Search Result
Results for "
extracts
" in MedChemExpress (MCE) Product Catalog:
1434
Inhibitors & Agonists
29
Biochemical Assay Reagents
20
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
-
- HY-122924
-
3-Galloylquinic acid
|
Others
|
Neurological Disease
|
Theogallin (3-Galloylquinic acid) is an active ingredient in decaffeinated green tea extract. Theogallin has antidepressive and cognition enhancing effect .
|
-
-
- HY-N7602
-
|
Others
|
Others
|
10-Hydroxy majoroside is a methanol extract isolated from plantago asiatica .
|
-
-
- HY-N3947
-
|
Bacterial
|
Infection
|
Glepidotin B is a dihydroflavonol compound isolated from the extracts of American licorice, Glycyrrhiza lepidota (Leguminosae). Glepidotin B is an antimicrobial agent .
|
-
-
- HY-N8551
-
|
Others
|
Infection
Cancer
|
(5E)-7-Oxozeaenol is an active fungal extract that is cytotoxic. (5E)-7-Oxozeaenol exhibits antibacterial, mitochondrial transmembrane potential, and NF-κB effects .
|
-
-
- HY-N11083
-
|
Others
|
Others
|
Dihydroisocucurbitacin B is an active compound. Dihydroisocucurbitacin B can be extracted from the roots of Wilbrandia ebracteata .
|
-
-
- HY-N3935
-
|
Others
|
Others
|
Gelomulide N is a compound that can be isolated from dichloromethane soluble extract of Gelonium aequoreum .
|
-
-
- HY-W278867
-
cis-Pinosylvin dimethyl ether
|
Others
|
Inflammation/Immunology
|
trans-3,5-Dimethoxystilbene (cis-Pinosylvin dimethyl ether) is a natural product that has been isolated from the benzene extract of the bark of jack pine (Pinus bunksiuna) .
|
-
-
- HY-N10887
-
|
GABA Receptor
|
Neurological Disease
|
Withasomniferolide B is a withanolide. Withasomniferolide B can be isolated from a GABAA receptor positive activator methanol extract of the roots of Withania somnifera .
|
-
-
- HY-N1797
-
|
Others
|
Metabolic Disease
|
3, 7-di-o-methylducheside A (Compound 2) is a ethyl acetate extract of Psittacanthus cucullaris. 3, 7-di-o-methylducheside A stimulates the formation of glycosaminoglycan chains. 3, 7-di-o-methylducheside A can be used to study the rate of glycosaminoglycan synthesis .
|
-
-
- HY-N7699
-
|
Others
|
Infection
|
D-Dimannuronic acid is an alginate extract from brown algae which can be used to synthesize sulfated polymannuronate (SPMG)-derived oligosaccharides .
|
-
-
- HY-N7699H
-
|
Others
|
Infection
|
D-Dimannuronic acid is an alginate extract from brown algae which can be used to synthesize sulfated polymannuronate (SPMG)-derived oligosaccharides .
|
-
-
- HY-N4142
-
Ideain chloride
|
Cholinesterase (ChE)
|
Cardiovascular Disease
|
Cyanidin-3-O-galactoside chloride (Ideain chloride) is a component from extract peel of hawthorn fruit (EPHF) with the value of 179.4 mg/g. EPHF exhibits strong AChE inhibitory activity .
|
-
-
- HY-N9241
-
|
Others
|
Neurological Disease
|
3-Hydroxy-7-methoxyflavone (compound 1) is a
flavonoid. 3-Hydroxy-7-methoxyflavone is isolated from natural Salvia
elegans. 3-Hydroxy-7-methoxyflavone has anti-anxiety effect
.
|
-
-
- HY-N3560
-
6-Methyltaxifolin
|
Others
|
Others
|
Cedeodarin is a taxifolin that can be isolated from Cedms deodara .
|
-
-
- HY-N2661
-
|
Others
|
Others
|
5,7-Dihydroxy-3,4',8-trimethoxyflavone (Substance E) can be isolated from Conyza stricta Willd .
|
-
-
- HY-N7072
-
|
Apoptosis
|
Metabolic Disease
Inflammation/Immunology
Cancer
|
Grape seed extract is a natural product, with anti-inflammatory and anti-proliferative effects. Grape seed extract shows inhibitory activity on the fat-metabolizing enzymes pancreatic lipase and lipoprotein lipase. Grape seed extract induces apoptotic in human colorectal cancer cells .
|
-
-
- HY-W127744
-
-
-
- HY-153126
-
|
Biochemical Assay Reagents
|
Others
|
Yeast extract is a concentrate of the soluble part of yeast, especially Saccharomyces cerevisiae. The main nutritional components of yeast extract include partly hydrolyzed protein with 35-40% of free amino acid, and it also contain B vitamins and some trace elements. Yeast extract can be used as nutrients for bacterial culture media .
|
-
-
- HY-N12033
-
|
Others
|
Cancer
|
4'-Demethylpodophyllotoxone is an intermediate product of the biotransformation of Alternaria alternata S-f6. After 4'-Demethylpodophyllotoxone is modified with 4-(2,3,5,6-tetramethylpyrazine-1) (4-TMP), the resulting novel compound can strongly inhibit the growth of human gastric cancer cell line (BGC-823) .
|
-
-
- HY-13749AS
-
|
Dipeptidyl Peptidase
Autophagy
|
Metabolic Disease
|
Sitagliptin-d4 (phosphate) is the deuterium labeled Sitagliptin phosphate. Sitagliptin phosphate (MK-0431 phosphate) is a potent inhibitor of DPP4 with an IC50 of 19 nM in Caco-2 cell extracts[1][2].
|
-
-
- HY-13749S1
-
MK-0431-d4 hydrochloride
|
Dipeptidyl Peptidase
Autophagy
|
Metabolic Disease
|
Sitagliptin-d4 (hydrochloride) is the deuterium labeled Sitagliptin[1]. Sitagliptin (MK-0431) is a potent inhibitor of DPP4 with an IC50 of 19 nM in Caco-2 cell extracts[2].
|
-
-
- HY-N0257
-
|
Others
|
Others
|
Epimedin A is a natural compound extracted from Herba Epimedii.
|
-
-
- HY-N0926
-
Columbamin; Dehydroisocorypalmine
|
Others
|
Others
|
Columbamine is a quaternary isoquinoline alkaloid extracted from plants.
|
-
-
- HY-N1135
-
-
-
- HY-N8491B
-
|
Others
|
Others
|
(-)-Dihydrocarveol is a metabolite that can be extracted from actinomycetes .
|
-
-
- HY-N12307
-
|
Others
|
Others
|
Gentiiridosides A is EtOH extract from Gentianella acuta .
|
-
-
- HY-N0895
-
Desacetylinulicin
|
Others
|
Infection
Cancer
|
Britannilactone(Desacetylinulicin) is a methanol extract of the dried flower of Inula britannica L.
|
-
-
- HY-N0855
-
Alisol-G; 25-Anhydroalisol A
|
Others
|
Others
|
Alisol G is a natural product extracted from Rhizoma Alismatis.
|
-
-
- HY-U00243
-
-
-
- HY-N4312
-
-
-
- HY-N2282
-
|
|
|
Zingiberen Newsaponin is extracted from isolated from Dioscorea zingiberensis.
|
-
-
- HY-N7705
-
|
Others
|
Others
|
Isoescin Ie is a derivative of Aescine in Aesculi Semen extract .
|
-
-
- HY-N7706
-
|
Others
|
Others
|
Escin Ie is a derivative of Aescine in Aesculi Semen extract .
|
-
-
- HY-N3586
-
Osmanthuside F
|
Others
|
Others
|
Cimidahurinine can be extracted from the seeds of Perilla frutescens .
|
-
-
- HY-N11979
-
|
Others
|
Others
|
Dihydronitidine is an alkaloid can be extracted from Zanthoxylum rhoifolium .
|
-
-
- HY-119642
-
|
Others
|
Others
|
Kopsinine is an indole alkaloid extracted from periwinkle flowers .
|
-
-
- HY-N4017
-
|
Others
|
Others
|
Ikshusterol is a sterol that can be extracted from Hibiscus moscheutos L .
|
-
-
- HY-N0879
-
ψ-Bufarenogin
|
Others
|
Cancer
|
Pseudobufarenogin is a natural compound extracted from toad species with unknown details.
|
-
-
- HY-N0922
-
-
-
- HY-N0167
-
-
-
- HY-N2186
-
|
|
|
Leucoside is a natural compound isolated from tea seed extract .
|
-
-
- HY-N6815
-
|
Others
|
Others
|
Isomogroside V is a sweetener, which extracted from Siraitia grosvenorii (Swingle).
|
-
-
- HY-145589
-
-
-
- HY-133905
-
|
Others
|
Others
|
Pandamine is a natural alkaloid that can be extracted from Panda oleosa .
|
-
-
- HY-N8235
-
|
Others
|
Others
|
Virgaureagenin F is a saponin that can be extracted from the rhizoma bolbostemmae .
|
-
-
- HY-N12092
-
-
-
- HY-N12365
-
|
Others
|
Others
|
Ginsenoside Rs2 is extracted from Panax ginseng root .
|
-
-
- HY-N12366
-
|
Others
|
Others
|
Ginsenoside Rs1 is extracted from Panax ginseng root .
|
-
-
- HY-N12433
-
|
Others
|
Others
|
Tenuiphenone B is a benzophenone isolated from the ethanolic extract of Polygala tenuifolia.
|
-
-
- HY-N0475
-
Hypolide; (+)-Triptophenolide
|
Androgen Receptor
|
Others
|
Triptophenolide is a colorless crystalline plate isolated from ethyl acetate extracts of Tripterygium wilfordii.
|
-
- HY-U00233
-
-
- HY-100119
-
-
- HY-N2271
-
|
|
|
Angeloylgomisin O, a lignin extract of Schisandra rubriflora. Anti-inflammatory properties .
|
-
- HY-N7021
-
-
- HY-N6243
-
-
- HY-N2293
-
|
|
|
Chamigrenal is a natural product that can be extract from the fruits of Schisandra sphenanthera .
|
-
- HY-19497
-
AVE-5530; BART-1741
|
|
|
Canosimibe is a cholesterol absorption inhibitor extracted from patent WO2004087655A1.
|
-
- HY-N1355
-
(+)-Reynosin
|
|
|
Reynosin is a compound isolated from a methanol extract of the fruits of Laurus nobilis .
|
-
- HY-N8662
-
-
- HY-107918
-
-
- HY-N9713
-
|
Others
|
Others
|
Dihydroxyaflavinine (Compound Ⅲ) is an indole metabolite extracted from Aspergillus flavus .
|
-
- HY-N9207
-
|
Others
|
Others
|
Germanicol acetate can be extracted from Euphorbia heterophylla L. and has phytotoxic activity .
|
-
- HY-N3597
-
Diacetylmartynoside
|
Others
|
Others
|
Clerodenoside A is a phenolic glycoside that can be extracted from the stem of Clerodendrum inerme .
|
-
- HY-N5065
-
|
Others
|
Others
|
Gentiournoside D is a natural compound that can be found in G. asclepiadea extracts .
|
-
- HY-N5154
-
|
Others
|
Others
|
Sanggenon W is an isoprenyl flavonoid extracted from mulberry root bark .
|
-
- HY-N0259
-
Epmedin B
|
Others
|
Others
|
Epimedin B, a component extracted from Epimedii Folium, is reported to have antiosteoporotic activity.
|
-
- HY-N0670
-
Tenacissimoside C
|
Others
|
Cancer
|
Tenacissoside H is a Chinese medicine monomer extracted, isolated from Caulis Marsdeniae Tenacissimae.
|
-
- HY-U00320
-
-
- HY-B2118
-
|
Others
|
Endocrinology
|
Pancreatin is the porcine pancreas extract (PPE) which contains the main pancreatic digestive enzymes.
|
-
- HY-100124
-
-
- HY-Y1888
-
-
- HY-100154
-
-
- HY-N0813
-
-
- HY-N2524
-
-
- HY-128937
-
|
Others
|
Cancer
|
EC1454 is an anti-tumor compound, extracted from US20170348376A1 .
|
-
- HY-N0440
-
-
- HY-U00312
-
|
MEK
|
Cancer
|
MEK-IN-1 is a MEK inhibitor extracted from patent WO2008076415A1.
|
-
- HY-117034
-
|
Others
|
Others
|
Rankinidine is an oxindole alkaloid that is isolated from the MeOH extract of the stem of Gelsemium rankinii .
|
-
- HY-N7341
-
|
Others
|
Others
|
8-Deacetylyunaconitine, a diterpenoid alkaloid, can be found in the root extract of A. forrestii .
|
-
- HY-N9451
-
-
- HY-N6572
-
|
Others
|
Others
|
Sutchuenmedin A is a prenylflavonoid. Sutchuenmedin A is isolated from the 70% EtOH extract of Epimedium sutchuenense .
|
-
- HY-W005637
-
-
- HY-145497
-
|
Others
|
Others
|
Dipentamethylenethiuram Tetrasulfide is a material for constructing rubber (extracted from patent CN112876756A) .
|
-
- HY-N3956
-
|
Others
|
Others
|
Glyasperin A is a flavonoid compound isolated from the acetone extract of the leaves of Macaranga gigantea .
|
-
- HY-N10864
-
|
Others
|
Others
|
Imbricataflavone A, a imbricataflavone, can be isolated from 70% ethanol extract of C. chinensis .
|
-
- HY-N1206
-
6-O-(E)-p-Coumaroylcatalpol
|
|
|
Specioside is a novel iridoid glycoside extracted from Catalpa speciosa Warder (Bignoniaceae) .
|
-
- HY-N11900
-
|
Others
|
Others
|
Dihydrodehydrodiconiferyl alcohol 9-Oglucoside can be extracted from G. mangostana L .
|
-
- HY-W194842
-
|
Others
|
Others
|
Harmalan (compound 8) is a alkaloid isolated from the extracts of the leaves of Flindersia laevicarpa .
|
-
- HY-N12370
-
|
Others
|
Others
|
Tenaxin I is a component extracted from Radix Scutellariae with neuraminidase inhibitory activity .
|
-
- HY-N12599
-
|
Others
|
Others
|
Stevioside E is a diterpenoid glycoside which can be extract from Stevia rebaudiana .
|
-
- HY-W794998
-
|
Others
|
Others
|
Cedarwood terpenes is a natural terpene mixture that can be extracted from cedar wood .
|
-
- HY-B0355
-
-
- HY-N0890
-
Tubeimoside-1; Lobatoside-H
|
Apoptosis
|
Cancer
|
Tubeimoside I(Lobatoside-H) is an extract from Chinese herbal medicine Bolbostemma paniculatum (MAXIM.
|
-
- HY-101819
-
|
Bacterial
|
Infection
|
Antibacterial compound 1 is a oxazolidinone extracted from patent WO1999037630A1 with antibacterial activities.
|
-
- HY-108324
-
-
- HY-14802C
-
|
RAR/RXR
Autophagy
|
Cancer
|
(+)-Talarozole is a potent inhibitor of retinoic acid metabolism extracted from patent WO 1997049704 A1.
|
-
- HY-14802D
-
|
RAR/RXR
Autophagy
|
Cancer
|
(-)-Talarozole is a potent inhibitor of retinoic acid metabolism extracted from patent WO 1997049704 A1.
|
-
- HY-19017
-
-
- HY-109073
-
-
- HY-B1179
-
-
- HY-103649
-
-
- HY-100172
-
|
Proteasome
|
Cancer
|
Proteasome-IN-1 is a proteasome inhibitor extracted from patent WO 2013142376 A1.
|
-
- HY-N2605
-
-
- HY-N2220
-
|
|
|
6-Formyl-isoophiopogonanone A is a homoisoflavonoidal extracted from Ophiopogon japonicas, with antioxidant activity .
|
-
- HY-N5041
-
|
Others
|
Others
|
9'''-Methyl salvianolate B is a methanolic extract of Cynoglossum columnae Ten. plants .
|
-
- HY-135298
-
-
- HY-135596
-
Diacyl-raloxifene hydrochloride; Raloxifene diacyl analog
|
Others
|
|
Raloxifene dimethyl ester hydrochloride is an analog of Raloxifene, extracted from patent US5464845A, compound 28 .
|
-
- HY-N7662
-
|
Others
|
Others
|
L-heptaguluronic acid heptasodium salt, extracted from seaweed, is the component of the natural biopolymers, alginates .
|
-
- HY-132819
-
LY-3411067
|
JAK
|
Others
|
Ilunocitinib (compound 27) is a JAK inhibitor (extracted from patent WO2009114512A1) .
|
-
- HY-N4169
-
|
Others
|
Inflammation/Immunology
|
Trametenolic acid is a lanostanol glycoside that isolated from the EtOH extract of the fruit bodies of Laetiporus versisporus .
|
-
- HY-N10978
-
|
Others
|
Others
|
(-)-8-Methoxyobliquin is a coumarin that can be extracted from the aerial parts of Helianthus heterophyllus .
|
-
- HY-N3899
-
8-Carboxygeraniol
|
Others
|
Others
|
Foliamenthic acid is a monoterpenoid compound that can be isolated from methanol extracts of the roots and leaves of the foliate .
|
-
- HY-153185
-
|
Others
ADC Cytotoxin
|
Cancer
|
Decyclohexanamine-Exatecan is a Camptothecin derivative, compound a, extracted from patent WO2020219287 A1.
|
-
- HY-N3374
-
10-O-Methylsarpagine
|
Others
|
Others
|
Lochnerine is an indole alkaloid can be isolated from the stem bark extract of Alstonia macrophylla .
|
-
- HY-N11916
-
|
Others
|
Cancer
|
Kadsuphilin A can be extracted from Kadsura coccinea (Lem.) and has weak antiproliferative activity .
|
-
- HY-N3621
-
|
Others
|
Others
|
Corchoionol C is a n-butanol-soluble fraction of the whole plant extract of Pulicaria undulate .
|
-
- HY-127029A
-
|
Others
|
Others
|
Umbelliprenin (compound 2) can be isolated from the chloroform extract of the roots of Heptaptera cilicica .
|
-
- HY-N3591
-
|
Others
|
Others
|
cis-Methylisoeugenol (compound 10) can be isolated from the MeOH extract of R. fasciculatum .
|
-
- HY-N12405
-
|
Calmodulin
|
Others
|
Encecalinol, extracted from aerial parts of Ageratina grandifolia, is a potent inhibitor of calmodulin inhibitor .
|
-
- HY-N3036
-
|
Others
|
Others
|
(rac)-Isovalerylshikonin (compound 372) is a naphthoquinone pigment present in hexane extracts of safflower roots .
|
-
- HY-N3739
-
|
Fungal
|
Others
|
Diacetonamine is a sporulation inducing factor which can be extracted from soybean curd residue .
|
-
- HY-10225
-
PXD101; PX105684
|
HDAC
Autophagy
|
Cancer
|
Belinostat (PXD101; PX105684) is a potent HDAC inhibitor with an IC50 of 27 nM in HeLa cell extracts.
|
-
- HY-16564
-
-
- HY-N0034
-
Arctiin
3 Publications Verification
Arctii; NSC 315527; Arctigenin-4-glucoside
|
NF-κB
|
Inflammation/Immunology
Cancer
|
Arctiin (NSC 315527) is a plant lignan extracted from burdock seeds and has anti-cancer activity.
|
-
- HY-N1505
-
|
Akt
|
Cardiovascular Disease
|
Loureirin A is a flavonoid extracted from Dragon's Blood, can inhibit Akt phosphorylation, and has antiplatelet activity.
|
-
- HY-104028A
-
-
- HY-N0701
-
|
Others
|
Cancer
|
(-)-Asarinin is a extract lignan from Asarum sieboldii Miq., mainly produced in roots of this herb[1].
|
-
- HY-N6925
-
|
Others
|
Cardiovascular Disease
|
Scutellarin methyl ester is a constituent of Breviscapine which is a crude extract of several flavonoids of Erigeron breviscapus .
|
-
- HY-U00348
-
4-(2,2-Difluoroethenyl)-α-ethyl-2-oxo-1-pyrrolidineacetamide
|
Others
|
Neurological Disease
|
Anticonvulsant agent 1 is an anticonvulsant agent extracted from patent WO2001062726A2, Compound 156.
|
-
- HY-119864
-
-
- HY-W017241
-
-
- HY-129208
-
|
Antibiotic
Fungal
|
Infection
|
Viridicatumtoxin is a new mycotoxin extracted from Penicillium viridicatum with a LD50 of 122.4 mg/kg in rats.
|
-
- HY-131790
-
|
Others
|
Cancer
|
3'-Amino-3'-deoxyadenosine is an antitumor agent extracted from Helminthosporium .
|
-
- HY-N1019
-
N-Methyl-11-hydroxyrankinidine
|
|
|
11-Hydroxyhumantenine is an alkaloid compound isolated from the EtOH extract of the stems of Gelsemium elegans .
|
-
- HY-N1605
-
|
Others
|
Others
|
17α-Neriifolin is a compound isolated from a methylene chloride extract of the seeds of Cerbera odollam .
|
-
- HY-N1043
-
|
|
|
13-O-Deacetyltaxumairol Z is a compound isolated from extracts of the Formosan Taxus mairei .
|
-
- HY-N11025
-
|
Others
|
Others
|
Kansenone, a euphane-type triterpene, can be isolated from a 60% EtOH extract of Euphorbia kansui .
|
-
- HY-N11100
-
|
Parasite
|
Infection
|
Geranin A is an A-type proanthocyanidin. Geranin A can be isolated from the antiprotozoal extract of Geranium niveum .
|
-
- HY-N11543
-
|
Others
|
Others
|
AH13, a bi-phenylethychromone, can be isolated from acetone extract of agalwood from Kalimantan .
|
-
- HY-N9909
-
|
Others
|
Others
|
7,8,3',4'-Tetrahydroxyflavanone is a flavonoid can be extracted from Acacia confusa .
|
-
- HY-N2975
-
3-Epiocotillol II
|
Others
|
Others
|
Cabraleadiol (3-Epiocotillol II) is isolated from the MeOH extract of the bark of Aglaia crassinervia .
|
-
- HY-N3290
-
Methyl p-methoxyphenylpropionate
|
Others
|
Others
|
Methyl p-methoxyhydrocinnamate is extracted from in liquid culture by the blue stain fungus Ophiostoma crassioaginata .
|
-
- HY-N3882
-
|
Others
|
Others
|
Eurycarpin A is isoflavonoid analog isolated from the ethanol extract of the Chinese folk medicine Crotalaria ferruginea .
|
-
- HY-N7927
-
|
Others
|
Others
|
(-)-Terpinen-4-ol can be extracted from Bark Beetle Polygraphus poligraphus .
|
-
- HY-N3440
-
|
Others
|
Others
|
Junipediol B (compound 18) can be isolated from the methanol extract of the leaves of Cephalotaxus Harrington .
|
-
- HY-N12190
-
|
Others
|
Others
|
Centellasaponin A (compound 10) is a pentacyclic triterpene saponin isolated from the methanolic extract of Centella asiatica .
|
-
- HY-N12239
-
|
Others
|
Others
|
Condurango glycoside E is a glycoside compound that can be isolated from the bark extract of Marsdenia cundurango .
|
-
- HY-N11921
-
|
Others
|
Others
|
Kadsurin A analogue-1 (Compound 8) is a lignan can be extracted from Piper argyrophylum .
|
-
- HY-N3309
-
|
Others
|
Others
|
Mearnsitrin (compound 8) is a flavonol that can be isolated from methanolic extract Myrcia multiflora DC .
|
-
- HY-N9125
-
-
- HY-N12515
-
|
Others
|
Metabolic Disease
|
Pinuseldarone (compound 1), extracted from Pinus eldarica needles regulats brown adipogenesis and thermogenesis .
|
-
- HY-N0701A
-
|
|
|
Asarinin is a extract lignan from Asarum sieboldii Miq., mainly produced in roots of this herb[1].
|
-
- HY-N3613
-
|
Others
|
Metabolic Disease
|
Conduritol A is a hypoglycemic agent which inhibits the absorption of glucose and can be extracted from Gymnema sylvestre .
|
-
- HY-138761
-
|
Prostaglandin Receptor
|
Inflammation/Immunology
Cancer
|
EP4 receptor antagonist 3 is a potent EP4 receptor antagonist, example 3,extracted from patent WO2010019796 A1. EP4 receptor antagonist 3 can be used for the reseacrh of EP4 receptor-mediated diseases, such as acute and chronic pain, osteoarthritis, rheumatoid arthritis and cancer .
|
-
- HY-20588
-
|
CRAC Channel
|
Others
|
CRAC intermediate 2 is a intermediate compound for CRAC inhibitor synthesis, extracted from patent WO 2013059666A1.
|
-
- HY-101750
-
|
Others
|
Cardiovascular Disease
|
Arrhythmias-Targeting Compound 1 is used in the research of arrhythmias, extracted from patent WO 2001028992 A2.
|
-
- HY-U00412
-
-
- HY-U00378
-
-
- HY-101730
-
|
Bacterial
|
Infection
|
Antibacterial compound 2 is a useful antibacterial agent extracted from patent US5652238, compound example 9.
|
-
- HY-U00392
-
-
- HY-N0659
-
-
- HY-104038
-
-
- HY-N0258
-
Hexandraside F
|
Others
|
Cancer
|
Epimedin A1 is a flavonoid extracted from Herba Epimedii which is one of commonly used Chinese medicines.
|
-
- HY-42937
-
Transcrocetin meglumine; trans-Crocetin meglumine
|
iGluR
|
Cancer
|
Crocetin (Transcrocetin) meglumine, extracted from saffron (Crocus sativus L.), acts as an NMDA receptor antagonist with high affinity.
|
-
- HY-16502
-
Transcrocetin disodium; trans-Crocetin disodium
|
iGluR
|
Cancer
|
Crocetin (Transcrocetin) disodium, extracted from saffron (Crocus sativus L.), acts as an NMDA receptor antagonist with high affinity.
|
-
- HY-100177
-
|
Others
|
Others
|
L-Threonine derivative-1 is a acetylsalicylic-L-threonine ester extracted from patent US 20060287244 A1.
|
-
- HY-100120
-
-
- HY-111471
-
-
- HY-N6249
-
-
- HY-N2376
-
|
Others
|
Others
|
Chrysin-7-O-glucuronide is a flavonoid extracted from Scutellaria baicalensis, with antioxidant activity .
|
-
- HY-N0687
-
|
Microtubule/Tubulin
|
Cancer
|
Vindoline, a vinca alkaloid extracted from the leaves of Catharanthus roseus, weakly inhibits tubulin self-assembly .
|
-
- HY-N1089
-
-
- HY-139758
-
-
- HY-139766
-
|
Bacterial
|
Infection
|
Antibacterial agent 49 (example 12) is a antibacterial agent (extracted from patent WO2013030735A1) .
|
-
- HY-139769
-
-
- HY-139770
-
-
- HY-139771
-
-
- HY-139772
-
-
- HY-139773
-
-
- HY-139774
-
-
- HY-139776
-
-
- HY-139778
-
-
- HY-12973
-
-
- HY-139757
-
-
- HY-141889
-
-
- HY-N1340
-
(-)-Rosthornin A; Isodopharicin C
|
Others
|
Others
|
Rosthornin A is a ent-kaurene diterpenoid compound, isolated from the ether extract of the dried leaves of Rabdosia rosthornii .
|
-
- HY-N10884
-
|
Others
|
Others
|
Withasomniferolide A is a withanolide, isolated from a GABAA receptor positive activator methanol extract of the roots of Withania somnifera .
|
-
- HY-N8332
-
Ox bile extract
|
Biochemical Assay Reagents
|
Others
|
Bile extract is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-156051
-
|
HCV
|
Infection
|
Tetrazolast is a HCV inhibitor with the inhibitory activity ranging from 5% to 20%, extracted from patent WO2005030774.
|
-
- HY-W671746
-
|
Others
|
Others
|
Thevetin A is a thevetia cardiac glycoside. Thevetin A can be isolated from the methanol extract of the seeds of Cascabela thevetioides .
|
-
- HY-N12251
-
|
Others
|
Others
|
Gymnoside IX (compound 2) can be isolated from the methanolic extract from the tubers of Gymnadenia conopsea .
|
-
- HY-N8452
-
|
Others
|
Others
|
Noroxyhydrastinine (compound 1) is an alkaloid. Noroxyhydrastinine can be isolated from the ethanolic extract of the roots of Thalictrum angustifolium .
|
-
- HY-N11985
-
|
Others
|
Others
|
Ophiopogonone C (compound 3) is an isoflavone compound isolated from the ethanol extract of Ophiopogon japonicus tubers .
|
-
- HY-126607
-
|
Others
|
Others
|
Sericic acid (compound 7) is a triterpenoid obtained from the methanol extract of blackberry (Rubus allegheniensis Port.) fruit .
|
-
- HY-N11922
-
|
Others
|
Neurological Disease
|
Ipalbidine is an alkaloid extracted from ipomoea Hardwickki Hemsl. Ipalbidine has dose-dependent analgesic effects .
|
-
- HY-149157
-
|
Others
|
Metabolic Disease
|
L-Lysine orotate is a salt of L-lysine and orotic acid that can potentiate the toxicity of an extract of the mushroom Amanita phalloides .
|
-
- HY-N12352
-
|
Others
|
Others
|
Eschweilenol C is a compound derivative ellagic acid from the aqueous fraction of the ethanolic extract of Terminalia fagifolia Mart. .
|
-
- HY-108170
-
|
Parasite
|
Others
|
Pyrethrin II is a insecticidal ingredient of pyrethrins. Pyrethrins is a biogenic insecticide, that can be extracted from Chrysanthemum cinerariifolium .
|
-
- HY-N8482
-
|
Others
|
Others
|
Zinnol (compound 5) is a zinniol-related compound with phytotoxicity which can be extracted from Alternaria cichorii .
|
-
- HY-N12596
-
|
Others
|
Others
|
Uralenol-3-methyl ether is a flavonol which can be extracted from Daphne giraldii .
|
-
- HY-N0841
-
Dihydrobrusatol; NSC310616
|
Parasite
Antibiotic
|
Infection
|
Bruceine A(NSC310616; Dihydrobrusatol) is a natural quassinoid compound extracted from the dried fruits of Brucea javanica (L.
|
-
- HY-19772
-
|
HDAC
|
Cancer
|
HDAC-IN-3 is a histone deacetylase (HDAC) inhibitor, extracted from patent WO/2008040934 A1.
|
-
- HY-N0145
-
-
- HY-13873
-
-
- HY-22166
-
|
Others
|
Metabolic Disease
|
Glycolic acid oxidase inhibitor 1 is a glycolate oxidase inhibitor, extracted from patent EP0021228A1, in Table IV.
|
-
- HY-N6584
-
-
- HY-N1978
-
|
|
|
3'-Methoxypuerarin (3'-MOP) is an isoflavone extracted from radix puerariae that shows neuron protection activity.
|
-
- HY-100257
-
-
- HY-125381
-
-
- HY-128722
-
|
HIV
|
Infection
|
HIV-1 inhibitor-3 is a HIV infection inhibitor extracted from patent US2018360927 .
|
-
- HY-N2623
-
Prangenidin
|
Others
|
Cancer
|
Alloimperatorin (Prangenidin), a coumarin compound, is extracted from Angelica dahurica. Alloimperatorin (Prangenidin) has antitumor activity .
|
-
- HY-128940
-
|
ADC Linker
|
Cancer
|
EC089 is a cleavable linker used in conjugates of tubulysins and folates, and extracted from patent WO2011069116A1 .
|
-
- HY-N2401
-
-
- HY-U00377
-
-
- HY-U00314
-
|
Others
|
Neurological Disease
|
Anti-neurodegeneration agent 1 a neurodegeneration-targeting compound extracted from patent WO2008039514A1, Compound I.
|
-
- HY-111471A
-
|
JAK
|
Inflammation/Immunology
|
JAK-IN-5 hydrochloride is an inhibitor of JAK extracted from patent US20170121327A1, compound example 283 .
|
-
- HY-131268
-
-
- HY-N7657
-
|
Others
|
Others
|
L-octaguluronic acid octasodium salt is extracted from seaweed. L-octaguluronic acid octasodium salt is the component of the natural biopolymers, alginates .
|
-
- HY-113332
-
-
- HY-116349
-
-
- HY-N5080
-
|
Others
|
Inflammation/Immunology
|
Isoscoparin is a flavonoid that could be isolated from EtOAc extract of Gentiana algida Pall. Isoscoparin possesses antioxidant activity .
|
-
- HY-N9372
-
-
- HY-N8347
-
|
Others
|
Others
|
Dalbergin is a composition of the extract from the Dalbergia Sissoo Linn. knot wood. Dalbergin demonstrats notable antioxidant ability .
|
-
- HY-N9694
-
|
Bacterial
|
Infection
|
Essential oils, Melaleuca alternifolia is extracted from the leaves of Melaleuca alternifolia, has bactericidal and anti-inflammatory activies .
|
-
- HY-143581
-
-
- HY-N1339
-
(-)-Rosthornin B
|
|
|
Rosthornin B is a ent-kaurene diterpenoid compound, isolated from the ether extract of the dried leaves of Rabdosia rosthornii .
|
-
- HY-147571
-
-
- HY-N11539
-
|
Others
|
Others
|
7-O-Primverosylpseudobaptigenin is a natural product that can be isolated from the alcoholic extract of the roots of the Amur maackia .
|
-
- HY-154799
-
|
Others
|
Cancer
|
Anticancer agent 112 is a potent anti-cancer agent for cancer research, extracted from patent WO2020198567 .
|
-
- HY-N3492
-
|
Others
|
Others
|
Isoderrone is a new isoflavone isolated from the methanol extractives from white lupin (cv. Kievskij Mutant) roots .
|
-
- HY-N3496
-
|
Others
|
Others
|
Isochandalone is a new isoflavone isolated from the methanol extractives from white lupin (cv. Kievskij Mutant) roots .
|
-
- HY-N1628
-
1-Hydroxybaccatin I
|
Others
|
Others
|
1β-Hydroxybaccatin I (1-Hydroxybaccatin I) can be extracted from Taxus wallichiana .
|
-
- HY-N8319
-
|
Others
|
Others
|
Leojaponin (compound 2 ) is a labdane diterpene. Leojaponin can be isolated from the EtOH extract of the herb Leonurus japonicus .
|
-
- HY-N12359
-
|
Others
|
Others
|
Mulberrofuran B can be isolated from the Ethanol extract of Morus alba. Mulberrofuran B has antioxidant activity .
|
-
- HY-N9898
-
|
Others
|
Others
|
Sinocrassoside C1 is a natural compound isolated from themethanolic extract of the whole plant ofSinocrassula indica (Crassulaceae) .
|
-
- HY-N12060
-
|
Others
|
Others
|
Ginkgo biloba extract a natural product isolated from Ginkgo biloba, and can be used for Atherosclerosis and cardiovascular study .
|
-
- HY-160670
-
-
- HY-160671
-
-
- HY-13033
-
CDK inhibitor II
|
CDK
|
Cancer
|
CDK-IN-2 is a potent and specific CDK9 inhibitor with IC50 of <8 nM, extracted from reference 1, example 4.
|
-
- HY-13749A
-
-
- HY-13749B
-
-
- HY-N0286
-
-
- HY-U00273
-
-
- HY-U00300
-
|
Others
|
Cancer
|
Cancer-Targeting Compound 1 is used in the research of hormone-related cancer, extracted from patent WO 2008021331 A2.
|
-
- HY-13788C
-
-
- HY-110390
-
|
Others
|
Cardiovascular Disease
|
GR148672X is a triacyglycerol hydrolase (TGH) inhibitor with an IC50 of 4 nM extracted from patent WO 2001016358 A2.
|
-
- HY-111353
-
-
- HY-136556
-
-
- HY-117771A
-
|
Others
|
Metabolic Disease
|
DO34 analog is a triazole DAGL(α) inhibitor extracted from patent WO2017096315 A1, compound 100.
|
-
- HY-114423
-
-
- HY-111777
-
-
- HY-126216
-
|
TAM Receptor
|
Cancer
|
TAM-IN-2 is a TAM inhibitor extracted from patent US 20170275290 A1, pyrrolotriazine compound 0904 .
|
-
- HY-N4183
-
|
Others
|
Cancer
|
Licoflavone C is a prenyl-flavone extracted from Genista ephedroides, reduces the genotoxicity of cancer agents in human peripheral lymphocytes .
|
-
- HY-D1061
-
|
Fluorescent Dye
|
Others
|
2,4,5,6-Tetraaminopyrimidine is a coloring agent extracted from patent US20170258692A1, compound A .
|
-
- HY-N0547
-
|
Others
|
Metabolic Disease
|
Nomilin is a limonoid compound obtained from the extracts of citrus fruits. Nomilin is an anti-obesity and anti-hyperglycemic agent .
|
-
- HY-U00436
-
-
- HY-135889
-
|
Bacterial
|
Infection
|
CPFX2090 is a cephalosporin antibacterial compound extracted from patent WO2013052568A1, Compound Example 16g .
|
-
- HY-W002339
-
|
DNA/RNA Synthesis
|
Others
|
3-Hydroxy-2-methylpyridine, isolated from alkaline extracts of cocoa, is used in the synthesis of pyrimidine .
|
-
- HY-133865
-
|
Others
|
Others
|
Diacetoxy-6-gingerdiol is a diarylheptanoid isolated from the dichloromethane extract of rhizomes of ginger (Zingiber officinale Roscoe) .
|
-
- HY-138945
-
-
- HY-N6255
-
|
Others
|
Inflammation/Immunology
Cancer
|
Ilexgenin A is a pentacyclic triterpenoid, which extracted from Ilex hainanensis Merr. Ilexgenin A can be used for the research of inflammation and cancer .
|
-
- HY-139616
-
|
Others
|
Others
|
Sec61-IN-2 (A347) is a protein secretion inhibitor (extracted from patent WO2020176863) .
|
-
- HY-139617
-
|
Others
|
Others
|
Sec61-IN-2 (A3) is a protein secretion inhibitor (extracted from patent WO2020176863) .
|
-
- HY-145590
-
|
ROR
|
Cancer
|
Retezorogant is a retinoid-related orphan receptor γ (RORγ) antagonist, extracted from patent WO2016093342 A1.
|
-
- HY-112267
-
-
- HY-143729
-
-
- HY-N11696
-
|
Others
|
Inflammation/Immunology
|
1-Oxotanshinone IIA (Compound 6) is extracted from Perovskia artemisioides and has significant anti-inflammatory activity .
|
-
- HY-N9099
-
|
Others
|
Others
|
3-(4-Hydroxyphenyl)propan-2-one is a compound that can be extracted from Xanthocercis zambesiaca .
|
-
- HY-N11285
-
|
Others
|
Others
|
1,2,6-Tri-O-galloyl-β-D-glucose can be extracted from Sanguisorba oficinalis .
|
-
- HY-N7762
-
|
Others
|
Others
|
Chrysanthellin A is the main saponin-based compound from the extract of Chrysanthellum americanum. Chrysanthellin A can be used in the reserach of digestive impairments .
|
-
- HY-N8532
-
|
Others
|
Others
|
(1’S)-Dehydropestalotin (Compound 4) is a compound that can be isolated from the AcOEt extract of the fungus Xylaria feejeensis .
|
-
- HY-78036
-
Citronic acid; Methylfumaric acid
|
Others
Endogenous Metabolite
|
Others
|
Mesaconic acid is an active product that can be extracted from Saxifraga stolonifera. Mesaconic acid is used as a fire retardant and is a competitive inhibitor of fumarate reduction .
|
-
- HY-N12580
-
|
Others
|
Metabolic Disease
|
Mussaenosidic acid is an active product that can be extracted from Pedicularis kerneri Dalla Torre. Mussaenosidic acid shows weak antiglycation activity .
|
-
- HY-N2954
-
|
Others
|
Others
|
Borapetoside F is a furanoditerpene which can be extracted from T. crispa and has been suggested to have edible toxicity .
|
-
- HY-126722
-
|
Others
|
Inflammation/Immunology
|
Lipoxin A4 methyl ester is a stable synthetic analog of lipoxin with anti-inflammatory properties that can be extracted from arachidonic acid .
|
-
- HY-151263
-
|
HDAC
G-quadruplex
|
Cancer
|
G4/HDAC-IN-1 (compound a6) is a G4/HDAC dual-targeting compound. G4/HDAC-IN-1 inhibits intracellular HDAC activity with an IC50 value of 1.1 μM, and induces G4 formation. G4/HDAC-IN-1 inhibits TNBC proliferation and tumor growth in TNBC xenograft model. G4/HDAC-IN-1 can be used for the research of cancer .
|
-
- HY-10247
-
|
Raf
|
Cancer
|
BRAF inhibitor is a B-Raf inhibitor extracted from patent WO/2011103196 A1, Compound P-0850.
|
-
- HY-U00362
-
|
Proteasome
|
Neurological Disease
|
Neurodegenerative Disorder-Targeting Compound 1 is a calpain inhibitor extracted from patent WO2010128102A1, compound example 63 .
|
-
- HY-17477
-
|
Others
|
Inflammation/Immunology
|
Guacetisal is obtained from the esterification of acetylsalicylic acid with guaiacol which has the potential for chronic bronchitis treatment extracted from patent CN 106866420 A.
|
-
- HY-U00429
-
|
Others
|
Neurological Disease
|
NOT Receptor Modulator 1 is a nuclear receptor NOT modulator extracted from patent WO 2008034974 A1, Example 39 in table1.
|
-
- HY-115122
-
-
- HY-B2208
-
|
Others
|
Others
|
Glycol salicylate is a derivative of salicylic acid and can be used to improve the aesthetic appearance of the skin, extracted from patent US 20150148320 A1.
|
-
- HY-B2121
-
Naproxen impurity O
|
iGluR
|
Neurological Disease
|
6-Methoxy-2-naphthoic acid is an NMDA receptor modulator extracted from patent WO 2012019106 A2.
