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Cat. No.: HY-114791

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Lobelanidine

Lobelanidine is an alkaloid. Lobelanidine can be isolated from Lobelia spp. Lobelanidine is an antagonist of α3β2/α3β4 and α7 nAChR, and inhibits nicotine- and choline-evoked receptor responses. Lobelanidine exhibits anti-addiction properties. Lobelanidine can be used in addiction research.

For research use only. We do not sell to patients.

CAS No.: 552-72-7
Formula: C₂₂H₂₉NO₂
Molecular Weight:339.47

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

Lobelanidine Chemical Structure

CAS No.: 552-72-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Lobelanidine is an alkaloid. Lobelanidine can be isolated from Lobelia spp. Lobelanidine is an antagonist of α3β2/α3β4 and α7 nAChR, and inhibits nicotine- and choline-evoked receptor responses. Lobelanidine exhibits anti-addiction properties. Lobelanidine can be used in addiction research^[1]^[2]^[3]^[4]^[5]^[6].

IC₅₀ & Target

IC₅₀: 2.8 μM (α7 nAChR), 8.2 μM (α3β2/α3β4 nAChR)

Cellular Effect

Cell Line	Type	Value	Description	References
SH-SY5Y	IC50	2.8 μM	Antagonism of α3β2/α3β4 nAChR in SH-SY5Y human neuroblastoma cells assessed as inhibition of agonist-evoked calcium flux after 5 min pre-incubation with Lobelanidine by FLIPR assay. Antagonism of α3β2/α3β4 nAChR in SH-SY5Y human neuroblastoma cells assessed as inhibition of agonist-evoked calcium flux after 5 min pre-incubation with Lobelanidine by FLIPR assay.	26434115
SH-SY5Y	IC50	8.2 μM	Antagonism of α7 nAChR in SH-SY5Y human neuroblastoma cells assessed as inhibition of choline-evoked calcium flux in presence of PNU120596 after 5 min pre-incubation with Lobelanidine by FLIPR assay. Antagonism of α7 nAChR in SH-SY5Y human neuroblastoma cells assessed as inhibition of choline-evoked calcium flux in presence of PNU120596 after 5 min pre-incubation with Lobelanidine by FLIPR assay.	26434115

In Vitro

Lobelanidine (5 min) is a neutral antagonist at α3β2/α3β4 and α7 nAChR in SH-SY5Y cells, with IC₅₀ values of 2.8 µM and 8.2 µM respectively^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

Chemical Information

CAS No. 552-72-7
Molecular Weight 339.47
Formula C₂₂H₂₉NO₂
SMILES

O[C@@H](C1=CC=CC=C1)C[C@@H]2N([C@@H](CCC2)C[C@@H](C3=CC=CC=C3)O)C
Structure Classification
- Alkaloids
- Other Alkaloids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. LEE J, et al. Piperidine derivatives. Part 1. Lobelan and related compounds. The Journal of Organic Chemistry. 1944;9(6):537-46.

[2]. Paz C, et al. (-)-Pentylsedinine, a New Alkaloid from the Leaves of Lobelia tupa with Agonist Activity at Nicotinic Acetylcholine Receptor. Natural product communications. 2015 Aug;10(8):1355-7.

[3]. Fatoki TH, et al. Functional compounds of Lobelia inflata revealed novel potential targets for chronic cough therapy. J Adv Med Pharma Sci. 2018;19:1-3.

[4]. Nardin T, et al. Targeted and untargeted profiling of alkaloids in herbal extracts using online solid-phase extraction and high-resolution mass spectrometry (Q-Orbitrap). Journal of mass spectrometry : JMS. 2016 Sep;51(9):729-41.

[5]. Zhang N, et al. One-step pH shifting for simultaneous protein extraction and bioactive encapsulation from oilseed meals. Food chemistry. 2026 Sep 14;529:151160.

[6]. RAHARJO F S, et al. IDENTIFICATION OF POTENTIAL ALKALOID ANTAGONISTS TO EXPAND SMOKING-CESSATION THERAPEUTICS AND PROVIDE ALTERNATIVE TREATMENTS FOR NICOTINE DEPENDENCE VIA AN IN SILICO APPROACH[J].

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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