78969-72-9
78969-72-9
Chemical Structure
Guanfu base G
- CAS No.: 78969-72-9
- Formula:C26H33NO7
- Molecular Weight:471.54
IUPAC Name: (2S,3aR,3a1R,5S,5aS,7R,8R,9R,10S,10aS,10bS)-7-hydroxy-3a-methyl-12-methylenedecahydro-1H,4H,7H-5,7,10b-(epimethanetriyl)-6a,9-ethanodibenzo[cd,f]indole-2,8,10-triyl triacetate
InChIKey: CXQAPRGJWIADOG-UUOXRBFMSA-N
SMILES: CC(O[C@H]([C@]1([H])[C@H]2OC(C)=O)[C@@]3([H])[C@@]45C6[C@]2(O)C3(CC1=C)C[C@@]7([H])[C@]4([H])[C@@](C)(C[C@H](OC(C)=O)C5)C[N@]67)=O
Biological Activity: Guanfu base G is an antiarrhythmic alkaloid isolated from Aconitum coreanum. Guanfu base G inhibits HERG channel current with an IC50 of 17.9 μM[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Guanfu base G | 99.91% | Guanfu base G is an antiarrhythmic alkaloid isolated from Aconitum coreanum. Guanfu base G inhibits HERG channel current with an IC50 of 17.9 μM. | ||||||||||||||||||||
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References
- [1]. Zhang L, et al. Simultaneous determination of Guanfu base G and its active metabolites by UPLC-MS/MS in rat plasma and its application to a pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Apr 15;957:1-6. [Content Brief]
- [2]. Huang X, et al. Comparative effects of Guanfu base A and Guanfu base G on HERG K+ channel. J Cardiovasc Pharmacol. 2012 Jan;59(1):77-83. [Content Brief]