|
-
- HY-N0098
-
p-Vanillin; m-Methoxy-p-hydroxybenzaldehyde; p-Hydroxy-m-methoxybenzaldehyde
|
Endogenous Metabolite
|
Others
|
Vanillin (p-Vanillin) is a single molecule extracted from vanilla beans and also a popular odor used widely in perfume, food and medicine.
|
-
- HY-Y1887
-
|
Biochemical Assay Reagents
|
Others
|
Cottonseed oil is a cooking oil extracted from the seeds of cotton plants and has been generally considered the most insecticidal of vegetable oils.
|
-
- HY-N1475
-
|
|
|
Nicotiflorin is a flavonoid glycoside extracted from a traditional Chinese medicine Carthamus tinctorius. Nicotiflorin shows potent antiglycation activity and neuroprotection effects.
|
-
- HY-122404
-
Xanthocillin X
|
MEK
ERK
Autophagy
|
Cancer
|
Xantocillin (Xanthocillin X) is a marine agent extracted from Penicillium commune, induces autophagy through inhibition of the MEK/ERK pathway .
|
-
- HY-N3651
-
|
Bacterial
|
Infection
|
Curzerenone is one of constituents of leaf essential oil extracted from L. pulcherrima. Shows slight inhibitory effective against E. coli .
|
-
- HY-N0563
-
|
Fluorescent Dye
|
Others
|
Alizarin is a natural dye extracted from the roots of madder plant and has been widely used as a pigment in textile fabrics and paintings .
|
-
- HY-N3625
-
Coronalonic acid
|
NF-κB
|
Inflammation/Immunology
|
Coronalolic acid, extract from the apical bud of Gardenia sootepenesis Hutch, inhibits TNF-α-induced NF-κB activity and NO production .
|
-
- HY-N0528
-
Buddleoside; Linarine
|
Cholinesterase (ChE)
|
Neurological Disease
|
Linarin (Buddleoside), isolated from the flower extract of Mentha arvensis, shows selective dose dependent inhibitory effect on acetylcholinesterase (AChE) .
|
-
- HY-135781
-
|
Others
|
Cancer
|
H-Arg(Pbf)-OMe hydrochloride is an arginine analogue extracted from patent US20150197500A1, Compound Arg-06 .
|
-
- HY-U00310
-
|
Others
|
Neurological Disease
|
Neuromuscular-targeting compound 1, extracted from patent WO2009099594 A1, Paragraph 0100, is useful in treatment of neuromuscular diseases.
|
-
- HY-10216
-
BAY 869766 R enantiomer; RDEA119 R enantiomer
|
MEK
|
Cancer
|
Refametinib R enantiomer is a MEK inhibitor extracted from patent WO2007014011A2, compound 1022, has an EC50 of 2.0-15 nM.
|
-
- HY-U00395
-
-
- HY-18625
-
|
VEGFR
|
Cancer
|
VEGFR-2-IN-5 is a VEGFR2 inhibitor extracted from patent WO2013055780A1, Page 69 .
|
-
- HY-18625A
-
|
VEGFR
|
Cancer
|
VEGFR-2-IN-5 hydrochloride is a VEGFR2 inhibitor extracted from patent WO2013055780A1, Page 69 .
|
-
- HY-137093
-
-
- HY-109173
-
BAY 1902607
|
P2X Receptor
|
Neurological Disease
|
Filapixant is a purinoreceptor antagonist extracted from patent WO2016091776A1, example 348. Filapixant is the active reference substance of Eliapixant .
|
-
- HY-137452
-
-
- HY-145551
-
|
Others
|
Inflammation/Immunology
|
Atinvicitinib is a kind of pyrazole compound. Atinvicitinib has the potential for the research of atopic dermatitis (extracted from patent WO2021123094A1) .
|
-
- HY-24463
-
|
Others
|
Others
|
3,4-Di-O-acetyl-L-fucal is the reactant for synthesis antibiotics (extracted from patent WO1999026956A1) .
|
-
- HY-U00362A
-
|
Others
|
Neurological Disease
|
(Rac)-Neurodegenerative Disorder-Targeting Compound 1 is a calpain inhibitor (extracted from patent WO2010128102A1, compound 63) .
|
-
- HY-143728
-
-
- HY-145826
-
|
Bcl-2 Family
|
Cancer
|
Mcl-1 inhibitor 8 is a MCL-1 inhibitor, example 228, extracted from patent WO2019222112 .
|
-
- HY-N1827
-
|
|
|
3-epi-Maslinic acid is an acidic pentacyclic triterpene isolated from Hexane and dichloromethane extracts of Platostoma africanum P. Beauv .
|
-
- HY-N1603
-
|
Others
|
Others
|
16-o-Acetyldarutigenol (compound 4) is an ent-pimarane diterpenoid compound isolated from the ethanol extract of Siegesbeckia orientalis .
|
-
- HY-147780
-
|
Others
|
Cancer
|
Fissitungfine B is a compound extracted from the tropical medicinal plant Fissistigma tungfangense. Fissitungfine B has strong anticancer activity .
|
-
- HY-N1626
-
|
Others
|
Others
|
1β-Hydroxy-2-oxopomolic acid is a compound isolated from methanolic extract of leaves of Eriobotrya deflexa .
|
-
- HY-150617
-
M4076; ATM Inhibitor-5
|
ATM/ATR
|
Cancer
|
Lartesertib (M4076) is a potent inhibitor of serine/threonine protein kinase ATM (extracted from patent WO2022058351A1) .
|
-
- HY-N10955
-
|
Others
|
Inflammation/Immunology
|
Dichotomine H is a P-carboline alkaloid that can be extracted from Stellaria dichotoma L. Dichotomine H has good antiallergic activity .
|
-
- HY-N3612A
-
(-)-Communic acid
|
Others
|
Others
|
trans-Communic acid is a diterpenoid. trans-Communic acid can be isolated from ethyl acetate extract of young cones of hinoki (Chamaecyparis obtusa Endl.) .
|
-
- HY-153186
-
|
Liposome
|
Others
|
LNP Lipid-3 is an ionizable lipid extracted from patent WO2021113777A, and can be used for the generation of Lipid nanoparticles (LNPs).
|
-
- HY-156603
-
|
c-Met/HGFR
|
Cancer
|
Canlitinib is a tyrosine kinase inhibitor, extracted from patent WO2018072614 (IV-2). Canlitinib has the potential for cancer study.
|
-
- HY-N3652
-
|
Others
|
Infection
|
Cuspidiol (compound 3) is a CH2Cl2 extract of Fagara zanthoxyloides Lam. Cuspidiol has antifungal and antioxidative activity .
|
-
- HY-N0491
-
(-)-Lupinidine sulfate
|
nAChR
|
Neurological Disease
|
(-)-Sparteine (sulfate) is a quinolizidine alkaloid that can be extracted from Lupinus. (-)-Sparteine (sulfate) inhibits the release of acetylcholine and has anticonvulsant effects .
|
-
- HY-N12014
-
|
Others
|
Others
|
Triptotriterpenic acid C is a ursolic-type acid that can be isolated from total glycosides extracted from the root of Tripterygium wilfordii Hook.f. .
|
-
- HY-119637
-
|
Others
|
Others
|
Frangufoline is a 4(14)-type cyclopeptide alkaloid, that can be isolated from the root bark extract of Ziziphus cambodiana Pierre .
|
-
- HY-137583
-
|
Others
|
Inflammation/Immunology
|
Peltatoside is a flavone which can be extracted from Annona crassilfora Mart, with an anti-inflammatory activity and can be used for relative research .
|
-
- HY-N2087
-
|
Others
|
Metabolic Disease
|
Ligupurpuroside A is an active product that can be extracted from Ligustrum robustum. Ligupurpuroside A acts as a natural inhibitor of lipase in a competitive manner .
|
-
- HY-12039
-
Bafetinib analog
|
Bcr-Abl
|
Cancer
|
Lyn-IN-1 (Bafetinib analog) is a potent and selective dual Bcr-Abl/Lyn inhibitor, extracted from patent WO2014169128A1.
|
-
- HY-N0009
-
|
Amyloid-β
Influenza Virus
|
Neurological Disease
|
Geniposide is an iridoid glucoside extracted from Gardenia jasminoidesEllis fruits; exhibits a varity of biological activities such as anti-diabetic, antioxidative, antiproliferative and neuroprotective activities.
|
-
- HY-13749
-
-
- HY-N0348
-
|
Others
|
Inflammation/Immunology
|
Dexamethasone 9,11-epoxide, a compound extracted from patent CN 106520896 A and RU 2532902 C1, is an intermediate in the preparation of dexamethasone.
|
-
- HY-103036
-
-
- HY-U00420
-
-
- HY-100084
-
|
|
|
Methyl-3β-hydroxycholenate is a ROR gamma modulator extracted from patent US20110263046 A1, in figure 2.
|
-
- HY-112275
-
-
- HY-135864
-
|
Ras
|
Cancer
|
KRAS inhibitor-6 is a potent KRAS G12C inhibitor, extracted from patent WO2017087528A1, compound A .
|
-
- HY-100171
-
-
- HY-130261
-
|
Bcl-2 Family
|
Cancer
|
Mcl-1 antagonist 1 is a Mcl-1 protein antagonist extracted from patent WO2019173181, compound 200 .
|
-
- HY-136604
-
|
RAD51
|
Cancer
|
RAD51-IN-3 is a Rad51 inhibitor extracted from patent WO2019051465A1, compound Example 66A .
|
-
- HY-100261
-
-
- HY-111463
-
-
- HY-111911
-
|
Amyloid-β
|
Neurological Disease
|
Xanthocillin X permethyl ether is a natural compound isolated from fungal extracts, with Aβ-42 lowering activity .
|
-
- HY-N6667
-
|
Others
|
Others
|
Glucovanillin extracted from Vanilla planifolia Andrews and simultaneously transformed to vanillin by a combination of enzyme activities involving cell wall degradation and glucovanillin hydrolysis.
|
-
- HY-N2209
-
|
|
|
Angeloylgomisin H, as a major lignin extract of Schisandra rubriflora, has the potential to improve insulin-stimulated glucose uptake by activating PPAR-γ .
|
-
- HY-N0263
-
|
Others
|
Inflammation/Immunology
|
Toosendanin, a triterpenoid extracted from the bark of fruit of Melia toosendan Sieb. et Zucc., possesses analgesic, insecticidal and anti-inflammatory activities .
|
-
- HY-136339
-
-
- HY-138698
-
|
Deubiquitinase
|
Others
|
FT206 is an inhibitor of carboxamides as ubiquitin-specific protrase extracted from patent WO 2020033707 A1, example 11-1 .
|
-
- HY-145567
-
PH94B
|
Others
|
Neurological Disease
|
Fasedienol is a neurochemical stimulator of the vomeronasal organ (VON). Fasedienol alleviates the symptoms of PMS and anxiety (extracted from patent WO1998014194A1) .
|
-
- HY-145825
-
|
Bcl-2 Family
|
Cancer
|
Mcl-1 inhibitor 7 is a potent Mcl-1 inhibitor, example 35, extracted from patent WO2020097577A .
|
-
- HY-N2749
-
|
Others
|
Others
|
7-Hydroxy-5,8-dimethoxyflavanone is a compound isolated from the ethanol extract of the whole plants of Sarcandra hainanensis .
|
-
- HY-N10423
-
(-)-Cubebin
|
Others
|
Inflammation/Immunology
|
Cubebin is a dibenzylbutyrolactone lignan isolated from the crude hexane extract of the leaves of Zanthoxyllum naranjillo. Cubebin shows a significant anti-inflammatory activity .
|
-
- HY-W009141
-
Glyceryl palmitate
|
P-glycoprotein
|
Cancer
|
1-Monopalmitin, a bitter melon extract, inhibits the P-glycoprotein (P-gp) activity in intestinal Caco-2 cells .
|
-
- HY-N9500
-
|
Apoptosis
Topoisomerase
|
Cancer
|
Ganoderic acid X is a lanostanoid triterpene that can be extracted from Ganoderma amboinense. Ganoderic acid X inhibits topoisomerases and induces apoptosis of cancer cells .
|
-
- HY-N10673
-
|
Others
|
Cancer
|
10α-Hydroxyepigambogic acid can be extracted from Garcinia hanburyi. 10α-Hydroxyepigambogic acid can be used in the research of tumors .
|
-
- HY-148878
-
|
Ras
|
Cancer
|
Ras modulator-1 is a modulator of Ras. Ras modulator-1 is an active compound extracted from patent US20120302581 .
|
-
- HY-N3954
-
Glutin-5-en-3β-O-acetate; Glutinol acetate
|
Others
|
Others
|
Glutinyl acetate is a triterpene that can be extracted from Dorstenia arifolia. Triterpenes are reported to exhibit anti-inflammatory, antimicrobial, antiviral, cytotoxic and cardiovascular effects .
|
-
- HY-N8737
-
|
Others
|
Others
|
Desrhamnosylmartynosideis extracted from the root of Scutellaria prostrata. Desrhamnosylmartynoside has absorption bands assignable to hydroxyl,α,β-unsanturate carbonyl groups .
|
-
- HY-156604
-
|
Btk
|
Cancer
|
Cinsebrutinib is a Bruton's tyrosine kinase inhibitor, extracted from patent WO2021207549 (compound 5-6). Cinsebrutinib has the potential for cancer study.
|
-
- HY-N4217
-
|
Others
|
Others
|
Saikosaponin I is a triterpene saponin extracted from Bupleurum falcatum L. Saikosaponin can be used to treat fever, inflammation, liver disease, and nephritis .
|
-
- HY-N12409
-
|
STAT
|
Cancer
|
Neocucurbitacin A (compound 7) is STAT3 inhibitor a compound extracted from Aquilaria crassna pericarp. Neocucurbitacin A can be used for anticancer research .
|
-
- HY-N9112
-
|
Bacterial
|
Infection
|
Eriodictyol 7, 3'-dimethyl ether (compound 11) is the first flavonoid extract from B. riparia with antioxidant and antibacterial activity .
|
-
- HY-161091
-
|
Fungal
|
Infection
|
AM-2-19 (SF001) is an ergosterol-extracting polyene antifungal that is discovered through modifications to the amphotericin B toxin by chemists .
|
-
- HY-123080
-
|
Others
|
Others
|
Tanshinol B is a bioactive component of Salvia miltiorrhiza, which can be isolated from the 50% ethanol extract of the roots and rhizomes of Seaweed prowazekii .
|
-
- HY-N12579
-
|
Others
|
Inflammation/Immunology
|
Desacylsenegasaponin B is an active product that can be extracted from? root of Polygala tenuifolia. Desacylsenegasaponin B has potential anti-inflammatory activity .
|
-
- HY-N0892
-
-
- HY-N0856
-
23-O-Acetylalisol C; Alisol C monoacetate
|
Others
|
Cardiovascular Disease
|
Alisol C 23-acetate, a natural product extracted from Alisma orinentale, can significantly and strongly inhibit DTH response after oral administration.
|
-
- HY-B0923
-
Dantron; Chrysazin; 1,8-Dihydroxyanthraquinone
|
AMPK
Autophagy
Bacterial
Virus Protease
|
Cancer
|
Danthron is a natural product extracted from the traditional Chinese medicine Salvia miltiorrhiza Bunge. Danthron functions in regulating glucose and lipid metabolism by activating AMPK.
|
-
- HY-U00059
-
|
Others
|
Metabolic Disease
|
Pyrrole-derivative1 is extracted from patent WO/2002/085851A1, example 2, developed for the treatment of diabetic disease.
|
-
- HY-101766
-
BGB-3111 analog
|
Btk
|
Inflammation/Immunology
|
Btk inhibitor 2 (BGB-3111 analog) is a Bruton's tyrosine kinase (BTK) inhibitor extracted from patent US 20170224688 A1.
|
-
- HY-W016622
-
7-Methyl-2H-1,5-benzodioxepin-3(4H)-one
|
Others
|
Others
|
Watermelon ketone is fragrance chemical compound with special odorant which has been widely used in the fragrance industry, extracted from patent CN 103058984 A.
|
-
- HY-128523
-
-
- HY-111887
-
RAD51-IN-2
|
RAD51
|
Cancer
|
Emzadirib (RAD51-IN-2) is a RAD51 inhibitor extracted from patent WO2019/051465A1 .
|
-
- HY-135866
-
|
Ras
|
Cancer
|
KRAS inhibitor-8 is a potent KRAS G12C inhibitor, extracted from patent WO2017087528A1, compound C .
|
-
- HY-112494
-
|
Ras
|
Cancer
|
KRas G12C inhibitor 1 is a compound that inhibits KRas G12C, extracted from patent US 20180072723 A1.
|
-
- HY-112491
-
|
Ras
|
Cancer
|
KRas G12C inhibitor 1 is a compound that inhibits KRas G12C, extracted from patent US 20180072723 A1.
|
-
- HY-14898
-
-
- HY-112493
-
|
Ras
|
Cancer
|
KRas G12C inhibitor 3 is a compound that inhibits KRas G12C, extracted from patent US 20180072723 A1.
|
-
- HY-112492
-
|
Ras
|
Cancer
|
KRas G12C inhibitor 2 is a compound that inhibits KRas G12C, extracted from patent US 20180072723 A1.
|
-
- HY-135865
-
|
Ras
|
Cancer
|
KRAS inhibitor-7 is a potent KRAS G12C inhibitor, extracted from patent WO2017087528A1, compound B .
|
-
- HY-114336
-
|
Phosphatase
|
Inflammation/Immunology
|
Enocyanin is an anthocyanin extracted from grapes. Enocyanin shows inhibitory effect on the leucine aminopeptidase, acid phosphatase, γ-glutamyl transpeptidase and esterase activity .
|
-
- HY-N6008
-
|
Others
|
Others
|
7-O-Methyl morroniside is an iridoid glycoside (IG) extracted from Cornus officinalis fructus, used in many traditional Chinese medicines .
|
-
- HY-N0398
-
|
Opioid Receptor
|
Neurological Disease
|
Sec-O-Glucosylhamaudol is a natural compound extracted from Peucedanum japonicum Thunb, decreases levels of μ-opioid receptor, with analgesic effect .
|
-
- HY-N2628
-
|
Others
|
Metabolic Disease
|
Erigeroside is as a derivatives of -glucose extracted from Satureja khuzistanica Jamzad. Erigeroside has good ability of anti-oxidation and scavenging oxidation free radical .
|
-
- HY-15122
-
-
- HY-135884
-
AG-946; PKR activator 2
|
Pyruvate Kinase
|
Cardiovascular Disease
|
Tebapivat (PKR activator 2) is a potent pyruvate kinase-R (PKR) activator extracted from patent WO2019035863A1, compound 385 .
|
-
- HY-128523A
-
|
Others
|
Inflammation/Immunology
|
Kgp-IN-1 hydrochloride is an arginine-specific gingipain (Rgp) inhibitor extracted from patent WO2017201322A1, compound 13-R .
|
-
- HY-111948
-
-
- HY-138202
-
|
Src
|
Inflammation/Immunology
|
Lck-IN-1 is a potent lymphocyte protein tyrosine kinase (Lck) inhibitor extracted from patent WO2007013673A1, example 48 .
|
-
- HY-138695
-
-
- HY-W004289
-
|
Others
|
Others
|
Methyl pentadecanoate is a fatty acid ester, can be isolated from L. wallichi extracts. Methyl pentadecanoate is obtained by condensation of the carboxy group of pentadecanoic acid with the hydroxy group of methanol .
|
-
- HY-132847
-
SCD-044
|
LPL Receptor
|
Others
|
Vibozilimod (SCD-044, example 33) is a S1p1 receptor agonist (extracted from patent WO2012140020A1) .
|
-
- HY-132806
-
RG-7816; RO-7017773
|
GABA Receptor
|
Neurological Disease
|
Alogabat (example 8) is a GABAA α5 receptor positive allosteric modulators (PAMs) (extracted from patent WO2018104419A1) .
|
-
- HY-113427A
-
|
Antibiotic
|
Cancer
|
cis-Vaccenic acid, the antiviral extract from Rhodopseudomonas capsulate and the predominant active component of Rhodopseudomonas capsulate , acts a potential fetal hemoglobin inducer .
|
-
- HY-120333
-
|
Antibiotic
Fungal
Bacterial
|
Infection
|
Antibiotic PF 1052 is an antibiotic extracted from a natural product library. Antibiotic PF 1052 has an inhibitory effect on murine neutrophil migration .
|
-
- HY-145017
-
|
Ras
|
Cancer
|
KRAS G12C inhibitor 20 is a KRAS G12C inhibitor extracted from patent CN112694475A, example 1 .
|
-
- HY-D1107
-
|
PARP
|
Others
|
NCT-TFP is PARP probe used to identifying Poly(ADP-ribose) polymerases (PARP) inhibitors (extracted from patent US20190331688A1) .
|
-
- HY-N1496
-
|
|
|
15,16-Di-O-acetyldarutoside (compound 5) is an ent-pimarane diterpenoid compound isolated from the ethanol extract of Siegesbeckia orientalis .
|
-
- HY-N9311
-
|
Others
|
Others
|
2,3-Dihydroxy-4-methoxybenzoic acid is a compound isolated from extracted from sweet cherry fruits (Prunus avium) .
|
-
- HY-N1670
-
|
Others
|
Others
|
2'',4''-Di-O-(Z-p-Coumaroyl)afzelin (compound 9) is a compound isolated from the leaf extract of Machilusphilippinense Merr. .
|
-
- HY-32135
-
|
Others
|
Inflammation/Immunology
|
N-Phenethylbenzamide is an active compound. N-Phenethylbenzamide can be extracted from Liriodendron tulipifera. N-Phenethylbenzamide can be used for the research of inflammatory diseases .
|
-
- HY-125115
-
|
Others
|
Others
|
Jatrophane 3 is a kind of jatrophane diterpene polyester that can be isolated from the highly irritant extract of whole fresh plants of E. peplus L. (Euphorbiaceae) .
|
-
- HY-125116
-
|
Others
|
Others
|
Jatrophane 2 is a kind of jatrophane diterpene polyester that can be isolated from the highly irritant extract of whole fresh plants of E. peplus L. (Euphorbiaceae) .
|
-
- HY-126389
-
-
- HY-133223
-
|
Others
|
Cancer
|
Hispidanin B is a natural product that can be extracted from the rhizomes of Isodon hispida. Hispidanin B has cytotoxic activities against cancer cells .
|
-
- HY-136951
-
|
DNA/RNA Synthesis
|
Cancer
|
cp028 is a potent pre-mRNA splicing inhibitor. cp028 inhibits splicing in HeLa nuclear extract with an IC50 value of 54 µM .
|
-
- HY-N3527
-
|
Others
|
Cancer
|
Calyxin B can be extracted from the seeds of Alpinia blepharocalyx. Calyxin B has anti-proliferative activity and can be used in cancer research .
|
-
- HY-N0174
-
Cryptotanshinon; Tanshinone c
|
STAT
Autophagy
|
Cancer
|
Cryptotanshinone is a natural compound extracted from the root of Salvia miltiorrhiza Bunge that shows antitumor activities. Cryptotanshinone inhibits STAT3 with an IC50 of 4.6 μM.
|
-
- HY-N0938
-
|
Fluorescent Dye
|
Others
|
Safflower yellow is extracted from the flowers of the plant safflower (Carthamus tinctorius) and as the traditional Chinese medicine it has been extensively used for the treatment of cardio cerebrovascular diseases.
|
-
- HY-101832
-
-
- HY-U00301
-
|
Others
|
Cardiovascular Disease
|
Anti-hypertensive sulfonanilide 1 is a potent antihypertensive agent extracted from patent EP0338793A2, compound XVIIIa,b*, example No.1.
|
-
- HY-B2187
-
Diacetotoluide
|
Others
|
Metabolic Disease
|
Diacetazotol inhibits dioxin-induced ethoxyresorufin-O-deethylase (EROD) activity with IC50 of 75±4 nM. Diacetazotol extracts from patent US20070032458, compound 3.
|
-
- HY-15122A
-
-
- HY-126292
-
|
Ras
|
Cancer
|
KRAS G12C inhibitor 13 is a KRAS G12C inhibitor extracted from patent WO2018143315A1, compound 30 .
|
-
- HY-111465
-
|
CDK
|
Cancer
|
CDK8-IN-4 is an inhibitor of CDK8 extracted from patent WO2014090692A1, compound example 16, with an IC50 of 0.2 nM.
|
-
- HY-129181
-
|
FGFR
|
Cancer
|
FGFR4-IN-4 (compound 693) is a FGFR4 inhibitor with anti-tumor activity, extracted from patent WO2018113584A1 .
|
-
- HY-N2518
-
-
- HY-N6881
-
|
Others
|
Cardiovascular Disease
|
Gypenoside XIII is belonging to the gypenosides. Gypenosides, extracted from Gynostemma pentaphyllum, have various pharmacological properties and protect against cardiovascular diseases, especially atherosclerosis .
|
-
- HY-N0714
-
|
NF-κB
Autophagy
|
Cancer
|
Berbamine is a natural compound extracted from traditional Chinese medicine Phellodendron amurense Rupr. with anti-tumor, immunomodulatory and cardiovascular effects. Berbamine is a calcium channel blocker.
|
-
- HY-108277
-
|
Apoptosis
|
Cancer
|
Ginsenoside F5, from crude extracts of flower buds of Panax ginseng, remarkably inhibits the growth of HL-60 cells by the apoptosis pathway .
|
-
- HY-131658
-
|
VEGFR
|
Others
|
VEGFR-2-IN-6 (example 64) is a VEGFR2 inhibitor (angiogenesis modulator), which is extracted from patent WO 02/059110 .
|
-
- HY-103035
-
|
Phosphodiesterase (PDE)
|
Cancer
|
BIO-32546 (example 12b, S-isomer) is an autotaxin (ATX) modulator (IC50: 1 nM), extracted from the patent US20170158687A1 .
|
-
- HY-139326
-
-
- HY-N8377
-
|
TRP Channel
|
Inflammation/Immunology
|
Capsiate, as a capsaicin analogue extracted from a non-pungent cultivar of CH-19 sweet red pepper, is an orally active agonist of TRPV1 .
|
-
- HY-139911
-
|
Ras
|
Cancer
|
KRAS G12D inhibitor 7 is a potent inhibitor of KRAS G12D (extracted from patent WO2021108683, compound 114) .
|
-
- HY-145584
-
JPI-547/OCN-201
|
PARP
|
Cardiovascular Disease
Neurological Disease
|
Nesuparib is a potent inhibitor of PARP. Nesuparib is useful for the research of neuropathic pain, neurodegenerative disease, and cardiovascular disease (extracted from patent WO2016200101A2) .
|
-
- HY-145596
-
ZTS-00007928
|
Bacterial
|
Infection
|
Sirpefenicol (ZTS-00007928) is a phenicol antibacterial agent. Sirpefenicol can be used in bacterial infections in animals (extracted from patent WO2020068607A1) .
|
-
- HY-145458
-
|
GCGR
|
Metabolic Disease
|
GLP-1 receptor agonist 9 is a GLP-1 receptor agonist, example 7, extracted from WO2020234726 A1 .
|
-
- HY-145018
-
|
Ras
|
Cancer
|
KRAS G12C inhibitor 21 is a KRAS G12C inhibitor extracted from patent WO2021219090A1, example 7 .
|
-
- HY-145019
-
|
Ras
|
Cancer
|
KRAS G12C inhibitor 22 is a KRAS G12C inhibitor extracted from patent WO2021219072A1, example 120 .
|
-
- HY-143568
-
-
- HY-N9454
-
|
Others
|
Cancer
|
Garcinoic acid is the vitamin E analogue extracted from Garcinia Kola seeds. Garcinoic acid shows a marked antiproliferative effect on glioma C6 cancer cells .
|
-
- HY-143733
-
|
EGFR
|
Cancer
|
HER2-IN-5 is a potent and orally active HER-2 inhibitor, example 10, extracted from patent WO2021164697 .
|
-
- HY-N1018
-
|
|
|
11-Hydroxygelsenicine is a 11-hydroxy-substituted gelsedine-type indole alkaloid compound isolated from the EtOH extract of the stems of Gelsemium elegans .
|
-
- HY-N0975
-
|
Others
|
Metabolic Disease
|
1,11b-Dihydro-11b-hydroxymaackiain, a pterocarpane extract from the stems of Erycibe expansa, show a hepatoprotective effect .
|
-
- HY-147113
-
|
Others
|
Others
|
2-Methyl-3-buten-1-ol is a component of ylang-ylang oils can be extracted from the flowers .
|
-
- HY-46760
-
|
Liposome
|
Others
|
CCD Lipid01 is a cationic lipid useful in the delivery of biologically active agents to cells and tissues (extracted from patent WO2015095340 A1) .
|
-
- HY-107989
-
|
Antibiotic
|
Endocrinology
|
Urofollitropin is a protein extract of human menopausal urine. Urofollitropin has the function of promoting follicle development and maturation, but contains very small amounts of urinary proteins .
|
-
- HY-N10672
-
|
Antibiotic
|
Infection
Inflammation/Immunology
|
Kuguacin R is a cucurbitane-type triterpenoid that can be extracted from Momordica charantia L. Kuguacin R possess anti-inflammatory, antimicrobial and anti-viral activities .
|
-
- HY-N10694
-
|
Others
|
Others
|
Rehmannioside B is a desacyl derivative of Picrorhizaoside B, which can be isolated from the methanol extract of the rhizomes of Picrorhiza kurroa Royle ex Benth. (Plantaginaceae) .
|
-
- HY-N11702
-
|
Others
|
Others
|
Kaempferol-3-O-robinoside-7-Oglucoside is a double-chain flavonol triglycoside can be extracted from Withania somnifera .
|
-
- HY-N12175
-
|
Others
|
Others
|
3β-Hydroxytaraxast-20-en-16-one is a natural product isolated from eucalyptol/alcohol extract .
|
-
- HY-N12367
-
|
Others
|
Others
|
Oroxylin 7-O-glucoside is a flavone. Oroxylin 7-O-glucoside can be isolated from? hot methanol extracts of? Scutellaria ouata .
|
-
- HY-N12439
-
|
Others
|
Others
|
2,2′-Dihydroxy-4,6-dimethoxy-3-methylacetophenone can be isolated from the EtOAc extract of spurge stems.
|
-
- HY-N1477
-
Dencichin; ODAP
|
|
|
Dencichin is a non-protein amino acid originally extracted from Panax notoginseng, and can inhibit HIF-prolyl hydroxylase-2 (PHD-2) activity.
|
-
- HY-N12575
-
|
Others
|
Others
|
Physcion-8-O-(6'-O-malonyl)-glucoside can be extracted from the root tuber of Polygonum multiflorum Thunb .
|
-
- HY-13277
-
|
IRAK
|
Inflammation/Immunology
|
IRAK inhibitor 3 is an interleukin-1 (IL-I) receptor-associated kinase (IRAK) kinase modulator extracted from patent WO2008030579 A2.
|
-
- HY-50737
-
|
Deubiquitinase
|
Cancer
|
DUB-IN-3 is a potent deubiquitinase (USP) enzyme inhibitor extracted from reference compound 22c with an IC50 of 0.56 μM for USP8 .
|
-
- HY-79511
-
O-Desmorpholinopropyl Gefitinib
|
FAAH
Autophagy
|
Others
|
FAAH-IN-2 (O-Desmorpholinopropyl Gefitinib) is a potent FAAH(fatty acid amide hydrolase) inhibitor extracted from Patent WO/2008/100977A2.
|
-
- HY-N0706
-
|
Apoptosis
Autophagy
|
Cancer
|
Gracillin is a steroidal saponin that can be extracted from the roots of the plant and has anti-tumor properties. Gracillin can induce cancer cell apoptosis and autophagy .
|
-
- HY-19762
-
SCD inhibitor 1
|
Stearoyl-CoA Desaturase (SCD)
|
Cancer
|
GSK1940029 (SCD inhibitor 1) is a stearoyl-coa desaturase (SCD) inhibitor extracted from patent WO/2009060053 A1, compound example 16.
|
-
- HY-101430
-
-
- HY-P1350
-
|
Bacterial
|
Infection
|
H-Lys-Trp-Lys-OH is a small molecule peptide which displays antibacterial and antiviral activities extracted from patent CN 104072579 A, Compound AMP12.
|
-
- HY-U00416
-
|
Ras
|
Cancer
|
ARS-1323, the racemate of ARS-1620, is a novel inhibitor of mutant K-ras G12C extracted from patent WO 2015054572 A1.
|
-
- HY-111483
-
AZD0364
|
ERK
|
Cancer
|
Tizaterkib (AZD0364) is a potent and selective ERK2 inhibitor extracted from patent WO2017080979A1, compound example 18, has an IC50 of 0.6 nM.
|
-
- HY-112165
-
-
- HY-129171
-
-
- HY-114168
-
|
Ras
|
Cancer
|
KRAS G12C inhibitor 5 is a KRas G12C inhibitor extracted from patent WO2017201161A1, Compound example 147 .
|
-
- HY-100325
-
-
- HY-126296
-
-
- HY-N0546
-
Nuezhenoside
|
CaSR
|
Metabolic Disease
|
Ligustroflavone, extracted from Ligustrum lucidum, is a potential candidate as calcium-sensing receptor (CaSR) antagonist. Ligustroflavone exhibits protective effects against diabetic osteoporosis in mice .
|
-
- HY-125847
-
|
Others
|
Cancer
|
Salvianolic acid F is a kind of Salvianolic Acids. Salvianolic Acids is the most effective and abundant compounds extracted from Salvia miltiorrhiza, with good anti-oxidative activity .
|
-
- HY-10217
-
|
Thrombin
|
Cardiovascular Disease
|
Thrombin Inhibitor 2 is a small molecule direct thrombin inhibitor, extracted from US8541580B2.
Thrombin Inhibitor 2 has antithrombotic activity .
|
-
- HY-101159
-
|
ADC Linker
|
Cancer
|
Mal-amido-PEG8-C2-acid (example 142) is a nonclaevable ADC linker, extracted from patent US2018339985 .
|
-
- HY-N5040
-
|
Others
|
Inflammation/Immunology
|
Ilexhainanoside D is the main triterpenoid saponin extracted from Ilex hainanensis Merr., and the combination of Ilexhainanoside D and ilexsaponin A1 has anti-inflammation effect .
|
-
- HY-129490
-
|
Phosphodiesterase (PDE)
|
Cancer
|
Enpp-1-IN-1 is a Ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1) inhibitor extracted from patent WO2019046778, Example 55 .
|
-
- HY-135883
-
-
- HY-U00390
-
|
JAK
|
Cancer
|
JAK3-IN-7 is a potent and selective JAK3 inhibitor extracted from patent WO2011013785A1, has an IC50 of <0.01 μM.
|
-
- HY-U00068
-
|
PPAR
|
Metabolic Disease
|
PPARα-MO-1 is a potent PPARα modulator extracted from patent WO/2004/110982A1, formula I.
|
-
- HY-U00288
-
4-(3-Cyano-5,6-difluoroindol-1-yl)-2-hydroxybenzoic acid
|
Xanthine Oxidase
|
Metabolic Disease
|
Xanthine oxidase-IN-1 is a xanthine oxidase inhibitor extracted from patent WO2008126898A1, page 68, compound example 3, with an IC50 of 6.5 nM.
|
-
- HY-119580
-
|
Others
|
Inflammation/Immunology
|
Leucocyanidin is an active anti-ulcerogenic ingredient was extracted from Litchi Chinensis. Leucocyanidin demonstrates a significant protective effect against Aspirin-induced erosions in rat models .
|
-
- HY-131435
-
|
CD73
|
Cancer
|
CD73-IN-2 is a potent CD73 inhibitor extracted from WO2020151707A1, example 1, has an IC50 of 0.09 nM .
|
-
- HY-N7421
-
|
Others
|
Neurological Disease
|
Smilagenin acetate is a sapogenin derivative extracted from patent US20030004147A1. Smilagenin acetate increases the expression of acetylcholine m2 receptors and can be used for the research of dementia .
|
-
- HY-112301A
-
trans-BLU-667
|
RET
|
Cancer
|
trans-Pralsetinib (trans-BLU-667) is a rearranged during transfection (RET) inhibitor extracted from patent US20170121312A1, Compound Example 129 .
|
-
- HY-136773
-
-
- HY-131974
-
-
- HY-136073
-
|
Wnt
|
Cancer
|
Wnt pathway activator 2 is a potent Wnt activator extracted from patent WO2012024404A1, compound 2, has an EC50s of 13 nM .
|
-
- HY-136306
-
|
Beta-lactamase
Bacterial
|
Infection
|
Metallo-beta-lactamase ligand 1 is a class B β-lactamase inhibitor with antibacterial activity extracted from patent WO2019221122A1, compound A .
|
-
- HY-130797
-
-
- HY-114017
-
-
- HY-N9524
-
|
Acyltransferase
|
Metabolic Disease
|
Ilexoside XLVIII is an acyl CoA cholesteryl acyl transferase (ACAT) inhibitor. Ilexoside XLVIII is a triterpene saponin isolated from an aqueous extract of the leaves of Ilex kudincha .
|
-
- HY-139910
-
|
Ras
|
Cancer
|
KRAS G12D inhibitor 6 is a potent inhibitor of KRAS G12D (extracted from patent WO2021108683A1, compound 112) .
|
-
- HY-145106
-
-
- HY-145109
-
-
- HY-19990
-
-
- HY-N1770
-
3,4-Didehydrosapriparaquione
|
|
|
12-Hydroxysapriparaquinone (compound 8) is a rearranged 4,5-seco-abietane diterpenoid isolated from the petroleum ether extract of the root of Salvia rhytidea .
|
-
- HY-N11021
-
|
Others
|
Others
|
Feruloyl tyramine, an amide compound, can be isolated from ethanol extract of hemp seed. Feruloyl tyramine injected into the lateral ventricle caused hypothermia and dyskinesia in mice .
|
-
- HY-124433
-
iso-Tridecanoic methyl ester
|
Biochemical Assay Reagents
|
Others
|
Methyl 11-Methyldodecanoate is a methylated fatty acid methyl ester that has been used as a standard for the quantitative analysis of 11-methyl lauric acid in vernix and M. oleifera extracts.
|
-
- HY-N8617
-
|
Caspase
|
Cancer
|
Trijuganone C, a natural product extracted from Salvia miltiorrhiza, inhibits the proliferation of cancer cells through induction of apoptosis mediated by mitochondrial dysfunction and caspase activation .
|
-
- HY-N1580
-
|
|
|
Pyrroside B (compound 1) can be isolated from the methanol (MeOH) extract of the aerial part of Piper elongatum VAHL. Pyrroside B has antioxidative activity .
|
-
- HY-N12343
-
|
Bacterial
Fungal
|
Infection
|
Tetrahydrorhombifoline is one of quinolizidine alkaloids in the aerial parts of Genista vuralii A. Duran & H. Dural (Fabaceae). The alkaloid extract of G. vuralii has antibacterial and antifungal activities .
|
-
- HY-N12471
-
|
Others
|
Cancer
|
Gossypetin 3′-O-glucoside is a gossypetin derivative. Gossypetin 3′-O-glucoside can be isolated from ethanolic extracts after Soxhlet extraction .
|
-
- HY-W748456
-
|
Others
|
Others
|
Apigenin-7-O-sulfate is a major flavonoid which is found to be a distinctive feature of plants from the Bay of Cadiz and can be extracted from these plants .
|
-
- HY-N8520
-
|
Bacterial
|
Infection
Cancer
|
Variculanol is an antimicrobial, anticancer and anti-HCV NS3/4A Protease agent which can be extracted from marine fungus Aspergillus versicolor .
|
-
- HY-16355
-
|
PI3K
|
Cancer
|
NVP-QAV-572 is a PI3K inhibitor extracted from patent US7998990B2, Compound Example 8, has an IC50 of 10 nM.
|
-
- HY-N0858
-
|
HIV
|
Infection
|
Gomisin G is an ethanolic extract of the stems of Kadsura interior; exhibits potent anti-HIV activity with EC50 and therapeutic index (TI) values of 0.006 microgram/mL and 300, respectively.
|
-
- HY-N0776
-
-
- HY-U00292
-
|
AMPK
|
Metabolic Disease
|
AMPK activator 1 is an AMPK activator extracted from patent WO2013116491A1, compound No.1-75, has an EC50 of <0.1μM.
|
-
- HY-U00308
-
-
- HY-10013A
-
MK-0364 racemate
|
Cannabinoid Receptor
|
Neurological Disease
|
Taranabant racemate (MK-0364 racemate) is an antagonist and/or inverse agonist of the Cannabinoid-1 (CB1) receptor extracted from patent WO 2004048317 A1 .
|
-
- HY-12424A
-
|
Others
|
Cancer
|
42-(2-Tetrazolyl)rapamycin is a proagent compound of a rapamycin analog extracted from patent US 20080171763 A1, Example 1. Rapamycin is a specific mTOR inhibitor.
|
-
- HY-103695
-
|
CD73
|
Cancer
|
CD73-IN-1 is an inhibitor of CD73 which can be used in the treatment of cancer extracted from patent WO 2017153952 A1, example 80.
|
-
- HY-112219A
-
-
- HY-102998
-
-
- HY-101526
-
RA03546849
|
c-Fms
|
Inflammation/Immunology
|
GENZ-882706 is a potent colony stimulating factor-1 receptor (CSF-1R) Inhibitor extracted from patent WO 2017015267A1.
|
-
- HY-130680
-
|
Syk
|
Cancer
|
Syk-IN-3, a potent spleen tyrosine kinase (Syk) inhibitor, extracted from patent WO2011075515A1, compound example 152, has an IC50 of 1 nM .
|
-
- HY-12219B
-
|
Others
|
Metabolic Disease
|
MSI-1701 is an analogue of MSI-1436 which can control weight gain and blood glucose level extracted from patent US 7410959 B1.
|
-
- HY-N3386
-
|
Bacterial
|
Infection
|
Licoricone is an flavonoid extracted from licorice, exhibits anti-helicobacter pylori activity against the CLAR and AMOX-resistant strain as well as four CLAR (AMOX)-sensitive strains .
