2318-18-5
2318-18-5
Chemical Structure
Senkirkin
Synonym(s): Senkirkine; Renardin
- CAS No.: 2318-18-5
- Formula:C19H27NO6
- Molecular Weight:365.42
IUPAC Name: (1R,4Z,6R,7R,11Z)-4-ethylidene-7-hydroxy-6,7,14-trimethyl-2,9-dioxa-14-azabicyclo[9.5.1]heptadec-11-ene-3,8,17-trione
InChIKey: HPDHKHMHQGCNPE-QLJRNOHWSA-N
SMILES: O=C(/C(C[C@@H](C)[C@]1(O)C)=C\C)O[C@](C2=O)([H])CCN(C)C/C=C2/COC1=O
Biological Activity: Senkirkin is a pyrrolizidine alkaloid derived from Tussilago farfara. Senkirkin induces chromosomal damage in lymphocytes and is metabolized by CYP3A4[1][2].
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Senkirkin | 98.79% | Senkirkin is a pyrrolizidine alkaloid derived from Tussilago farfara. Senkirkin induces chromosomal damage in lymphocytes and is metabolized by CYP3A4. | ||||||||||||||||||||
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Senkirkin (Standard) | ≥98% | Senkirkin (Standard) is the analytical standard of Senkirkin. This product is intended for research and analytical applications. Senkirkin is a pyrrolizidine alkaloid derived from Tussilago farfara. Senkirkin induces chromosomal damage in lymphocytes and is metabolized by CYP3A4. | ||||||||||||||||||||
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References
- [1]. Fashe MM, et al. In silico prediction of the site of oxidation by cytochrome P450 3A4 that leads to the formation of the toxic metabolites of pyrrolizidine alkaloids. Chem Res Toxicol. 2015;28(4):702-710. [Content Brief]
- [2]. C. Kraus, et al. Untersuchung einiger Pyrrolizidinalkaloide auf chromosomenschädigende Wirkung in menschlichen Lymphocyten in vitro. Planta Med 1985; 51(2): 89-91
