Macrophyllionium and macrophyllines A and B, oxindole alkaloids from Uncaria macrophylla

  • J Nat Prod. 2011 Jan 28;74(1):12-5. doi: 10.1021/np1004938.
Kou Wang  1 ,  Xiao-Yu Zhou ,  Yuan-Yuan Wang ,  Ming-Ming Li ,  Yin-Shan Li ,  Li-Yan Peng ,  Xiao Cheng ,  Yan Li ,  Yi-Ping Wang ,  Qin-Shi Zhao
Affiliations
  • 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
PMID: 21070010 DOI: 10.1021/np1004938
Abstract

An unusual oxindole alkaloid inner salt, macrophyllionium (1), and a pair of new tetracyclic Oxindole Alkaloids, macrophyllines A (2) and B (3), together with six known Alkaloids, were isolated from the aerial parts of Uncaria macrophylla. Corynantheidine (8) exhibited moderate cytotoxicity against HL-60 and SW480 cells with IC(50) values of 13.96 and 23.28 μM, respectively. Dihydrocorynantheine (9) exhibited significant vasodilating activity against phenylephrine-induced contraction in rat thoracic aorta rings (IC(50) = 6.73 μg/mL). In addition, compounds 2, 6, and 9 showed weak inhibitory action on KCl-induced contraction.

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