|
-
- HY-N2558
-
|
Others
|
Cancer
|
Murrayone, a coumarin-containing compound extracted from M. paniculata, is the most bioactive substance in this species and is a cancer metastasis chemopreventive agent based on its unique pharmacological properties .
|
-
- HY-N0564
-
-
- HY-N2417
-
|
Bacterial
|
Infection
|
Stearyl glycyrrhetinate, a major component in licorice extract, has a MIC against S. aureus strains of more than 256 mg/L. Stearyl glycyrrhetinate has antibacterial effects .
|
-
- HY-135516
-
SM-04554; Wnt pathway activator 1
|
Wnt
|
Cancer
|
Dalosirvat (SM-04554) is a potent Wnt activator extracted from patent WO2012024404A1, compound 1, has an EC50s of 28-29 nM .
|
-
- HY-N7494
-
|
Others
|
Cancer
|
Pentacosane is one of the major components in the acetone extract from Curcuma raktakanda and is also in the essential oil from the leaves of Malus domestica. Pentacosane exhibit anti-cancer activities .
|
-
- HY-136773A
-
ALK2-IN-4 succinate
|
TGF-β Receptor
|
Metabolic Disease
|
ALK2-IN-4 succinate is a potent ALK2 inhibitor extracted from patent WO2020086963A1, compound Formula I free base .
|
-
- HY-N4232
-
|
Autophagy
|
Inflammation/Immunology
|
Clematichinenoside AR is a major active ingredient that could be extracted from the traditional Chinese herb Clematis chinensis and has potent pharmacological effects on various diseases, including atherosclerosis (AS) .
|
-
- HY-13749C
-
(S)-MK-0431 phosphate
|
|
|
(S)-Sitagliptin phosphate is the less active S-enantiomer of Sitagliptin phosphate. Sitagliptin phosphate (MK-0431 phosphate) is a potent inhibitor of DPP4 with an IC50 of 19 nM in Caco-2 cell extracts .
|
-
- HY-N9381
-
|
Endogenous Metabolite
|
|
Kaempferol 3,4'-diglucoside is a flavonol isolated from the aqueous methanolic extract of norway spruce buds. Kaempferol 3,4'-diglucoside is identified in the needles .
|
-
- HY-139084
-
|
Others
|
Others
|
XL388-C2-NH2 is a monomeric compound extracted from patent WO2019212990A1, Monomer Z .
|
-
- HY-135898
-
-
- HY-139316
-
|
IRAK
PROTACs
|
Cancer
|
PROTAC IRAK4 degrader-5 is a Cereblon-based IRAK4 degrader extracted from patent US20190192668A1, compound I-171 .
|
-
- HY-139423
-
-
- HY-139760
-
|
Bacterial
|
Infection
|
Antibacterial agent 43 is an antibacterial agent extracted from patent WO2013030735A1, example 6. Antibacterial agent 43 can be used for the research of bacterial infections .
|
-
- HY-139761
-
|
Bacterial
|
Infection
|
Antibacterial agent 44 is an antibacterial agent extracted from patent WO2013030735A1, example 7. Antibacterial agent 44 can be used for the research of bacterial infections .
|
-
- HY-139763
-
|
Bacterial
|
Infection
|
Antibacterial agent 46 is an antibacterial agent extracted from patent WO2013030735A1, example 9. Antibacterial agent 46 can be used for the research of bacterial infections .
|
-
- HY-139754
-
|
Bacterial
|
Infection
|
Antibacterial agent 37 is an antibacterial agent extracted from patent WO2015063714A1, compound B. Antibacterial agent 37 can be used for the research of bacterial infections .
|
-
- HY-139755
-
|
Bacterial
|
Infection
|
Antibacterial agent 38 is an antibacterial agent extracted from patent WO2015063714A1, compound C. Antibacterial agent 38 can be used for the research of bacterial infections .
|
-
- HY-145577
-
|
Others
|
Neurological Disease
|
Lafadofensine is the monoamines reuptake inhibitor. Lafadofensine has th sufficient effects after short-term administration (extracted from patent WO2006121218A1, compound 1) .
|
-
- HY-W001957
-
4-Acetylbutyric acid; 5-Oxohexanoic acid; NSC-5281
|
Antibiotic
|
Infection
|
Glurate (4-Acetylbutyric acid; 5-Oxohexanoic acid) can be used to construct antiviral agents (acyclic nucleoside esters) (extracted from patent WO1997030052A1) .
|
-
- HY-115918
-
Xanthoangelol E
|
Others
|
Infection
|
XA-E is a compound purified from a methanol-ethyl acetate extract from A. keiskei. XA-E displays anti-ZIKV activity with an IC50 value of 22.0 µM .
|
-
- HY-N1160
-
|
Bacterial
|
Infection
|
Tetrahydroxysqualene is a triterpene, possessing antimycobacterial activity against Mycobacterium tuberculosis with an MIC of 10.0 μg/mL. Tetrahydroxysqualene can be isolated from the methanolic extracts of Rhus taitensis Guill .
|
-
- HY-150403
-
-
- HY-N7761
-
Tetrahydro tanshinone I
|
Others
|
Cancer
|
Trijuganone B (Tetrahydro tanshinone I) can be extracted from from the roots of Salvia miltiorrhiza f. alba. Trijuganone B inhibits the proliferation of leukemia cells .
|
-
- HY-N3866
-
|
COX
|
Inflammation/Immunology
|
Esculentic acid is a selective COX-2 inhibitor and has anti-inflammatory effect. Esculentic acid is a pentacyclic triterpenoid that can be extracted from the Chinese herb Phytolacca esculenta .
|
-
- HY-13749D
-
-
- HY-N10133
-
3′-Prenylnaringenin
|
Bacterial
|
Others
|
Licoflavanone (compopund 2) is a flavanone. Licoflavanone can be isolated from the MeOH extract of Air-dried leaves of G. glabra var. typica. Licoflavanone has antibacterial activity .
|
-
- HY-127067
-
|
Akt
EGFR
mTOR
|
Inflammation/Immunology
Cancer
|
Yuanhuadin, extracted from Genkwa Flos Daphne genkwa, has antitumor activity through inhibiting Akt/mTOR and EGFR pathways, induce cell-cycle arrest and abortion .
|
-
- HY-N12431
-
|
Others
|
Cancer
|
Machilin A is a lignan isolated from the methanolic extract of Phoebe bark. Machilin A inhibits melanin biosynthesis in B-16 mouse melanoma cells with an IC50 of 39.9 μM.
|
-
- HY-N12551
-
|
Others
|
Others
|
2-O-β-D-Glucopyranosylcucurbitacin F 25-acetate is a cucurbitacin glucoside that can isolated from the more polar fractions of the MeOH extract of Cigarrilla mexicana .
|
-
- HY-N12525
-
|
Others
|
Inflammation/Immunology
|
Bartsioside is an anti-inflammatory agent which can be extracted from C. deserticola. Bartsioside exerts no significant cytotoxicity under 40 μM to BV-2 cells .
|
-
- HY-B0355R
-
BN-52020 (Standard)
|
GABA Receptor
Endogenous Metabolite
|
Inflammation/Immunology
|
Ginkgolide A (Standard) is the analytical standard of Ginkgolide A. This product is intended for research and analytical applications. Ginkgolide A (BN-52020) is an extract from in Ginkgo biloba and a g-aminobutyric acid (GABA) antagonist.
|
-
- HY-N12566
-
|
Others
|
Neurological Disease
|
Erinacin B is a active product that can be extracts from the mycelia of Hericium erinaceum. Erinacin B shows potent stimulating activity of nerve growth factor (NGF)-synthesis .
|
-
- HY-11105
-
XL147 analogue
|
PI3K
Apoptosis
|
Cancer
|
Pilaralisib analogue (XL147 analogue) is a representative and selective PI3Kα inhibitor extracted from patent WO2012006552A1, Compound 147 in Table 1.
|
-
- HY-10497
-
|
c-Met/HGFR
VEGFR
|
Cancer
|
BMS-794833 is a VEGFR2 and Met inhibitor extracted from patent WO2009094417, compound example 1; has IC50s of 15 and 1.7 nM, respectively.
|
-
- HY-N0040
-
-
- HY-100380
-
|
Thrombopoietin Receptor
|
Cardiovascular Disease
|
TPO agonist 1 is a thrombopoietin (TPO) agonist extracted from patent WO2008134338A1, compound TPO mimetic. It would be useful as promoters of thrombopoiesis and megakaryocytopoiesis to treat thrombocytopenia .
|
-
- HY-U00054
-
-
- HY-U00321
-
-
- HY-U00417
-
|
Ras
|
Cancer
|
ARS-1630, a less active enantiomer of ARS-1620, is a novel inhibitor of mutant K-ras G12C extracted from patent WO 2015054572 A1.
|
-
- HY-103620
-
|
ROCK
|
Inflammation/Immunology
|
ROCK2-IN-2 is a selective ROCK2 inhibitor extracted from patent US20180093978A1, Compound A-30, has an IC50 of <1 μM.
|
-
- HY-135089
-
-
- HY-111810
-
-
- HY-N1516
-
|
Apoptosis
|
Cancer
|
Ganoderenic acid D is a triterpene identified from the effective compounds of Ganoderma lucidum extract (GLE). Ganoderenic acid D inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis .
|
-
- HY-128726
-
|
Itk
|
Inflammation/Immunology
|
ITK inhibitor 2 is a interleukin-2-inducible T-cell kinase (ITK) inhibitor extracted from patent WO2011065402A1, compound 4, with an IC50 of 2 nM.
|
-
- HY-N6942
-
|
Others
|
Metabolic Disease
Cancer
|
Mogroside IV-A, a triterpenoid glycoside isolated from the extracts of Luo Han Guo, is a nonsugar sweetener. Mogrosides are sweeter than sucrose. Mogrosides exhibit antioxidant, antidiabetic and anticancer activities .
|
-
- HY-N6945
-
|
Others
|
Metabolic Disease
Cancer
|
Mogroside IV, a triterpenoid glycoside isolated from the extracts of Luo Han Guo, is a nonsugar sweetener. Mogrosides are sweeter than sucrose. Mogrosides exhibit antioxidant, antidiabetic and anticancer activities .
|
-
- HY-N1941
-
|
|
|
Isosinensetin, a polymethoxylated flavone extracted from pericarpium citri reticulatae viride, exhibits inhibition on P-glycoprotein (P-gp) in MDR1-MDCKII cells .
|
-
- HY-N3075
-
-
- HY-W002110
-
3-Hydroxy-4-methoxyphenylacetic acid; iso-HVA; Homoisovanillic acid
|
Endogenous Metabolite
|
Cancer
|
Isohomovanillic acid (3-Hydroxy-4-methoxyphenylacetic acid) is extracted from urine at pH 2 by ethyl acetate. Isohomovanillic acid is not found in appreciable values in many normal human urines .
|
-
- HY-135088
-
-
- HY-N1713
-
|
|
|
29-Nor-20-oxolupeol, extracted from Impatiens basamina, reduces NO levels in LPS-activated murine microglial cells with an IC50 of 44.21 µM .
|
-
- HY-N3977
-
-
- HY-137179
-
|
Biochemical Assay Reagents
|
Others
|
Glyco-diosgenin is a synthetic surfactant and detergent for extracting proteins from membranes for structure and function studies, and single-particle cryo-electron microscopy (cryoEM) studies of membrane proteins .
|
-
- HY-12813
-
-
- HY-138181
-
MRX-I phosphoramidic acid
|
Others
|
Others
|
Contezolid phosphoramidic acid is an intermediate in the synthesis of proagents of antibacterial oxazolidinone agent MRX-I. Contezolid phosphoramidic acid is extracted from patent WO2015127316A1, Intermediate 3, Method I .
|
-
- HY-126378
-
|
Ser/Thr Protease
|
Inflammation/Immunology
|
LSP-249 (example 35), extracted from patent WO2016011209A1, is a plasma kallikrein inhibitor under the study for angioedema, with an EC50 less than 100 nM in cell .
|
-
- HY-138944
-
|
SGLT
|
Metabolic Disease
|
SGLT1/2-IN-1 is a dual SGLT1/SGLT2 inhibitor extract from WO2015032272A1, compound 2 .
|
-
- HY-N6606
-
|
Bacterial
|
Others
|
Delphinidin-3-O-galactoside (chloride) is an anthocyanin that extracts from wheat flour. Delphinidin-3-O-galactoside (chloride) can be used for the research of antioxidant and antimicrobial .
|
-
- HY-145107
-
-
- HY-145120
-
|
Raf
|
Cancer
|
B-Raf IN 2 is a potent and selective BRAF inhibitor extracted from patent WO2021116055A1, compound Ia. B-Raf IN 2 can be used for the research of cancer .
|
-
- HY-145585
-
MIJ-821
|
iGluR
|
Neurological Disease
|
Onfasprodil is negative allosteric modulator of NR2B. Onfasprodil in combination with GABA receptor regulator has the potential for the research of Alzheimer's disease (extracted from patent CN111481543A) .
|
-
- HY-142518
-
|
VEGFR
|
Cancer
|
EGFR-IN-26 is a EGFR inhibitor extracted from patent WO2019162323A1 compound I-028. EGFR-IN-26 can be used for the research of cancer .
|
-
- HY-145995
-
|
Others
|
Others
|
CS12192 is a compound improving survival and weight gain. CS12192 has the potential for the research of graft-versus-host disease (GVHD) (extracted from the patent CN112773802A) .
|
-
- HY-101850
-
|
Biochemical Assay Reagents
|
Others
|
MOPSO is a biological zwitterionic buffer with the useful pH range from 6.2 to 7.6. MOPSO has been employed as a buffer component of charcoal yeast extract medium .
|
-
- HY-148830
-
|
Liposome
|
Others
|
Piperazine-bis(ethyl octadeca-9,12-dienoate) is a cationic lipid extracted from patent WO2023036148A1, and can be used for the generation of Lipid nanoparticles (LNPs).
|
-
- HY-N12001
-
|
Others
|
Neurological Disease
|
6-Epiagarotetrol is a neuroprotective agent can be extracted from Aquilaria sinensis. 6-Epiagarotetrol has a protective effect on corticosterone-induced PC12 cell damage .
|
-
- HY-N2140
-
|
|
|
Herpetone, the ethylacetate extract, is a lignan compound. Herpetone can be isolated from the seeds of Herpetospermum caudigerum. Herpetone significantly improved the cell viability, and has a protective effect on hepatocytes in vitro .
|
-
- HY-W700539S
-
|
Isotope-Labeled Compounds
|
Others
|
N1-Acetyl triethylenetetramine-d4 is deuterated N1-Acetyl triethylenetetramine and can be used as an internal standard in plasma extracts .
|
-
- HY-N3007A
-
|
Others
|
Inflammation/Immunology
|
(E)-Naringenin chalcone is an orally active anti-allergic agent. (E)-Naringenin chalcone also has antioxidant, anti-inflammatory activities. (E)-Naringenin chalcone can improve adipocyte functions. (E)-Naringenin chalcone inhibits histamine release from rat peritoneal mast cell .
|
-
- HY-N8243
-
|
Others
|
Metabolic Disease
|
Coreopsin is a natural product that can be isolated from Coreopsis tinctoria Nutt. flower. Coreopsin can be used for hypertension and diabetes research .
|
-
- HY-17388
-
|
Cholinesterase (ChE)
|
Neurological Disease
|
(±)-Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD).
|
-
- HY-15884
-
|
HIV
|
Infection
|
GSK2838232 inhibit HIV reverse transcriptase activity across a broad panel of HIV-1 isolates, extracted from patent WO/2013090664A1, compound51.
|
-
- HY-U00413
-
-
- HY-108940
-
-
- HY-125873
-
|
Ras
|
Cancer
|
KRAS G12C inhibitor 15 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 22, has an IC50 of 5 nM .
|
-
- HY-129749
-
-
- HY-125875
-
|
Ras
|
Cancer
|
KRAS G12C inhibitor 17 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 82, has an IC50 of 5 nM .
|
-
- HY-125874
-
|
Ras
|
Cancer
|
KRAS G12C inhibitor 16 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 39, has an IC50 of 97 nM .
|
-
- HY-114428
-
|
PI3K
|
Cancer
|
P110δ-IN-1 is a potent and selective inhibitor of P110δ extracted from patent WO 2014055647 A1, with an IC50 of 8.4 nM .
|
-
- HY-N0332
-
-
- HY-N2197
-
|
|
|
Hirsuteine is an indole alkaloid extracted from Uncaria rhynchophylla. Hirsuteine non-competitively antagonizes nicotine-mediated dopamine release by blocking ion permeation through nicotinic receptor channel complexes .
|
-
- HY-N4095
-
-
- HY-N0726
-
Dracohodin perochlorate
|
Apoptosis
|
Cancer
|
Dracorhodin perchlorate (Dracohodin perochlorate) is a natural product extracted from a natural medicine Dragon's blood. Dracorhodin perchlorate inhibits cell proliferation and induces cell cycle arrest and apoptosis .
|
-
- HY-N7029
-
|
Others
|
Cancer
|
3',4',5',5,7-Pentamethoxyflavone, a natural flavonoid extracted from Rutaceae plants, sensitizes chemoresistant cancer cells to chemotherapeutic agents by inhibition of Nrf2 pathway .
|
-
- HY-125872
-
|
Ras
|
Cancer
|
KRAS G12C inhibitor 14 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 17, has an IC50 of 18 nM .
|
-
- HY-N4309
-
|
Others
|
Cardiovascular Disease
|
Lotusine is a pure alkaloid extracted from the green seed embryo of Nelumbo nucifera Gaertn. Lotusine shows effects on the action potentials in myocardium and slow inward current in cardiac Purkinje fibers .
|
-
- HY-W042039
-
|
Calcium Channel
|
Cardiovascular Disease
|
Methyl homoveratrate, a metabolite of RWJ-26240 in vivo, can be identified in plasma, urine and faecal extract. McN5691 (RWJ-26240) is a voltage-sensitive calcium channel blocker .
|
-
- HY-N7439
-
|
PGC-1α
|
Metabolic Disease
|
Mogroside VI B, a cucurbitane glucoside, separated from the crude extract of Siraitia grosvenorii. Mogroside VI B shows effect on activating PGC-1α transcription .
|
-
- HY-136567
-
|
Raf
|
Cancer
|
TBAP-001 (Synthesis 13), extracted from patent WO2015075483A1, is a pan-RAF kinase inhibitor, with an IC50 of 62 nM in BRAF V600E kinase assay .
|
-
- HY-136613
-
|
Bacterial
|
Infection
|
Demethyl linezolid is a impurity of linezolid. Demethyl linezolid is a useful antimicrobial agent extracted from patent WO1995007271A1, example 9, effective against a number of human and veterinary pathogens .
|
-
- HY-138040
-
|
Ligands for E3 Ligase
|
Cancer
|
CRBN modulator-1, a Thalidomide analog and a CRBN modulator extracted from WO2020006262A1, compound 10, has an IC50 of 3.5 μM and a Ki of 0.98 μM .
|
-
- HY-110325
-
|
Sodium Channel
|
Neurological Disease
|
PF-04885614 is a potent NaV1.8 inhibitor, extracted from patent US2018328915. PF-04885614 has potential for neurological and neurodevelopmental diseases treatment .
|
-
- HY-111351
-
-
- HY-111451
-
M1774; ATR inhibitor 1
|
ATM/ATR
|
Cancer
|
Tuvusertib (M1774; ATR inhibitor 1) is a selective and orally active ATR inhibitor extracted from patent WO2015187451A1, compound I-l, with a Ki value below 1 μΜ .
|
-
- HY-U00304
-
|
Aurora Kinase
|
Cancer
|
Aurora B inhibitor 1 is an Aurora B (Aurora-1) inhibitor extracted from patent WO2007059299A1, compound 1-3, has a Ki value of <0.010 uM.
|
-
- HY-105686
-
-
- HY-141647
-
|
Dopamine Receptor
|
Others
|
[18F]-Labeled L-dopa precursor is a precursor for synthesis of 18F-labeled L-dopa extracted from patent WO2014095739A1, example 8 .
|
-
- HY-139957
-
-
- HY-145592
-
RO7020531; RG7854
|
Toll-like Receptor (TLR)
|
Infection
|
Ruzotolimod is the agonist of TLR7. Ruzotolimod has the potential for the research of HBV, COVID-19 or SARS-CoV-2 infection (extracted from patent WO2021130195A1) .
|
-
- HY-132977
-
|
Others
|
Others
|
BTTAA-OH is a kind of tris(triazolylmethyl)amine compound. BTTAA-OH has the potential for the research of labeling and/or imaging in living system (extracted from patent WO2012021390A1) .
|
-
- HY-113862
-
|
Fluorescent Dye
|
Others
|
PHOME is a fluorogenic substrate for sEH. sEH can hydrolyze the epoxy ring in the PHOME substrate. PHOME can be used for fluorescent epoxide hydrolase assay (extracted from patent CN113402447A) .
|
-
- HY-Y0586
-
|
|
|
2,4,5-Trimethoxybenzoic acid is a compound identified in purple perilla extracts. 2,4,5-Trimethoxybenzoic acid inhibits M1 macrophage phenotype-mediated inflammation in diabetes .
|
-
- HY-131515
-
-
- HY-D1500
-
|
Fluorescent Dye
|
Others
|
Fluorescent NIR 885 is a cyanine near-infrared-absorbing dye. Fluorescent NIR 885 can be used as a photoprotective agent (extracted from patent WO2014006589 compound 1-35) .
|
-
- HY-W355129
-
|
Others
|
Cancer
|
MeIQx, a dietary aromatic amine, is mutagenic compound could be isolated from present in fried beef and beef extracts. MeIQx binds covalently to hemoglobin. MeIQx induces liver tumors .
|
-
- HY-N7542
-
|
Others
|
Others
|
Praeroside II is an angular-type pyranocoumarm glycoside. Praeroside II can be isolated from the n-butanol-extracts of P. praeruptorum Dunn. Praeroside II can be used for pharmacological study .
|
-
- HY-N8914
-
|
Others
|
Others
|
Isoshinanolone is a natural product that can be extracted from Plumbago capensis. Isoshinanolone has mosquito larvicidal activity against fourth instar larvae of A. aegypti, with an IC50 value of 1.26 μg/mL .
|
-
- HY-121597
-
|
Others
|
Others
|
Yuankanin is a genkwanin-5-bioside, the sugar moiety being composed of xylose and glucose. Yuankanin can be isolated from the methanol extract of the aerial parts of Gnidia involucrata (Thymelaeaceae) .
|
-
- HY-122949
-
|
DGK
|
Metabolic Disease
|
Momordicine I, a triterpenoid compound extracted from momordica charantia L. Momordicine I alleviates isoproterenol-induced cardiomyocyte hypertrophy through suppression of PLA2G6 and DGK-ζ .
|
-
- HY-139593S
-
-
- HY-N11993
-
|
Cholinesterase (ChE)
|
Others
|
Aloveroside A is a triglucosylnaphthalene derivative isolated from ethanolic extract of aloe vera. Aloveroside A has weak bACE inhibitory activity (inhibition rate at a dose of 100 μg/mL is approximately 18.68%) .
|
-
- HY-N1221
-
|
|
|
Stigmast-4-en-3,6-dione is an anti-inflammatory and anti-allergic agent which can be extracted from Hibiscus cannabinus and Piper betle .
|
-
- HY-N3411
-
13E-Labdene-8α,15-diol; Copal-8α,15-diol
|
Others
|
Others
|
Labd-13(E)-ene-8α,15-diol is a diterpene with the labdane skeleton which can be extracted from Cistus symphytijbfolius .
|
-
- HY-W411439
-
|
Others
|
Metabolic Disease
|
1-O-p-Coumaroyl-β-D-glucose can promote glucose uptake in HuH7 cells, and be be extracted from Luffa cylindrica (L.) Roem (sponge gourds) .
|
-
- HY-N8761
-
|
NO Synthase
|
Metabolic Disease
|
Kihadanin A (compound 3) is a limonoid NOS3 inhibitor that can be isolated from the methanol extract of Dictamnus dasycarpus root bark. Kihadanin A is useful in the study of hyperuricemia (HUA) [3].
|
-
- HY-32735
-
PG490
|
NF-κB
Apoptosis
|
Cancer
|
Triptolide is a diterpenoid triepoxide extracted from the root of Tripterygium wilfordii with immunosuppressive, anti-inflammatory, antiproliferative and antitumour effects. Triptolide is a NF-κB activation inhibitor .
|
-
- HY-18604
-
|
Ras
|
Cancer
|
K-Ras G12C-IN-1 is a novel and irreversible inhibitor of mutant K-ras G12C extracted from patent WO 2014152588 A1.
|
-
- HY-19758A
-
|
Sirtuin
|
Cancer
|
Sirtuin modulator 1 is a modulator of SIRTl, a homolog of SIRT3, with EC1.5 of < 1 μM, extracted from patent WO 2010071853 A1, Compound No.4.
|
-
- HY-19761
-
|
RIP kinase
|
Cancer
|
RIP2 kinase inhibitor 2 is a receptor interacting protein-2 (RIP2) kinase inhibitor extracted from patent WO/2014043437 A1, compound example 9.
|
-
- HY-N0360
-
|
SARS-CoV
|
Cardiovascular Disease
|
Dihydrotanshinone I is a natural compound extracted from Salvia miltiorrhiza Bunge which has been widely used for treating cardiovascular diseases. Dihydrotanshinone I exhibits entry-blocking effect for MERS-CoV.
|
-
- HY-B2175
-
Aluminum diacetylsalicylate
|
Others
|
Inflammation/Immunology
|
Aspirin Aluminum is a novel intermolecular compound which can inhibit gastrointestinal mucosal disorders induced by NSAIDs (non-steroidal anti-inflammatory agents) extracted from patent WO 2010064441 A1.
|
-
- HY-131132
-
SHP2-IN-6
|
SHP2
Phosphatase
|
Cancer
|
JAB-3068 (SHP2-IN-6) is a potent SHP2 inhibitor, extracted from patent WO2017211303A1, compound 7, has an IC50 of 25.8 nM .
|
-
- HY-111468
-
|
Bcl-2 Family
|
Cancer
|
Mcl1-IN-3 is an inhibitor of Mcl1 extracted from patent WO2015153959A2, compound example 57; has an IC50 and Ki of 0.67 and 0.13 μM, respectively.
|
-
- HY-102048
-
|
STAT
Apoptosis
|
Cancer
|
STAT5-IN-2 is a STAT5 inhibitor, extracted from reference 1, example 17f. STAT5-IN-2 has potent antileukemic effect .
|
-
- HY-111429
-
|
YAP
|
Cancer
|
YAP/TAZ inhibitor-1 is a YAP/TAZ inhibitor extracted from patent WO2017058716A1, Compound 1, has an IC50 of <0.100 μΜ in firefly luciferase assay .
|
-
- HY-111940
-
|
Raf
|
Inflammation/Immunology
|
LUT014 is a B-Raf inhibitor with an IC50 of 11.7 nM, and developed to reduce dose-limiting acneiform lesions associated EGFR Inhibitors treatment. Extracted from patent WO 2019026065A2 .
|
-
- HY-116649
-
-
- HY-13707
-
Stannsoporfin; SnMP
|
Others
|
Metabolic Disease
|
Tin(IV) mesoporphyrin IX dichloride (Stannsoporfin) is a heme oxygenase (HO) inhibitor being developed for the prevention of hyperbilirubinemia in infants at risk of developing jaundice, extracted from patent WO2011103196A1 .
|
-
- HY-N6017
-
|
HDAC
|
Cancer
|
Bakkenolide A is a natural product extracted from Petasites tricholobus. Bakkenolide A inhibits leukemia by regulation of HDAC3 and PI3K/Akt-related signaling pathways .
|
-
- HY-N4117
-
|
Bacterial
|
Infection
|
Hamamelitannin, a polyphenol extracted from the bark of Hamamelis virginiana, is a quorum-sensing (QS) inhibitor. Hamamelitannin increases antibiotic susceptibility of staphylococcus aureus biofilms by affecting peptidoglycan biosynthesis and eDNA release .
|
-
- HY-135379
-
|
Drug Metabolite
|
Cardiovascular Disease
|
Atorvastatin acetonide is an impurity of Atorvastatin, and extracted from patent WO2011131605A1, Compound 4. Atorvastatin is an orally active HMG-CoA reductase inhibitor and has the ability to effectively decrease blood lipids .
|
-
- HY-136301
-
|
Others
|
Inflammation/Immunology
|
Acid secretion-IN-1 is a polycyclic compound extracted from patent WO2018024188A1, Compound Example 17.4. Acid secretion-IN-1 is synthesized and used in the IDO inhibitor synthetic experiment .
|
-
- HY-N3925
-
|
Bacterial
|
Infection
Metabolic Disease
Inflammation/Immunology
|
Ganoderol A is a terpenoid extracted from Ganoderma lucidum with antimicrobial activities. Ganoderol A inhibits cholesterol synthesis pathway and has significant anti-inflammatory activity and protection against ultraviolet A (UVA) damage .
|
-
- HY-135793
-
|
Others
|
Cancer
|
Macropa-NH2 diester is a compound can be used for imaging during the investigation of cancer. Macropa-NH2 diester is compound 210 extracted from patent WO2018187631 .
|
-
- HY-N9331
-
Cimicidanol-3-O-β-d-xyloside
|
Others
|
Metabolic Disease
|
Cimicifugoside H-1, a cyclolanostanol xyloside, is a major constituent of C. foetida L. extract. Cimicifugoside H-1 inhibits bone resorption and ovariectomy-induced bone loss .
|
-
- HY-W012531
-
|
HIV
SARS-CoV
Endogenous Metabolite
|
Infection
|
2-Hydroxycinnamic acid is isolated from the methanol extract of Cinnamomum cassia. 2-Hydroxycinnamic acid shows inhibitory effects on infection of HIV/SARS-CoV S pseudovirus with an IC50 of 0.3 mM
|
-
- HY-139707
-
-
- HY-145073
-
|
PROTACs
Estrogen Receptor/ERR
|
Cancer
|
PROTAC ER Degrader-10 is a potent PROTAC ER degrader and can be used for cancer research. PROTAC ER Degrader-10 is extracted from patent WO2021133886, example 36.
|
-
- HY-144880
-
|
ADC Cytotoxin
EGFR
Drug Metabolite
|
Cancer
|
SC209, an ADC cytotoxin extracted from patent WO2021247798, is used in synthesis of anti-EGFR antibody-drug conjugate ADC. SC209 is a metabolite of STRO-002 .
|
-
- HY-144422
-
|
RET
|
Cancer
|
RET-IN-15 is a rearranged during transfection (RET) kinase inhibitor extracted from patent WO2021115457A1 compound 51. RET-IN-15 can be used for the research of cancer .
|
-
- HY-N9294
-
|
Others
|
Others
|
2',4'-Dihydroxy-7-methoxy-8-prenylflavan (compound 6) is a compound isolated from a chloroform-soluble extract of dried Morus alba fruits .
|
-
- HY-150402
-
|
Drug-Linker Conjugates for ADC
|
Cancer
|
MC-Gly-Gly-Phe-Gly-amide-cyclopropanol-amide-Exatecan is a pharmaceutical composition containing antibody agent conjugate (ADC). (extracted from patent WO2021190581 Example 1-8) .
|
-
- HY-129271
-
Deltorphin A; Dermenkephalin
|
Opioid Receptor
|
Others
|
Deltorphin (Deltorphin A; Dermenkephalin) is a biological active peptide. (Deltorphin A peptide was isolated from skin extracts of the South American frog, Phyllomedusa sauvagei. Deltorphin A is a potent and selective agonist for the delta-opioid receptor.)
|
-
- HY-N8604
-
|
Others
|
Inflammation/Immunology
|
Methyl 4-O-caffeoylquinate is an extract naturally
derived from the leaf ofIlex paraguariensis. Methyl
4-O-caffeoylquinate has human neutrophilic elastase (HNE) inhibitory activity
.
|
-
- HY-N12028
-
|
Others
|
Others
|
Acacetin 7-O-glucuronide is a glucuronide isolated from the methanolic leaf extract of Acacetin. Acacetin 7-O-glucuronide has potential applications in the development of nutraceuticals and pharmaceutical formulations .
|
-
- HY-121908
-
|
ATP Synthase
|
Cancer
|
FCPT, an ATP competitive inhibitor, induces a tight-binding of kinesin-5 onto microtubules and induced loss of microtubules selectively at the poles of Xenopus extract spindles without altering microtubule dynamics .
|
-
- HY-N0880
-
|
Others
|
Cancer
|
Cinobufotalin is a cardiotonic steroids or bufadienolides, is extracted from the skin secretions of the giant toads. Cinobufotalin has been used as a cardiotonic, diuretic and a hemostatic agent, Cinobufotalin is also a potential anti-lung cancer agent .
|
-
- HY-18769
-
IDO-IN-4
|
Indoleamine 2,3-Dioxygenase (IDO)
|
Cancer
|
BMS-978587 (IDO-IN-4) is an indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor, extracted from patent WO2014150677A1, Compound example 1 enantiomer 1.
|
-
- HY-N2020
-
-
- HY-100083
-
|
HIV
|
Others
|
Dolutegravir intermediate-1 is a synthetic intermediate of Dolutegravir extracted from patent WO 2016125192 A2. Dolutegravir is an integrase inhibitor developed for the treatment of human immunodeficiency virus (HIV)-1 infection.
|
-
- HY-P1355
-
|
Calcineurin
|
Inflammation/Immunology
|
Cyclosporin A-Derivative 1 is a crystalline intermediate derived from the opening of cyclosporin A extracted from patent WO 2013167703 A1. Cyclosporin A is an immunosuppressive agent which can bind to the cyclophilin and inhibit calcineurin.
|
-
- HY-128831
-
-
- HY-125997
-
|
Btk
|
Inflammation/Immunology
|
BTK inhibitor 10 is a potent and orally active Bruton kinase (BTK) inhibitor, extracted from patent WO2018145525, example 33. BTK inhibitor 10 has a potential for rheumatoid arthritis treatment .
|
-
- HY-129169
-
|
Deubiquitinase
|
Cancer
|
USP7-IN-6 is a potent ubiquitin specific protease 7 (USP7) inhibitor, extracted from patent WO2017212010A1, example 25, has an IC50 of 6.8 nM .
|
-
- HY-N2072
-
Transcrocetin; trans-Crocetin
|
iGluR
Endogenous Metabolite
|
Cancer
|
Crocetin (Transcrocetin), extracted from saffron (Crocus sativus L.), acts as an NMDA receptor antagonist with high affinity . Crocetin is capable of crossing the blood-brain barrier and reach the central nervous system (CNS) .
|
-
- HY-N6850
-
|
HSP
Endogenous Metabolite
|
|
Calenduloside E (CE) is a natural pentacyclic triterpenoid saponin extracted from Aralia elata. Calenduloside E (CE) has anti-apoptotic potent by targeting heat shock protein 90 (Hsp90) .
|
-
- HY-N1933
-
|
|
|
Allocryptopine, a derivative of tetrahydropalmatine, is extracted from Macleaya cordata (Thunb.) Pers. Papaveraceae. Allocryptopine has antiarrhythmic effects and potently blocks human ether-a-go-go related gene (hERG) current .
|
-
- HY-N6030
-
(Rac)-Dencichin; (Rac)-ODAP
|
HIF/HIF Prolyl-Hydroxylase
|
Others
|
(Rac)-Dencichine ((Rac)-Dencichin) is the racemate of Dencichin. Dencichin is a non-protein amino acid originally extracted from Panax notoginseng, and can inhibit HIF-prolyl hydroxylase-2 (PHD-2) activity .
|
-
- HY-N6010
-
|
Others
|
Others
|
8-hydroxybergapten is O-methylated by cell-free extracts of Ruta cells to isopimpinellin, in reactions mediated by discrete O-methyltransferases. 8-hydroxybergapten has excellent anti-wrinkle effect .
|
-
- HY-N1402
-
Sophoridine N-oxide
|
|
|
Oxysophoridine (Sophoridine N-oxide) is a bioactive alkaloid extracted from the Sophora alopecuroides Linn. Oxysophoridine (Sophoridine N-oxide) shows anti inflammatory, anti oxidative stress and anti apoptosis effects .
|
-
- HY-N2050
-
Desmethylbellidifolin
|
|
|
1,3,5,8-Tetrahydroxyxanthone (Desmethylbellidifolin) is a natural xanthone extracted from Swertia chirata. 1,3,5,8-Tetrahydroxyxanthone has antispasmodic effect and anti-inflammatory activity .
|
-
- HY-18770A
-
NLG-1486
|
|
|
IDO-IN-6 (NLG-1486) is an indoleamine 2,3-dioxygenase (IDO) inhibitor extracted from patent WO WO2012142237A1, Compound 1486, has an IC50 of <1 μM.
|
-
- HY-132988
-
|
Amino Acid Derivatives
|
Others
|
Fmoc-Tyr(3-F,tBu)-OH is a cyclic peptide compound with high membrane permeability and can specifically binds to a target molecule (extracted from patent WO2018225864A1) .
|
-
- HY-144419
-
|
Adenosine Receptor
|
Cancer
|
Adenosine receptor antagonist 3 is a potent antagonist of adenosine receptor. Adenosine receptor antagonist 3 has the potential for the research of cancer disease (extracted from patent WO2019233994A1, compound 1) .
|
-
- HY-144209
-
|
CD73
|
Cancer
|
CD73-IN-6 is a CD73 inhibitor extracted from patent WO2022007677A1 compound 2. CD73-IN-6 can be used for the research of cancer .
|
-
- HY-121397
-
|
ROS Kinase
|
Inflammation/Immunology
|
Phyltetralin (Compound 10) is a natural product than can be isolated from the hexane-ethyl acetate extract of Phyllanthus amarus leaves. Phyltetralin possesses immunosuppressive effects on different lineages of innate immune system .
|
-
- HY-N4309A
-
|
Others
|
Cardiovascular Disease
|
Lotusine (hydroxide) is a pure alkaloid extracted from the green seed embryo of Nelumbo nucifera Gaertn. Lotusine (hydroxide) shows effects on the action potentials in myocardium and slow inward current in cardiac Purkinje fibers .
|
-
- HY-N10603
-
Baihuaqianhuoside
|
Others
|
Inflammation/Immunology
|
Praeroside (Baihuaqianhuoside), a coumarin glycoside. Praeroside can be extracted from the root of Peucedanum praeruptorum and Heracleum dissectum. Praeroside shows anti-inflammatory activity in vitro. Praeroside can be used for the research of inflammation .
|
-
- HY-N10685
-
TCD
|
Others
|
Others
|
3,7,25-Trihydroxycucurbita-5,23-dien-19-al (TCD) is a natural product, that can be isolated from the chloroform extract of the leaves of Momordica foetida .
|
-
- HY-N8589
-
|
Others
|
Others
|
(-)-Epiafzelechin-3-O-gallate is a natural product that can be isolated from the water extract of Pu-erh tea. (-)-Epiafzelechin-3-O-gallate shows antioxidant activity .
|
-
- HY-N3642
-
Erythrabyssin I; Erythrabissin I
|
Others
|
Cancer
|
Cristacarpin can be extracted from the stem bark of Erythrina suberosa, promotes endoplasmic reticulum (ER) stress, leading to sublethal reactive oxygen species (ROS) production and ultimately cell death through senescence .
|
-
- HY-119580B
-
2,3-trans-3,4-trans-Leucocyanidin; 3,4-trans-Leucocyanidin; (2R,3S,4R)-Leucocyanidin
|
Others
|
Inflammation/Immunology
|
(+)-Leucocyanidin is the isoform of Leucocyanidin (HY-119580), is an active anti-ulcerogenic ingredient was extracted from Litchi Chinensis. Leucocyanidin demonstrates a significant protective effect against Aspirin-induced erosions in rat models .
|
-
- HY-N1251
-
|
|
|
Scholaricine (compound 13 ) is an alkaloid isolated from the leaf and stem-bark extracts of Alstonia spatulata. Scholaricine reverse multidrug resistance in vincristine-resistant KB cells with an IC50 value of 13.35 μM .
|
-
- HY-N2809
-
|
Others
|
Others
|
Acantrifoside E (Compound 8) is a nature compound. Acantrifoside E can be isolated from the 90% ethanol extract of Salacia cochinchinensis. Acantrifoside E has none α-glucosidase inhibitory activity .
|
-
- HY-N3872
-
|
Others
|
Others
|
Ethyl β-D-glucopyranoside (compound 10) is a kind of phenolic compound. Ethyl β-D-glucopyranoside can be isolated from ethanolic extract of Scabiosa stellata LS.
|
-
- HY-N7324
-
|
COX
|
Inflammation/Immunology
|
Dehydroperilloxin is a natural compound isolated from the dichloromethane extract of the stems of Perilla frutescens var. acuta. Dehydroperilloxin possesses inhibitory activity against cyclooxygenase-1, with the IC50 value of 30.4 μM .
|
-
- HY-N12552
-
Hemslecin A 2-O-β-d-glucopyranoside
|
Others
|
Infection
|
Cucurbitacin IIa 2-O-β-D-glucoside is a glycoside cucurbitacin isolated from the genus Hemsleya (Cucurbitaceae). Extracts of Hemsleya have the potential to be used in research on bronchitis, bacillary dysentery, and tuberculosis .
|
-
- HY-117887
-
BLU-782; IPN-60130; ALK2-IN-1
|
TGF-β Receptor
|
Cancer
|
ALK2-IN-1 is a activin receptor-like kinase-2 (ALK2) inhibitor extracted from patent WO2017181117A1, Compound 876, has an IC50 of <10 nM .
|
-
- HY-N12710
-
Orobanchoside; Oraposide
|
Flavivirus
|
Infection
|
Crenatoside is a phenylethanol glycoside compound that can be isolated from the ethyl acetate of the tree extract of T. stans var. stans with EC50 value of 34.78 μM. Crenatoside has anti-Zika virus activity .
