected]@](C[[email protected]](/C(C(OC)=O)=C\OC)[[email protected]](CC)C4)([H])N4CC3

    Structure Classification
    Source
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 83.33 mg/mL (216.74 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.6010 mL 13.0049 mL 26.0098 mL
    5 mM 0.5202 mL 2.6010 mL 5.2020 mL
    10 mM 0.2601 mL 1.3005 mL 2.6010 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.08 mg/mL (5.41 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.08 mg/mL (5.41 mM); Clear solution

    *All of the co-solvents are available by MCE.
    Purity & Documentation

    Purity: 99.76%

    References
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    Product Name:
    Corynoxine B
    Cat. No.:
    HY-N0901A
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