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Cat. No.: HY-122509

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Senkirkin

(Synonyms: Senkirkine; Renardin)

Senkirkin is a pyrrolizidine alkaloid derived from Tussilago farfara. Senkirkin induces chromosomal damage in lymphocytes and is metabolized by CYP3A4.

For research use only. We do not sell to patients.

Purity: 98.79%
CAS No.: 2318-18-5
Formula: C₁₉H₂₇NO₆
Molecular Weight:365.42

Storage:

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Senkirkin Chemical Structure

CAS No.: 2318-18-5

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Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Bioz

Biological Activity

Description

Senkirkin is a pyrrolizidine alkaloid derived from Tussilago farfara. Senkirkin induces chromosomal damage in lymphocytes and is metabolized by CYP3A4^[1]^[2].

All Cytochrome P450 Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A204	IC₅₀	221 μg/mL Compound: 6	Cytotoxicity against human A204 cells after 24 hrs by soft agar colony forming assay Cytotoxicity against human A204 cells after 24 hrs by soft agar colony forming assay	[PMID: 3210016]

In Vitro

Senkirkin binds to human CYP3A4^[1].
Senkirkin (100 μM; 10 min preincubation, 60 min incubation with NADPH) is metabolized by cDNA-expressed human CYP3A4 and human liver microsomes^[1].
Senkirkin (50-1000 μM; 24 hours) exhibits weak mitosis-inhibitory activity, and reduces the mitotic index to 24.5% at the concentration of 1000 μM in in vitro stimulated human primary lymphocytes^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2318-18-5
Appearance Solid
Molecular Weight 365.42
Formula C₁₉H₂₇NO₆
Color White to off-white
SMILES

O=C(/C(C[C@@H](C)[C@]1(O)C)=C\C)O[C@](C2=O)([H])CCN(C)C/C=C2/COC1=O
Synonyms

Senkirkine; Renardin
Structure Classification
- Alkaloids
- Other Alkaloids
Initial Source
- Plants
- Compositae
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (643 KB)
- English - EN (643 KB)
- Français - FR (643 KB)
- Deutsch - DE (643 KB)
- Norwegian - NO (643 KB)
- Español - ES (643 KB)
- Swedish - SV (643 KB)
- Italian - IT (643 KB)
- Portuguese - PT (643 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Fashe MM, et al. In silico prediction of the site of oxidation by cytochrome P450 3A4 that leads to the formation of the toxic metabolites of pyrrolizidine alkaloids. Chem Res Toxicol. 2015;28(4):702-710. [Content Brief]

[2]. C. Kraus, et al. Untersuchung einiger Pyrrolizidinalkaloide auf chromosomenschädigende Wirkung in menschlichen Lymphocyten in vitro. Planta Med 1985; 51(2): 89-91

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
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- In Vitro
Chemical Information
Purity & Documentation
References

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Senkirkin

Macrocyclic Compound Library

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All Cytochrome P450 Isoforms

Biological Activity

Chemical Information

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Help & FAQs

Senkirkin

Macrocyclic Compound Library

MCE Bioactive Compound Library

Natural Product Library Plus

All Cytochrome P450 Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

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Help & FAQs

Senkirkin Related Classifications

Cat. No.: HY-122509