|
-
- HY-13231
-
|
CDK
HIV
|
Infection
|
CDK9-IN-1 is a novel, selective CDK9 inhibitor for the treatment of HIV infection, with an IC50 of 39 nM for CDK9/CycT1, extracted from reference, compound 87.
|
-
- HY-13057
-
Glucose-conjugated MGMT inhibitor
|
DNA Methyltransferase
|
Cancer
|
O6BTG-octylglucoside is a potent O 6-methylguanine-DNAmethyl-transferase (MGMT) inhibitor, with IC50s of 32 nM in vitro (cell extracts) and 10 nM in HeLa S3 cells.
|
-
- HY-N0044
-
-
- HY-18770
-
NLG-1489
|
Indoleamine 2,3-Dioxygenase (IDO)
|
Cancer
|
IDO-IN-5 (NLG-1489) is an indoleamine 2,3-dioxygenase (IDO) inhibitor extracted from patent WO WO2012142237A1, compound 1489, has an IC50 of 1-10 μM.
|
-
- HY-100342
-
|
Btk
|
Cancer
|
Ibrutinib-biotin is a probe that consists of Ibrutinib linked to biotin via a long chain linker, extracted from patent WO2014059368A1 Compound 1-5, has an IC50 of 0.755-1.02 nM for BTK.
|
-
- HY-U00424
-
Vitamin D3 derivative
|
VD/VDR
|
Metabolic Disease
|
Chol-5-en-24-al-3β-ol is a steroid compound (Vitamin D3 derivative) extracted from patent US 4354972 A, Compound IX.
|
-
- HY-107902
-
|
HBV
HCV
HIV
Influenza Virus
|
Infection
|
RIG-1 modulator 1 is an anti-viral compound which can be useful for the treatment of viral infections including influenza virus, HBV, HCV and HIV extracted from patent WO 2015172099 A1.
|
-
- HY-N0800
-
(-)-Protosappanin B
|
Apoptosis
|
Cancer
|
Protosappanin B is a phenolic compound extracted from Caesalpinia sappan. Anti-cancer activity . Protosappanin B induces apoptosis and causes G1 cell cycle arrest in human bladder cancer cells .
|
-
- HY-10792A
-
-
- HY-N0770
-
|
Apoptosis
|
Inflammation/Immunology
Cancer
|
Isoliensinine is a bisbenzylisoquinoline alkaloid extracted from the seed embryo of Nelumbo nucifera, with anti-oxidant and anti-inflammatory and anti-cancer activities. Isoliensinine induces apoptosis in triple-negative human breast cancer cells .
|
-
- HY-N4084
-
|
Apoptosis
|
Cancer
|
Thonningianin A, an ellagitannin, is isolated from the methanolic extract of the African medicinal herb, Thonningia sanguinea. The antioxidant properties of Th A involve radical scavenging, anti-superoxide formation and metal chelation. Anti-cancer activities .
|
-
- HY-19845A
-
|
Dopamine Receptor
|
Neurological Disease
|
Piperidine-MO-1 is a modulator of dopamine receptor extracted from patent WO/2005/121087A1, compound example 2; exhibits an ED50 of 68 μmol/kg on increase of DOPAC in the rat striatum.
|
-
- HY-18770C
-
NLG-1487
|
|
|
IDO-IN-8 (NLG-1487) is an indoleamine 2,3-dioxygenase (IDO) inhibitor extracted from patent WO WO2012142237A1, compound 1487, has an IC50 of 1-10 μM.
|
-
- HY-131132A
-
SHP2-IN-6 hydrochloride
|
SHP2
Phosphatase
|
Cancer
|
JAB-3068 (SHP2-IN-6) hydrochloride is a potent SHP2 inhibitor with an IC50 of 25.8 nM. JAB-3068 hydrochloride is extracted from patent WO2017211303A1, compound 7 .
|
-
- HY-128978
-
|
Phosphatase
|
Metabolic Disease
|
(E,E)-RAMB4 is a potent and selective potent protein tyrosine phosphatase-1B (PTP1B) inhibitor extracted from patent CN103626692A, example 1 .
|
-
- HY-139019
-
|
Acyltransferase
|
Inflammation/Immunology
|
ACAT-IN-2 is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor extracted from patent EP1236468A1, example 187. ACAT-IN-2 inhibits NF-κB mediated transcription .
|
-
- HY-139026
-
|
Acyltransferase
|
Inflammation/Immunology
|
ACAT-IN-9 is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor extracted from patent EP1236468A1, example 207. ACAT-IN-9 inhibits NF-κB mediated transcription .
|
-
- HY-141453
-
|
RIP kinase
|
Cancer
|
Desmethyl-WEHI-345 analog is a protein kinase inhibitor extracted from patent WO2012003544A1, example 12. Desmethyl-WEHI-345 analog can be used for the research of colon cancer .
|
-
- HY-141690A
-
|
PI3K
|
Cancer
|
PI3K-IN-19 hydrochloride is a phosphotidylinositol-3-kinase (PI3K) inhibitor extracted from patent WO2017153220, step 5 .
|
-
- HY-139412
-
|
PI3K
|
Cancer
|
Gilmelisib is an antineoplastic. Gilmelisib is a PI3K inhibitor (IC50 <1 nM for PI3K p110α) extracted from WO2017101847 A1, compound 1 .
|
-
- HY-145450
-
|
Others
|
Cancer
|
ATR-IN-9 is a potent inhibitor of Ataxia-telangiectasia and RAD-3-related protein kinase (ATR) extracted from patent WO2020087170A1, compound 59, has an IC50 of 10 nM .
|
-
- HY-145723
-
|
FLT3
FGFR
|
Inflammation/Immunology
Cancer
|
MAX-40279 is a dual and potent inhibitor of FLT3 kinase and FGFR kinase. MAX-40279 has the potential for the research of acute myelogenous leukemia (AML) (extracted from patent WO2021180032) .
|
-
- HY-145723A
-
|
FLT3
FGFR
|
Inflammation/Immunology
Cancer
|
MAX-40279 hydrochloride is a dual and potent inhibitor of FLT3 kinase and FGFR kinase. MAX-40279 hydrochloride has the potential for the research of acute myelogenous leukemia (AML) (extracted from patent WO2021180032) .
|
-
- HY-144682
-
|
Others
|
Neurological Disease
|
O-GlcNAcase-IN-4 is a O-GlcNAcase inhibitor extracted from patent WO2018140299A1 Formulaic Ic. O-GlcNAcase-IN-4 can be used for the research of neurodegenerative diseases and disorders, such as Alzheimer's disease .
|
-
- HY-N10356
-
|
Others
|
Neurological Disease
|
4,27-Dimethyl withaferin A is a synthetic analog of withanolide natural products. 4,27-Dimethyl withaferin A has the potential for the research of neurodegenerative diseases (extracted from patent WO2015077780A1) .
|
-
- HY-120273
-
|
Glucocorticoid Receptor
|
Metabolic Disease
Inflammation/Immunology
|
Glucocorticoids receptor agonist 3 is a potent agonist of glucocorticoids receptor. Glucocorticoids receptor agonist 3 is useful to research diseases, such as obesity, diabetes, and inflammation (extracted from patent WO2000066522A1, compound 345) .
|
-
- HY-143545
-
|
RET
|
Cancer
|
RET-IN-8 is a rearranged during transfection (RET) kinase inhibitor extracted from patent WO2021093720A1 compound I-1. RET-IN-8 can be used for the research of cancer .
|
-
- HY-144058
-
|
JAK
|
Inflammation/Immunology
|
JAK-IN-18 is a potent inhibitor of JAK. JAK-IN-18 is useful for the research of multiple diseases, particularly ocular, skin, and respiratory diseases (extracted from patent WO2018204238A1, compound 1) .
|
-
- HY-145950
-
|
DNA Methyltransferase
|
Cancer
|
2′-Deoxy-5-nitrocytidine is a DNA Methyltransferase inhibitor extracted from patent CN108498529A. 2′-Deoxy-5-nitrocytidine can be used for the research of cancer .
|
-
- HY-144195
-
-
- HY-144194
-
-
- HY-145959
-
|
iGluR
|
Neurological Disease
|
AMPA receptor antagonist-3 is an AMPA receptor antagonist extracted from patent US20070027143A1. AMPA receptor antagonist-3 can be used for the research of central nervous system disorders .
|
-
- HY-145917
-
|
Others
|
Neurological Disease
|
SARM1-IN-2 is a SARM1 inhibitor extracted from patent WO2019236890A1 example 82. SARM1-IN-2 can be used for the research of axonal degeneration .
|
-
- HY-145965
-
|
Ferroportin
|
Metabolic Disease
|
Ferroportin-IN-1 is a ferroportin inhibitor extracted from patent WO2020123850A1 compound 23. Ferroportin-IN-1 can be used for the research of diseases caused by a lack of hepcidin or iron metabolism disorders .
|
-
- HY-N1014
-
|
|
|
11α,12β-Di-O-acetyltenacigenin B is a polyoxypregnane compound isolated from the CHCl(3)-soluble fraction of the ethanolic extract of the stem of Marsdenia tenacissima .
|
-
- HY-N10890
-
|
Others
|
Cancer
|
Alpinoid D, a diarylheptanoid, can be isolated from the MeOH extract from the rhizomes of Alpinia officinarum Hance. Alpinoid D shows cytotoxic effect against IMR-32 human neuroblastoma cell line .
|
-
- HY-N0098R
-
p-Vanillin (Standard); m-Methoxy-p-hydroxybenzaldehyde (Standard); p-Hydroxy-m-methoxybenzaldehyde (Standard)
|
Endogenous Metabolite
|
Others
|
Vanillin (Standard) is the analytical standard of Vanillin. This product is intended for research and analytical applications. Vanillin (p-Vanillin) is a single molecule extracted from vanilla beans and also a popular odor used widely in perfume, food and medicine.
|
-
- HY-156576
-
|
DGK
|
Cancer
|
DGKα-IN-6 is a DGKα inhibitor with the IC50 of 1.377 nM, extracted from patent WO2022271650 (compound 143). DGKα-IN-6 has the potential for cancer study.
|
-
- HY-156577
-
|
DGK
|
Cancer
|
DGKα-IN-7 is a DGKα inhibitor with the IC50 of 6.225 nM, extracted from patent WO2022271684 (compound 100). DGKα-IN-7 has the potential for cancer study.
|
-
- HY-N3706
-
|
Fungal
|
Infection
|
Dehydro-α-lapachone can be isolated from the methanol extract of stems of Catalpa ovata G Don. Dehydro-α-lapachone inhibits mycelial growth of Botrytis cinerea with IC50 value 0.41 mg/L .
|
-
- HY-N2703
-
|
Glucosidase
|
Metabolic Disease
|
6β-Hydroxyipolamiide can be isolated from the methanolic extract of S. jamaicensis leaves. 6β-Hydroxyipolamiide has α-glucosidase inhibitory activity with an IC50 of 539.17 μg/mL .
|
-
- HY-N2926
-
|
Parasite
|
Infection
|
β-Carboline-1-propionic acid is a alkaloid which can be extracted from Ailanthus altissima. β-Carboline-1-propionic acid can be used as an antileishmanial agent .
|
-
- HY-N7399
-
|
Others
|
Others
|
Dipalmitin is an active product that can be extracted from? root tuber of Typhonium giganteum Engl. Dipalmitin is a diacylglycerol that contains the saturated 16-carbon fatty acid Palmitic acid (HY-N0830) at two positions .
|
-
- HY-13984
-
|
EGFR
|
Cancer
|
Mutant EGFR inhibitor is a potent and selective mutant EGFR inhibitor extracted from patent WO 2013014448 A1; inhibits EGFR L858R, EGFR Exon 19 deletion and EGFR T790M.
|
-
- HY-102031
-
YY-20394
|
PI3K
|
Inflammation/Immunology
Cancer
|
Linperlisib (YY-20394) is a potent, orally bioavailable and selective inhibitor of PI3Kδ extracted from patent WO 2015055071 A1, compound 10; has an IC50 of 6.4 nM .
|
-
- HY-U00453
-
-
- HY-P1348
-
|
GCGR
|
Metabolic Disease
|
GLP-1 moiety from Dulaglutide is a 31-amino acid fragment of Dulaglutide which is a glucagon-like peptide 1 receptor (GLP-1) agonist, extracted from patent US 20160369010 A1.
|
-
- HY-100270
-
|
ROCK
|
Cancer
|
Rho-Kinase-IN-1 is a Rho kinase (ROCK) inhibitor (Ki values of 30.5 and 3.9 nM for ROCK1 and ROCK2, respectively) extracted from US20090325960A1, compound 1.008 .
|
-
- HY-129167
-
|
Epigenetic Reader Domain
|
Cancer
|
Menin-MLL inhibitor 4 is an inhibitor of Menin- MLL (mixed-lineage leukemia protein) interaction extracted from patent WO2017214367, compound example 1. Menin-MLL inhibitor 4 has antitumor activity .
|
-
- HY-111996
-
|
Potassium Channel
|
Inflammation/Immunology
|
Kv3 modulator 1 is a Kv3 voltage-gated potassium channel modulator extracted from patent WO2018020263A1, Compound X. Kv3 modulator 1 has the potential for inflammatory pain treatment .
|
-
- HY-117491
-
|
Epigenetic Reader Domain
|
Cancer
|
BRD4 Inhibitor-10 is a potent BRD4-BD1 inhibitor extracted from patent WO2015022332A1, Compound II-25, has an IC50 of 8 nM .
|
-
- HY-P1355A
-
|
Calcineurin
|
Others
|
Cyclosporin A-Derivative 1 (Free base) is a crystalline intermediate derived from the opening of cyclosporin A extracted from patent WO 2013167703 A1. Cyclosporin A is an immunosuppressive agent which can bind to the cyclophilin and inhibit calcineurin.
|
-
- HY-101097
-
|
|
|
PD-1-IN-17 is a programmed cell death-1 (PD-1) inhibitor extracted from patent WO2015033301A1, Compound 12, inhibits 92% splenocyte proliferation at 100 nM .
|
-
- HY-N7028
-
-
- HY-N2247A
-
|
Platelet-activating Factor Receptor (PAFR)
|
Metabolic Disease
|
(+)-Guaiacin is a compound extracted of the bark of Machilus wangchiana Chun. (Lauraceae). (+)-Guaiacin shows potent in vitro activities against the release of β-glucuronidase in rat polymorphonuclear leukocytes (PMNs) induced by platelet-activating factor (PAF) .
|
-
- HY-N0730
-
|
Autophagy
Apoptosis
|
Neurological Disease
Inflammation/Immunology
|
Diosgenin glucoside, a saponin compound extracted from Trillium tschonoskii, provides neuroprotection by regulating microglial M1 polarization. Diosgenin glucoside protects against spinal cord injury by regulating autophagy and alleviating apoptosis .
|
-
- HY-12136
-
-
- HY-111588
-
-
- HY-100585
-
Splitomycin
|
HDAC
|
Cancer
|
Splitomicin (Splitomycin) is a selective Sir2p inhibitor. Splitomicin inhibits NAD +-dependent HDAC activity of Sir2 protein. Splitomicin induces dose-dependent inhibition of HDAC in the yeast extract with an IC50 of 60 μM .
|
-
- HY-N0746
-
|
Others
|
Cancer
|
Oxysophocarpine is an alkaloid extracted from Sophora alopecuroides. Oxysophocarpine has neuroprotective and anti-nociceptive effects on the central and peripheral nervous systems . Oxysophocarpine inhibits the growth and metastasis of oral squamous cell carcinoma (OSCC) .
|
-
- HY-N1098
-
|
HIF/HIF Prolyl-Hydroxylase
|
Inflammation/Immunology
|
Velutin is an aglycone extracted from Flammulina velutipes, with inhibitory activity against melanin biosynthesis. Velutin reduces osteoclast differentiation and down-regulates HIF-1α through the NF-κB pathway .
|
-
- HY-N0676
-
|
Influenza Virus
|
Infection
Cancer
|
Dehydroandrographolide can be extracted from herbal medicine Andrographis paniculata Nees. Dehydroandrographolide reduces oxidative stress in LPS-induced acute lung injury by inactivating iNOS. Dehydroandrographolide has anti-infective activity .
|
-
- HY-112718
-
|
PROTACs
Epigenetic Reader Domain
|
Cancer
|
PROTAC BET Degrader-10 is a potent BET protein BRD4 degrader extracted from patent WO2017007612A1, example 37, connected by ligands for Cereblon and BRD4, with a DC50 of 49 nM .
|
-
- HY-79583
-
|
Glutaminase
|
Cancer
|
Glutaminase-IN-3 (compound 657) is a potent glutaminase inhibitor with an IC50 of 0.24 μM for Glutaminase 1 (GLS1). Glutaminase-IN-3 is extracted from patent WO2014089048A1, compound 657 .
|
-
- HY-139027
-
|
Acyltransferase
|
Inflammation/Immunology
|
ACAT-IN-10 is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor extracted from patent EP1236468A1, example 197. ACAT-IN-10 weakly inhibits NF-κB mediated transcription .
|
-
- HY-139027A
-
|
Acyltransferase
|
Inflammation/Immunology
|
ACAT-IN-10 dihydrochloride is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor extracted from patent EP1236468A1, example 197. ACAT-IN-10 dihydrochloride weakly inhibits NF-κB mediated transcription .
|
-
- HY-139023
-
|
Acyltransferase
|
Inflammation/Immunology
|
ACAT-IN-6 is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor extracted from patent EP1236468A1, example 200. ACAT-IN-6 potently inhibits NF-κB mediated transcription .
|
-
- HY-139751
-
|
Beta-lactamase
Bacterial
|
Infection
|
β-Lactamase-IN-4 is a β-lactamase inhibitor extracted from patent WO2013149121A1, compound 708. β-Lactamase-IN-4 can be used for the research of bacterial infections .
|
-
- HY-139779
-
|
Beta-lactamase
Bacterial
|
Infection
|
β-Lactamase-IN-5 is a β-lactamase inhibitor extracted from patent WO2013149121A1, compound 720. β-Lactamase-IN-5 can be used for the research of bacterial infections .
|
-
- HY-139861
-
-
- HY-145195
-
-
- HY-145581
-
AZD4831
|
Glutathione Peroxidase
|
Cardiovascular Disease
|
Mitiperstat (AZD4831) is the potent inhibitor of myeloperoxidase (MPO). Mitiperstat is particularly useful in the research of prophylaxis of cardiovascular disorders such as heart failure and coronary artery disease related conditions (extracted from patent US20160152623A1) .
|
-
- HY-144057
-
|
JAK
|
Inflammation/Immunology
|
JAK-IN-17 is a potent inhibitor of JAK. JAK-IN-17 is useful for the research of multiple diseases, particularly ocular, skin, and respiratory diseases (extracted from patent WO2021185305A1, compound 9-1) .
|
-
- HY-143431
-
|
CDK
|
Cancer
|
Cdc7-IN-17 is a potent CDC7 inhibitor with an IC50 of <10 μM, extracted from patent WO2018217439A1. Cdc7-IN-17 can be used for cancer research .
|
-
- HY-144097
-
|
EGFR
|
Inflammation/Immunology
Cancer
|
HER2-IN-8 is a HER-2 inhibitor extracted from patent WO2021179274A1 compound 107. HER2-IN-8 can be used for the research of cancer and inflammation .
|
-
- HY-Y1310
-
|
|
|
Sodium alginate is the sodium salt of alginic acid. Sodium alginate can be extracted and purified from brown seaweed Laminaria japonica. Sodium alginate can be used in food additives and pharmaceuticals, adsorb heavy metal ions, and has mucosal-protective and hemostatic effects .
|
-
- HY-W127711
-
|
Fluorescent Dye
|
Others
|
Fast Blue B Salt is a coloring agent that dissolves fats and phenolic compounds extracted from rye, as well as diazonium. Fast Blue B Salt can be used for the semiquantification of alkylresorcinols in rye and produces a color precipitate in the presence of acetone .
|
-
- HY-N11667
-
|
Others
|
Infection
Cancer
|
18-O-Demethylpederin is a pederin analogue. Pederin is a natural polyketide compound extracted from Paederus for the first time. It is a non-protein insect toxin with a broad spectrum of biological activities, including antibacterial, antiviral, and antitumor .
|
-
- HY-N3048
-
|
Others
|
Cardiovascular Disease
|
Piperlotine D is an antiplatelet aggregation agent. Piperlotine D can be extracted from Piper lolot with antiplatelet aggregation activity. Piperlotine D inhibits arachidonic acid-induced platelet aggregation with an IC50 of 43.4 μg/mL .
|
-
- HY-N8730
-
|
Others
|
Neurological Disease
|
7,8,3 ',4 '-Tetramethoxyflavone is an extract
isolated from natural pomegranate juice and seeds. 7,8,3 ',4' -Tetramethoxyflavone has a protective effect on the neurotoxicity of
paraquat-induced Parkinson's disease mouse model .
|
-
- HY-N8859
-
16-Hydroxyiridal
|
Others
|
Others
|
Isoiridogermanal can be isolated from the extract of rhizomes of Iris tectorum Maxim. Isoiridogermanal is cytotoxic with IC50 values of 11 μM and 23 μM against MCF-7 and C32 cell lines.
|
-
- HY-160283
-
|
PI3K
|
Cancer
|
PI3K-IN-50 is a phosphotidylinositol-3-kinase (PI3K) inhibitor extracted from patent WO2023239710A1, example 35 .
|
-
- HY-155988
-
-
- HY-N9966
-
|
Others
|
Others
|
Sanggenol O? is an active product that can be extracted from Morus alba. Sanggenol O? has hepatoprotective and neuroprotective activities with EC50s more than 80 μM in HepG2 and HT22 cells .
|
-
- HY-131616
-
|
Others
|
Inflammation/Immunology
|
Ethyl α-eleostearate is isolated from the ethanolic extract of Pseudo-nitzschia australis (PAEE). The PAEE of Pseudomonas australis has anti-neuroinflammatory effects, inhibiting intracellular ROS as well as pro-inflammatory mediators and cytokines .
|
-
- HY-17511
-
Potassium azaorotate; Potassium otastat; Oteracil potassium
|
Others
|
Metabolic Disease
|
Potassium oxonate is an inhibitor of uricase, inhibits the phosphorylation of 5-FU to 5-fluorouridine-5'-monophosphate catalyzed by pyrimidine phosphoribosyl-transferase in a different manner from allopurinol in cell-free extracts and intact cells in vitro.
|
-
- HY-N0120A
-
Piceid
|
Autophagy
Apoptosis
Mitophagy
|
Inflammation/Immunology
Cancer
|
Polydatin (Piceid), extracted from the roots of Reynoutria japonica, a widely used traditional Chinese remedies, possesses anti-inflammatory activity in several experimental models. Polydatin (Piceid) inhibits G6PD and induces oxidative and ER stresses.
|
-
- HY-128829
-
|
Potassium Channel
|
Inflammation/Immunology
|
Kv3 modulator 2 (formula (I)) is a potent Kv3 channels modulator extracted from patent WO2018109484A1, compound formula (I) , has analgesic activity and is used in the prophylaxis or treatment of related disorders .
|
-
- HY-N6845
-
|
DNA/RNA Synthesis
|
Cancer
|
3-Isomangostin, extracted from Garciniamangostana.L. shell, is a potent MutT homologue 1 (MTH1) inhibitor with an IC50 value of 52 nM. 3-Isomangostin would be an attractive chemical tool for the development of anticancer agents .
|
-
- HY-N5106
-
|
Apoptosis
|
Cancer
|
(E)-Flavokawain A, a chalcone extracted from Kava, has anticarcinogenic effect. (E)-Flavokawain A induces apoptosis in bladder cancer cells by involvement of bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice .
|
-
- HY-79369
-
|
ADC Linker
|
Cancer
|
Succinic anhydride is a cyclic anhydride and a nonclaevable ADC linker extracted from patent WO2009064913A1. Succinic anhydride can react with compound 4 of the patent to link the proagent to an amine or hydroxy 1 group of a targeting polypeptide .
|
-
- HY-135831
-
|
Aryl Hydrocarbon Receptor
|
Cancer
|
AHR antagonist 2 is a potent aryl hydrocarbon receptor (AHR) antagonist, extracted from patent WO2019101641A1, compound example 1, with IC50s of 0.885 and 2.03 nM for human and mouse AhR .
|
-
- HY-135829
-
|
Aryl Hydrocarbon Receptor
|
Cancer
|
BAY 2416964 is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018146010A1, example 192, has an IC50 of 341 nM. BAY 2416964 has the potential for solid tumors treatment .
|
-
- HY-21292
-
SU4949
|
|
|
SU5214 is a potent VEGFR2 inhibitor extracted from patent US5834504A, SU5214, has IC50s of 14.8 µM (FLK-1) and 36.7 µM (EGFR), respectively .
|
-
- HY-P2457
-
|
Bacterial
|
Infection
Inflammation/Immunology
|
rCRAMP (rat) is the rat cathelin-related antimicrobial peptide. rCRAMP (rat) contributes to the antibacterial activity in rat brain peptide/protein extracts. rCRAMP (rat) is a potential key player in the innate immune system of rat CNS .
|
-
- HY-N7699A
-
|
TNF Receptor
|
Neurological Disease
Inflammation/Immunology
|
D-Trimannuronic acid, an alginate oligomer is extracted from seaweed. D-Trimannuronic acid can induce TNF‐α secretion by mouse macrophage cell lines. D-Trimannuronic acid can be used for the research of pain and vascular dementia .
|
-
- HY-101097A
-
|
PD-1/PD-L1
|
Cancer
|
PD-1-IN-17 TFA is a programmed cell death-1 (PD-1) inhibitor extracted from patent WO2015033301A1, Compound 12, inhibits 92% splenocyte proliferation at 100 nM .
|
-
- HY-N7766
-
|
Apoptosis
|
Inflammation/Immunology
Cancer
|
Rubropunctatin, an orange azaphilone pigment, is isolated from the extracts of Monascus pilosus-fermented rice (red-mold rice). Rubropunctatin has anti-inflammatory, immunosuppressive and antioxidative effects, and also exhibits anti-tumor activity .
|
-
- HY-121381
-
|
Phosphodiesterase (PDE)
|
Others
|
Kuraridine is a prenylated flavonol extract from the roots of Sophora flavescens. Kuraridine has an inhibitory effect on cGMP specific phosphodiesterase type 5 (PDE5) (IC50=0.64 μM) .
|
-
- HY-134594
-
|
E1/E2/E3 Enzyme
|
Cancer
|
SENP1-IN-1 is a specific deSUMOylation protease 1 (SENP1) inhibitor extracted from patent CN110627860, Compound 29. SENP1-IN-1 is developed for tumor radiosensitivity enhancement .
|
-
- HY-134595
-
|
E1/E2/E3 Enzyme
|
Cancer
|
SENP1-IN-2 is a specific deSUMOylation protease 1 (SENP1) inhibitor extracted from patent CN110627860, Compound 30. SENP1-IN-2 is developed for tumor radiosensitivity enhancement .
|
-
- HY-134596
-
|
E1/E2/E3 Enzyme
|
Cancer
|
SENP1-IN-3 is a specific deSUMOylation protease 1 (SENP1) inhibitor extracted from patent CN110627860, Compound 17. SENP1-IN-3 is developed for tumor radiosensitivity enhancement .
|
-
- HY-134597
-
|
E1/E2/E3 Enzyme
|
Cancer
|
SENP1-IN-4 is a specific deSUMOylation protease 1 (SENP1) inhibitor extracted from patent CN110627860, Compound 21. SENP1-IN-4 is developed for tumor radiosensitivity enhancement .
|
-
- HY-10652
-
|
JAK
|
Inflammation/Immunology
Cancer
|
JAK-2/3-IN-1 is a potent JAK-2 and JAK-3 inhibitor extracted from patent US8163732B2, compound 46, has Kis of <250 nM for both isoforms .
|
-
- HY-112191
-
|
PI3K
|
Cancer
|
PI3K-IN-10 is a potent pan-PI3K inhibitor as a benzimidazole derivative, compound 332, extracted from patent WO2018057808A1 .
|
-
- HY-138843
-
-
- HY-139245
-
|
ADC Linker
|
Cancer
|
MC-Ala-Ala-Asn-PAB is a linker extracted from patent CN104147612A, page 14. MC-Ala-Ala-Asn-PAB can be used to synthesis the tumor microenvironment specific activated micromolecular targeted conjugate .
|
-
- HY-132980
-
|
Ras
|
Cancer
|
KRAS G12C inhibitor 19 is a potent inhibitor of KRAS G12C. KRAS G12C inhibitor 19 significantly inhibits tumor growth (extracted from patent WO2021118877A1) .
|
-
- HY-145191
-
-
- HY-145192
-
-
- HY-145193
-
-
- HY-145601
-
TT 00420
|
Aurora Kinase
VEGFR
|
Cancer
|
Tinengotinib is the modulator of one or more protein kinases such as Aurora kinase and VEGFR kinase. Tinengotinib has the potential for the research of these kinase abnormalities diseases mediated, especially cancer-related diseases (extracted from patent WO2018108079A1) .
|
-
- HY-145723B
-
|
FLT3
FGFR
|
Inflammation/Immunology
Cancer
|
MAX-40279 hemifumarate is a dual and potent inhibitor of FLT3 kinase and FGFR kinase. MAX-40279 hemifumarate has the potential for the research of acute myelogenous leukemia (AML) (extracted from patent WO2021180032) .
|
-
- HY-145723C
-
|
FLT3
FGFR
|
Inflammation/Immunology
Cancer
|
MAX-40279 hemiadipate is a dual and potent inhibitor of FLT3 kinase and FGFR kinase. MAX-40279 hemiadipate has the potential for the research of acute myelogenous leukemia (AML) (extracted from patent WO2021180032) .
|
-
- HY-125772
-
Acetylpodocarpic dimer; APD
|
LXR
|
Cardiovascular Disease
|
Acetyl podocarpic acid anhydride is a potent, semisynthetic liver X receptor(LXR) agonist derived from extracts of the mayapple. Acetyl podocarpic acid anhydride has the potential to be useful for the prevention and research of atherosclerosis, especially in the context of low HDL levels .
|
-
- HY-144093
-
|
MAP4K
|
Infection
|
HPK1-IN-26 is a HPK1 and GLK inhibitor extracted from patent WO2021254118A1 compound 1. HPK1-IN-26 can be used for the research of animal pathogen infection .
|
-
- HY-N1875
-
p-Hydroxybenzyl Et ether
|
|
|
4-(Ethoxymethyl)phenol (p-Hydroxybenzyl Et ether) is a potent antioxidant from Amburana cearensis leaf extract, with in vitro cytogenotoxic properties. Amburana cearensis leaves can be used foe the research of respiratory diseases and inflammations .
|
-
- HY-P3685
-
|
CRFR
|
Endocrinology
|
[Met(O)21] Corticotropin Releasing Factor, ovine is a corticotropin releasing factor isolated from ovine hypothalamic extracts. Corticotropin releasing factor (CRF) is a hypothalamic hormone, which stimulates the secretion of adrenocorticotrophic hormone (ACTH) .
|
-
- HY-N7486
-
|
Others
|
Cancer
|
Chamaejasmenin B can be extracted from Stellera chamaejasme L. Chamaejasmenin B suppresses cancer cells migration and invasion. Chamaejasmenin B inhibits tumor metastasis. Chamaejasmenin B can be used in the research of cancers, such as breast cancers .
|
-
- HY-N10791
-
|
Others
|
Infection
|
Neobritannilactone B, a sesquiterpene, can be isolated from the chloroform fraction of the I. britannica. Neobritannilactone B is cytotoxic. Other extracts of I. britannica are also Dihydrofolate reductase (DHFR) inhibitors, which inhibit Shigella dysenteriae type 1 .
|
-
- HY-134013
-
|
Others
|
Cancer
|
Piperitenone oxide (lippione), a monoterpene, can be isolated from the n-hexane extract from spearmint (Mentha spicata) leaves. Piperitenone oxide is a potent inducer of differentiation in a RCM-1 human colon cancer cell line .
|
-
- HY-N0098S3
-
|
Endogenous Metabolite
|
Others
|
Vanillin- 13C is the 13C labeled Vanillin[1]. Vanillin (p-Vanillin) is a single molecule extracted from vanilla beans and also a popular odor used widely in perfume, food and medicine[2][3].
|
-
- HY-153452
-
|
Ser/Thr Protease
|
Cardiovascular Disease
|
PCSK9-IN-16 is a potent PCSK9 inhibitor. PCSK9-IN-16 is extracted from patent WO2020150474, example 87, has the potential for hypercholesterolemia and other cardiovascular diseases research .
|
-
- HY-153564
-
|
ROCK
|
Inflammation/Immunology
|
ROCK-IN-6 is a potent and selectiveROCK2 inhibitor with an IC50 of 2.19 nM. ROCK-IN-6 is extracted from patent WO2021164351 A1, example 7, has the potential for glaucoma and retinal diseases research .
|
-
- HY-154954
-
OGM; GPR68-IN-1
|
GPR68
|
Inflammation/Immunology
|
Ogremorphin (GPR68-IN-1) is a potent GPR68 inhibitor with an EC50of 170 nM. Ogremorphin is extracted from patent WO2020214896 (OGM1), and can be used for autoimmune chronic inflammatory diseases research .
|
-
- HY-N7321
-
|
Others
|
Cancer
|
Eucomol has potent cytotoxicity against KKU-M156 and HepG2 cells with the IC50 values of 7.12 and 25.76? μg/mL, respectively. Eucomol can be isolated from an ethanolic extract of D. cochinchinensis .
|
-
- HY-N8225
-
(-)-Manassantin B
|
Others
|
Others
|
Manassantin B (compound 6) is a kind of lignan. Manassantin B can be isolated from the ethyl acetate extract of the roots of Saururus chinensis. Manassantin B has cytotoxicities against HT-29 with an IC50 value of 12 μM .
|
-
- HY-157370
-
|
Biochemical Assay Reagents
|
Others
|
Blood Enrichment Medium can be used for enrichment culture of pathogenic bacteria in blood. Blood Enrichment Medium ingredients include peptone, beef extract powder, NaCl, glucose, sodium citrate, para-aminobenzoic acid, magnesium sulfate, phenol red .
|
-
- HY-160247
-
|
Drug-Linker Conjugates for ADC
|
Others
|
Boc-Lys-PEG8-N-bis(D-glucose) (compound 89-5) is a drug linker that can be used in the synthesis of antibody-drug conjugates (ADCs) extracted from patent WO2023280227A2 .
|
-
- HY-135663
-
|
Others
|
Cancer
|
Methyl jasmonate is a phytohormone involved in plant defenses under stress conditions. Methyl jasmonate can improve antioxidant properties of blueberry leaf extracts (mainly anthocyanins), and decrease the viability and migration capacity of AGS cells. Anticarcinogenic activity .
|
-
- HY-10531
-
|
EGFR
|
Cancer
|
ARRY-380 analog, an inhibitor of EGFR (ErbB1), is extracted from patent WO2015153959A2, compound 249 . ARRY-380 is a potent, selective, ATP-competitive, orally active inhibitor of HER2 .
|
-
- HY-N0677
-
|
Influenza Virus
|
Infection
Inflammation/Immunology
Cancer
|
Dehydroandrographolide succinate, extracted from herbal medicine Andrographis paniculata (Burm f) Nees, is widely used for the treatment of viral pneumonia and viral upper respiratory tract infections because of its immunostimulatory, anti-infective and anti-inflammatory effect .
|
-
- HY-N4299
-
|
Others
|
Metabolic Disease
|
Caesappanin C, a biphenyl dimer from the ethanolic extract of the heartwood of Indonesian Caesalpinia sappan L., shows strong proliferation stimulating activity against the primary osteoblastic cells in vitro. Caesappanin C has the potential to stimulate bone formation and regeneration .
|
-
- HY-N4080
-
|
mAChR
|
Inflammation/Immunology
|
Cyclobuxine D is a steroidal alkaloid extracted from Buxus microphylla. Cyclobuxine D has a significant bradycardic effect in the rat heart and an inhibitory action on acetylcholine and Ba ++−induced contraction of the longitudinal muscle isolated from the rabbit jejunum .
|
-
- HY-N1581
-
Nigakilactone D
|
|
|
Quassin (Nigakilactone D) is a bioactive triterpenoid from stem bark extract of Quassia amara. Quassin inhibits P. falciparum with an IC50 of 0.15 μM. Quassin possesses reversible antifertility, anti-estrogenic and anti-plasmodial activity .
|
-
- HY-N6949
-
-
- HY-N2420
-
|
Apoptosis
|
Cancer
|
Flavokawain A, a proming anticarcinogenic agent, is a chalcone from kava extract with anti-tumor activity. Flavokawain A induces cell apoptosis by involvement of Bax protein-dependent and mitochondria-dependent apoptotic pathway. Flavokawain A has the potential for the study of bladder cancer .
|
-
- HY-N7687
-
|
PPAR
|
Metabolic Disease
Inflammation/Immunology
|
Caulophyllogenin is a triterpene saponin extracted from M. polimorpha. Caulophyllogenin is a partial PPARγ agonist, with an EC50 of 12.6 μM. Caulophyllogenin can be used for the research of type-2 diabetes, obesity, metabolic syndrome and inflammation .
|
-
- HY-109574
-
|
Raf
|
Cancer
|
Raf inhibitor 2 is a potent raf kinase (IC50<1.0 μM) inhibitor, compound 32, extracted from patent EP1003721B1. Raf inhibitor 2 can be used for cancer research .
|
-
- HY-138247
-
EX-A4764; UUN51204
|
Beta-lactamase
Bacterial
Antibiotic
|
Infection
|
β-Lactamase-IN-2 is a beta-lactamase inhibitor, extracted from patent WO 2019075084 A1, compound 1. β-Lactamase-IN-2 has anti-microbial and anti-bacterial effects .
|
-
- HY-139139
-
|
Methionine Adenosyltransferase (MAT)
|
Cancer
|
MAT2A inhibitor 3 is a methionine adenosyltransferase 2A (MAT2A) inhibitor extracted from patent WO2020123395A1, compound 24, has an IC50 of <200 nM. MAT2A inhibitor 3 can be used for the research of cancers .
|
-
- HY-141515
-
|
Opioid Receptor
|
Neurological Disease
|
BMS-986121 is a positive allosteric modulator (PAM) of the μ opioid receptor extracted from patent WO2014107344. BMS-986121 is built on a chemical scaffold representing a new chemotype for μ receptor PAMs .
|
-
- HY-139315
-
|
PROTACs
IRAK
|
Cancer
|
PROTAC IRAK4 degrader-4 is a Cereblon-based PROTAC as interleukin-1 receptor-associated kinase 4 (IRAK4) degrader extracted from patent US20190192668A1, compound I-127 .
|
-
- HY-139317
-
|
PROTACs
IRAK
|
Cancer
|
PROTAC IRAK4 degrader-6 is a Cereblon-based PROTAC as interleukin-1 receptor-associated kinase 4 (IRAK4) degrader extracted from patent US20190192668A1, compound I-172 .
|
-
- HY-139612
-
JDQ-443; NVP-JDQ443
|
Ras
PERK
|
Cancer
|
Opnurasib (JDQ-443) (NVP-JDQ443) is an orally active, potent, selective, and covalent KRAS G12C inhibitor (extracted from patent WO2021120890A1). Opnurasib shows antitumor activity .
|
-
- HY-134377
-
ASP0367; MA-0211
|
PPAR
|
Metabolic Disease
|
Bocidelpar is a modulator of peroxisome proliferator-activated receptor delta (PPAR-δ). Bocidelpar improves mitochondrial biogenesis and function in Duchenne Muscular Dystrophy (DMD) muscle cells (extracted from patent WO2017062468A1, compound 2b) .
|
-
- HY-145588
-
INCB54707
|
JAK
|
Inflammation/Immunology
|
Povorcitinib (INCB54707) is a potent and selective JAK1 inhibitor that effectively reduces abscesses and inflammatory nodules. Povorcitinib is used to study cutaneous lupus erythematosus (CLE) and lichen planus (LP) (information extracted from patent WO2021076124A1).
|
-
- HY-128724
-
|
p97
|
Cancer
|
CB-5339 is an oral activity potent p97 inhibitor with an IC50 <30 nM. CB-5339 can be used for leukemia research . CB-5339 extracted from WO2015109285A1 compound FF07.
|
-
- HY-142478
-
|
Ras
|
Cancer
|
KRAS G12C inhibitor 29 is a KRAS G12C inhibitor extracted from patent WO2021252339A1, compound 3. KRAS G12C inhibitor 29 can be used for the research of cancer .
|
-
- HY-142481
-
|
Ras
|
Cancer
|
KRAS G12C inhibitor 30 is a KRAS G12C inhibitor extracted from patent WO2021252339A1, compound 2. KRAS G12C inhibitor 30 can be used for the research of cancer .
|
-
- HY-142485
-
|
Ras
|
Cancer
|
KRAS G12C inhibitor 31 is a KRAS G12C inhibitor extracted from patent WO2021252339A1, compound 1. KRAS G12C inhibitor 31 can be used for the research of cancer .
|
-
- HY-142490
-
|
Ras
|
Cancer
|
KRAS G12C inhibitor 33 is a KRAS G12C inhibitor extracted from patent WO2021244603A1, compound 1. KRAS G12C inhibitor 33 can be used for the research of cancer .
|
-
- HY-N1023
-
|
|
|
11-O-Galloylbergenin is a compound isolated from ethanolic extract of Mallotus philippinensis. 11-O-Galloylbergenin has analgesic and anti-inflammatory activities. 11-O-Galloylbergenin is a lead compound for management of pain and inflammation .
|
-
- HY-N10131
-
(+)-Biatractylolide
|
Apoptosis
|
Neurological Disease
Cancer
|
Biatractylolide is a compound isolated from the ethyl acetate extract of Atractylodes macrocephala. Biatractylolide has antitumor and antioxidant activities. Biatractylolide improves cell viability, inhibits the apoptosis of cells induced by glutamate, and reduces the activity of LDH. Biatractylolide has neuroprotective effects .
