2. NF-κB
  3. NF-κB
  4. (−)-N-Hydroxyapiosporamide

(−)-N-Hydroxyapiosporamide (NHAP), an alkaloid, is an NF-κB inhibitor with potent antitumor activity in vitro and in vivo. (−)-N-Hydroxyapiosporamide can be used for the research of colorectal cancer (CRC).

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(−)-N-Hydroxyapiosporamide

(−)-N-Hydroxyapiosporamide Chemical Structure

CAS No. : 1205676-02-3

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(−)-N-Hydroxyapiosporamide Related Antibodies

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Description

(−)-N-Hydroxyapiosporamide (NHAP), an alkaloid, is an NF-κB inhibitor with potent antitumor activity in vitro and in vivo. (−)-N-Hydroxyapiosporamide can be used for the research of colorectal cancer (CRC)[1].

Cellular Effect
Cell Line Type Value Description References
HCT-116 IC50
0.93 μM
Compound: NHAP
Cytotoxicity against human HCT-116 cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay
Cytotoxicity against human HCT-116 cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay
[PMID: 37243616]
HCT-116 IC50
2.8 μM
Compound: NHAP
Cytotoxicity against human HCT-116 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay
Cytotoxicity against human HCT-116 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay
[PMID: 37243616]
HCT-15 IC50
0.57 μM
Compound: NHAP
Cytotoxicity against human HCT-15 cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay
Cytotoxicity against human HCT-15 cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay
[PMID: 37243616]
HT-29 IC50
0.57 μM
Compound: NHAP
Cytotoxicity against human HT-29 cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay
Cytotoxicity against human HT-29 cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay
[PMID: 37243616]
HT-29 IC50
0.61 μM
Compound: NHAP
Cytotoxicity against human HT-29 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay
Cytotoxicity against human HT-29 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay
[PMID: 37243616]
RKO IC50
0.57 μM
Compound: NHAP
Cytotoxicity against human RKO cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay
Cytotoxicity against human RKO cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay
[PMID: 37243616]
SW-620 IC50
0.57 μM
Compound: NHAP
Cytotoxicity against human SW620 cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay
Cytotoxicity against human SW620 cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay
[PMID: 37243616]
SW480 IC50
0.57 μM
Compound: NHAP
Cytotoxicity against human SW480 cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay
Cytotoxicity against human SW480 cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay
[PMID: 37243616]
Molecular Weight

445.51

Formula

C24H31NO7
CAS No.
SMILES

O=C([C@]1([C@]2([C@@]([H])(C[C@@H](CC2)C)C=C[C@H]1C)[H])[H])C3=C(C([C@@]4([C@H]5[C@@H]([C@@H](CC4)O)O5)O)=CN(O)C3=O)O
Structure Classification
Initial Source

Apiospora montagnei
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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(−)-N-Hydroxyapiosporamide Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(−)-N-Hydroxyapiosporamide1205676-02-3NHAPNF-κBNuclear factor-κBNuclear factor-kappaBalkaloidantitumorcolorectal cancer (CRC)Inhibitorinhibitorinhibit

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