1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. Guanfu base G

Guanfu base G 

Cat. No.: HY-N5006
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Guanfu base G is an antiarrhythmic alkaloid isolated from Aconitum coreanum. Guanfu base G inhibits HERG channel current with an IC50 of 17.9 μM.

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Guanfu base G Chemical Structure

Guanfu base G Chemical Structure

CAS No. : 78969-72-9

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Description

Guanfu base G is an antiarrhythmic alkaloid isolated from Aconitum coreanum. Guanfu base G inhibits HERG channel current with an IC50 of 17.9 μM[1][2].

IC50 & Target

IC50: 17.9 μM (HERG channel)[2]

In Vitro

The effects of Guanfu base G is investigated in human embryonic kidney 293 (HEK293) cells transiently transfected with HERG complementary DNA using a whole-cell patch clamp technique. Guanfu base G inhibits HERG channel current in concentration-, voltage-, and time-dependent manners. Guanfu base G shifts the activation curve in a negative direction and accelerated channel inactivation but shows no effect on the inactivation curve. Moreover, Guanfu base G also accelerates channel recovery from inactivation[2].

In Vivo

Guanfu base G (5 mg/kg; intravenous injection; for 5-1200 minutes; rats) treatment in rats after 15 min could be detected the presence of Guanfu base A, about 10% of Guanfu base G in vivo could metabolize to Guanfu base A, which may be related to the metabolic enzymes in the body and its nature-related compounds, however, the substance in the body to eliminate more quickly, could be detected only around 240 min. The pharmacokinetic behavior of Guanfu base G is better in rats, the T1/2 is 4.16 hours. These results indicate that Guanfu base G has a relatively suitable elimination half-life[1].

Animal Model: Rats[1]
Dosage: 5 mg/kg
Administration: Intravenous injection; for 5, 15, 30, 45, 60, 120, 240, 360, 480, 600, 720, 960 and 1200 minutes (Pharmacokinetic study)
Result: The pharmacokinetic behavior was better in rats, the T1/2 was 4.16 hours.
Molecular Weight

471.54

Formula

C₂₆H₃₃NO₇

CAS No.

78969-72-9

SMILES
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Guanfu base GPotassium ChannelKcsAInhibitorinhibitorinhibit

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Guanfu base G
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