|
-
- HY-N9253
-
|
Others
|
Others
|
2,2-Dimethyl-6-phenylpyrano[3,4-b]pyran-8-one (Compound 2) is a pyranone isolated from the hexane extract of the aerial parts of Hypericum choisianum .
|
-
- HY-N9588
-
|
Others
|
Cancer
|
Pedaliin is a bioactive component obtained from the ethanol extract of Sesame (Sesamum indicum L.) leaves (SLs). Pedaliin shows in vitro antioxidant and anti-colon cancer efficacy with radical scavenging activity and ferric reducing antioxidant power (FRAP) .
|
-
- HY-N10605
-
|
SARS-CoV
Influenza Virus
|
Infection
|
Maniwamycin E is a maniwamycin derivative isolated from the culture extract of thermotolerant Streptomyces sp. JA74. Maniwamycin E shows antiviral activity against SARS-CoV-2 and influenza (H1N1) virus .
|
-
- HY-N7173
-
|
Parasite
|
Infection
|
7-Methoxy-β-carboline-1-propionic acid (compound 46) is a cytotoxic and antimalarial compound. 7-Methoxy-β-carboline-1-propionic acid can be extracted from the roots of Eurycoma longifolia .
|
-
- HY-N8307
-
|
Others
|
Cardiovascular Disease
Inflammation/Immunology
|
Syringaresinol is a lignan that can be extracted from from Dragon’s Blood of Dracaena cambodiana. Syringaresinol has anti-inflammatory activity. Syringaresinol also causes vasorelaxation. Syringaresinol elevates NO production through the phosphorylation and dimerization of endothelial NO synthase .
|
-
- HY-N10087
-
|
Bacterial
|
Infection
|
Angustifoline, an alkaloid, can be isolated from Lupinus angustifolius L. alkaloid extract. Angustifoline exhibits antimicrobial activity. Angustifoline could have bacteriostatic effects against S. aureus, B. subtilis, E. coli, P. aeruginosa and B. thuringiensis .
|
-
- HY-N9172
-
|
Others
|
Cancer
|
Eupaglehnin C is a germacrane-type sesquiterpenoi. Eupaglehnin C can be isolated from the MeOH extract of Eupatorium glehni (Compositae). Eupaglehnin C has cytotoxic activity against HeLa-S3 cancer cell lines .
|
-
- HY-N0098S2
-
p-Vanillin-13C6; m-Methoxy-p-hydroxybenzaldehyde-13C6; p-Hydroxy-m-methoxybenzaldehyde-13C6
|
Endogenous Metabolite
|
Others
|
Vanillin- 13C6 is the 13C labeled Vanillin[1]. Vanillin (p-Vanillin) is a single molecule extracted from vanilla beans and also a popular odor used widely in perfume, food and medicine[2][3].
|
-
- HY-153936
-
|
Apoptosis
ROS Kinase
|
Others
|
Methyl 12-methyltridecanoate ((R)-betaxolol hydrochloride) is a biosurfactant extracted from Brevibacterium casei LS14.Methyl 12-methyltridecanoate provides a novel approach for functionalizing the silver nanoparticles higher biocompatibility in vivo environmental .
|
-
- HY-N12345
-
|
Others
|
Others
|
5-Dexyexcoecafolin B is a tigliane-type diterpenoid isolated from the EtOAc extract of Excoecaria acerifolia Didr. 5-Dexyexcoecafolin B has anti-HIV-1 activity with a EC50 value of 0.036 μM .
|
-
- HY-157017
-
|
Biochemical Assay Reagents
|
Others
|
Julichrome Q3.5 (Compound 4) is a bioherbicide that completely inhibits the growth of cabbage. Julichrome Q3.5 can be isolated from the supernatant extract of strain Streptomyces sp. NEAU-HV44 .
|
-
- HY-N12547
-
|
Others
|
Others
|
19-OD-Carboxyglucopyranosyl-12-O--D-glucopyranosyl-11,16-dihydroxyabieta-8,11,13-triene was isolated from the acetone-soluble extract of Clerodendrum bungei roots .
|
-
- HY-U00457
-
|
IKK
|
Cancer
|
TBK1/IKKε-IN-1 is a dual TBK1 and IKKε inhibitor extracted from patent US20160376283 A1, Compound 274 in Example 60, has IC50s of <100 nM.
|
-
- HY-136535
-
hTrkA-IN-1
|
Trk Receptor
|
Inflammation/Immunology
|
Anizatrectinib (hTrkA-IN-1) is a potent and orally active inhibitor of TrkA kinase with an IC50 of 1.3 nM, compound 2 extracted from patent WO2015175788. Anizatrectinib can be used for the study of inflammatory disease, such as prostatitis, pelvic, et al .
|
-
- HY-N6744
-
|
Apoptosis
|
Infection
Cancer
|
Chaetoglobosin A, the active principle within the extract of Penicillium aquamarinium, is a member of the cytochalasan family. Chaetoglobosin A preferentially induces apoptosis. Chaetoglobosin A targets filamentous actin in CLL cells and thereby induces cell-cycle arrest and inhibits membrane ruffling and cell migration .
|
-
- HY-N1407
-
|
|
|
Polygalaxanthone III is extracted from polygala tenuifolia wild, has inhibitory effect towards CYP450 enzyme. Polygalaxanthone III inhibits chlorzoxazone 6-hydroxylation catalyzed by CYP2E1 with an IC50 of 50.56 μM .
|
-
- HY-N6016
-
|
Apoptosis
|
Cancer
|
Bacopaside II, an extract from the medicinal herb Bacopa monnieri, blocks the Aquaporin-1 (AQP1) water channel and impairs migration of cells that express AQP1. Bacopaside II induces cell cycle arrest and apoptosis .
|
-
- HY-108285
-
|
Others
|
Inflammation/Immunology
|
(Rac)-Telmesteine is a protease inhibitor and is thus a suitable enzyme stabilizer extracted from patent WO 2017220302 A1, compound II-1. (Rac)-Telmesteine can be used as an enzyme stabilizer in protease-containing detergents and cleaning agents .
|
-
- HY-125970
-
|
Prostaglandin Receptor
|
Endocrinology
|
CRTh2 antagonist 2 is selective and potent CRTH2 antagonist extracted from patent US20140148470A1, compound Example 1, has an IC50 of ≤10 nM. CRTh2 antagonist 2 can be used in research of androgenic alopecia .
|
-
- HY-138843A
-
-
- HY-113427AS
-
|
Antibiotic
|
Cancer
|
cis-Vaccenic acid-d13 is the deuterium labeled cis-Vaccenic acid. cis-Vaccenic acid, the antiviral extract from Rhodopseudomonas capsulate and the predominant active component of Rhodopseudomonas capsulate[1], acts a potential fetal hemoglobin inducer[2].
|
-
- HY-145034
-
-
- HY-145554
-
|
Others
|
Others
|
Bafrekalant is a diazabicyclic substituted imidazo[l,2-a]pyrimidine-derivative. Bafrekalant has the potential for the research of breathing disorders, including sleep-related breathing disorders such as obstructive and central sleep apnea and snoring (extracted from patent WO2018228907A1).
|
-
- HY-142511
-
|
Ras
|
Cancer
|
KRAS G12C inhibitor 34 is a KRAS G12C inhibitor extracted from patent WO2021239058A1, compound Z1. KRAS G12C inhibitor 34 can be used for the research of cancer .
|
-
- HY-144179
-
|
Methionine Adenosyltransferase (MAT)
|
Cancer
|
MAT2A-IN-4 is a methionine adenosyltransferase 2A (MAT2A) inhibitor extracted from patent WO2020123395A1 compound 426 . MAT2A-IN-4 can be used for the research of cancer .
|
-
- HY-145588A
-
INCB54707 phosphate
|
JAK
|
Inflammation/Immunology
|
Povorcitinib (INCB54707) phosphate is a potent and selective JAK1 inhibitor that effectively reduces abscesses and inflammatory nodules. Povorcitinib phosphate can be used to study cutaneous lupus erythematosus (CLE) and lichen planus (LP) (information extracted from patent WO2021076124A1).
|
-
- HY-N1864
-
|
|
|
3-O-trans-p-Coumaroyltormentic acid is a triterpene having no cytotoxic activity. However, 3-O-cris-p-Coumaroyltormentic acid is a cytotoxic triterpene, can be isolated from the methanol extract of Goreishi (the feces of Trogopterus xanthipes Milne-Edwards) .
|
-
- HY-N10087A
-
|
Bacterial
|
Infection
|
Angustifoline hydrochloride, an alkaloid, can be isolated from Lupinus angustifolius L. alkaloid extract. Angustifoline hydrochloride exhibits antimicrobial activity. Angustifoline hydrochloride could have bacteriostatic effects against S. aureus, B. subtilis, E. coli, P. aeruginosa and B. thuringiensis .
|
-
- HY-W250120
-
|
Biochemical Assay Reagents
|
Others
|
Konjac glucomannan (Viscosity≥15000mPa.s) is an acetylated (1-4)-beta-D-glucomannan extracted from the tuber of konjac or konjac root. In Japan, it is a dietary supplement intended to reduce calorie intake because it swells in water.
|
-
- HY-N3283
-
|
Parasite
|
Infection
|
6-Methylhydroxyyangolensate is a limonoid can be extracted from Khaya grandifoliola. 6-Methylhydroxyyangolensate has low antimalarial activity in vitro, with an IC50 of 21.59 μg/ml against P. falciparum (W2/Indochina clone) .
|
-
- HY-N3974
-
(+)-Griffipavixanthone
|
Apoptosis
|
Cancer
|
Griffipavixanthone can be extracted from Garcinia schomburgkiana. Griffipavixanthone induces cell apoptosis through mitochondrial apoptotic pathway accompanying with ROS production. Griffipavixanthone is an anti-cancer agent. Griffipavixanthone is a weak sucrase inhibitor (IC50: 4.58 mM) .
|
-
- HY-150617A
-
(Rac)-M4076; (Rac)-ATM Inhibitor-5
|
ATM/ATR
|
Cancer
|
(Rac)-Lartesertib ((Rac)-M4076; (Rac)-ATM Inhibitor-5) is an isoform of Lartesertib (HY-150617), which is a potent inhibitor of serine/threonine protein kinase ATM (extracted from patent WO2022058351A1) .
|
-
- HY-N11970
-
|
Angiotensin-converting Enzyme (ACE)
|
Metabolic Disease
|
Isocrenatoside (compound 6) is a cyclic octapeptide and an inhibitor of angiotensin-converting enzyme (ACE). Isocrenatoside is isolated from the ethanolic extract of Microtoena prainiana stems. Studies have found that the inhibitory efficiency of 1 mg/mL Isocrenatoside can reach 99.3% .
|
-
- HY-N10079
-
Jatrophan
|
SHP2
|
Cancer
|
Suchilactone (Jatrophan) is a lignan extracted from Monsonia angustifolia E.Mey. Suchilactone binds to SHP2 and inhibits SHP2 activation, thereby inhibiting ERK-mediated cell proliferation. Suchilactone can be ued in acute myeloid leukaemia (AML) .
|
-
- HY-W009048
-
DCH18C6; Perhydrodibenzo-18-crown-6
|
Biochemical Assay Reagents
|
Others
|
Dicyclohexano-18-crown-6-ether selectively extracts lysine-rich cytochrome c proteins from other cationic proteins under weakly acidic and neutral conditions, demonstrating specificity in ligand-protein interactions .
|
-
- HY-19764
-
|
RIP kinase
|
Cancer
|
GSK2983559 active metabolite is an active metabolite of GSK2983559. GSK2983559 active metabolite is a receptor interacting protein-2 (RIP2) kinase inhibitor extracted from patent WO/2014043446 A1, compound example 1.
|
-
- HY-N1504
-
|
PAI-1
Potassium Channel
ERK
JNK
|
Metabolic Disease
|
Loureirin B, a flavonoid extracted from Dracaena cochinchinensis, is an inhibitor of plasminogen activator inhibitor-1 (PAI-1), with an IC50 of 26.10 μM; Loureirin B also inhibits KATP, the phosphorylation of ERK and JNK, and has anti-diabetic activity.
|
-
- HY-111234
-
|
Indoleamine 2,3-Dioxygenase (IDO)
|
Cancer
|
IDO-IN-11 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.18 μM (Kinase) and 0.014 μM (Hela Cell), extracted from patent WO 2016041489 A1, compound 13.
|
-
- HY-112254
-
-
- HY-110387
-
|
Indoleamine 2,3-Dioxygenase (IDO)
|
Cancer
|
IDO-IN-9 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.011 μM (Kinase) and 0.0018 μM (Hela Cell), extracted from patent WO 2016041489 A1, compound 6.
|
-
- HY-N2185
-
(5R)-trans-1,7-diphenyl-5-hydroxy-6-hepten-3-one
|
|
|
(5R,6E)-5-Hydroxy-1,7-diphenyl-6-hepten-3-one is the methylene chloride extract of Alpinia nutans, has antioxidant activity .
|
-
- HY-N4193
-
|
Acyltransferase
|
Cardiovascular Disease
|
Glabrol (Compound 1), One isoprenyl flavonoid was isolated from ethanol extract of licorice roots, is a potent and non-competitive Acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitor with an IC50 value of 24.6 μM for rat liver microsomal ACAT activity .
|
-
- HY-N7206
-
|
Others
|
Metabolic Disease
|
5-O-Methylvisamminol, a (furo) chromone identified in the extract of T. glauca, has a limited occurrence in the plant kingdom. 5-O-Methylvisamminol is useful in (chemical) phylogeny and is a possible excellent chemotaxonomic marker (family and/or subfamily level) for Apiaceae .
|
-
- HY-136464
-
|
β-catenin
|
Cancer
|
β-catenin-IN-2 is a potent β-catenin inhibitor, compound H1B1, extracted from patent US20150374662A1. β-catenin-IN-2 can be used for the study of colorectal cancer .
|
-
- HY-130264
-
|
HIF/HIF Prolyl-Hydroxylase
|
Cancer
|
HIF-2α-IN-2 is a hypoxia-inducible factors (HIF-2α) inhibitor extracted from patent WO2015035223A1, Compound 232, has an IC50 of 16 nM in scintillation proximity assay (SPA) .
|
-
- HY-135967
-
|
DNA/RNA Synthesis
|
Cancer
|
MTH1-IN-2 is a MutT homolog 1 (MTH1) inhibitor extracted from patent WO2016135138A1, Compound (6), MTH1-IN-2 can be used for the research of cancer. Anti-tumor activity .
|
-
- HY-N8110
-
|
Others
|
Others
|
8-Chloro-2-(2-phenylethyl)-5,6,7-trihydroxy-5,6,7,8-tetrahydrochromone, a chromone derivative, can be found in MeOH extract of withered wood of Aquilaria sinensis .
|
-
- HY-139292
-
|
Amino Acid Derivatives
|
Cancer
|
Fmoc-NH-PEG6-alcohol is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-NH-PEG6-alcohol is extracted from patent WO2016030791, example comp 91 .
|
-
- HY-145194
-
-
- HY-N7330
-
|
HIV Integrase
HIV
|
Infection
|
Integracin B is a potent dimeric alkyl aromatic inhibitor of HIV-1 integrase discovered from the screening of fungal extracts using an in vitro assay. Integracin B inhibits both coupled and strand transfer activity of HIV-1 integrase .
|
-
- HY-145925B
-
|
Epigenetic Reader Domain
|
Cancer
|
CFT8634 is an oral activity degrader targeting BRD9 extracted from patent WO2021178920A1 compound 174. CFT8634 can be used for the research of synovial sarcoma and SMARCB1-deleted solid tumors .
|
-
- HY-N1035
-
|
|
|
Urs-12-ene-3β,16β,22α-triol is a terpenoid compound isolated from the ethanol extract of fresh aerial parts of the Patagonian shrub Nardophyllum bryoides .
|
-
- HY-N0098S1
-
|
Endogenous Metabolite
|
Others
|
4- Hydroxy- 3- methoxy benzaldehyde- d3 is the deuterium labeled Vanillin[1]. Vanillin (p-Vanillin) is a single molecule extracted from vanilla beans and also a popular odor used widely in perfume, food and medicine[2][3].
|
-
- HY-N7494S
-
|
Isotope-Labeled Compounds
|
Cancer
|
Pentacosane-d52 is the deuterium labeled Pentacosane[1]. Pentacosane is one of the major components in the acetone extract from Curcuma raktakanda and is also in the essential oil from the leaves of Malus domestica. Pentacosane exhibit anti-cancer activities[2].
|
-
- HY-153935
-
-
- HY-N12032
-
|
Others
|
Others
|
Acacetin 7-O-β-D-xylopyranosyl-(1→2)[α-L-rhamnopyranosyl-(1→6)]-β-D-glucopyranoside (Compound 10), a flavone glycoside, can be isolated from extracts of the leaves of Robinia pseudoacacia .
|
-
- HY-N0776R
-
3'-Methylquercetin (Standard)
|
MEK
PI3K
Endogenous Metabolite
|
Cardiovascular Disease
Inflammation/Immunology
Cancer
|
Isorhamnetin (Standard) is the analytical standard of Isorhamnetin. This product is intended for research and analytical applications. Isorhamnetin is a flavonoid compound extracted from the Chinese herb Hippophae rhamnoides L.. Isorhamnetin suppresses skin cancer through direct inhibition of MEK1 and PI3K.
|
-
- HY-112597
-
REN001 free acid; HPP593 free acid; Pparδ agonist
|
PPAR
|
Metabolic Disease
|
Mavodelpar free acid is a PPARδ agonist extracted from patent US20180071304, compound example 10. Mavodelpar (free acid) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-129179
-
APG-2575; Bcl-2/Bcl-xl inhibitor 1
|
Bcl-2 Family
|
Cancer
|
Lisaftoclax (compound 6) is a dual Bcl-2 and Bcl-xl inhibitor with anti-tumor activity, extracted from patent WO2018027097A1. Lisaftoclax exhibits IC50 values of 2 nM and 5.9 nM for Bcl-2 and Bcl-xl, respectively .
|
-
- HY-100132
-
|
Histone Acetyltransferase
|
Cancer
|
P300/CBP-IN-5 is a potent p300/CBP histone acetyltransferase inhibitor extracted from patent WO2016044770A1, Example 715, has an IC50 of 18.8 nM .
|
-
- HY-112762
-
|
Arenavirus
|
Infection
|
LHF-535 is an antiviral agent extracted from patent WO2013123215A2, Compound 38, has EC50s of <1 μM, <1 μM, <1 μM, and 1-10 μM for Lassa, Machupo, Junin, and VSVg virus, respectively .
|
-
- HY-114339
-
|
CDK
|
Cancer
|
CDK4/6-IN-2 is a potent CDK4 and CDK6 inhibitor extracted from patent US20180000819A1, Compound 1, has IC50s of 2.7 and 16 nM for CDK4 and CDK6, respectively .
|
-
- HY-N6980
-
|
HIV
|
Infection
Cancer
|
Licorice glycoside C2 is a oleanane-type triterpene oligoglycoside isolated from Glycyrrhiza uralensis. Various biological activities are associated with licorice extracts, such as anti-viral, anti-microbial, antioxidant, anti-inflammatory, anti-ulcer, anti-cancer and anti-HIV effects .
|
-
- HY-N2116
-
|
PTEN
Phosphatase
|
Cancer
|
Ginkgolic acid C17:1, extracted from Ginkgo biloba Leaves, suppresses constitutive and inducible STAT3 activation through induction of PTEN and SHP-1 tyrosine phosphatase. Ginkgolic acid C17:1 has anticancer effects .
|
-
- HY-N6641
-
|
Others
|
Inflammation/Immunology
Cancer
|
Monascin is a kind of azaphilonoid pigments extracted from Monascus pilosus-fermented rice (red-mold rice). Monascin also exhibits anti-tumor-initiating activity and anti-inflammatory activity with oral administration. Monascin inhibits the activation of NOR 1 (an NO donor) .
|
-
- HY-10549
-
|
PI3K
|
Cancer
|
PI3Kγ inhibitor 1 is a PI3Kδ and PI3Kγ inhibitor extracted from patent WO2014004470A1, Compound 168 in Table 4, has IC50s of <100 nM.
|
-
- HY-N7496
-
|
Apoptosis
|
Cancer
|
Odoroside A is an active ingredient extracted from the leaves of Nerium oleander Linn. Odoroside A has anti-cancer activity. Odoroside A could induce apoptosis and cell cycle arrest through ROS/p53 signaling pathway, leading to the tumor cell death .
|
-
- HY-124607
-
|
GSK-3
|
Neurological Disease
|
(R)-BRD3731 is a GSK3 inhibitor extracted from patent US20160375006A1, compound example 273, has IC50s of 1.05 and 6.7 μM for GSK3β and GSK3α, respectively .
|
-
- HY-137978
-
GNS561
|
Others
|
Metabolic Disease
Inflammation/Immunology
Cancer
|
Ezurpimtrostat (compound 2-2) is a potent and orally active anti-fibrotic agent. Ezurpimtrostat can be used for the research of fibrosis, cancer, autophagy and cathepsins B (CTSB), L (CTSL) and D (CTSD) related diseases (extracted from patent WO2020048694 A1) .
|
-
- HY-32735S
-
PG490-d3
|
Isotope-Labeled Compounds
NF-κB
Apoptosis
|
Cancer
|
Triptolide-d3 is the deuterium labeled Triptolide. Triptolide is a diterpenoid triepoxide extracted from the root of Tripterygium wilfordii with immunosuppressive, anti-inflammatory, antiproliferative and antitumour effects. Triptolide is a NF-κB activation inhibitor[1][2][3][4][5][6].
|
-
- HY-139908
-
|
SARS-CoV
|
Infection
|
MERS-CoV-IN-1 exhibits excellent inhibitory activity against coronavirus. MERS-CoV-IN-1 is useful as a pharmaceutical composition for preventing coronavirus-induced diseases (MERS-CoV and SARS) (extracted from patent WO2018174442A1, compound 1) .
|
-
- HY-145600
-
|
Opioid Receptor
Arrestin
|
Neurological Disease
|
Tegileridine is the potent agonist of opioid receptor (MOR). Tegileridine is an oxa spiro derivative which reduces the side effects mediated by β-arrestin. Tegileridine has the potential for the research of pains and pains-related diseases (extracted from patent WO2017063509A1) .
|
-
- HY-145062
-
|
Phosphodiesterase (PDE)
|
Cancer
|
Enpp-1-IN-4 is a potent inhibitor of ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1). Enpp-1-IN-4 has the potential for the research of cancer diseases (extracted from patent WO2019177971A1, compound 1) .
|
-
- HY-145759
-
|
MDM-2/p53
|
Cancer
|
Mutant p53 modulator-1 is a mutant p53 modulator. Mutant p53 modulator-1 reduces the progression of cancers that contain a p53 mutation (extracted from patent WO2021231474A1, compound 231B) .
|
-
- HY-142924
-
|
ATM/ATR
|
Cancer
|
ATR-IN-8 is a potent inhibitor of ATR. ATR is a key enzyme in the homologous recombination repair pathway and belongs to the PIKK family. ATR-IN-8 has the potential for the research of cancer diseases (extracted from patent WO2021143821A1, compound 3) .
|
-
- HY-147563
-
|
RET
|
Cancer
|
RET-IN-17 is a potent inhibitor of RET. RET-IN-17 has the potential for the research of pain associated with IBS and other gastrointestinal disorders and for the research of cancers with constitutive RET kinase activity (extracted from patent WO2016038552A1, compound 1) .
|
-
- HY-153436
-
|
RIP kinase
|
Cancer
|
RIP1 kinase inhibitor 6 is a potent and selective RIP1 kinase inhibitor with an IC50 of < 100 nM in human R1P1 kinase assay. RIP1 kinase inhibitor 6 is extracted from patent WO2020103884, example 80 .
|
-
- HY-N0530
-
Dryocrassin
|
Apoptosis
Influenza Virus
|
Cancer
|
Dryocrassin ABBA (Dryocrassin) is an orally active phloroglucinol derivative that can be extracted from Phyllopteris officinalis. Dryocrassin ABBA has antitumor and antiviral activity. Dryocrassin ABBA induced apoptosis of human hepatocellular carcinoma cells through mitochondrial pathway mediated by Caspase .
|
-
- HY-112950
-
|
RET
|
Cancer
|
RET-IN-1 is a RET kinase inhibitor extracted from patent WO2018071447A1, Compound Example 552, has IC50s of 1 nM, 7 nM, and 101 nM for RET (WT), RET (V804M) , and RET (G810R), respectively .
|
-
- HY-N0677A
-
Potassium dehydroandrographolide succinate
|
Antibiotic
|
Infection
Inflammation/Immunology
Cancer
|
Kalii Dehydrographolidi Succinas (Potassium dehydroandrographolide succinate), extracted from herbal medicine Andrographis paniculata (Burm f) Nees, is widely used for the treatment of viral pneumonia and viral upper respiratory tract infections because of its immunostimulatory, anti-infective and anti-inflammatory effect .
|
-
- HY-N0484
-
|
Autophagy
Mitophagy
Apoptosis
|
Cardiovascular Disease
Cancer
|
Liensinine is an autophagy/mitophagy inhibitor. Liensinine, a major isoquinoline alkaloid, extracted from the seed embryo of Nelumbo nucifera Gaertn, has a wide range of biological activities, including anti-arrhythmias, anti-hypertension, anti-pulmonary fibrosis, relaxation on vascular smooth muscle, etc .
|
-
- HY-136256
-
DCC-3014
|
c-Fms
c-Kit
|
Cancer
|
Vimseltinib (DCC-3014) is a c-FMS (CSF-IR) and c-Kit dual inhibitor extracted from patent WO2014145025A2, Compound Example 10, has IC50s of <0.01 μM and 0.1-1 μM, respectively .
|
-
- HY-N1389
-
Carmine red
|
|
|
Carmine (Carmine red), a natural red dye extracted from the dried females of the insect Dactylopius coccus var. Costa (cochineal). Carmine is a widely used food additive. Carmine provokes both an immediate hypersensitivity and a delayed systemic response with cutaneous expression .
|
-
- HY-12812
-
|
Phosphodiesterase (PDE)
|
Neurological Disease
Cancer
|
Autotaxin modulator 1 is an autotaxin (ATX) enzyme inhibitor, extracted from patent WO 2014018881 A1, Compound Example 12b. Autotaxin modulator 1 is expected to be useful for researching demyelination due to injury or disease, as well as for researching proliferative disorders such as cancer .
|
-
- HY-132268
-
|
Calcium Channel
|
Neurological Disease
|
Cav 2.2 blocker 2 is a Cav2.2 calcium channel blocker extracted from patent WO2017046581A1, compound 1. Cav 2.2 blocker 2 can reverses hyperalgesia associated with an injury or inflammation in conjunction with the opioid .
|
-
- HY-139600
-
|
Histone Demethylase
|
Cancer
|
KDM2B-IN-3 is a histone demethylase KDM2B inhibitor extracted from patent WO2016112284A1, compound 183c. KDM2B-IN-3 can be used for the research of cancer .
|
-
- HY-139601
-
|
Histone Demethylase
|
Cancer
|
KDM2B-IN-4 is a histone demethylase KDM2B inhibitor extracted from patent WO2016112284A1, compound 182b. KDM2B-IN-4 can be used for the research of cancer .
|
-
- HY-145604
-
RG7774
|
Cannabinoid Receptor
|
Neurological Disease
|
Vicasinabin (RG7774) is the potent agonist of cannabinoid receptor 2 (CB2). Vicasinabin has the potential for the research of human diseases including chronic pain, atherosclerosis, regulation of bone mass, neuroinflammation, and other related diseases (extracted from patent US20130116236A1) .
|
-
- HY-143421
-
CMG
|
Drug Metabolite
|
Cancer
|
Curcumin monoglucuronide is known as a glucuronic acid conjugate, which is one of the in vivo metabolites of curcumin. Curcumin monoglucuronide is used for research on the metabolism of curcumin and examination of its development as a pharmaceutical. Curcumin monoglucuronide has the potential for the research of cancer disease (extracted from patent WO2022004873A1) .
|
-
- HY-143736
-
|
RAD51
|
Cancer
|
RAD51-IN-5 is a potent inhibitor of RAD51. RAD51 is a eukaryote gene. RAD51-IN-5 has the potential for the research of conditions involving mitochondrial defects (extracted from patent WO2021164746A1, compound 3) .
|
-
- HY-143737
-
|
RAD51
|
Cancer
|
RAD51-IN-6 is a potent inhibitor of RAD51. RAD51 is a eukaryote gene. RAD51-IN-6 has the potential for the research of conditions involving mitochondrial defects (extracted from patent WO2021164746A1, compound 23) .
|
-
- HY-143741
-
|
RAD51
|
Cancer
|
RAD51-IN-7 is a potent inhibitor of RAD51. RAD51 is a eukaryote gene. RAD51-IN-7 has the potential for the research of conditions involving mitochondrial defects (extracted from patent WO2021164746A1, compound 71) .
|
-
- HY-N0098S
-
p-Vanillin-13C,d3; m-Methoxy-p-hydroxybenzaldehyde-13C,d3; p-Hydroxy-m-methoxybenzaldehyde-13C,d3
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Endogenous Metabolite
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Others
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Vanillin- 13C,d3 is the 13C and deuterium labeled Vanillin[1]. Vanillin (p-Vanillin) is a single molecule extracted from vanilla beans and also a popular odor used widely in perfume, food and medicine[2][3].
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- HY-N8228
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Bacterial
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Infection
Inflammation/Immunology
Cancer
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17-Hydroxyneomatrine, extracted from Sophora flavescens, can well inhibit the growth of human cervical carcinoma Hela cells, has the wide-range antibacterial, anti-allergy, anti-tumor, anti-arrhythmia, swelling-subsiding diuresis, immunizing, and biological regulation functions .
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- HY-N0611
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α-Boswellic acid
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Others
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Neurological Disease
Inflammation/Immunology
Cancer
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alpha-Boswellic acid (α-Boswellic acid) is an orally active pentacyclic triterpenoid compound that can be extracted from frankincense. alpha-Boswellic acid has anti-inflammatory and antitumor activities. alpha-Boswellic acid can be used in Alzheimer's disease (AD) research .
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- HY-103663
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MAK683
1 Publications Verification
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Histone Methyltransferase
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Cancer
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MAK683 is an embryonic ectoderm development (EED) inhibitor extracted from patent US20160176882 A1, compound example 2. MAK683 exhibits IC50s of 59, 89, 26 nM in EED Alphascreen binding, LC-MS and ELISA assay .
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- HY-N1778
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O-Methylferulic acid
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Reactive Oxygen Species
Virus Protease
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Infection
Cancer
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3,4-Dimethoxycinnamic acid (O-Methylferulic acid) is a monomer extracted and purified from Securidaca inappendiculata Hassk. 3,4-Dimethoxycinnamic acid exerts anti-apoptotic effects on L-02 cells via the ROS-mediated signaling pathway . Anti-apoptotic effects .
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- HY-N0406
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Others
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Inflammation/Immunology
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2"-O-beta-L-galactopyranosylorientin is extracted from the flowers of Trollius ledebouri. 2"-O-beta-L-galactopyranosylorientin involves transporter mediated efflux in addition to passive diffusion and is the substrate of multidrug resistance protein 2 (MRP2). Anti-inflammatory effect .
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- HY-129172A
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- HY-131453A
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Mitochondrial Metabolism
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Metabolic Disease
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Mitochondrial respiration-IN-1 hydrobromide (compound 49) is a potent mitochondrial inhibitor (IC50=8.8 mg/mL) extracted from patent US20110301180A1, compound 49. Mitochondrial respiration-IN-1 hydrobromide significantly reduces mitochondrial respiration in platelets .
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- HY-141552
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Others
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Cardiovascular Disease
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FC9402 is a potent and selective sulfide quinone oxidoreductase (SQOR) inhibitor extracted from patent WO 2020/146636 A1. FC9402 attenuates TAC-induced cardiomyocyte hypertrophy and left ventricle (LV) fibrosis. FC9402 can be used for cardiovascular regulation .
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- HY-A0298
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Histone Methyltransferase
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Cancer
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EZH2-IN-2 is a EZH2 inhibitor extracted from patent WO2018133795A1, Compound Example 69, with an IC50 of 64 nM. EZH2-IN-2 can be used for the research of cancer or precancerous condition related to EZH2 activity .
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- HY-145361
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Eukaryotic Initiation Factor (eIF)
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Cancer
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eIF4A3-IN-7 is a potent inhibitor of eIF4A3. eIF4A3-IN-7 has the potential for researching cancer and other dysproliferative diseases (extracted from patent WO2019161345A1, Compound 8) .
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- HY-143766
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Influenza Virus
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Infection
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Cap-dependent endonuclease-IN-13 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-13 has the potential for the research of influenza virus infection (only influenza A) (extracted from patent WO2021180147A1, compound I-1) .
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- HY-143752
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Influenza Virus
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Infection
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Cap-dependent endonuclease-IN-8 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-8 inhibits replication of orthomyxoviruses (including influenza A, influenza B and influenza C) (extracted from patent CN111410661A, compound I-196) .
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- HY-142697
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Others
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Cardiovascular Disease
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SGC agonist 1 is a potent agonist of soluble guanylate cyclase (SGC). SGC agonist 1 improves solubility combined with high cell permeability. SGC agonist 1 has the potential for the research of cardiovascular disease (extracted from patent WO2016030354A1, compound 18A) .
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- HY-145686
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Others
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Inflammation/Immunology
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AV023 is a potent inhibitor of ANKRD22. AV023 promotes the expansion of gastrointestinal mucosal epithelial stem cells and indirectly activates the Wnt classical pathway, which helps the recovery of damaged gastrointestinal mucosal tissues in the body (extracted from patent CN111205231B) .
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- HY-142926
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Estrogen Receptor/ERR
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Cancer
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ER degrader 2 is a potent degrader of estrogen receptor (ER). The estrogen signaling system plays an important role in regulating cell growth, differentiation and apoptosis. ER degrader 2 has the potential for the research of cancer diseases (extracted from patent CN112830919A, compound 1) .
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- HY-103663A
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Histone Methyltransferase
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Cancer
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MAK683 hydrochloride is an embryonic ectoderm development (EED) inhibitor extracted from patent US20160176882 A1, compound example 2. MAK683 exhibits IC50s of 59, 89, 26 nM in EED Alphascreen binding, LC-MS and ELISA assay .
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- HY-143735
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RAD51
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Cancer
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RAD51-IN-4 is a potent inhibitor of RAD51. RAD51 is a eukaryote gene. RAD51-IN-4 has the potential for the research of conditions involving mitochondrial defects (extracted from patent WO2019014315A1, compound R12) .
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- HY-137823
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Endogenous Metabolite
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Cancer
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4-Nitrophenyl-N-acetyl-β-D-galactosaminide has inhibitory activity against GlcNAc and GalNAc with Kis of 1.15 mM and 0.51 mM, respectively. 4-Nitrophenyl-N-acetyl-β-D-galactosaminide is extracted from Trichomonas foetus (T. foetus)
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- HY-147204
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Drug-Linker Conjugates for ADC
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Cancer
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Mc-Alanyl-Alanyl-Asparagine-PAB-MMAE (compound S6) is a potent anticancer agent, which can be specific activated by tumor microenvironment. Mc-Alanyl-Alanyl-Asparagine-PAB-MMAE can suppress tumor growth in mice (extracted from patent CN104147612A) .
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- HY-P3885
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- HY-N3554
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(+)-Catechol 7-β-D-xylopyranoside
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Others
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Others
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Catechin-7-O-β-D-xylopyranoside is an antioxidant compound with strong DPPH free radical scavenging ability. Catechin-7-O-β-D-xylopyranoside can be extracted from birch inner bark and nepeta stem bark .
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- HY-N1672
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5,7,2 ',6 '-Tetrahydroxyflavanone is an extract isolated from Scutellaria baicalensis. 5,7,2 ',6 '-Tetrahydroxyflavanone has significant antibacterial activity against gram-positive bacteria. 5,7,2 ',6 '-Tetrahydroxyflavanone can be used to study the treatment of inflammatory diseases .
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- HY-N3344
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Fungal
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Others
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Macrocarpal C can be isolated from the 95 % ethanol extract of fresh leaves of E. globulus. Macrocarpal C inhibits the growth of T. mentagrophytes via an increase in the permeability of the fungal membrane. Macrocarpal C increases the production of intracellular ROS and? induces apoptosis as a consequence of DNA fragmentation .
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- HY-N12030
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Others
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Others
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Acacetin 7-O-β-D-glucuronopyranosyl-(1→2)[α-L-rhamnopyranosyl-(1→6)]-β-D-glucopyranoside (compound 8) is a flavonoid glycoside that can be obtained from black locust (Leguminosae ) isolated from leaf extract .
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- HY-157067
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Ras
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Cancer
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KRAS G12C inhibitor 62 is a KRAS G12C inhibitor. KRAS G12C inhibitor 62 has the potential for the research of KRAS G12C-mediated cancer (extracted from patent WO2021121367A1) .
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- HY-163113
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Others
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Cancer
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Anticancer agent 180 (compound 4) is a secondary metabolite present in fungal strains and extracted through physical interaction with Streptomyces sp. Anticancer agent 180 has potential anti-tumor activity and can inhibit the migration of MDA-MB-231 breast cancer cells .
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- HY-19702
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Pyruvate Kinase
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Metabolic Disease
Inflammation/Immunology
Cancer
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PKR activator 3 is a pyruvate kinase isoform PKR activator extracted from patent WO2014139144A1, compound 160. PKR activator 3 can be used for the research of PKR function related diseases, including cancer, diabetes, obesity, autoimmune disorders, and benign prostatic hyperplasia .
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- HY-107371
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NSC95682
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IRE1
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Cancer
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6-Bromo-2-hydroxy-3-methoxybenzaldehyde (NSC95682) is an IRE-1α inhibitor with an IC50 of 0.08 μM, extracted from patent WO 2008154484 A1, IRE-lα inhibitor compound 3-5.
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- HY-129172
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- HY-N7140
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γ-Linolenic acid
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Endogenous Metabolite
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Metabolic Disease
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Gamma-linolenic acid (γ-Linolenic acid) is an omega-6 (n-6), 18 carbon (18C-) polyunsaturated fatty acid (PUFA) extracted from Perilla frutescens. Gamma-linolenic acid supplements could restore needed PUFAs and mitigate the disease .
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- HY-114661
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PROTAC Linkers
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Cancer
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m-PEG4-Tos is a derivative of silybin ethers, extracted from patent CN105037337A (compound III-b). m-PEG4-Tos is a PEG-based PROTAC linker can be used in the synthesis of Silymarin (HY-W043277) .
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- HY-135090
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PROTAC Linkers
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Cancer
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Tos-PEG8-m is a derivative of silybin ethers, extracted from patent CN105037337A (compound III-d). Tos-PEG8-m is a PEG-based PROTAC linker can be used in the synthesis of Silymarin (HY-W043277) .
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- HY-W042501
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PROTAC Linkers
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Cancer
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m-PEG5-Tos is a derivative of silybin ethers, extracted from patent CN105037337A (compound III-c). m-PEG5-Tos is a PEG-based PROTAC linker can be used in the synthesis of Silymarin (HY-W043277) .
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- HY-N0479
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(-)-Licarin B
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PPAR
GLUT
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Metabolic Disease
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Licarin B, a nitric oxide production inhibitor extracted from the component of the seeds of Myristica fragrans, improves insulin sensitivity via PPARγ and activation of GLUT4 in the IRS-1/PI3K/AKT pathway .
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- HY-130515
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CDK
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Cancer
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Cdc7-IN-3 (compound I-A) is a potent Cdc7 kinase inhibitor extracted from patent WO2019165473A1, compound I-B. Cdc7 is a serine-threonine protein kinase enzyme which is essential for the initiation of DNA replication in the cell cycle .
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- HY-12820
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Antibiotic-202
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Bacterial
Antibiotic
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Infection
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Sibofimloc (Antibiotic-202) is a first-in-class, gut-restricted, orally active FimH adhesion inhibitor extracted from patent WO2014100158A1, Compound Example 202. Sibofimloc has anti-bacterial infective activity. Sibofimloc is developed for inflammatory bowel disease (IBD) .
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- HY-138193
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LMNG
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Others
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Others
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Lauryl maltose neopentyl glycol (LMNG) is a detergent that can solubilize and stabilize membrane proteins. Lauryl maltose neopentyl glycol extracts integral membrane proteins from membranes, and improves substantially the stability of various membrane proteins, including G protein-coupled receptors and respiratory complexes .
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- HY-139076
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Epigenetic Reader Domain
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Metabolic Disease
Cancer
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Menin-MLL inhibitor 19, a potent exo-aza spiro inhibitor of menin-mll interaction, example A17, extracted from patent WO2019120209A1. Menin-MLL inhibitor 19 can be used for the reseaech of various diseases, such as cancer, myelodysplastic syndrome (MDS) and diabetes .
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- HY-141535A
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Interleukin Related
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Infection
Inflammation/Immunology
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IL-17 modulator 1 (disodium) is an orally active, highly efficacious IL-17 modulator extracted from patent WO 2020127685. IL-17 modulator 1 (disodium) can be used for the research of diseases including psoriasis, ankylosing spondylitis and psoriatic arthritis .
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- HY-139323
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-
- HY-141799
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Ligands for Target Protein for PROTAC
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Cancer
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Dimethyl-F-OICR-9429-COOH a ligand for WD40 repeat domain protein 5 (WDR5) extracted from patent WO2019246570A1 intermediate 19. Dimethyl-F-OICR-9429-COOH can be used in the synthesis of PROTACs .
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- HY-143770
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Influenza Virus
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Infection
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Cap-dependent endonuclease-IN-16 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-16 is a pyridone polycyclic derivative. Cap-dependent endonuclease-IN-16 has the potential for the research of influenza (extracted from patent CN112778330A, compound 15A) .
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- HY-142925
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Estrogen Receptor/ERR
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Cancer
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ER degrader 1 is a potent degrader of estrogen receptor (ER). The estrogen signaling system plays an important role in regulating cell growth, differentiation and apoptosis. ER degrader 1 has the potential for the research of cancer diseases (extracted from patent WO2021139756A1, compound 11) .
