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Cat. No.: HY-W748415

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Acronycine

(Synonyms: Acronine)

Acronycine (Acronine) is an acridone alkaloid.

For research use only. We do not sell to patients.

CAS No.: 7008-42-6
Formula: C₂₀H₁₉NO₃
Molecular Weight:321.37

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Acronycine Chemical Structure

CAS No.: 7008-42-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Acronycine (Acronine) is an acridone alkaloid^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	>100 μM Compound: Acronycine	In vitro cytotoxic activity against human lung A549 cell line) In vitro cytotoxic activity against human lung A549 cell line)	[PMID: 12036369]
HaCaT	IC₅₀	3.2 μM Compound: 1, Acronycine	Antiproliferative activity against human HaCaT cells assessed as dispersed cells after 48 hrs by phase-contrast microscopic analysis Antiproliferative activity against human HaCaT cells assessed as dispersed cells after 48 hrs by phase-contrast microscopic analysis	[PMID: 20850910]
HCT-116	IC₅₀	>100 μM Compound: Acronycine	In vitro cytotoxic activity against human colon HCT116 cell line In vitro cytotoxic activity against human colon HCT116 cell line	[PMID: 12036369]
HL-60	IC₅₀	26.2 μM Compound: acronycine	Ability to inhibit human leukemic HL-60 cell growth in culture Ability to inhibit human leukemic HL-60 cell growth in culture	[PMID: 1635067]
HL-60	IC₅₀	26.2 μM Compound: Acronycine	In vitro antitumor activity against HL60 (Human leukemia) cells. In vitro antitumor activity against HL60 (Human leukemia) cells.	10.1016/S0960-894X(97)00117-0
HRT-18 cell line	IC₅₀	>100 μM Compound: Acronycine	In vitro cytotoxic activity against human colon HRT-18 cell line In vitro cytotoxic activity against human colon HRT-18 cell line	[PMID: 12036369]
HT-29	IC₅₀	>100 μM Compound: Acronycine	Inhibitory concentration of compound against proliferation of colon carcinoma HT-29 cell line Inhibitory concentration of compound against proliferation of colon carcinoma HT-29 cell line	[PMID: 12031316]
HT-29	IC₅₀	>100 μM Compound: Acronycine	In vitro cytotoxic activity against human colon HT-29 cell line In vitro cytotoxic activity against human colon HT-29 cell line	[PMID: 12036369]
KB 3-1	IC₅₀	3.7 μM Compound: 1	Antiproliferative activity against human KB-3-1 cell line by MTT assay Antiproliferative activity against human KB-3-1 cell line by MTT assay	[PMID: 16722658]
KB 3-1	IC₅₀	3.7 μM Compound: 1	Cytotoxicity against human KB-3-1 cells after 96 hrs by MTT assay Cytotoxicity against human KB-3-1 cells after 96 hrs by MTT assay	[PMID: 18947222]
KB 3-1	IC₅₀	3.7 μM Compound: 1	Cytotoxicity against human KB-3-1 cells after 96 hrs by MTT assay Cytotoxicity against human KB-3-1 cells after 96 hrs by MTT assay	[PMID: 25360689]
L1210	IC₅₀	10.4 μM Compound: 1	Cytotoxicity against mouse L1210 cells after 48 hrs by MMT assay Cytotoxicity against mouse L1210 cells after 48 hrs by MMT assay	[PMID: 10096866]
L1210	IC₅₀	19.9 μM Compound: 1	In vitro inhibition of L1210 cell proliferation. In vitro inhibition of L1210 cell proliferation.	[PMID: 10882366]
L1210	IC₅₀	27 μM Compound: Acronycine	Inhibitory concentration of compound against proliferation of murine leukemia L1210 cell line Inhibitory concentration of compound against proliferation of murine leukemia L1210 cell line	[PMID: 12031316]
L1210	IC₅₀	27 μM Compound: Acronycine	In vitro cytotoxic activity against murine leukemia cell line L1210 In vitro cytotoxic activity against murine leukemia cell line L1210	[PMID: 12036369]
L1210	IC₅₀	23 μM Compound: 1	Antiproliferative activity against mouse L1210 cell line by MTT assay Antiproliferative activity against mouse L1210 cell line by MTT assay	[PMID: 16722658]
L1210	IC₅₀	23 μM Compound: 1	Cytotoxicity against mouse L1210 cells after 48 hrs by MTT assay Cytotoxicity against mouse L1210 cells after 48 hrs by MTT assay	[PMID: 18947222]
L1210	IC₅₀	10.4 μM Compound: 10	Cytotoxicity against mouse L1210 cells Cytotoxicity against mouse L1210 cells	[PMID: 19191562]
L1210	IC₅₀	23 μM Compound: 1	Cytotoxicity against mouse L1210 cells after 48 hrs by MTT assay Cytotoxicity against mouse L1210 cells after 48 hrs by MTT assay	[PMID: 25360689]
L1210	IC₅₀	21 μM Compound: Acronycine	Cytotoxicity against mouse L1210 cells after 48 hrs by coulter counter method Cytotoxicity against mouse L1210 cells after 48 hrs by coulter counter method	[PMID: 29324343]
L1210	IC₅₀	23 μM Compound: 1	Cytotoxicity against mouse L1210 cells assessed as cell growth inhibition Cytotoxicity against mouse L1210 cells assessed as cell growth inhibition	[PMID: 35717872]
L1210	IC₅₀	24.1 μM Compound: 1	Compound was tested in vitro for cytotoxicity on L1210 leukemic cells by using MTT assay. Compound was tested in vitro for cytotoxicity on L1210 leukemic cells by using MTT assay.	[PMID: 8941390]
L1210	IC₅₀	25 μM Compound: 1	Cytotoxicity against mouse L1210 cells after 48 hrs by MMT assay Cytotoxicity against mouse L1210 cells after 48 hrs by MMT assay	[PMID: 9514007]

Chemical Information

CAS No. 7008-42-6
Molecular Weight 321.37
Formula C₂₀H₁₉NO₃
SMILES

O=C1C2=C(N(C3=C4C=CC(C)(OC4=CC(OC)=C13)C)C)C=CC=C2
Synonyms

Acronine
Structure Classification
- Alkaloids
- Acridone Alkaloids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Govindachari T R, et al. Alkaloids of Glycosmis pentaphylla (Retz.) correa. Tetrahedron, 1966, 22(10): 3245-3252.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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