552-72-7
552-72-7
Chemical Structure
Lobelanidine
- CAS No.: 552-72-7
- Formula:C22H29NO2
- Molecular Weight:339.47
IUPAC Name: 2,2'-(1-methylpiperidine-2,6-diyl)bis(1-phenylethan-1-ol)
InChIKey: OWGJQNXIWMMDTH-COPRSSIGSA-N
SMILES: O[C@@H](C1=CC=CC=C1)C[C@@H]2N([C@@H](CCC2)C[C@@H](C3=CC=CC=C3)O)C
Biological Activity: Lobelanidine is an alkaloid. Lobelanidine can be isolated from Lobelia spp. Lobelanidine is an antagonist of α3β2/α3β4 and α7 nAChR, and inhibits nicotine- and choline-evoked receptor responses. Lobelanidine exhibits anti-addiction properties. Lobelanidine can be used in addiction research[1][2][3][4][5][6].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Lobelanidine | Lobelanidine is an alkaloid. Lobelanidine can be isolated from Lobelia spp. Lobelanidine is an antagonist of α3β2/α3β4 and α7 nAChR, and inhibits nicotine- and choline-evoked receptor responses. Lobelanidine exhibits anti-addiction properties. Lobelanidine can be used in addiction research. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. LEE J, et al. Piperidine derivatives. Part 1. Lobelan and related compounds. The Journal of Organic Chemistry. 1944;9(6):537-46.
- [2]. Paz C, et al. (-)-Pentylsedinine, a New Alkaloid from the Leaves of Lobelia tupa with Agonist Activity at Nicotinic Acetylcholine Receptor. Natural product communications. 2015 Aug;10(8):1355-7.
- [3]. Fatoki TH, et al. Functional compounds of Lobelia inflata revealed novel potential targets for chronic cough therapy. J Adv Med Pharma Sci. 2018;19:1-3.
- [4]. Nardin T, et al. Targeted and untargeted profiling of alkaloids in herbal extracts using online solid-phase extraction and high-resolution mass spectrometry (Q-Orbitrap). Journal of mass spectrometry : JMS. 2016 Sep;51(9):729-41.
- [5]. Zhang N, et al. One-step pH shifting for simultaneous protein extraction and bioactive encapsulation from oilseed meals. Food chemistry. 2026 Sep 14;529:151160.
- [6]. RAHARJO F S, et al. IDENTIFICATION OF POTENTIAL ALKALOID ANTAGONISTS TO EXPAND SMOKING-CESSATION THERAPEUTICS AND PROVIDE ALTERNATIVE TREATMENTS FOR NICOTINE DEPENDENCE VIA AN IN SILICO APPROACH[J].