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- HY-142927
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Estrogen Receptor/ERR
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Cancer
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ER degrader 3 is a potent degrader of estrogen receptor (ER). The estrogen signaling system plays an important role in regulating cell growth, differentiation and apoptosis. ER degrader 3 has the potential for the research of cancer diseases (extracted from patent WO2018233591A1, compound 1) .
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- HY-143734
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EGFR
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Cancer
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HER2-IN-6 is a potent inhibitor of HER2. HER2-IN-6 has the potential for the research of wild and/or mutant EGFR and/or HER2 kinase mediated tumor (extracted from patent WO2021164697A1, compound 11) .
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- HY-147594
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CD73
|
Cancer
|
CD73-IN-13 is a potent inhibitor of CD73. CD73 is closely associated with tumor growth, angiogenesis and metastasis. CD73-IN-13 be used for preparing a medicament for tumor-related diseases (extracted from patent CN114437039A, compound 7) .
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- HY-119767
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VEGFR
Apoptosis
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Cancer
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Jolkinolide A is a diterpenoid, can be extracted from the roots of Euphorbia fischeriana Steud. Jolkinolide A exhibits anti-tumor activity, by affecting on angiogenesis of tumor tissues. Jolkinolide A significantly inhibits the Akt-STAT3-mTOR signaling pathway and reduces the expression of VEGF in A549 cells .
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- HY-117616
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(+)-Laurotetanine
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NF-κB
|
Cancer
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Laurotetanine ((+)-Laurotetanine) is an potent and orally active isoquinoline alkaloid and could be extracted from the roots of Litsea cubeba (Lour.) Pers. Laurotetanine exerts an anti-asthmatic effect by inhibition of IgE, histamine, and inflammatory reactions via down-regulating MUC5AC and NF-κB signaling pathways .
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- HY-157359
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Biochemical Assay Reagents
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Others
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Bacterial Organophosphorus Medium can be used to determine the efficiency of phosphorus bacteria in decomposing organic phosphorus in phosphorus bacteria fertilizers. Bacterial Organophosphorus Medium ingredients include glucose, ammonium sulfate, yeast extract, sodium chloride, potassium chloride, magnesium sulfate, ferrous sulfate, manganese sulfate, lecithin, calcium carbonate, agar .
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- HY-145193A
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- HY-U00286
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5-HT Receptor
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Cardiovascular Disease
|
5-HT2A antagonist 1 is a 5-HT2A antagonist extracted from patent US5728835A and JP 1007727. 5-HT2A antagonist 1 may be useful in treatment of gastrointestinal disorders circulatory disorders.
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- HY-N0712
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Autophagy
|
Cardiovascular Disease
Inflammation/Immunology
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Typhaneoside, extracted from Typha angustifolia L., Typhaneoside can inhibit the excessive autophagy of hypoxia/reoxygenation cells and increase the phosphorylation of Akt and mTOR. Typhaneoside has certain effects on the cardiovascular system, including lowering blood lipid levels, promoting antiatherosclerosis activities, as well as improving immune and coagulation function .
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- HY-115688
-
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Others
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Cardiovascular Disease
Metabolic Disease
Inflammation/Immunology
|
TXNIP-IN-1 is TXNIP-TRX (thioredoxin-interacting protein- thioredoxin) complex inhibitor extracted from patent US20200085800A1, Compound 1. TXNIP-IN-1 can be used in the research of TXNIP-TRX complex associated metabolic disorder (diabetes), cardiovascular disease, or inflammatory disease .
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-
- HY-136788
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AKST4290
|
CCR
|
Neurological Disease
Inflammation/Immunology
|
ALK4290 (AKST4290) is a potent and orally active CCR3 inhibitor extracted from patent US20130261153A1, compound Example 2, with a Ki of 3.2 nM for hCCR3 . ALK4290 can be used for the research of neovascular age-related macular degeneration and Parkinsonism .
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- HY-130516
-
|
CDK
|
Cancer
|
Cdc7-IN-4 (compound I-C) is a potent Cdc7 kinase inhibitor extracted from patent WO2019165473A1, compound I-C. Cdc7 is a serine-threonine protein kinase enzyme which is essential for the initiation of DNA replication in the cell cycle .
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- HY-130519
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|
CDK
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Cancer
|
Cdc7-IN-7 (compound I-E) is a potent Cdc7 kinase inhibitor extracted from patent WO2019165473A1, compound I-E. Cdc7 is a serine-threonine protein kinase enzyme which is essential for the initiation of DNA replication in the cell cycle .
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- HY-P2159
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Opioid Receptor
Endogenous Metabolite
|
Neurological Disease
|
Dynorphin A (1-8) is the predominant opioid peptide identified in placental tissue extracts. Dynorphin A (1-8) is the most likely natural ligand of the kappa receptor. The binding of 3H-Bremazocine to the purified kappa receptor is inhibited by Dynorphin A (1-8) (IC50=303 nM) .
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- HY-126415
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Others
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Cardiovascular Disease
Neurological Disease
Inflammation/Immunology
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Magnesium Lithospermate B, a derivative of caffeic acid tetramer, and is extracted from Salviae miltiorrhizae. Magnesium Lithospermate B is widely used for the research of cardiovascular diseases, and it can protect against glucose-induced intracellular oxidative damage. Magnesium Lithospermate B also suppresses neuroinflammation and attenuates neurodegeneration .
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- HY-111623
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|
Deubiquitinase
|
Cancer
|
USP30 inhibitor 11 is a selective and potent ubiquitin specific peptidase 30 (USP30) inhibitor with an IC50 of 0.01 µΜ, the example 83 extracted from patent WO2017009650A1. USP30 inhibitor 11 is used for the study of cancer and conditions involving mitochondrial dysfunction .
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-
- HY-101093B
-
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PD-1/PD-L1
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Cancer
|
PD-1-IN-20 is the less active enantiomer of PD-1-IN-1. PD-1-IN-1 is an inhibitor of programmed cell dealth-1 (PD-1) extracted from patent WO 2015033299 A1, compound example 4 .
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- HY-109198
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ME-401; PWT-143
|
PI3K
|
Cancer
|
Zandelisib (ME-401) is a phosphatidylinositol 3-kinase (PI3K) inhibitor extracted from patent WO2019183226 A1, Compound Example 1. Zandelisib selectively inhibits p110δ with an IC50 of 3.5 nM. Zandelisib functions as an antineoplastic .
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-
- HY-100754B
-
(2R,5S)-PF-06651600
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JAK
|
Inflammation/Immunology
|
(2R,5S)-Ritlecitinib ((2R,5S)-PF-06651600) is a potent and selective JAK3 inhibitor (IC50=144.8 nM) extracted from patent US20150158864A1, example 68 .
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-
- HY-130517
-
|
CDK
|
Cancer
|
Cdc7-IN-5 (compound I-B) is a potent Cdc7 kinase inhibitor extracted from patent WO2019165473A1, compound I-B. Cdc7 is a serine-threonine protein kinase enzyme which is essential for the initiation of DNA replication in the cell cycle .
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-
- HY-N9507
-
|
Apoptosis
FGFR
|
Cancer
|
Picrasidine Q, an alkaloid component extracted from Angelica keiskei species, has the capacity of anti-cell transformation and anti-cancer. Picrasidine Q induces cell apoptosis and G1 phase arrest in human esophageal cancer cell lines, and directly inhibits FGFR2 kinase activity .
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-
- HY-132846
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TAS0953/HM06
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RET
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Others
|
Vepafestinib (TAS0953/HM06; compound 6) is a RET inhibitor (extracted from patent WO2019039439) . Vepafestinib is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-141885
-
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Others
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Metabolic Disease
|
APOL1-IN-1 is a apolipoprotein L1 (APOL1) inhibitor extracted from patent WO2020131807A1 compound 87. APOL1-IN-1 can be used for the research of focal segmental glomerulosclerosis (FSGS) and non-diabetic kidney disease (NDKD) .
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-
- HY-145571
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D-1553
|
Ras
|
Cancer
|
Garsorasib is a potent inhibitor of KRAS G12C with an IC50 of 10 nM. Garsorasib has the potential for the research of various cancer such as pancreatic cancer, endometrial cancer, colorectal cancer, or lung cancer (non-small cell lung cancer) (extracted from patent WO2020233592A1, compound 2) .
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-
- HY-138996
-
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GCGR
|
Metabolic Disease
|
GLP-1 receptor agonist 8 is a potent agonist of GLP-1 R. GLP-1 receptor agonist 8 has the potential for the research of diabetes, obesity, and nonalcoholic fatty liver disease (NAFLD) (extracted from patent WO2019239319A1, compound 17) .
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- HY-N8989
-
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Others
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Metabolic Disease
|
(1,5E,11E)-Tridecatriene-7,9-diyne-3,4-diacetate, isolated from the ethanol extract of Atractylodes lancea rhizome, displays significant lipase inhibition with an IC50 value of 23.9 µg/mL. Antiobesity Effect .
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- HY-139331
-
|
Proteasome
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Neurological Disease
Inflammation/Immunology
Cancer
|
20S Proteasome-IN-1 is a 26S proteasome inhibitor extracted from patent WO2006128196A2 compound 2. 20S Proteasome-IN-1 has the potential for cancer, immune-related disorders, inflammation, ischemic conditions, neurodegenerative disorders and other diseases research .
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- HY-144070A
-
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Estrogen Receptor/ERR
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Cancer
|
(Rac)-ErSO-DFP is a derivative of ErSO-DFP and a selective small molecule Erα biomodulator. (Rac)-ErSO-DFP againsts ERα+ breast cancer (including resistant tumors) by hyperactiving the Erα-dependent a-UPR (extracted from patent WO2022087234A1) .
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- HY-D0143A
-
|
Flavivirus
Dengue virus
Parasite
Potassium Channel
|
Infection
|
Quinine dihydrochloride is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine dihydrochloride is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV with an IC50 of 169 μM .
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-
- HY-N11137
-
|
Bacterial
|
Infection
|
3′-Omethyl-5′-hydroxydiplacone (compound 2), an C-6-geranylflavonoid, can be isolated from the ethanol extract of Paulownia tomentosa fruits. 3′-Omethyl-5′-hydroxydiplacone has antibacterial activity against Gram-positive bacteria .
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-
- HY-D0348
-
Disperse Blue 7; 1,4-DiOH-5,8-bis(2-OHethyl)aminoanthraquinone
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Biochemical Assay Reagents
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Others
|
Celliton Fast Blue Green B (Disperse Blue 7), a blue-green dye used in textiles. The aqueous extract of Celliton Fast Blue Green B causes no signs of skin irritation and sensitization in laboratory animals. Celliton Fast Blue Green B colored textiles with no irritation in human .
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- HY-113471A
-
|
Apoptosis
Bacterial
|
Infection
Cancer
|
(S)-(-)-Perillic acid is a terpenoid plant extract with antimicrobial and anticancer activities. (S)-(-)-Perillic acid induces cell apoptosis and cell cycle arrest, and increases the levell of Bax, Bcl2, p21 and caspase-3 proteins. (S)-(-)-Perillic acid can be used for cancer and infection research .
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- HY-P3028
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Ficin
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Biochemical Assay Reagents
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Others
Metabolic Disease
|
Ficain is an enzyme extract composed of several proteases that can be isolated from Ficus hispida L. and the latex of fig (Ficus carica). Ficain has different specificities in different proportions during fruit ripening. Ficain is widely used in protein hydrolysis, food, production of bioactive peptides and antibody fragments .
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- HY-N3240
-
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Others
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Neurological Disease
|
Mulberrofuran C (compound 11) is an isoprene based flavonoid compound that can be extracted from the root bark of mulberry trees. Mulberrofuran C has protective effect on t-BHP induced oxidative stress with EC50 value of 1.02 μM. Mulberrofuran C has hepatoprotective and neuroprotective activities .
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-
- HY-50162
-
|
Free Fatty Acid Receptor
|
Metabolic Disease
|
GPR120 modulator 1 is a G protein coupled receptor 120 (GPR120) modulator extracted from patent US8394841B2, compound example F1. GPR120 modulator 1 can be used for the research of diseases associated with abnormal or deregulated GPR120, such as diabetes .
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-
- HY-50172
-
|
Free Fatty Acid Receptor
|
Metabolic Disease
|
GPR120 modulator 2 is a G protein coupled receptor 120 (GPR120) modulator extracted from patent US8394841B2, compound example F13. GPR120 modulator 2 can be used for the research of diseases associated with abnormal or deregulated GPR120, such as diabetes .
|
-
- HY-109585
-
|
IRAK
|
Inflammation/Immunology
Cancer
|
IRAK4-IN-7 is a selective, potent and orally active interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor, extracted from patent WO2015104688 (example 1). IRAK4-IN-7 has the potential for cancer and inflammatory diseases treatment .
|
-
- HY-126293
-
|
Apelin Receptor (APJ)
|
Cardiovascular Disease
|
Apelin agonist 1 is an oral selective apelin agonist AM-2995, a agonist of the APJ (APLNR, angiotensin receptor like-1) receptor, may be used in the treatment of cardiovascular conditions. Apelin agonist 1 is extracted from patent WO 2018097944 (210.0), Example 210.0 .
|
-
- HY-136220
-
|
Aryl Hydrocarbon Receptor
|
Cancer
|
AHR antagonist 5, a potent and orally active aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018195397, example 39, has an IC50 of < 0.5 µΜ. AHR antagonist 5 significantly inhibits tumor growth combined with checkpoint inhibitor anti-PD-1 .
|
-
- HY-126298
-
|
Raf
|
Cancer
|
RAF mutant-IN-1 is a RAF kinase inhibitor, extracted from patent WO2019107987A1, with IC50 values of 21 nM, 30 nM and 392 nM for C-RAF 340D/Y341D, B-RAF V600E and B-RAF WT, respectively .
|
-
- HY-N2438
-
|
Ras
|
Others
|
Methylophiopogonanone B, homoisoflavonoid, is extracted from the root of Ophiopogon japonicas, shows high antioxidant ability . Methylophiopogonanone B increases GTP-Rho and acts via the Rho signaling pathway, inducing cell morphological change via actin cytoskeletal reorganization, including dendrite retraction and stress fiber formation .
|
-
- HY-N1620
-
|
Others
|
Cardiovascular Disease
|
1-Cinnamoylpyrrolidine (Compound 3), a crude extract prepared from Piper caninum, is a DNA strand scission agent, induces the relaxation of supercoiled pBR322 plasmid DNA .
1-Cinnamoylpyrrolidine (Compound 4) inhibits platelet aggregation induced by PAF with an IC50 of 37.3 μM .
|
-
- HY-137246
-
|
CD73
|
Cancer
|
CD73-IN-3 is a potent CD73 inhibitor (IC50=7.3 nM in Calu6 human cell assay). CD73-IN-3, example 2 extracted from patent WO2019168744 A1, has the potential for cancer research .
|
-
- HY-103715
-
|
NOD-like Receptor (NLR)
|
Inflammation/Immunology
|
NLRP3 modulators 1 is the potent modulator of NLRP3. NLRP3 modulators 1 agonizes or partially agonizes NLRP3 that are useful for researching a condition, disease or disorder in which a decrease in LRP3 activity contributes to the pathology (extracted from patent WO2017184746A1, compound 107) .
|
-
- HY-144139
-
|
Estrogen Receptor/ERR
|
Cancer
|
Estrogen receptor antagonist 3 is a potent antagonist of estrogen receptor (ER). The estrogen signaling system plays an important role in regulating cell growth, differentiation and apoptosis. Estrogen receptor antagonist 3 has the potential for the research of cancer diseases (extracted from patent WO2021213358A1, compound 7) .
|
-
- HY-144202
-
|
Estrogen Receptor/ERR
|
Cancer
|
Estrogen receptor antagonist 4 is a potent antagonist of estrogen receptor (ER). The estrogen signaling system plays an important role in regulating cell growth, differentiation and apoptosis. Estrogen receptor antagonist 4 has the potential for the research of cancer diseases (extracted from patent WO2021213358A1, compound 1) .
|
-
- HY-133699
-
|
Ligands for E3 Ligase
|
Others
|
Pomalidomide-PEG4-COOH is a E3 ligase ligand-linker conjugate. Pomalidomide-PEG4-COOH contains the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology (extracted from patent WO2017184995A1) .
|
-
- HY-139612A
-
(S)-NVP-JDQ443
|
Ras
PERK
|
Cancer
|
(S)-JDQ-443 is an isomer of JDQ-443 (HY-139612). JDQ-443 is an orally active, potent, selective, and covalent KRAS G12C inhibitor (extracted from patent WO2021120890A1). JDQ-443 shows antitumor activity .
|
-
- HY-145925C
-
|
Epigenetic Reader Domain
|
Cancer
|
(S,R)-CFT8634 is a selective and orally active BRD9 protein degrader. (S,R)-CFT8634 has the potential for the research of disorders mediated by BRD9, including but not limited to abnormal cellular proliferation (extracted from patent WO2021178920A1, compound 176) .
|
-
- HY-N1671
-
|
Others
|
Infection
|
2',5,6',7-Tetraacetoxyflavanone is an extract isolated from Scutellaria baicalensis. 2',5,6',7-Tetraacetoxyflavanone shows significant antibacterial activity against gram-positive bacteria. 2',5,6',7-Tetraacetoxyflavanone can be used to study the treatment of inflammatory diseases .
|
-
- HY-W670700
-
|
Others
|
Others
|
2,5-Dihydroxy-4-methoxyacetophenone (compounds 3) can be isolated from the 80% methanol extract of roots of Cynanchum paniculatum Kitagawa. 2,5-Dihydroxy-4-methoxyacetophenone inhibits glutamate-induced cytotoxicity in hippocampal HT22 cell line .
|
-
- HY-136788A
-
AKST4290 dihydrochloride
|
CCR
|
Inflammation/Immunology
|
ALK4290 dihydrochloride (AKST4290 dihydrochlorid) is a potent and orally active CCR3 inhibitor extracted from patent US20130261153A1, compound Example 2, with a Ki of 3.2 nM for hCCR3 . ALK4290 can be used for the research of neovascular age-related macular degeneration and Parkinsonism .
|
-
- HY-125665
-
|
Apoptosis
|
Cardiovascular Disease
Cancer
|
Pheophorbide A is an intermediate product in the chlorophyll degradation pathway. Pheophorbide A can be used as a photosensitizer. Pheophorbide A is a lymphatic vascular activator. Pheophorbide A has antitumor activity. Pheophorbide A can be used for human lymphatic vascular insufficiencies research .
|
-
- HY-79369S
-
|
Isotope-Labeled Compounds
ADC Linker
|
Cancer
|
Succinic anhydride-d4 is the deuterium labeled Succinic anhydride. Succinic anhydride is a cyclic anhydride and a nonclaevable ADC linker extracted from patent WO2009064913A1. Succinic anhydride can react with compound 4 of the patent to link the proagent to an amine or hydroxy 1 group of a targeting polypeptide[1].
|
-
- HY-111820
-
|
Casein Kinase
|
Inflammation/Immunology
|
CK1-IN-1 is a casein kinase 1 (CK1) inhibitor extracted from patent WO2015119579A1, compound 1c, has IC50s of 15 nM, 16 nM, 73 nM for CK1δ, and CK1ε, p38σ MAPK, respectively .
|
-
- HY-N2208
-
|
|
|
4-Hydroxylonchocarpin is a chalcone compound from an extract of Psoralea corylifolia. 4-Hydroxylonchocarpin increases phosphorylation of p38 MAPK, JNK and ERK. 4-Hydroxylonchocarpin has diverse pharmacological activities, including antibacterial, antifungal, anticancer, antireverse transcriptase, antitubercular, antimalarial, anti-inflammatory and antioxidant activities .
|
-
- HY-128761
-
|
Epigenetic Reader Domain
|
Cancer
|
CBP/EP300-IN-2 is an inhibitor of CBP/EP300 with IC50 values of 1.07 nM and 5.96 nM for CBP/HTRF and Myc, respectively. CBP/EP300-IN-2, example 25, is extracted from patent WO2017205538A1 .
|
-
- HY-128680
-
|
c-Fms
|
Cancer
|
c-Fms-IN-9 is a c-FMS inhibitor extracted from patent WO2014145023A1, Compound Example 7. c-Fms-IN-9 inhibits unphosphorylated c-FMS kinase (uFMS) and uKIT with IC50s of <0.01 μM and 0.1-1 μM, respectively .
|
-
- HY-N7690
-
|
Others
|
Metabolic Disease
|
3,5,7,3′,4′-Pentamethoxyflavone is a polymethoxyflavonoid that can be extracted from Kaempferia parviflora. 3,5,7,3′,4′-Pentamethoxyflavone can induce adipogenesis on 3T3-L1 preadipocytes by regulating transcription factors at an early stage of differentiation .
|
-
- HY-N8537
-
|
Fungal
|
Infection
|
Enfumafungin, a triterpene glycoside, is isolated from extracts derived from fungus Hormonema carpetanum. Enfumafungin is an antifungal compound that is acting on the fungal cell wall, as the (1,3)-beta-D-glucan synthase inhibitor. Enfumafungin is specific for yeasts and fungi (excluding Cryptococcus) and does not inhibit the growth of Bacillus subtilis .
|
-
- HY-W036733
-
|
Biochemical Assay Reagents
|
Others
|
4-Hydroxy-4-methylcyclohexanone is a useful synthetic reagent extracted from patent JP2009022162A. 4-Hydroxy-4-methylcyclohexanone can be used to synthesize trans-4-amino-1-methylcyclohexanol which is intermediate of pharmaceutical synthesis .
|
-
- HY-124676A
-
|
Apoptosis
|
Cancer
|
DB2115 (tertahydrochloride) is a potent inhibitor of myeloid master regulator PU.1. DB2115 (tertahydrochloride) has the potential for researching cancers, including hematologic cancers such as leukemia, as well as other conditions associated with PU. 1 dysfunction (extracted from patent WO2017223260A1, compound DB2115) .
|
-
- HY-145122
-
|
Others
|
Metabolic Disease
|
ELOVL1-IN-1 is an ELOVL1 inhibitor extracted from patent WO2018107056A1, compound 87. ELOVL1-IN-1 can reduce very long chain fatty acid levels. ELOVL1-IN-1 can be used for the research of adrenoleukodystrophy (ALD) .
|
-
- HY-145550
-
BI894999
|
Epigenetic Reader Domain
|
Cancer
|
Amredobresib is a potent inhibitor of BET. Amredobresib inhibits the binding of bromodomains to acetylated lysines on histone H3 and H4 and thus acts as important regulators of gene transcription. Amredobresib is useful for the research of acute myeloid leukemia (AML) and cancer (extracted from patent WO2019145410A1 and WO2021175824A1) .
|
-
- HY-142931
-
|
ATM/ATR
|
Neurological Disease
Cancer
|
ATM-IN-1 is a potent inhibitor of ATM. ATM is located mainly in the nucleus and microsomes and is involved in cell cycle progression and in the cell cycle checkpoint response to DNA damage. ATM-IN-1 has the potential for the research of cancer and neurology diseases (extracted from patent WO2021139814A1, compound 3) .
|
-
- HY-143615
-
|
RET
|
Cancer
|
RET-IN-10 is a potent inhibitor of RET. RET loss of function mutations leads to Hirschsprung's disease, while its gain of function mutations is associated with a variety of human tumors. RET-IN-10 has the potential for the research of cancer diseases (extracted from patent WO2021135938A1, compound 18) .
|
-
- HY-147597
-
|
CDK
|
Cancer
|
CDK7-IN-13 is a potent inhibitor of CDK7. CDK7-IN-13 is a pyrimidinyl derivative compound. CDK7-IN-13 has the potential for the research of various cancers, especially the cancer with transcriptional dysregulation (extracted from patent CN114249712A, compound 1) .
|
-
- HY-147600
-
|
CDK
|
Cancer
|
CDK7-IN-15 is a potent inhibitor of CDK7. CDK7-IN-15 is a pyrimidinyl derivative compound. CDK7-IN-15 has the potential for the research of various cancers, especially the cancer with transcriptional dysregulation (extracted from patent CN114249712A, compound 8) .
|
-
- HY-147602
-
|
CDK
|
Cancer
|
CDK7-IN-17 is a potent inhibitor of CDK7. CDK7-IN-17 is a pyrimidinyl derivative compound. CDK7-IN-17 has the potential for the research of various cancers, especially the cancer with transcriptional dysregulation (extracted from patent CN114249712A, compound 1) .
|
-
- HY-147603
-
|
CDK
|
Cancer
|
CDK7-IN-18 is a potent inhibitor of CDK7. CDK7-IN-18 is a pyrimidinyl derivative compound. CDK7-IN-18 has the potential for the research of various cancers, especially the cancer with transcriptional dysregulation (extracted from patent CN114249712A, compound 15) .
|
-
- HY-147598
-
|
CDK
|
Cancer
|
CDK7-IN-14 is a potent inhibitor of CDK7. CDK7-IN-14 is a pyrimidinyl derivative compound. CDK7-IN-14 has the potential for the research of various cancers, especially the cancer with transcriptional dysregulation (extracted from patent CN114249712A, compound 3) .
|
-
- HY-112436A
-
|
Trk Receptor
|
Neurological Disease
Cancer
|
(3S,4R)-PF-6683324 is a tropomyosin-related kinase (Trk) inhibitor extracted from patent WO2015092610A1 example 9. (3S,4R)-PF-6683324 has the potential for the research of pain and cancer .
|
-
- HY-B0433B
-
|
Flavivirus
Dengue virus
Parasite
Potassium Channel
|
Infection
|
Quinine hemisulfate is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine hemisulfate is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV with an IC50 of 169 μM .
|
-
- HY-N0120AR
-
Piceid (Standard)
|
Autophagy
Apoptosis
Mitophagy
|
Inflammation/Immunology
Cancer
|
Polydatin (Standard) is the analytical standard of Polydatin. This product is intended for research and analytical applications. Polydatin (Piceid), extracted from the roots of Reynoutria japonica, a widely used traditional Chinese remedies, possesses anti-inflammatory activity in several experimental models. Polydatin (Piceid) inhibits G6PD and induces oxidative and ER stresses.
|
-
- HY-W783267
-
|
Glucosidase
|
Metabolic Disease
|
α-Glucosidase-IN-35 (compound 1) is a kind of chromene. α-Glucosidase-IN-35 can be isolated from the aqueous extract of the aerial parts of Brickellia cavanillesii. α-Glucosidase-IN-35 is a potent inhibitor of α-glucosidase with an IC50 value of 0.169 mg/mL .
|
-
- HY-N0044R
-
Ginsenoside B2(Standard); Panaxoside Re(Standard); Sanchinoside Re (Standard)
|
Amyloid-β
NF-κB
JNK
Endogenous Metabolite
|
Neurological Disease
Inflammation/Immunology
Cancer
|
Ginsenoside Re (Standard) is the analytical standard of Ginsenoside Re. This product is intended for research and analytical applications. Ginsenoside Re (Ginsenoside B2) is an extract from Panax notoginseng. Ginsenoside Re decreases the β-amyloid protein (Aβ). Ginsenoside Re plays a role in antiinflammation through inhibition of JNK and NF-κB.
|
-
- HY-B2121R
-
Naproxen impurity O (Standard)
|
iGluR
|
Neurological Disease
|
6-Methoxy-2-naphthoic acid (Standard) is the analytical standard of 6-Methoxy-2-naphthoic acid. This product is intended for research and analytical applications. 6-Methoxy-2-naphthoic acid is an NMDA receptor modulator extracted from patent WO 2012019106 A2.
|
-
- HY-12291
-
HMSL 10017-101-1
|
Raf
|
Cancer
|
HG6-64-1 is a potent and selective B-Raf inhibitor extracted from patent WO 2011090738 A2, example 9 (XI-1); has a IC50 of 0.09 μM on B-raf V600E transformed Ba/F3 cells.
|
-
- HY-19773
-
|
Beta-lactamase
Bacterial
|
Infection
|
β-Lactamase-IN-1 is an inhibitor of β-Lactamase extracted from patent WO2016027249A1, page 77. β-Lactamase-IN-1 can be used to prepare of tricyclic nitrogen containing compound. β-Lactamase-IN-1 can be used for the research of neisseria gonorrhea infection .
|
-
- HY-128527
-
|
PROTACs
Estrogen Receptor/ERR
|
Cancer
|
PROTAC ER Degrader-3 is an intermediate for synthesis of PAC. PAC, consists the ADCs linker and PROTACs, conjugated to an antibody. PAC extracts from patent WO2017201449A1, compound LP2. PAC conjugated to an antibody is a more marked estrogen receptor-alpha (ERα) degrader compared to PROTAC (without Ab) .
|
-
- HY-128830
-
|
Potassium Channel
|
Inflammation/Immunology
|
Kv3 modulator 3 (Compound 4) is a selective modulator of Kv3.1 and/or Kv3.2 and/or Kv3.3 channels extracted from patent WO2017098254A1, compound 4, has analgesic activity for use in the prophylaxis o or treatment of pain .
|
-
- HY-N0510
-
Aristolochic acid I; TR 1736
|
NF-κB
|
Cancer
|
Aristolochic acid A (Aristolochic acid I; TR 1736) is the main component of plant extract Aristolochic acids, which are found in various herbal plants of genus Aristolochia and Asarum. Aristolochic acid A significantly reduces both activator protein 1 (AP-1) and NF-κB activities. Aristolochic acid A reduces BLCAP gene expression in human cell lines .
|
-
- HY-N0315
-
Allicin
4 Publications Verification
Diallyl thiosulfinate
|
Bacterial
Antibiotic
|
Infection
|
Allicin (diallyl thiosulfinate) is isolated from garlic including Diallyl monosulfide, Diallyl disulfide, Diallyl trisulfide, Diallyl tetrasulfide, and Methyl allyl disulphide etc. They accounts for 98% of the extract. Allicin (diallyl thiosulfinate) has highly potent antimicrobial activity, and inhibits growth of a variety of microorganisms, among them antibiotic-resistant strains .
|
-
- HY-N6663
-
|
COX
|
Inflammation/Immunology
|
3-Carene is a bicyclic monoterpene in essential oils extracted from pine trees. 3-Carene inhibits nociceptive stimulus-induced inflammatory infiltrates and COX-2 overexpression, and with antinociceptive effect. 3-Carene stimulates the activity and expression of alkaline phosphatase that is an early phase marker of osteoblastic differentiation .
|
-
- HY-N0288
-
|
Fatty Acid Synthase (FASN)
Virus Protease
Bacterial
Apoptosis
|
Inflammation/Immunology
Cancer
|
Lycorine is a natural alkaloid extracted from the Amaryllidaceae plant. Lycorine is a potent and orally active SCAP inhibitor with a Kd value 15.24 nM. Lycorine downregulates the SCAP protein level without changing its transcription . Lycorine is also a melanoma vasculogenic inhibitor . Lycorine can be used for the study of prostate cancer and metabolic diseases .
|
-
- HY-120947
-
|
Others
|
Neurological Disease
|
AV-105 is a Florbetapir ( 18F)-radiolabeled slyrylpyridine tosylate precursor extracted from patent WO2010078370A1, example 1.5. AV-105 can synthesize 18F-radiolabeled compounds, which are used for positron emission tomography (PET) imaging of neurodegenerative diseases of the brain .
|
-
- HY-128528
-
|
PROTACs
Estrogen Receptor/ERR
|
Cancer
|
PROTAC ER Degrader-2 is an intermediate for synthesis of PAC. PAC, consists the ADCs linker and PROTACs, conjugated to an antibody. PAC extracts from patent WO2017201449A1, compound LP2. PAC conjugated to an antibody is a more marked estrogen receptor-alpha (ERα) degrader compared to PROTAC (without Ab) .
|
-
- HY-137298
-
|
Aminopeptidase
|
Inflammation/Immunology
|
LTA4H-IN-1 is a potent inhibitor of leukotriene A4 hydrolase (LTA4H) extracted from patent WO2015092740A1, example 29, has an IC50 of 2 nM. LTA4H-IN-1 can be used for the research of inflammatory and autoimmune disorders .
|
-
- HY-N0312
-
|
Phosphatase
Bacterial
|
Infection
Metabolic Disease
|
Rhein-8-glucoside calcium, an anthraquinone compound, is isolated from the EtOH extract of the roots of Saussurea lappa. Rhein-8-glucoside calcium is an hPTP1B inhibitor, with an IC50 of 11.5 μM. Rhein-8-glucoside calcium has antibacterial effects .
|
-
- HY-131448
-
|
Others
|
Metabolic Disease
|
A3051 is a potent and orally active inhibtor of CXXC5-DVL extracted from patent WO2020079569, has an IC50 of 63.06 nM. A3334 can be used for the research of high fat diet (HFD)-induced and methionine-choline deficient diet (MCD)-induced phenotypes such as obesity, diabetes, and NASH .
|
-
- HY-141535
-
|
Interleukin Related
|
Infection
Inflammation/Immunology
|
IL-17 modulator 1 is an orally active, highly efficacious small molecule IL-17 modulators extracted from patent WO 2020127685. IL-17 modulator 1 can be used for the research of preventing, researching or ameliorating a variety of diseases including psoriasis, ankylosing spondylitis and psoriatic arthritis .
|
-
- HY-135653A
-
(Rac)-BPN-19186
|
Epoxide Hydrolase
|
Neurological Disease
|
(Rac)-EC5026 ((Rac)-BPN-19186) is a potent piperidine inhibitor of soluble epoxide hydrolase (sEH) extracted from patent WO2019156991A1, page 39, has a Ki of 0.06 nM. (Rac)-EC5026 can be used for the research of Parkinson's disease and dementia with Lewy Bodies (DLB) .
|
-
- HY-145578
-
X842
|
Others
|
Inflammation/Immunology
|
Linaprazan glurate inhibits exogenously or endogenously stimulated gastric acid secretion. Linaprazan glurate exhibits several advantageous properties, such as fast onset, high in vivo potency and/or long duration of action. Linaprazan glurate is useful in the research of gastrointestinal inflammatory diseases and peptic ulcer diseases (extracted from patent WO2010063876A1) .
|
-
- HY-116877
-
|
COX
|
Cancer
|
C2 Ceramide (d14:1/2:0) is a composition for diagnosing diseases associated with cyclooxygenase 2 (COX2) overexpression. C2 Ceramide (d14:1/2:0) exhibits a strong binding activity to COX2 protein (extracted from patent WO2019235824A1).
|
-
- HY-142671
-
|
ATM/ATR
|
Cancer
|
ATR-IN-5 is a potent inhibitor of ATR. ATR is a class of protein kinases involved in genome stability and DNA damage repair, and is a member of the PIKK family. ATR-IN-5 has the potential for the research of ATR kinase-mediated diseases such as proliferative diseases and cancer (extracted from patent CN112047938A, compound D24) .
|
-
- HY-143563
-
|
NOD-like Receptor (NLR)
|
Cancer
|
NLRP3 antagonist 1 is a potent antagonist of NLRP3. NLRP3 is mainly expressed in macrophages and neutrophils and is involved in the body's intrinsic immunity against pathogenic infections and stress injury. NLRP3 antagonist 1 has the potential for the research of cancer disease (extracted from patent WO2021114691A1, compound 3) .
|
-
- HY-143713
-
|
Aurora Kinase
|
Cancer
|
Aurora A inhibitor 1 is a potent and selective inhibitor of Aurora A. Aurora A has been implicated in cancers of diverse histological origin and may possess oncogenic properties when overexpressed. Aurora A inhibitor 1 has the potential for the research of cancer diseases mediated by aurora a (extracted from patent WO2021147974A1, compound 49) .
|
-
- HY-144065
-
|
Influenza Virus
|
Infection
|
Cap-dependent endonuclease-IN-19 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-19 is a spirocyclic pyridone derivative. Cap-dependent endonuclease-IN-19 has strong inhibitory effect on RNA polymerase activity of A virus (extracted from patent CN111410661A, compound 1) .
|
-
- HY-143747
-
|
Influenza Virus
|
Infection
|
Cap-dependent endonuclease-IN-5 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-5 inhibits influenza virus well, and/or has lower cytotoxicity, better in vivo pharmacokinetic properties and in vivo pharmacodynamic properties (extracted from patent WO2020078401A1, compound 13-1) .
|
-
- HY-142699
-
|
Somatostatin Receptor
|
Inflammation/Immunology
|
SSTR4 agonist 2 is a potent agonist of somatostatin receptor subtype 4 (SSTR4). SSTR4 pathway inhibits nociceptive and inflammatory processes. SSTR4 agonist 2 has the potential for the research of medical disorders related to SSTR4 (extracted from patent WO2014184275A1, compound 107) .
|
-
- HY-144867
-
|
HSP
|
Cancer
|
CCT245232 is a potent inhibitor of heat shock factor 1 (HSF1). HSF1 is the master regulator of the heat shock response, in which multiple genes are induced in response to temperature increase and other stresses. CCT245232 has the potential for the research of proliferative diseases, such as cancer (extracted from patent WO2015049535A1) .
|
-
- HY-144169
-
|
Dihydroorotate Dehydrogenase
DNA/RNA Synthesis
|
Inflammation/Immunology
Cancer
|
DHODH-IN-19 is a potent inhibitor of DHODH. DHODH is present in the inner membrane of human mitochondria and is an iron-containing flavin-dependent enzyme. DHODH-IN-19 inhibits tumor growth. DHODH-IN-19 has the potential for the research of cancer and inflammation disease (extracted from patent WO2021238881A1, compound 1) .
|
-
- HY-144137
-
|
Estrogen Receptor/ERR
|
Cancer
|
Estrogen receptor antagonist 1 is a selective estrogen receptor antagonist. Estrogen (E2) and estrogen alpha receptor (ERα) are important drivers of breast cancer development. Estrogen receptor antagonist 1 has the potential for the research of breast cancer diseases (extracted from patent WO2021249533A1, compound 4) .
|
-
- HY-144138
-
|
Estrogen Receptor/ERR
|
Cancer
|
Estrogen receptor antagonist 2 is a selective estrogen receptor downregulator. Estrogen (E2) and estrogen alpha receptor (ERα) are important drivers of breast cancer development. Estrogen receptor antagonist 2 has the potential for the research of breast cancer diseases (extracted from patent WO2021228210A1, compound 3) .
|
-
- HY-147202
-
|
Epigenetic Reader Domain
|
Cancer
|
BRD4 Inhibitor-24 (compound 3U) is a potent BRD4 inhibitor, BRD4 Inhibitor-24 shows antitumor activity against MCF7 and K652 cells, with IC50 values of 33.7 and 45.9 μM, respectively (extracted from patent CN107721975A) .
|
-
- HY-P3940
-
|
PKC
|
Others
|
Ac-MBP (4-14) Peptide is an acetylated MBP (4-14) peptide. MBP (4-14) Peptide is a very selective (protein kinase C) PKC substrate. Ac-MBP (4-14) Peptide can be used for PKC assay in extracts without prior purification to eliminate interfering protein kinases or phosphatases .
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-
- HY-N1710
-
|
|
|
28-Deoxonimbolide is a nimbin (HY-N3187) type limonoid, that can be isolated from Azadirachta indica seed extracts. 28-Deoxonimbolide shows anticancer activity. 28-Deoxonimbolide induces apoptotic cell death in HL60 cells via both the mitochondrial- and the death receptor-mediated pathways .
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-
- HY-142074
-
(+)-Inophyllum B
|
Reverse Transcriptase
HIV
|
Infection
|
Inophyllum B ((+)-Inophyllum B) is a potent HIV Reverse Transcriptase inhibitor with an IC50 value of 38 nM. Inophyllum B inhibits HIV-1 (IC50=1.4 μM) in vitro cell culture. Inophyllum B can be isolated from the acetone extract of the giant African snail, Achatina fulica .
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-
- HY-N3824
-
|
Others
|
Others
|
ent-Atisane-3β,16α,17-triol is a compound that can be isolated from the acetone extract of roots of Euphorbia sieboldiana. ent-Atisane-3β,16α,17-triol is a natural control product .
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-
- HY-139335
-
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
VH 101 phenol-alkylC4-amine dihydrochloride is a von-Hippel-Lindau protein ligand (VHL), and incorporates an E3 ligase ligand plus an alkylC4 linker. VH 101 phenol-alkylC4-amine dihydrochloride can be used for PROTAC research extracted from patent WO2022051326A1.
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-
- HY-161239A
-
|
Antibiotic
|
Infection
Cancer
|
IB-96212 (compound 5) is a member of oligomycin class which can be extracted ftom the marine Micromonospora sp. L-25-ES25-008 ref. IB-96212 is an antitumor antibiotic against P-388, it also exhibits antimicrobial activity against Micrococcus luteus .
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-
- HY-125140
-
|
Others
|
Others
|
ω-3 Arachidonic acid is a poly fatty acid that is essential for growth and development in infants. ω-3 Arachidonic acid inhibits arachidenol-CoA synthetase with Ki values of 14 µM. It also inhibited arachidenol-CoA synthetase of calf brain extract with IC50 values of about 5 µM .
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-
- HY-N0041
-
Gypenoside IV
|
NF-κB
COX
NO Synthase
|
Inflammation/Immunology
Cancer
|
Ginsenoside Rb3 is extracted from steamed Panax ginseng C. A. Meyer. Ginsenoside Rb3 exhibits inhibitory effect on TNFα-induced NF-κB transcriptional activity with an IC50 of 8.2 μM in 293T cell lines. Ginsenoside Rb3 also inhibits the induction of COX-2 and iNOS mRNA.
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-
- HY-N2022
-
|
Glucosidase
|
Inflammation/Immunology
Cancer
|
Castanospermine is a natural alkaloid that can be extracted from black beans or the Moreton Bay chestnut tree (Castanospermum australae). Castanospermine is an α/ β-glucosidase inhibitor. Castanospermine has anti-inflammatory, antiviral replication and anti-metastatic effects on prostate cancer. Castanospermine can be used as an immunosuppressant to prevent transplant rejection .
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-
- HY-129189
-
|
Ras
|
Cancer
|
RAS GTPase inhibitor 1 (example 51) is a RAS GTPase inhibitor with anti-tumor activity, extracted from patent WO2018212774A1. RAS GTPase inhibitor 1 (example 51) exhibits an EC50 less than 1 μM for at least one nucleotide exchange and an IC50 less than 1 μM in H727 cells .
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-
- HY-129657
-
|
GCGR
|
Metabolic Disease
|
GLP-1 receptor agonist 4 is a glucagon-like peptide-1 receptor (GLP-1R) agonist extracted from patent WO2009111700A2, compound 87, has an EC50 of 64.5 nM. GLP-1 receptor agonist 4 can be used in the research for treatment of diabetes .
|
-
- HY-112762A
-
|
Arenavirus
|
Infection
|
(E)-LHF-535 is the E-isomer of LHF-535. LHF-535 is an antiviral agent extracted from patent WO2013123215A2, Compound 38, has EC50s of <1 μM, <1 μM, <1 μM, and 1-10 μM for Lassa, Machupo, Junin, and VSVg virus, respectively .
|
-
- HY-103665
-
|
STING
|
Cancer
|
STING agonist-3, extracted from patent WO2017175147A1 (example 10), is a selective and non-nucleotide small-molecule STING agonist with a pEC50 and pIC50 of 7.5 and 9.5, respectively. STING agonist-3 has durable anti-tumor effect and tremendous potential to improve treatment of cancer .
|
-
- HY-N0392
-
|
Toll-like Receptor (TLR)
PI3K
Akt
NF-κB
|
Inflammation/Immunology
|
Polygalasaponin F, an oleanane-type triterpenoid saponin extracted from Polygala japonica, decreases the release of the inflammatory cytokine tumor necrosis factor a (TNFa). Polygalasaponin F reduces neuroinflammatory cytokine secretion through the regulation of the TLR4-PI3K/AKT-NF-kB signaling pathway .
|
-
- HY-N0047
-
|
JNK
mTOR
Akt
PDK-1
Autophagy
Apoptosis
|
Cancer
|
Polyphyllin I is a bioactive constituent extracted from Paris polyphylla, has strong anti-tumor activity. Polyphyllin I is an activator of the JNK signaling pathway and is an inhibitor of PDK1/Akt/mTOR signaling. Polyphyllin I induces autophagy, G2/M phase arrest and apoptosis .
|
-
- HY-N0261
-
|
TNF Receptor
COX
|
Cardiovascular Disease
Inflammation/Immunology
|
Aurantio-obtusin is a anthraquinone compound that can be extracted from cassia seed. Aurantio-obtusin has the effects of decreasing blood pressure, decreasing blood lipids and anti-inflammatory.Aurantio-obtusin is an orally active vasodilator. Aurantio-obtusin ameliorates hepatic steatosis through AMPK/ autophagy- and AMPK/TFEB mediated inhibition of lipid accumulation .
|
-
- HY-N0284
-
|
PI3K
Akt
|
Inflammation/Immunology
Cancer
|
Esculetin is an active ingredient extracted mainly from the bark of Fraxinus rhynchophylla. Esculetin inhibits platelet-derived growth factor (PDGF)-induced airway smooth muscle cells (ASMCs) phenotype switching through inhibition of PI3K/Akt pathway. Esculetin has antioxidant, antiinflammatory, and antitumor activities .
|
-
- HY-114181
-
|
IRAK
Cyclic GMP-AMP Synthase
|
Inflammation/Immunology
|
IRAK4-IN-4 is an interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor extracted from patent CN107163044A, Compound15, has an IC50 of 2.8 nM. IRAK4-IN-4 also inhibits cyclic GMP-AMP synthase (cGAS) with an IC50 of 2.1 nM .
|
-
- HY-103665A
-
|
STING
|
Cancer
|
STING agonist-3 trihydrochloride, extracted from patent WO2017175147A1 (example 10), is a selective and non-nucleotide small-molecule STING agonist with a pEC50 and pEC50 of 7.5 and 9.5, respectively. STING agonist-3 trihydrochloride has durable anti-tumor effect and tremendous potential to improve treatment of cancer .
|
-
- HY-142672
-
|
ATM/ATR
|
Cancer
|
ATR-IN-6 is a potent inhibitor of ATR. ATR is a class of protein kinases involved in genome stability and DNA damage repair, and is a member of the PIKK family. ATR-IN-6 has the potential for the research of ATR kinase-mediated diseases such as proliferative diseases and cancer (extracted from patent WO2021233376A1, compound A22) .
|
-
- HY-144047
-
|
HBV
DNA/RNA Synthesis
|
Infection
|
HBV-IN-16 is a potent inhibitor of covalently closed circular DNA (cccDNA). cccDNA serves as the template for viral RNA transcription and subsequent viral DNA generation. HBV-IN-16 is a quinoline derivative. HBV-IN-16 has the potential for the research of HBV infection (extracted from patent WO2019121357A1, compound 1) .
|
-
- HY-144045
-
|
HBV
DNA/RNA Synthesis
|
Infection
|
HBV-IN-14 is a potent inhibitor of covalently closed circular DNA (cccDNA). cccDNA serves as the template for viral RNA transcription and subsequent viral DNA generation. HBV-IN-14 is a pyridinopyrimidinones compound. HBV-IN-14 has the potential for the research of HBV infection (extracted from patent WO2021190502A1, compound 5) .
|
-
- HY-143768
-
|
Influenza Virus
|
Infection
|
Cap-dependent endonuclease-IN-14 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-14 inhibits the replication of influenza virus. Cap-dependent endonuclease-IN-14 has the potential for the research of viral infections caused by influenza viruses (extracted from patent CN113620948A, compound 1-c) .
|
-
- HY-143769
-
|
Influenza Virus
|
Infection
|
Cap-dependent endonuclease-IN-15 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-15 inhibits the replication of influenza virus. Cap-dependent endonuclease-IN-15 has the potential for the research of viral infections caused by influenza viruses (extracted from patent CN113226327A, compound c-1) .
|
-
- HY-144066
-
|
Influenza Virus
|
Infection
|
Cap-dependent endonuclease-IN-21 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-21 inhibits the replication of influenza virus. ap-dependent endonuclease-IN-21 has the potential for the research of influenza virus infection (influenza A) (extracted from patent WO2021233302A1, compound 8B or 8A) .
|
-
- HY-144067
-
|
Influenza Virus
|
Infection
|
Cap-dependent endonuclease-IN-23 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-23 inhibits the replication of influenza virus. ap-dependent endonuclease-IN-23 has the potential for the research of influenza virus infection (influenza A) (extracted from patent WO2021233302A1, compound 8A or 8B) .
|
-
- HY-144068
-
|
Influenza Virus
|
Infection
|
Cap-dependent endonuclease-IN-25 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-25 is a macrocyclic pyridotriazine derivative. Cap-dependent endonuclease-IN-25 has the potential for the research of viral infections caused by viruses belonging to the Orthomyxoviridae family (extracted from patent WO2020075080A1, compound 4) .
|
-
- HY-144875
-
|
CDK
|
Cancer
|
CTX-712 is a potent inhibitor of cdc2-like kinase (CLK). CTX-712 inhibits CLK kinase activity, and thus inhibits cancer survival and cancer cell growth. CTX-712 has the potential for the research of cancer disease (extracted from patent JPWO2017188374A1, compound 286) .
|
-
- HY-145761
-
|
iGluR
|
Neurological Disease
|
AMPA-IN-1 is a potent inhibitor of AMPA receptor. AMPA receptors are receptors that are widely expressed in the brain, and play a central role in the regulation of fast excitatory synaptic transmission and synaptic plasticity. AMPA-IN-1 has the potential for the research of various central diseases including epilepsy (extracted from patent WO2017082288A1, compound 14) .
|
-
- HY-142917
-
|
Others
|
Metabolic Disease
|
THR-β agonist 4 is a potent agonist of THR-β. THR-β agonist 4 has the potential for the research of metabolic diseases such as obesity, hyperlipidemia, hypercholesterolemia, diabetes and other conditions such as steatosis and non-alcoholic steatohepatitis (NASH), atherosclerosis and other related conditions and diseases (extracted from patent WO2021143706A1, compound 72) .
|
-
- HY-143613
-
|
Others
|
Metabolic Disease
|
THR-β agonist 2 is a potent agonist of THR-β. THR-β agonist 2 has the potential for the research of metabolic diseases such as obesity, hyperlipidemia, hypercholesterolemia, diabetes and other conditions such as steatosis and non-alcoholic steatohepatitis (NASH), atherosclerosis and other related conditions and diseases (extracted from patent WO2021121210A1, compound 3) .
|
-
- HY-143614
-
|
Others
|
Metabolic Disease
|
THR-β agonist 3 is a potent agonist of THR-β. THR-β agonist 3 has the potential for the research of metabolic diseases such as obesity, hyperlipidemia, hypercholesterolemia, diabetes and other conditions such as steatosis and non-alcoholic steatohepatitis (NASH), atherosclerosis and other related conditions and diseases (extracted from patent WO2021129827A1, compound 6) .
|
-
- HY-144204
-
|
Estrogen Receptor/ERR
|
Endocrinology
Cancer
|
Estrogen receptor antagonist 5 is a potent antagonist of Estrogen receptor. The estrogen receptor is a ligand-activated transcriptional regulatory protein that mediates induction of a variety of biological effects through its interaction with endogenous estrogens. Estrogen receptor antagonist 5 has the potential for the research of metastatic disease (extracted from patent WO2017174757A1, compound 165) .
|
-
- HY-144206
-
|
Estrogen Receptor/ERR
|
Endocrinology
|
Estrogen receptor antagonist 6 is a potent antagonist of Estrogen receptor. The estrogen receptor is a ligand-activated transcriptional regulatory protein that mediates induction of a variety of biological effects through its interaction with endogenous estrogens. Estrogen receptor antagonist 6 has the potential for the research of metastatic disease (extracted from patent WO2017174757A1, compound 166) .
|
-
- HY-144096
-
|
Histone Methyltransferase
|
Cancer
|
EZH2-IN-11 is a potent inhibitor of E2HZ. The oncogenic activities of EZH2 have been shown by a number of studies in various different cancer types. EZH2-IN-11 has the potential for the research of cancer diseases (extracted from patent WO2019204490A1, compound 17) .
|
-
- HY-146519
-
|
Trk Receptor
|
Cancer
|
TRK-IN-14 is a potent inhibitor of TRK. Protein kinases play a critical role in the control of cell growth and differentiation and are responsible for the control of a wide variety of cellular signal transduction processes. TRK-IN-14 has the potential for the research of TRK-related diseases (extracted from patent WO2012034091A1, compound X-47) .
|
-
- HY-146522
-
|
Trk Receptor
|
Cancer
|
TRK-IN-16 is a potent inhibitor of TRK. Protein kinases play a critical role in the control of cell growth and differentiation and are responsible for the control of a wide variety of cellular signal transduction processes. TRK-IN-16 has the potential for the research of TRK-related diseases (extracted from patent WO2012034091A1, compound X-21) .
|
-
- HY-146518
-
|
Trk Receptor
|
Cancer
|
TRK-IN-13 is a potent inhibitor of TRK. Protein kinases play a critical role in the control of cell growth and differentiation and are responsible for the control of a wide variety of cellular signal transduction processes. TRK-IN-13 has the potential for the research of TRK-related diseases (extracted from patent WO2012034091A1, compound X-24) .
|
-
- HY-146521
-
|
Trk Receptor
|
Cancer
|
TRK-IN-15 is a potent inhibitor of TRK. Protein kinases play a critical role in the control of cell growth and differentiation and are responsible for the control of a wide variety of cellular signal transduction processes. TRK-IN-15 has the potential for the research of TRK-related diseases (extracted from patent WO2012034091A1, compound X-55) .
|
-
- HY-147564
-
|
RET
|
Neurological Disease
Cancer
|
RET-IN-18 is a pyridone compound. is a potent inhibitor of RET. RET-IN-18 is a potent inhibitor of RET. RET-IN-18 has the potential for the research of diseases related to irritable bowel syndrome (IBS) and other gastrointestinal disorders, as well as cancers, and neurodegenerative diseases (extracted from patent WO2022017524A1, compound 1) .
|
-
- HY-144046
-
|
HBV
DNA/RNA Synthesis
|
Infection
|
HBV-IN-15 is a potent inhibitor of covalently closed circular DNA (cccDNA). cccDNA serves as the template for viral RNA transcription and subsequent viral DNA generation. HBV-IN-15 is a flavone derivative. HBV-IN-16 has the potential for the research of HBV infection (extracted from patent WO2020052774A1, compound 2) .
|
-
- HY-N2203A
-
|
Others
|
Others
|
Vitexin2''-O-p-trans-coumarate is a flavonoid, can be isolated from the Et acetate-soluble fraction of the ethanolic extract of the seeds of Trigonella foenum-graecum. Vitexin2''-O-p-trans-coumarate strongly promotes 2BS cell proliferation induced by H2O2 .
|
-
- HY-N9895
-
|
Others
|
Infection
Inflammation/Immunology
|
3,5-Dicaffeoyl-epi-quinic acid can be extracted from Chrysanthemum morifolium. 3,5-Dicaffeoyl-epi-quinic acid has antioxidant activities. 3,5-Dicaffeoyl-epi-quinic acid can scavenge DPPH radical and superoxide anion radical, with IC50s of 5.6 and 2.9 μg/mL respectively .
|
-
- HY-79369S1
-
|
ADC Linker
|
Cancer
|
Succinic anhydride- 13C2 is the 13C labeled Succinic anhydride[1]. Succinic anhydride is a cyclic anhydride and a nonclaevable ADC linker extracted from patent WO2009064913A1. Succinic anhydride can react with compound 4 of the patent to link the proagent to an amine or hydroxy 1 group of a targeting polypeptide[2].
|
-
- HY-N2095
-
Atractylon
|
Influenza Virus
|
Infection
Inflammation/Immunology
|
Atractylone (Atractylon) is a sesquiterpenoid extracted from Atractylodis Rhizoma. Atractylone (Atractylon) alleviates influenza A virus (IAV)-induced lung injury via regulating the TLR7 signaling pathway, and acts as a promising agent for IAV treatment. Atractylone (Atractylon) inhibits the degranulation of mast cell and exhibits potential for the treatment of mast cell-mediated allergic reactions .
|
-
- HY-16462
-
|
CDK
|
Cancer
|
CDK9-IN-2 is a special cyclin-dependent kinase 9 (CDK9) inhibitor, extracted from patent WO/2012131594A1, compound CDKI(8), has an IC50 of 5 nM and 7 nM in H929 multiple myeloma(MM) cell line (72 hours) and A2058 skin cell line (72 hours), respectively.
|
-
- HY-19322C
-
(1S,3R,5R)-LGH447 dihydrochloride
|
Pim
|
Cancer
|
(1S,3R,5R)-PIM447 (dihydrochloride) an PIM inhibitor extracted from patent US 20100056576 A1, compound example 72, has IC50 values of 0.095 μM for Pim1, 0.522 μM for Pim2 and 0.369 μM for Pim3.
|
-
- HY-112098
-
|
PROTACs
Estrogen Receptor/ERR
|
Cancer
|
PROTAC ERα Degrader-1 comprises an ubiquitin E3 ligase binding group, a linker and a protein binding group. PROTAC ERα Degrader-1 extracts from patent WO2017201449A1, compound P1. PROTAC ERα Degrader-1 is an estrogen receptor-alpha (ERα) degrader.
|
-
- HY-N6246
-
|
NF-κB
ERK
|
Inflammation/Immunology
Cancer
|
Asperulosidic Acid (ASPA), a bioactive iridoid glycoside, is extracted from the herbs of Hedyotis diffusa Willd. Asperulosidic Acid (ASPA) has anti-tumor, anti-oxidant, and anti-inflammatory activities .
ASPA is related to the inhibition of inflammatory cytokines (TNF-α, IL-6) and mediators via suppression of the NF-κB and mitogen-activated protein kinase (MAPK) signaling pathways .
|
-
- HY-N2571
-
|
Reverse Transcriptase
HIV
|
Infection
|
Corydine is a naturally occurring alkaloid which can be extracted from plants such as Croton echinocarpus leaves. Corydine is efficient on inhibiting reverse transcriptase (RT) activity with an IC50 of 356.8 μg/mL. Corydine displays significant in vitro anti-HIV potential, inhibiting 40% of the HIV-1 reverse transcriptase enzyme activity at a concentration of 450 μg/mL of Corydine .
|
-
- HY-W017316
-
4-Carvomenthenol
|
Endogenous Metabolite
Bacterial
Fungal
|
Infection
Inflammation/Immunology
Cancer
|
Terpinen-4-ol (4-Carvomenthenol) is a naturally occurring monoterpene, and can be extracted from a variety of aromatic plants. Terpinen-4-ol is a potent bactericidal agent which possess antifungal , anti-inflammatory and antitumor properties as well, suggesting Terpinen-4-ol to be used for relevant research .
|
-
- HY-N7073
-
|
SARS-CoV
|
Infection
Neurological Disease
Inflammation/Immunology
Cancer
|
Silymarin is an extract of the milk thistle (Silybum marianum). Silymarin is an effective SARS-CoV-2 main protease (M pro) inhibitor. Silymarin can significantly reduce tumor cell proliferation, angiogenesis as well as insulin resistance. Silymarin has the chemopreventive effect on hepatocellular carcinoma (HCC). Silymarin has the potential for COVID-19 research .
|
-
- HY-U00318
-
|
JAK
|
Inflammation/Immunology
|
JAK-IN-11 is a potent and selective JAK inhibitor extracted from patent WO2012122452A1, Compound II, has the potential for the skin disorders (such as cutaneous lupus) treatment . JAK-IN-11 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-112294
-
|
Tie
VEGFR
|
Cardiovascular Disease
Inflammation/Immunology
Cancer
|
TIE-2/VEGFR-2 kinase-IN-1 is used for the synthesis of TIE-2 and/or VEGFR-2 inhibitors, extracted from patent WO2003022852, example 14. TIE-2/VEGFR-2 kinase-IN-1 is used for the study of diseases associated with inappropriate angiogenesis .
|
-
- HY-136584
-
|
Others
|
Cardiovascular Disease
Metabolic Disease
|
2,2,14,14-Tetramethyl-8-oxopentadecanedioic acid is a ketone compound extracted from patent WO2002030860A2, compound example II-9. 2,2,14,14-Tetramethyl-8-oxopentadecanedioic acid can be used for the research of cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders .
|
-
- HY-136866
-
|
γ-secretase
|
Neurological Disease
|
Aβ42-IN-2 is a γ-secretase modulator extracted from patent WO2016070107, compound example 36. Aβ42-IN-2 has an IC50 of 6.5 nM for Αβ42. Aβ42-IN-2 can be used for the research of Alzheimer's disease .
|
-
- HY-N7683
-
|
Glucosidase
|
Metabolic Disease
|
Prunetin 5-O-β-D-glucopyranoside is an isoflavone isolated from extracts of Potentilla astracanica. Prunetin 5-O-β-D-glucopyranoside is a potent and uncompetitive inhibitor of α-glucosidase, with an IC50 of 56.05 μg/mL. Prunetin 5-O-β-D-glucopyranoside can be used for the research of type-2 diabetes .
|
-
- HY-138061
-
|
Flavivirus
Dengue virus
DNA/RNA Synthesis
|
Infection
|
DENV-IN-2 is a potent dengue viral replication inhibitor extracted from patent WO2018215315A1, compound 6AB, has an EC50 of 0.016 nM. DENV-IN-2 shows high potent activity against all four serotypes of the Dengue virus with EC50s ranging from 0.013 to 0.029 nM .
|
-
- HY-138281
-
|
Complement System
|
Inflammation/Immunology
|
Complement factor D-IN-2 is an inhibitor of complement factor D extracted from patent WO2015130838A1, compound 190. Complement factor D-IN-2 targets factor D and inhibits the complement cascade at an early and essential point in the alternative complement pathway. Complement factor D-IN-2 can be used for the research of autoimmune diseases .
|
-
- HY-139504
-
CC-99677
|
MAPKAPK2 (MK2)
|
Inflammation/Immunology
|
Gamcemetinib (CC-99677) is a potent, covalent, and irreversible inhibitor of the mitogen-activated protein (MAP) kinase-activated protein kinase-2 (MK2) pathway in both biochemical (IC50=156.3 nM) and cell based assays (EC50=89 nM). Gamcemetinib is extracted from patent WO2020236636, compound 1 .
|
-
- HY-145424
-
|
CDK
|
Others
|
CDK7-IN-10 is a CDK7 inhibitor with an IC50 of less than 100 nM, extracted from patent WO2021016388A1, compound I-1. CDK7-IN-10 is useful in inhibiting the activity of a kinase. CDK7-IN-10 has the potential of inhibiting cell growth and inducing cell apoptosis .
|
-
- HY-145359
-
|
Eukaryotic Initiation Factor (eIF)
|
Cancer
|
eIF4A3-IN-5 is a potent inhibitor of eukaryotic initiation factor 4A (eIF4A), such as eIF4AI and eIF4AII. eIF4A3-IN-5 has the potential for the research of eIF4A dependent diseases, including the research of cancer (extracted from patent US20170145026A1) .
|
-
- HY-145360
-
|
Eukaryotic Initiation Factor (eIF)
|
Cancer
|
eIF4A3-IN-6 is a potent inhibitor of eukaryotic initiation factor 4A (eIF4A), such as eIF4AI and eIF4AII. eIF4A3-IN-6 has the potential for the research of eIF4A dependent diseases, including the research of cancer (extracted from patent US20170145026A1) .
|
-
- HY-145309
-
|
Eukaryotic Initiation Factor (eIF)
|
Cancer
|
eIF4E-IN-3 is a potent inhibitor of eukaryotic initiation factor 4e (eIF4e). eIF4E-IN-3 has the potential for researching eIF4e dependent diseases, including the research of cancer (extracted from patent WO2021003157A1, compound 485) .
|
-
- HY-143714
-
|
Cathepsin
|
Inflammation/Immunology
|
Cathepsin K inhibitor 2 is a potent inhibitor of cathepsin K. Cathepsin K, Cat K is a cysteine protease expressed under the control of CTSK gene and closely related to osteoporosis, whose main function is to hydrolyze collagen. Cathepsin K inhibitor 2 has the potential for the research of osteoarthfitis (extracted from patent WO2021147882A1, compound 78) .
|
-
- HY-142806
-
|
ROR
|
Inflammation/Immunology
|
RORγt inverse agonist 26 is a potent reverse agonist of RORγt. RORγt inverse agonist 26 regulates the differentiation of Th17 cells and inhibits the production of IL-17. RORγt inverse agonist 26 has the potential for the research of inflammation and autoimmune diseases (extracted from patent WO2021228215A1, compound 1) .
|
-
- HY-142703
-
|
ROR
|
Inflammation/Immunology
|
RORγt inverse agonist 28 is a potent reverse agonist of RORγt. RORγt inverse agonist 28 regulates the differentiation of Th17 cells and inhibits the production of IL-17. RORγt inverse agonist 28 has the potential for the research of inflammation and autoimmune diseases (extracted from patent WO2021228215A1, compound 6) .
|
-
- HY-143583
-
|
Others
|
Neurological Disease
Cancer
|
ATX inhibitor 10 is a potent inhibitor of ATX. ATX inhibitor 10 is s nitrogen-containing heterocyclic compound. ATX plays a role in causing pathological conditions including fibrosis, arthritis, neurodegeneration, neuropathic pain, and cancer. ATX inhibitor 10 has the potential for the research of ATX related diseases (extracted from patent WO2021115375A1, compound 35) .
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- HY-146530
-
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Others
|
Neurological Disease
Cancer
|
c-ABL-IN-4 is a potent inhibitor of c-Abl. Activation of c-Abl has been implicated in various diseases, notably cancer. c-ABL-IN-4 has the potential for the research of neurodegenerative diseases (amyotrophic lateral sclerosis (ALS) and Parkinson’s disease (PD) and cancer (extracted from patent WO2021048567A1, compound 54) .
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-
- HY-146528
-
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Others
|
Neurological Disease
Cancer
|
c-ABL-IN-3 is a potent inhibitor of c-Abl. Activation of c-Abl has been implicated in various diseases, notably cancer. c-ABL-IN-3 has the potential for the research of neurodegenerative diseases (amyotrophic lateral sclerosis (ALS) and Parkinson’s disease (PD) and cancer (extracted from patent WO2021048567A1, compound 50) .
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-
- HY-144062
-
|
SARS-CoV
|
Infection
|
INSCoV-614(1B) is a potent inhibitor of M pro (3CL pro). Proteases (PL pro and 3CL pro) are involved with transcription and replication of the virus. INSCoV-614(1B) has the potential for the research of SARS-CoV-2 infection (extracted from patent WO2021219089A1) .
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-
- HY-147585
-
|
Complement System
|
Inflammation/Immunology
|
C5aR-IN-1 is a potent inhibitor of C5aR. Increased level of C5a has been associated with disorders such as autoimmune disorders and inflammatory disorders. C5aR-IN-1 has the potential for the research of inflammation diseases (extracted from patent WO2022028586A1, compound 47) .
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-
- HY-147586
-
|
Complement System
|
Inflammation/Immunology
|
C5aR-IN-2 is a potent inhibitor of C5aR. Increased level of C5a has been associated with disorders such as autoimmune disorders and inflammatory disorders. C5aR-IN-2 has the potential for the research of inflammation diseases (extracted from patent WO2022028586A1, compound 49) .
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-
- HY-147587
-
|
Complement System
|
Inflammation/Immunology
|
C5aR-IN-3 is a potent inhibitor of C5aR. Increased level of C5a has been associated with disorders such as autoimmune disorders and inflammatory disorders. C5aR-IN-3 has the potential for the research of inflammation diseases (extracted from patent WO2022028586A1, compound 89) .
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-
- HY-N9698
-
|
Others
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Others
|
1,5-Diphenyl-2-penten-1-one is a natural product extracted from Stellera chamaejasme. 1,5-Diphenyl-2-penten-1-one has strong contact activity and very good anti-feedant activity against Aphis gossypii and Schizaphis graminum .
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-
- HY-P0099
-
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|
|
Pentapeptide-3 is a pentapeptide fragment of neurotoxin waglerin-1, it can be extracted from the venom of Temple Viper. Pentapeptide-3 is a competitive antagonist of nicotinic acetylcholine receptors (nAChRs), it can blocks nerves at the post-synaptic membrane. Pentapeptide-3 has anti-aging effects and it can be used together with other cosmetic peptides .
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-
- HY-N7178
-
|
Others
|
Others
|
Abieta-8,11,13-triene-7α,15,18-triol is an abietane diterpene. Abieta-8,11,13-triene-7α,15,18-triol can be isolated from the CHCl3 extract of the cones of Larix koempferi .
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-
- HY-P2733
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GPO
|
Endogenous Metabolite
|
Metabolic Disease
|
Glycerol-3-phosphate oxidase, E. coli (GPO) is a key intermediate in glycerol metabolism. Glycerol-3-phosphate oxidase can be extracted from Escherichia coli. Glycerol-3-phosphate oxidase is the skeleton of phospholipids in membrane lipids, and also the substrate of respiratory chain. Glycerol-3-phosphate oxidase produces electrons through oxidation .
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-
- HY-B2225B
-
Edible corn starch (from corn)
|
Biochemical Assay Reagents
Endogenous Metabolite
|
Others
|
Starch (from corn) is a carbohydrate extracted from the kernel of the corn plant. It contains two main components, namely amylose and amylopectin. Starches from corn have various applications in the food industry as thickeners, stabilizers and binders. It is commonly used in the production of products such as baked goods, snacks, sauces and soups. In addition, it can be used as a raw material for the production of biofuels and bioplastics.
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-
- HY-153425
-
|
PROTACs
|
Cancer
|
PROTAC SMARCA2 degrader-2 is a potent and selective SMARCA2/4 PROTAC degrader with an IC50 of <0.1 μΜ in HeLa HiBiT assay. PROTAC SMARCA2 degrader-2 is extracted from patent WO2023287787A1 and has the potential for SMARCA4-related or deficient cancer research .
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-
- HY-W780790
-
|
Others
|
Others
|
(Z,Z)-3,13-Octadecadienyl acetate is a compound that can be isolated from the pheromone gland extracts of female S. bicingulata moths. (Z,Z)-3,13-Octadecadienyl acetate is essential for attraction of male S. bicingulata moths. (Z,Z)-3,13-Octadecadienyl acetate can be used as bait to trap male moths .
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-
- HY-W010668
-
|
Flavivirus
Dengue virus
Parasite
Potassium Channel
|
Others
|
Quinine sulfate hydrate (2:1:4) is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine sulfate hydrate (2:1:4) is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV with an IC50 of 169 μM .
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-
- HY-N2939
-
|
Others
|
Others
|
Bis-5,5-Nortrachelogenin is isolated from active extract of root of Wikstroemia indica. Bis-5,5-Nortrachelogenin inhibits nitric oxide (NO) production in a lipopolysaccharide (LPS) and recombinant mouse interferon-γ(IFN-γ) activated murine macrophage-like cell line, RAW 264.7 with an IC50 value of 48.6 mM .
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-
- HY-N8029
-
|
Others
|
Others
|
6-Hydroxyapigenin 6-O-β-D-glucoside-7-O-β-D-glucuronide (compound 8) is a kind of flavonoid. 6-Hydroxyapigenin 6-O-β-D-glucoside-7-O-β-D-glucuronide can be isolated from the water extract of Carthamus tinctorius .
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-
- HY-N7165
-
|
Phosphatase
Bacterial
|
Infection
Metabolic Disease
|
3-O-cis-p-Coumaroyl maslinic acid (compound 16) is a natural compound isolated from the ethyl acetate extract of leaves of Miconia albicans.3-O-cis-p-Coumaroyl maslinic acid can inhibit PTP1B, with the IC50 of 0.46 μM, and shows antimicrobial activity on Gram-positive bacteria and yeasts .
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-
- HY-B0688
-
4,4′-Diaminodiphenyl sulfone; DDS
|
Antibiotic
Parasite
Bacterial
Reactive Oxygen Species
|
Infection
Inflammation/Immunology
|
Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities . Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al .
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-
- HY-101265
-
S1p receptor agonist 1
|
LPL Receptor
|
Inflammation/Immunology
|
Icanbelimod (S1p receptor agonist 1) is a potent and orally active S1P receptor agonist, exhibits an activity of inducing S1P1 internalization (EC50=9.83 nM). Icanbelimod has the potential for the study of arthritis and EAE (experimental autoimmune encephalitis). Icanbelimod is extracted from patent WO2015039587A1, Compound 2.
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-
- HY-P1597
-
|
PKA
PKC
|
Cancer
|
Malantide is a synthetic dodecapeptide derived from the site phosphorylated by cAMP-dependent protein kinase (PKA) on the β-subunit of phosphorylase kinase. Malantide is a highly specific substrate for PKA with a Km of 15 μM and shows protein inhibitor (PKI) inhibition >90% substrate phosphorylation in various rat tissue extracts . Malantide is also an efficient substrate for PKC with a Km of 16 μM .
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-
- HY-111827
-
-
- HY-N2274
-
12-Oleanene-3β,16β,23,28-tetrol; 3β,16β-12-Oleanene-3, 16,23,28-tetrol
|
|
|
23-Hydroxylongispinogenin (12-Oleanene-3β,16β,23,28-tetrol) is extracted from Lysimachia heterogenea Klatt. Lysimachia heterogenea Klatt is a perennial herb, which is used as a folk medicine in subduing swelling and detoxicating in China. The effective fraction LH-1 of L. heterogene has antitumor activity .
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-
- HY-N2512
-
|
FAAH
Bacterial
Fungal
Endogenous Metabolite
Autophagy
|
Infection
|
1-Monomyristin, extracted from Serenoa repens, inhibits the hydrolysis of 2-oleoylglycerol (IC50=32 μM) and fatty acid amide hydrolase (FAAH) activity (IC50=18 μM). 1-Monomyristin shows antibacterial activity against Staphylococcus aureus and Aggregatibacter actinomycetemcomitans and also antifungal activity against Candida albicans .
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-
- HY-N7018
-
|
Others
|
Inflammation/Immunology
|
20-Hydroxyganoderic Acid G is a lanostane triterpenoid obtained from the EtOH extract of fruiting bodies of the Ganoderma curtisii. 20-Hydroxyganoderic Acid G inhibits BV-2 microglia cells activated by LPS with an IC50 of 21.33 μM. 20-Hydroxyganoderic Acid G has therapeutic potential in the agent discovery of nerve inflammation diseases associated with microglia activated by LPS .
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-
- HY-19323A
-
(S)-AZD6738
|
ATM/ATR
|
Cancer
|
(S)-Ceralasertib ((S)-AZD6738) is extracted from patent WO2011154737A1, Compound II, exhibits an IC50 of 2.578 nM .
(S)-Ceralasertib is a potent and selective sulfoximine morpholinopyrimidine ATR inhibitor with excellent preclinical physicochemical and pharmacokinetic (PK) characteristics.
(S)-Ceralasertib is developed improving aqueous solubility and eliminates CYP3A4 time-dependent inhibition .
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-
- HY-W001189
-
|
Bacterial
Endogenous Metabolite
|
Infection
|
1,3-Dithiane is a protected formaldehyde anion equivalent that could serve as a useful labeled synthon . 1,3-Dithiane is also a sulfur-containing Maillard reaction products (MRPs) found in boiled beef extracts. 1,3-Dithiane shows a potent direct-acting mutagenicity toward S. typhimurium TA98 and TA100 .
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-
- HY-N7510
-
12-Methoxycarnosic acid
|
5 alpha Reductase
|
Infection
Cancer
|
12-O-Methylcarnosic acid (12-Methoxycarnosic acid), a diterpene carnosic acid isolated from the acetone extract of Salvia microphylla, is an active constituent of 5α-reductase inhibition with an IC50 value of 61.7 μM. 12-O-Methylcarnosic acid inhibits proliferation in LNCaP cells. 12-O-Methylcarnosic acid has antioxidant, anti-cancer and antimicrobial activity .
|
-
- HY-135830
-
|
Aryl Hydrocarbon Receptor
|
Cancer
|
AHR antagonist 4 is a 2-heteroaryl-3-oxo-2,3-dihydropyridazine-4-carboxamide compound and a potent aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018146010A1, example 293, has an IC50 of 82.2 nM. AHR antagonist 4 has anti-cancer effects .
|
-
- HY-132161
-
|
Drug-Linker Conjugates for ADC
|
Cancer
|
MP-PEG4-Val-Lys-Gly-7-MAD-MDCPT is a Camptothecin-linker compound extracted from patent WO2019195665A1, example 4-1. MP-PEG4-Val-Lys-Gly-7-MAD-MDCPT is a agent-linker conjugate for antibody-drug conjugate (ADC) .
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-
- HY-141798
-
|
Ligands for Target Protein for PROTAC
|
Cancer
|
OICR-9429-N-C2-NH2 is a ligand for Wd40 repeat domain protein 5 (WDR5) extracted from patent WO2019246570A1, intermediate 2. OICR-9429-N-C2-NH2 can be used in the synthesis of PROTACs .
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-
- HY-139791
-
XEN1101
|
Potassium Channel
|
Cancer
|
KCNQ2/3 activator-1 is an activator of Kv7.2/Kv7.3 (KCNQ2/3) potassium channel. KCNQ2/3 activator-1 has the potential in relieving pain (the main problem from medical treatment) (extracted from patent WO2021113757A1, compound A) .
|
-
- HY-145412
-
|
GCGR
|
Metabolic Disease
|
GLP-1 receptor agonist 7 is a potent agonist of glucagon-like peptide-1 (GLP-1). GLP-1 receptor agonist 7 has the potential for the research of GLP-1-associated diseases, disorders, and conditions including diabetes mellitus (extracted from patent WO2021219019A1, compound 130b) .
|
-
- HY-144048
-
|
EGFR
|
Cancer
|
EGFR-IN-31 is a potent inhibitor of EGFR. Overexpression and mutation of the epidermal growth factor receptor (EGFR) has been clearly demonstrated to lead to uncontrollable cell growth and is associated with the progression of most cancer diseases, especially NSCLC. EGFR-IN-31 has the potential for the research of diseases associated with EGFR mutations (extracted from patent WO2021185298A1, compound 2) .
|
-
- HY-144049
-
|
EGFR
|
Cancer
|
EGFR-IN-32 is a potent inhibitor of EGFR. Overexpression and mutation of the epidermal growth factor receptor (EGFR) has been clearly demonstrated to lead to uncontrollable cell growth and is associated with the progression of most cancer diseases, especially NSCLC. EGFR-IN-32 has the potential for the research of diseases associated with EGFR mutations (extracted from patent WO2021185297A1, compound 2) .
|
-
- HY-145709
-
|
Androgen Receptor
|
Cancer
|
Ar-V7-IN-1 is a potent inhibitor of Ar-V7. AR-V7 is a hormone-independent splice variant of the androgen receptor. Ar-V7-IN-1 has the potential for the research of various indications, in particular cancers such as prostate cancer (extracted from patent WO2018114781A1, compound 43) .
|
-
- HY-N9814
-
|
NO Synthase
|
Inflammation/Immunology
|
Shanciol B, isolated from the ethyl acetate extract of the air-dried whole plant of Pholidota imbricate Hook, inhibits nitric oxide (NO) production and 1,1-diphenyl-2-picrylhydrazil (DPPH) radical scavenging activity . Shanciol B is a microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor with anti-inflammatory activity .
|
-
- HY-143592
-
|
Ras
|
Cancer
|
KRAS G12C inhibitor 39 is a potent inhibitor of KRAS G12C. KRas is a highly attractable target of the pharmaceutical industry for cancer research. KRAS G12C inhibitor 39 has the potential for the research of KRAS G12C-mediated cancer (extracted from patent WO2019099524A1, compound 494) .
|
-
- HY-143589
-
JAB-21822; KRAS G12C inhibitor 36
|
Ras
|
Cancer
|
Glecirasib (KRAS G12C inhibitor 36) is a potent inhibitor of KRAS G12C. The Ras family of proteins is an important intracellular signaling molecule that plays an important role in growth and development. Glecirasib has the potential for the research of KRAS G12C-mediated cancer (extracted from patent WO2021121367A1, compound 1-2) .
|
-
- HY-143874
-
|
EGFR
|
Cancer
|
HER2-IN-7 is a potent inhibitor of HER2. Deregulation of ErbB family signalling modulates proliferation, invasion, metastasis, angiogenesis, and tumour cell survival. HER2-IN-7 has the potential for the research of diseases associated ErbBs (especially HER2), including cancer (extracted from patent WO2019214634A1, compound 23) .
|
-
- HY-144061
-
|
SARS-CoV
|
Infection
|
INSCoV-601I(1) is a potent inhibitor of M pro (3CL pro). Proteases (PL pro and 3CL pro) are involved with transcription and replication of the virus. INSCoV-601I(1) has the potential for the research of SARS-CoV-2 infection (extracted from patent WO2021219089A1) .
|
-
- HY-144063
-
|
SARS-CoV
|
Infection
|
INSCoV-600K(1) is a potent inhibitor of M pro (3CL pro). Proteases (PL pro and 3CL pro) are involved with transcription and replication of the virus. INSCoV-600K(1) has the potential for the research of SARS-CoV-2 infection (extracted from patent WO2021219089A1) .
|
-
- HY-Y1832
-
3-Methoxysalicylaldehyde
|
Fungal
|
Infection
Cancer
|
o-Vanillin (2-Vanillin) is a nature product, could be extracted from Vanilla planifolia, Pinus koraiensis fruit. o-Vanillin is a potent antifungal agent. o-Vanillin inhibits the growth of mycelia by disrupting the integrity of cell walls and cell membranes. o-Vanillin inhibits Doxorubicin (HY-15142A)- and 4-hydroperoxycyclophosphamide-induced NF-κB activation .
|
-
- HY-N9051
-
|
Glucosidase
|
Inflammation/Immunology
Cancer
|
6-Prenylquercetin-3-Me ether is a natural product that can be extracted from G. uralensis leaves.
6-Prenylquercetin-3-Me ether has radical scavenging activity toward DPPH. 6-Prenylquercetin-3-Me ether also has inhibitory activity against α-glucosidase .
|
-
- HY-N9228
-
|
Others
|
Cancer
|
5,7,3',4'-Tetrahydroxy-3-methoxy-8-geranylflavone is a prenylflavone with anti-proliferation effect on breast cancer cells. 5,7,3',4'-Tetrahydroxy-3-methoxy-8-geranylflavone can be isolated from an ethyl acetate-soluble extract of the barks of Broussonetia papyrifera .
|
-
- HY-156569
-
|
DGK
|
Inflammation/Immunology
Cancer
|
DGKα-IN-2 (example 48) is a DGKα inhibitor with the IC50 of 0.9 nM, extracted from patent WO2021105115. DGKα-IN-2 significantly enhances the anti-tumor effect of anti-PD-1 by increasing the proliferation and function of T cells. DGKα-IN-2 has the potential for cancer and immunology study.
|
-
- HY-156570
-
|
DGK
|
Inflammation/Immunology
Cancer
|
DGKα-IN-3 (example 25) is a DGKα inhibitor with the IC50 of 283 nM, extracted from patent WO2021105115. DGKα-IN-2 significantly enhances the anti-tumor effect of anti-PD-1 by increasing the proliferation and function of T cells. DGKα-IN-2 has the potential for cancer and immunology study.
|
-
- HY-156571
-
|
DGK
|
Cancer
|
DGKα-IN-4 (example 432) is a DGKα inhibitor with the IC50 of 0.1 nM, extracted from patent WO2021105117. DGKα-IN-2 significantly enhances the anti-tumor effect of anti-PD-1 by increasing the proliferation and function of T cells. DGKα-IN-3 has the potential for cancer and immunology study.
|
-
- HY-N12011
-
|
PGC-1α
|
Others
|
11-Oxoisomogroside V (compound 3) is a cucurbitacin isolated from the crude extract of Luo Han Guo. 11-Oxoisomogroside V activates the transcriptional activity of PGC-1α. In the luciferase experiment, the results showed that 10 μM and 20 μM 11-Oxoisomogroside V could increase the luciferase activity to 133.79% and 143.81% .
|
-
- HY-145552A
-
QR-01019K
|
Angiotensin Receptor
|
Metabolic Disease
|
Azilsartan mepixetil potassium (QR-01019K) is the antagonist of angiotensin II receptor. Azilsartan mepixetil potassium has stronger and longer blood pressure effect, more abvious and longer lasting heart rate lowering effect and high safety. Azilsartan mepixetil potassium has the potential for the research of hypertension, chronic heart failure and diabetic nephropathy (extracted from patent CN107400122A) .
|
-
- HY-N7160
-
|
Src
Apoptosis
|
Cancer
|
2-Hydroxy-3-methylanthraquinone (compound 1) is a natural compound isolated from a water extract of Hedyotis diffusa WILLD. 2-Hydroxy-3-methylanthraquinone shows inhibitory activity against protein tyrosine kinases v-src and pp60src, and induces growth arrest and apoptosis in the HepG2 cancer cells .
|
-
- HY-N12586
-
|
Reactive Oxygen Species
|
Endocrinology
|
Pheophytin a is a chlorophyll that can be isolated from S. vermiculata extracts. Pheophytin a has antioxidant activity with IC50 values of? 200.5 and 137.7 μg/mL for SOD, and NO respectively. Pheophytin a has reducing power with an IC50 value of 4.2 μg/mL . Pheophytin a has a cytotoxic effect on the MCF-7 cell line(IC50= 35.9 μg/mL)[1].
|
-
- HY-N2132
-
Flavokavain B
|
Apoptosis
|
Cancer
|
Flavokawain B (Flavokavain B) is a chalcone isolated from the root extracts of kava-kava plant and a potent apoptosis inducer for inhibiting the growth of various cancer cell lines. Flavokawain B (Flavokavain B) shows strong antiangiogenic activity. Flavokawain B (Flavokavain B) inhibits human brain endothelial cell (HUVEC) migration and tube formation with very low and non-toxic concentrations .
|
-
- HY-110028
-
|
Cannabinoid Receptor
Fatty Acid Synthase (FASN)
Androgen Receptor
|
Endocrinology
Cancer
|
Leelamine hydrochloride is a tricyclic diterpene molecule that is extracted from the bark of pine trees . Leelamine hydrochloride is a cannabinoid receptor type 1 (CB1) agonist and a inhibitor of SREBP1-regulated fatty acid/lipid synthesis in prostate cancer cells that is not affected by androgen receptor status. Leelamine hydrochloride suppresses transcriptional activity of androgen receptor, which is known to regulate fatty acid synthesis [2,3].
|
-
- HY-N0485
-
|
Autophagy
Mitophagy
|
Cardiovascular Disease
|
Liensinine Diperchlorate is a major isoquinoline alkaloid, extracted from the seed embryo of Nelumbo nucifera Gaertn. Liensinine Diperchlorate inhibits late-stage autophagy/mitophagy through blocking autophagosome-lysosome fusion. Liensinine Diperchlorate has a wide range of biological activities, including anti-arrhythmias, anti-hypertension, anti-pulmonary fibrosis, relaxation on vascular smooth muscle, etc .
|
-
- HY-135593
-
|
Others
|
Endocrinology
|
LY88074 analog 1 is a benzothiophene compound with nitrogen-containing non-basic side chains, Compound 26, extracted from patent EP0747380A1. LY88074 analog 1 is an agent for alleviating the symptoms of post-menopausal symptoms, such as osteoporosis, cardiovascular related pathological conditions, and estrogen-dependent cancer. LY88074 analog 1 can be used alone or in combination with estrogen or progestin .
|
-
- HY-P1597A
-
|
PKA
PKC
|
Cancer
|
Malantide TFA is a synthetic dodecapeptide derived from the site phosphorylated by cAMP-dependent protein kinase (PKA) on the β-subunit of phosphorylase kinase. Malantide TFA is a highly specific substrate for PKA with a Km of 15 μM and shows protein inhibitor (PKI) inhibition >90% substrate phosphorylation in various rat tissue extracts . Malantide TFA is also an efficient substrate for PKC with a Km of 16 μM .
|
-
- HY-B0688S
-
4,4′-Diaminodiphenyl sulfone-d8; DDS-d8
|
Antibiotic
Parasite
Bacterial
Reactive Oxygen Species
|
Infection
Inflammation/Immunology
Cancer
|
Dapsone-d8 is a deuterium labeled Dapsone. Dapsone is an orally active and blood-brain penetrant sulfonamide antibiotic with antibacterial, antigenic and anti-inflammatory activities[1]. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone can be used as an anticonvulsant and also in the research of skin and glioblastoma diseases[2][3][4][5].
|
-
- HY-W074648
-
|
Bacterial
|
Infection
|
Antibacterial agent 18 is a multi-arm AIE molecule extracted from patent CN110123801A, compound 23. Antibacterial agent 18 can be used for resisting Gram-positive and Gram-negative bacteria. Antibacterial agent 18 can be conjugated in the cell wall of rigid arm configuration insertion bacterium, and block cell wall turns sugar and turns peptide process, to inhibit or kill bacterium .
|
-
- HY-145390
-
|
Keap1-Nrf2
|
Inflammation/Immunology
|
Nrf2 activator-1 is a potent activator of NF-E2 related factor 2 (Nrf2). Nrf2 activator-1 has the potential for the research of COPD and other respiratory diseases, including asthma, Acute Lung Injury (ALI), Acute Respiratory Distress Syndrome (ARDS) and pulmonary fibrosis (extracted from patent WO2018109647A1) .
|
-
- HY-142452
-
|
Raf
|
Cancer
|
Pan-RAF kinase inhibitor 1 is a potent inhibitor of Pan-RAF kinase. Pan-RAF kinase inhibitor 1 regulates MAPK signaling by inhibiting RAF kinase, thereby exerting an effect on the proliferation of RAS-mutant tumor cells. Pan-RAF kinase inhibitor 1 has the potential for the research of cancer diseases (extracted from patent WO2021110141A1, compound 16B) .
|
-
- HY-143750
-
|
Influenza Virus
|
Infection
|
Cap-dependent endonuclease-IN-7 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-7 Inhibits the synthesis of viral mRNA and eventually inhibits virus proliferation. Cap-dependent endonuclease-IN-7 has the potential for the research of viral infections (including influenza A, influenza B and influenza C) (extracted from patent WO2020177715A1, compound 5)
|
-
- HY-142441
-
|
Others
|
Endocrinology
|
THR-β Agonist 1 is a potent and selective agonist of THRβ. Thyroid hormone receptor mediates the physiological activity of thyroid hormones which plays a key role in normal growth and development of the body and in maintaining metabolic balance. THR-β Agonist 1 has the potential for the research of thyroid hormone receptor-related diseases (extracted from patent WO2021104288A1, compound 2) .
|
-
- HY-144874
-
|
PARP
|
Neurological Disease
Cancer
|
AZ3391 is a potent inhibitor of PARP. AZ3391 is a quinoxaline derivative. PARP family of enzymes play an important role in a number of cellular processes, such as replication, recombination, chromatin remodeling, and DNA damage repair. AZ3391 has the potential for the research of diseases and conditions occurring in tissues in the central nervous system, such as the brain and spinal cord (extracted from patent WO2021260092A1, compound 23) .
|
-
- HY-143432A
-
|
CDK
|
Cancer
|
(S)-Cdc7-IN-18 is a potent inhibitor of CDC7. Overexpression of huCdc7 promotes overactivation of MCM2, an important marker of tumor cells, and thus promotes aberrant proliferation of tumor cells. (S)-Cdc7-IN-18 has the potential for the research of cancer diseases (extracted from patent WO2020239107A1, compound 1-1) .
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-
- HY-143588
-
|
Ras
|
Cancer
|
KRAS G12C inhibitor 35 is a potent inhibitor of KRAS G12C. The Ras family of proteins is an important intracellular signaling molecule that plays an important role in growth and development. KRAS G12C inhibitor 35 has the potential for the research of KRAS G12C-mediated cancer (extracted from patent CN112920183A, compound 3) .
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-
- HY-142938
-
|
ROR
|
Inflammation/Immunology
|
RORγt agonist 3 is a potent agonist of RORγt. RORγt agonist 3 promotes the differentiation of Th17 cells and enhances the levels of pro-inflammatory cytokines, thereby increasing the cytotoxicity of lymphocytes. RORγt agonist 3 inhibits the production of regulatory T cells, which suppresses the immune response (extracted from patent WO2021136326A1, compound 23) .
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-
- HY-142937
-
|
ROR
|
Inflammation/Immunology
|
RORγt agonist 2 is a potent agonist of RORγt. RORγt agonist 2 promotes the differentiation of Th17 cells and enhances the levels of pro-inflammatory cytokines, thereby increasing the cytotoxicity of lymphocytes. RORγt agonist 2 inhibits the production of regulatory T cells, which suppresses the immune response (extracted from patent WO2021136339A1, compound 17) .
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-
- HY-147584
-
|
Btk
|
Inflammation/Immunology
Cancer
|
BTK-IN-14 is a potent inhibitor of BTK. BTK plays an important role in signaling mediated by B cell antigen receptor (BCR) and Fcγreceptor (FcγR) in B cells and myeloid cells, respectively. BTK-IN-14 has the potential for the research of related diseases, especially autoimmune diseases, inflammatory diseases or cancer (extracted from patent WO2022057894A1, compound 1) .
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-
- HY-N11020
-
|
EBV
|
Infection
Inflammation/Immunology
|
Cabenoside D (compound 8) is a triterpenoid glycoside, which can be isolated from the methanol extract of lichen root. Cabenoside D shows anti-inflammatory activity and inhibits inflammation induced by 12-O-tetracylacyl hormone-13-acetate (TPA) in mice. Cabenoside D also inhibits TPA-induced Epstein-Barr virus (EBV) early antigen (EBV-EA) activation .
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-
- HY-153913
-
|
MMP
|
Inflammation/Immunology
|
MMP-9-IN-7 is a potent MMP9 inhibitor with an IC50 of 0.52 μM in proMMP9/MMP3 P126 activation assay. MMP-9-IN-7 is extracted from patent WO2012162468 (example 59), and can be used for MMP9/MMP13 mediated syndrome research .
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-
- HY-N6973R
-
|
RANKL/RANK
|
Inflammation/Immunology
|
Boldine (Standard) is the analytical standard of Boldine. This product is intended for research and analytical applications. Boldine is an aporphine isoquinoline alkaloid extracted from the root of Litsea cubeba and also possesses these properties, including antioxidant, anti-inflammatory and cytoprotective effects. Boldine suppresses osteoclastogenesis, improves bone destruction by down-regulating the OPG/RANKL/RANK signal pathway and may be a potential therapeutic agent for rheumatoid arthritis .
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-
- HY-N0403
-
|
Apoptosis
|
Inflammation/Immunology
|
2,3,4',5-Tetrahydroxystilbene 2-O-β-D-glucoside (TSG) is an active product that can be extracted from Polygonum multiflorum Thunb. TSG has anti-inflammatory, antioxidative, anti-atherosclerotic, anti-apoptotic, and free radical scavenging activities, TSG is also indicated to facilitate long-term potentiation and learning and memory in both normal and pathological conditions .
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-
- HY-19763
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PI3Kα inhibitor 1
|
PI3K
|
Cancer
|
BEBT-908 (PI3Kα inhibitor 1) is a selective PI3Kα inhibitor extracted from patent US/20120088764A1, Compound 243, has an IC50<0.1 μM, PI3Kα inhibitor 1 also inhibits HDAC (0.1 μM≤IC50≤1 μM) .
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-
- HY-101490
-
|
Phosphodiesterase (PDE)
|
Neurological Disease
|
PDE1-IN-2 is a PDE1 inhibitor extracted from patent WO2016/55618 A1, example 31. PDE1-IN-2 has IC50 values of 6 nM, 140 nM and 164 nM for PDE1C, PDE1B and PDE1A, respectvely. PDE1-IN-2 is developed for the research of neurodegenerative disorders and psychiatric disorders .
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-
- HY-129966
-
|
PROTACs
IRAK
|
Cancer
|
PROTAC IRAK4 degrader-1 is a Cereblon-based PROTAC interleukin-1 receptor-associated kinase 4 (IRAK4) degrader extracted from patent US20190192668A1 Compound I-210, makes <20%, >20-50%, and >50% IRAK4 degradation at 0.01, 0.1, and 1 μM in OCI-LY-10 cells, respectively .
|
-
- HY-110247
-
|
TNF Receptor
NF-κB
|
Cardiovascular Disease
Inflammation/Immunology
|
TRAF-STOP inhibitor 6877002, is a selective inhibitor of CD40-TRAF6 interaction, compound VII, shows inhibition of NF-κB activation in RAW cells, extracted from patent WO2014033122A1 . TRAF-STOP 6877002 prevents the progression of established atherosclerosis in mice, reduces leukocyte recruitment and reduces macrophage activation; reduces macrophage proliferation in atherosclerotic plaques .
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-
- HY-134622
-
|
CDK
GSK-3
|
Neurological Disease
Cancer
|
GSK-3/CDK5/CDK2-IN-1, an imidazole derivative, is an inhibitor of cdk5, cdk2, and GSK-3 extracted from patent WO2002010141A1, example 9a. GSK-3/CDK5/CDK2-IN-1 can be used for the research of cancer, and neurodegenerative diseases .
|
-
- HY-44809
-
|
HIF/HIF Prolyl-Hydroxylase
|
Cardiovascular Disease
Inflammation/Immunology
|
Izilendustat is a potent inhibitor of prolyl hydroxylase which can stabilize hypoxia inducible factor- 1 alpha (HIF- lα) and hypoxia inducible factor-2 (HIF-2). Izilendustat has the potential for researching diseases that relate to the body’s inmmune response like colitis and other inflammatory bowel diseases (extracted from patent WO2011057115A1 and WO2011057121A1) .
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-
- HY-145552
-
QR-01019
|
Angiotensin Receptor
|
Cardiovascular Disease
|
Azilsartan mepixetil is the antagonist of angiotensin II receptor. Azilsartan mepixetil has stronger and longer blood pressure effect, more abvious and longer lasting heart rate lowering effect and high safety. Azilsartan mepixetil achieves ideal protective effect for heart and kidney functions. Azilsartan mepixetil has the potential for the research of hypertension, chronic heart failure and diabetic nephropathy (extracted from patent CN107400122A) .
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-
- HY-144059
-
|
Akt
|
Cancer
|
AKT-IN-9 is a potent inhibitor of AKT. Protein kinase B (PKB, also known as AKT) is central to PI3K/AKT/mTOR signaling in cells, and its function is important for cell growth, survival, differentiation and metabolism. AKT-IN-9 has the potential for the research of breast and prostate cancer (extracted from patent WO2021185238A1, compound 1) .
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-
- HY-144060
-
|
Akt
|
Cancer
|
AKT-IN-10 is a potent inhibitor of AKT. Protein kinase B (PKB, also known as AKT) is central to PI3K/AKT/mTOR signaling in cells, and its function is important for cell growth, survival, differentiation and metabolism. AKT-IN-10 has the potential for the research of breast and prostate cancer (extracted from patent WO2021185238A1, compound 4) .
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-
- HY-142698
-
|
Others
|
Cardiovascular Disease
|
SGC agonist 2 is a potent agonist of soluble guanylate cyclase (SGC). Soluble guanylate cyclase is a key signal transduction enzyme in the NO-sGC-cGMP signaling pathway. SGC agonist 2 has the potential for the research of cardiovascular disease (heart failure, pulmonary hypertension, angina, myocardial infarction) and fibrotic diseases (renal fibrosis, systemic sclerosis) (extracted from patent WO2021219088A1, compound 031) .
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-
- HY-143582
-
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Others
|
Cancer
|
ATX inhibitor 9 is a potent inhibitor of ATX. ATX inhibitor 9 is a thickened heteroaryl derivatives compound. Autotaxin (ATX), also known as ENPP2, is a secreted enzyme that is highly expressed mainly in cancer cells, bronchial epithelial cells and alveolar macrophages in the lung. ATX inhibitor 9 has the potential for the research of cancer or fibrous degenerative disease (extracted from patent WO2021078227A1, compound 3) .
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-
- HY-143596
-
|
Ras
|
Cancer
|
KRAS G12C inhibitor 41 is a potent inhibitor of KRAS G12C. The Ras family of proteins is an important intracellular signaling molecule that plays an important role in growth and development. KRAS G12C inhibitor 41 has the potential for the research of KRAS G12C-mediated cancer (extracted from patent WO2021129824A1, compound 121) .
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-
- HY-143604
-
|
Ras
|
Cancer
|
KRAS G12D inhibitor 11 is a potent inhibitor of KRAS G12D. The Ras family of proteins is an important intracellular signaling molecule that plays an important role in growth and development. KRAS G12D inhibitor 11 has the potential for the research of KRAS G12D-mediated cancer (extracted from patent WO2021108683A1, compound 52) .
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-
- HY-143594
-
|
Ras
|
Cancer
|
KRAS G12C inhibitor 40 is a potent inhibitor of KRAS G12C. The Ras family of proteins is an important intracellular signaling molecule that plays an important role in growth and development. KRAS G12C inhibitor 40 has the potential for the research of KRAS G12C-mediated cancer (extracted from patent WO2021129824A1, compound 70) .
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-
- HY-143606
-
|
Ras
|
Cancer
|
KRAS G12D inhibitor 12 is a potent inhibitor of KRAS G12D. The Ras family of proteins is an important intracellular signaling molecule that plays an important role in growth and development. KRAS G12D inhibitor 12 has the potential for the research of KRAS G12D-mediated cancer (extracted from patent WO2021108683A1, compound 134) .
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-
- HY-143602
-
|
Ras
|
Cancer
|
KRAS G12D inhibitor 9 is a potent inhibitor of KRAS G12D. The Ras family of proteins is an important intracellular signaling molecule that plays an important role in growth and development. KRAS G12D inhibitor 9 has the potential for the research of KRAS G12D-mediated cancer (extracted from patent WO2021108683A1, compound 20) .
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-
- HY-143603
-
|
Ras
|
Cancer
|
KRAS G12D inhibitor 10 is a potent inhibitor of KRAS G12D. The Ras family of proteins is an important intracellular signaling molecule that plays an important role in growth and development. KRAS G12D inhibitor 10 has the potential for the research of KRAS G12D-mediated cancer (extracted from patent WO2021108683A1, compound 34) .
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-
- HY-143607
-
|
Ras
|
Cancer
|
KRAS G12D inhibitor 13 is a potent inhibitor of KRAS G12D. The Ras family of proteins is an important intracellular signaling molecule that plays an important role in growth and development. KRAS G12D inhibitor 13 has the potential for the research of KRAS G12D-mediated cancer (extracted from patent WO2021108683A1, compound 142) .
|
-
- HY-143590
-
|
Ras
|
Cancer
|
KRAS G12C inhibitor 37 is a potent inhibitor of KRAS G12C. The Ras family of proteins is an important intracellular signaling molecule that plays an important role in growth and development. KRAS G12C inhibitor 37 has the potential for the research of KRAS G12C-mediated cancer (extracted from patent WO2018143315A1, compound 65) .
|
-
- HY-143591
-
|
Ras
|
Cancer
|
KRAS G12C inhibitor 38 is a potent inhibitor of KRAS G12C. The Ras family of proteins is an important intracellular signaling molecule that plays an important role in growth and development. KRAS G12C inhibitor 38 has the potential for the research of KRAS G12C-mediated cancer (extracted from patent WO2021129820A1, compound 171) .
|
-
- HY-143598
-
|
Ras
|
Cancer
|
KRAS G12C inhibitor 42 is a potent inhibitor of KRAS G12C. The Ras family of proteins is an important intracellular signaling molecule that plays an important role in growth and development. KRAS G12C inhibitor 42 has the potential for the research of KRAS G12C-mediated cancer (extracted from patent WO2020146613A1, compound 10) .
|
-
- HY-143599
-
|
Ras
|
Cancer
|
KRAS G12D inhibitor 8 is a potent inhibitor of KRAS G12D. The Ras family of proteins is an important intracellular signaling molecule that plays an important role in growth and development. KRAS G12D inhibitor 8 has the potential for the research of KRAS G12D-mediated cancer (extracted from patent WO2021107160A1, compound 2) .
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-
- HY-144035
-
|
GCGR
|
Cancer
|
GLP-1R agonist 4 is a potent agonist of GLP-1R. Glucagon-like peptide-1 (GLP-1) is an intestinal hypoglycemic hormone secreted by L-cells in the lower gastrointestinal tract. GLP-1R agonist 4 has the potential for the research of diabetes (extracted from patent WO2019239319A1, compound 96) .
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-
- HY-147581
-
|
Btk
|
Inflammation/Immunology
Cancer
|
BTK-IN-11 is a potent inhibitor of BTK. BTK plays an important role in signaling mediated by B cell antigen receptor (BCR) and Fcγreceptor (FcγR) in B cells and myeloid cells, respectively. BTK-IN-11 has the potential for the research of related diseases, especially autoimmune diseases, inflammatory diseases or cancer (extracted from patent WO2022063101A1, compound Z2) .
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-
- HY-143377
-
|
CDK
|
Cancer
|
Cdc7-IN-8 is a potent inhibitor of Cdc7. Cdc7 is a serine/threonine kinase which activates MCM promotion by phosphorylating the microchromosome maintenance protein (MCM protein), an important element of the DNA replication initiator. Cdc7-IN-8 has the potential for the research of cancer diseases (extracted from patent WO2021032170A1, compound 1-1/1-2) .
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-
- HY-P3632
-
DADAD
|
Opioid Receptor
|
Neurological Disease
Metabolic Disease
|
[DAla2, DArg6] Dynorphin A, (1-13) (porcine) (DADAD) is an opioid peptide (dynorphinl-13, DYN) derivative found in porcine pituitary extracts. DYN is highly potent at the peripheral opioid receptors GPI and MVD, but is readily and rapidly degraded in vivo. [DAla2, DArg6] Dynorphin A, (1-13) (porcine) has some resistance to enzymatic cleavage and prevents peptide cleavage by enzymes .
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-
- HY-N3210
-
|
Others
|
Cancer
|
Nb-Demethylechitamine is an alkaloid isolated from the methanol extract of Alstonia rostrata twigs. Nb-Demethylechitamine has in vitro cytotoxic activity against several human cancer cell lines, including human myeloid leukemia HL-60, liver cancer SMMC-7721, lung cancer A-549, breast cancer MCF-7, and colon cancer SW480 cells .
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-
- HY-N7140R
-
γ-Linolenic acid (Standard)
|
Endogenous Metabolite
|
Metabolic Disease
|
Gamma-Linolenic acid (Standard) is the analytical standard of Gamma-Linolenic acid. This product is intended for research and analytical applications. Gamma-linolenic acid (γ-Linolenic acid) is an omega-6 (n-6), 18 carbon (18C-) polyunsaturated fatty acid (PUFA) extracted from Perilla frutescens. Gamma-linolenic acid supplements could restore needed PUFAs and mitigate the disease .
|
-
- HY-B1671
-
|
|
|
(+)-Kavain, a main kavalactone extracted from Piper methysticum, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na + and Ca 2+ channels . (+)-Kavain is shown to bind at the α4β2δ GABAA receptor and potentiate GABA efficacy . (+)-Kavain is used as a treatment for inflammatory diseases, its anti-inflammatory action has been widely studied .
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-
- HY-N0551
-
|
Caspase
Lipoxygenase
Apoptosis
|
Inflammation/Immunology
Cancer
|
Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibits the IKK Complex. Wedelolactone also inhibits 5-lipoxygenase (5-Lox) with an IC50 of 2.5 μM. Wedelolactone induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt. Wedelolactone can extract from Eclipta alba, and it can be used for the research of cancer .
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-
- HY-N2205
-
|
|
|
Esculentoside H (EsH) is a saponin isolated from the root extract of perennial plant Phytolacca esculenta .
Esculentoside H (EH) has anti-tumor activity, the mechanism is related to the capacity for TNFrelease .
Esculentoside H (EsH) suppresses colon cancer cell migration through blockage of the JNK1/2 and NF-κB signaling-mediated matrix metalloproteinases-9 (MMP-9) expression .
|
-
- HY-N6018
-
|
Caspase
TNF Receptor
SOD
Reactive Oxygen Species
|
Inflammation/Immunology
Cancer
|
Beta-Eudesmol has anticancer and anti-inflammatory activities. Beta-Eudesmol can induce apoptosis. Beta-Eudesmol is a neostigmine antagonist. Beta-Eudesmol can antagonize neostigmine-induced neuromuscular failure. Beta-Eudesmol can be used in the study of sepsis diseases. Beta-Eudesmol is a sesquiterpene-like compound that can be extracted from the rhizome of Atractylodes lancea .
|
-
- HY-135594
-
|
Estrogen Receptor/ERR
|
Metabolic Disease
|
4'-Raloxifene-β-D-glucopyranoside, a metabolite of Raloxifene, is a benzothiophene glucuronidated at the 4' postion. 4'-Raloxifene-β-D-glucopyranoside is a selective and orally active estrogen receptor antagonist. 4'-Raloxifene-β-D-glucopyranoside can be used for inhibiting bone loss and resorption, and lowering lipid levels. 4'-Raloxifene-β-D-glucopyranoside, example 5, is extracted from patent US5567820A .
|
-
- HY-135595
-
|
Estrogen Receptor/ERR
Drug Metabolite
|
Metabolic Disease
|
6-Raloxifene-β-D-glucopyranoside, a derivative of Raloxifene, is a benzothiophene glucuronidated at the 6' postion. 6-Raloxifene-β-D-glucopyranoside is a selective and orally active estrogen receptor antagonist. 6-Raloxifene-β-D-glucopyranoside can be used for inhibiting bone loss and resorption, and lowering lipid levels. 6'-Raloxifene-β-D-glucopyranoside, compound Ia, is extracted from patent US5567820A .
|
-
- HY-138295
-
|
Ras
|
Cancer
|
KRAS inhibitor-10 (compound 11) selectively and effectively inhibit RAS proteins, and particularly KRAS proteins. KRAS inhibitor-10 is an orally active anti-cancer agent and can be used for cancer research, such as pancreatic cancer, breast cancer, multiple myeloma, leukemia and lung cancer. KRAS inhibitor-10 is a tetrahydroisoquinoline compound (compound 11) extracted from patent WO2021005165 A1 .
|
-
- HY-132142
-
|
DNA/RNA Synthesis
|
Others
|
5-Propargylamino-dCTP is a nucleoside molecule extracted from patent US9035035B2, compound dCTP-PA. 5-Propargylamino-dCTP can conjugate to molecular markers for use in nucleic acid labeling or sequence analysis . 5-Propargylamino-dCTP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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-
- HY-145532
-
|
Apoptosis
NF-κB
Keap1-Nrf2
|
Inflammation/Immunology
Cancer
|
S-allylmercaptocysteine, an organic sulfur compound extracted from garlic, has anti-inflammatory and anti-oxidative effects for various pulmonary diseases. S-allylmercaptocysteine achieves its anti-cancer effect through a variety of pathways such as inducing the apoptosis of cancer cells through the TGF-β signaling pathway, or reducing the NF-κB activity and up-regulating Nrf2 to achieve the effects of anti-inflammation and anti-oxidation .
|
-
- HY-144036
-
|
DNA-PK
|
Cancer
|
DNA-PK-IN-3 is a potent inhibitor of DNA-PK. DNA-PK-IN-3 synergistically enhances the effect of radiotherapy and chemotherapy and effectively inhibits tumor growth. DNA-PK-IN-3 also effectively reduces the damage to normal cells and reducing side effects. DNA-PK-IN-3 has the potential for the research of cancer disease (extracted from patent WO2021213460A1, compound 4) .
|
-
- HY-144037
-
|
DNA-PK
|
Cancer
|
DNA-PK-IN-4 is a potent inhibitor of DNA-PK. DNA-PK-IN-4 is a imidazolinone derivative compound. DNA-PK-IN-4 inhibits DNA-PKcs activity, thus greatly reducing tumor DNA repair and inducing cells to enter the apoptotic program. DNA-PK-IN-4 has the potential for the research of cancer disease (extracted from patent WO2021209055A1, compound 27) .
|
-
- HY-144175
-
|
CDK
|
Cancer
|
CDK7-IN-12 is a potent inhibitor of CDK7. CDK7-IN-12 plays a key role in transcriptional regulation and cell cycle regulation. CDK7-IN-12 effectively inhibit malignant tumor proliferation in vitro and in vivo. CDK7-IN-12 has the potential for the research of cancer disease (extracted from patent WO2021249417A1, compound 43) .
|
-
- HY-126003
-
|
Aldehyde Dehydrogenase (ALDH)
|
Cancer
|
ALDH1A1-IN-2 is a potent inhibitor of aldehyde dehydrogenase 1a1 (aldh1a1). Aldehyde dehydrogenases (ALDH) constitute a family of enzymes that play a critical role in oxidizing various cytotoxic xenogenic and biogenic aldehydes. ALDH1A1-IN-2 has the potential for the research of cancer, inflammation, or obesity (extracted from patent WO2019089626A1, compound 295) .
|
-
- HY-142943
-
|
DNA-PK
|
Cancer
|
DNA-PK-IN-1 is a potent inhibitor of DNA-PK. DNA-dependent protein kinase (DNA-PK) is a DNA-PK enzyme complex composed of Ku70/Ku80 heterodimer and DNA-dependent protein kinase catalytic subunit (DNA-PKcs). DNA-PK-IN-1 has the potential for the research of cancer diseases (extracted from patent WO2021136463A1, compound 1) .
|
-
- HY-142944
-
|
DNA-PK
|
Cancer
|
DNA-PK-IN-2 is a potent inhibitor of DNA-PK. DNA-dependent protein kinase (DNA-PK) is a DNA-PK enzyme complex composed of Ku70/Ku80 heterodimer and DNA-dependent protein kinase catalytic subunit (DNA-PKcs). DNA-PK-IN-2 has the potential for the research of cancer diseases (extracted from patent WO2021136462A1, compound 1) .
|
-
- HY-143862
-
|
PPAR
|
Metabolic Disease
|
Pparδ agonist 7 is a potent agonist of Pparδ. The peroxisome proliferator-activated receptor (PPAR) is a member of the intranuclear receptor transcription factor superfamily that plays a key role in the regulation of metabolic homeostasis, inflammation, cell growth and differentiation in vivo. Pparδ agonist 7 has the potential for the research of non-alcoholic fatty liver disease (NAFLD) (extracted from patent WO2019105234A1, compound TM4) .
|
-
- HY-143868
-
|
MAP4K
|
Cancer
|
HPK1-IN-27 is a potent inhibitor of HPK1. MAP4K1 is also known as hematopoietic progenitor kinase 1 (HPK1). MAP4K1 is a serine/threonine kinase and member of the germinal center kinase family. HPK1-IN-27 has the potential for the research of cancer diseases (extracted from patent WO2019016071A1, compound 38) .
|
-
- HY-143871
-
|
MAP4K
|
Cancer
|
HPK1-IN-30 is a potent inhibitor of HPK1. MAP4K1 is also known as hematopoietic progenitor kinase 1 (HPK1). MAP4K1 is a serine/threonine kinase and member of the germinal center kinase family. HPK1-IN-30 has the potential for the research of cancer diseases (extracted from patent WO2021175271A1, compound 3) .
|
-
- HY-143863
-
|
PPAR
|
Metabolic Disease
|
Pparδ agonist 8 is a potent agonist of Pparδ. The peroxisome proliferator-activated receptor (PPAR) is a member of the intranuclear receptor transcription factor superfamily that plays a key role in the regulation of metabolic homeostasis, inflammation, cell growth and differentiation in vivo. Pparδ agonist 8 has the potential for the research of non-alcoholic fatty liver disease (NAFLD) (extracted from patent WO2021169769A1, compound TM2) .
|
-
- HY-147588
-
|
CD73
|
Cancer
|
CD73-IN-7 is a potent inhibitor of CD73. CD73 can catalyze the production of adenosine from extracellular 5'-phosphate adenosine (5'-AMP), and adenosine can induce immunosuppressive effects and promote tumor proliferation and/or metastasis. CD73-IN-7 be used for preparing a medicament for tumor-related diseases (extracted from patent WO2022052886A1, compound 13) .
|
-
- HY-147589
-
|
CD73
|
Cancer
|
CD73-IN-8 is a potent inhibitor of CD73. CD73 can catalyze the production of adenosine from extracellular 5'-phosphate adenosine (5'-AMP), and adenosine can induce immunosuppressive effects and promote tumor proliferation and/or metastasis. CD73-IN-8 be used for preparing a medicament for tumor-related diseases (extracted from patent WO2022052886A1, compound 57) .
|
-
- HY-147590
-
|
CD73
|
Inflammation/Immunology
|
CD73-IN-9 is a potent inhibitor of CD73. CD73 can catalyze the production of adenosine from extracellular 5'-phosphate adenosine (5'-AMP), and adenosine can induce immunosuppressive effects and promote tumor proliferation and/or metastasis. CD73-IN-9 be used for preparing a medicament for tumor-related diseases (extracted from patent WO2022068929A1, compound 2) .
|
-
- HY-147592
-
|
CD73
|
Inflammation/Immunology
Cancer
|
CD73-IN-11 is a potent inhibitor of CD73. CD73 can catalyze the production of adenosine from extracellular 5'-phosphate adenosine (5'-AMP), and adenosine can induce immunosuppressive effects and promote tumor proliferation and/or metastasis. CD73-IN-11 be used for preparing a medicament for tumor-related diseases (extracted from patent WO2022068929A1, compound 24) .
|
-
- HY-147591
-
|
CD73
|
Inflammation/Immunology
Cancer
|
CD73-IN-10 is a potent inhibitor of CD73. CD73 can catalyze the production of adenosine from extracellular 5'-phosphate adenosine (5'-AMP), and adenosine can induce immunosuppressive effects and promote tumor proliferation and/or metastasis. CD73-IN-10 be used for preparing a medicament for tumor-related diseases (extracted from patent WO2022068929A1, compound 4) .
|
-
- HY-N11844
-
|
Amylases
|
Metabolic Disease
|
Quercetin 3-(6″-caffeoylsophoroside) is an orally active α-amylase inhibitor, with an IC50 of 73.66 μg/mL. Quercetin 3-(6″-caffeoylsophoroside) presents in thehydro-methanolic extract of Cardamine hirsuta Linn. Quercetin 3-(6″-caffeoylsophoroside) shows the antidiabetic activities by oxidative stress reduction and α-amylase inhibition. Quercetin 3-(6″-caffeoylsophoroside) can be used for diabetes mellitus research .
|
-
- HY-N12349
-
|
Others
|
Others
|
Glucozaluzanin C is a lignan isolated from the MeOH extract of the roots of Ainsliaea acerifolia (Compositae). Glucozaluzanin C has ED50 value of 2.45 μg/mL, 1.37μg/mL, 0.40 μg/mL, 1.41 μg/mL, 1.43 μg/mL for A549 cells, SK-OV-3 cells, SK-MEL-2 cells, XF498 cells, HCT15 cells, respectively .
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- HY-B0688S1
-
4,4′-Diaminodiphenyl sulfone-d4; DDS-d4
|
Antibiotic
Parasite
Bacterial
Reactive Oxygen Species
|
Infection
Inflammation/Immunology
|
Dapsone-d4 is the deuterium labeled Dapsone. Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities[1]. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al[2][3].
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-
- HY-125996
-
|
FXR
|
Inflammation/Immunology
|
NR1H4 activator 1 is a potent and selective Famesoid X Receptor (FXR) agonist, extracted from patent WO2018152171A1, example 4. NR1H4 activator 1 shows strong FXR agonistic potency with a EC50 value of 1 nM in a Human FXR (NR1H4) Assay. NR1H4 activator 1 has the potential for treatment of gastrointestinal disease .
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- HY-N1970
-
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|
|
5,7-Dihydroxychromone, the extract of Cudrania tricuspidata, activates Nrf2/ARE signal and exerts neuroprotective effects against 6-hydroxydopamine (6-OHDA)-induced oxidative stress and apoptosis. 5,7-Dihydroxychromone inhibits the expression of activated caspase-3 and caspase-9 and cleaved PARP in 6-OHDA-induced SH-SY5Y cells .
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-
- HY-W007376
-
3-Formylindole
|
Endogenous Metabolite
|
Others
|
Indole-3-carboxaldehyde (3-Formylindole), a banlangen extract, is the product of the oxidative degradation of indole-3-acetic acid (IAA) by crude enzyme preparations from etiolated pea seedlings. Indole-3-carboxaldehyde is a biochemical used to prepare analogs of the indole phytoalexin cyclobrassinin. Indole-3-carboxaldehyde also enhances the epithelial barrier and anti-inflammatory activity in the intestinal tract .
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-
- HY-138139A
-
T785 hydrochloride
|
Toll-like Receptor (TLR)
|
Inflammation/Immunology
|
AXC-715 (T785) hydrochloride is a TLR7/TLR8 dual agonist, extracted from patent WO2020168017 A1 . AXC-715, compound D from WO2020190734A1, can be used for synthesis of antibody-adjuvant immunoconjugates, comprising an antibody construct that binds programmed death-ligand 1 (PD-L1) linked to one or more adjuvants .
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-
- HY-145394
-
|
CDK
|
Cancer
|
CDK7-IN-6 is a potent and selective cyclin-dependent kinase (CDK7) inhibitor (IC50≤100 nM), extracted from patent WO2019197549 A1, compound 210. CDK7-IN-6 is > 200-fold selective for CDK7 over CDK1, CDK2, and CDK5. CDK7-IN-6 can be used for the research of cancer .
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-
- HY-138139B
-
T785 trihydrochloride
|
Toll-like Receptor (TLR)
|
Inflammation/Immunology
|
AXC-715 (T785) trihydrochloride is a TLR7/TLR8 dual agonist, extracted from patent WO2020168017 A1 . AXC-715 trihydrochloride, compound D from WO2020190734A1, can be used for synthesis of antibody-adjuvant immunoconjugates, comprising an antibody construct that binds programmed death-ligand 1 (PD-L1) linked to one or more adjuvants .
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-
- HY-145026
-
|
ERK
|
Inflammation/Immunology
Cancer
|
ERK1/2 inhibitor 5 is a potent inhibitor of ERK1/2. Mitogen-activated protein kinase (MAPK) plays an extremely important role in the signal transduction pathway, and extracellular signal regulated kinase (ERK) is a member of the MAPK family. ERK1/2 inhibitor 5 has the potential for the research or prevention of cancer, inflammation or other proliferative diseases (extracted from patent WO2020238776A1) .
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-
- HY-145036
-
|
MAP4K
|
Inflammation/Immunology
Cancer
|
HPK1-IN-10 is potent inhibitor of HPK1. HPK1 is a serine/threonine protein kinase cloned from hematopoietic progenitor cells and belongs to the MAP4K family of mammalian Ste-20-related protein kinases. HPK1-IN-10 has the potential for the research of HPK1 related diseases (extracted from patent WO2021213317A1, compound 103) .
|
-
- HY-145037
-
|
MAP4K
|
Inflammation/Immunology
Cancer
|
HPK1-IN-11 is potent inhibitor of HPK1. HPK1 is a serine/threonine protein kinase cloned from hematopoietic progenitor cells and belongs to the MAP4K family of mammalian Ste-20-related protein kinases. HPK1-IN-11 has the potential for the research of HPK1 related diseases (extracted from patent WO2021213317A1, compound 2) .
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-
- HY-145038
-
|
MAP4K
|
Inflammation/Immunology
Cancer
|
HPK1-IN-12 is potent inhibitor of HPK1. HPK1 is a serine/threonine protein kinase cloned from hematopoietic progenitor cells and belongs to the MAP4K family of mammalian Ste-20-related protein kinases. HPK1-IN-12 has the potential for the research of HPK1 related diseases (extracted from patent WO2021213317A1, compound 85) .
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-
- HY-145039
-
|
MAP4K
|
Inflammation/Immunology
Cancer
|
HPK1-IN-13 is potent inhibitor of HPK1. HPK1 is a serine/threonine protein kinase cloned from hematopoietic progenitor cells and belongs to the MAP4K family of mammalian Ste-20-related protein kinases. HPK1-IN-13 has the potential for the research of HPK1 related diseases (extracted from patent WO2021213317A1, compound 64) .
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-
- HY-145040
-
|
MAP4K
|
Inflammation/Immunology
Cancer
|
HPK1-IN-14 is potent inhibitor of HPK1. HPK1 is a serine/threonine protein kinase cloned from hematopoietic progenitor cells and belongs to the MAP4K family of mammalian Ste-20-related protein kinases. HPK1-IN-14 has the potential for the research of HPK1 related diseases (extracted from patent WO2021213317A1, compound 79) .
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-
- HY-145064
-
|
Phosphodiesterase (PDE)
|
Infection
Cancer
|
Enpp-1-IN-6 is a potent inhibitor of ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1). The ENPP 1 has broad specificity and can cleave a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds nucleotides and nucleotide sugars. Enpp-1-IN-6 has the potential for the research of cancer and infectious diseases (extracted from patent WO2021203772A1, compound 51) .
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-
- HY-145065
-
|
Phosphodiesterase (PDE)
|
Infection
Cancer
|
Enpp-1-IN-7 is a potent inhibitor of ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1). The ENPP 1 has broad specificity and can cleave a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds nucleotides and nucleotide sugars. Enpp-1-IN-7 has the potential for the research of cancer and infectious diseases (extracted from patent WO2021203772A1, compound 51) .
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-
- HY-145069
-
|
Phosphodiesterase (PDE)
|
Cancer
|
Enpp-1-IN-8 is a potent inhibitor of ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1). The ENPP 1 has broad specificity and can cleave a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds nucleotides and nucleotide sugars. Enpp-1-IN-8 has the potential for the research of cancer and infectious diseases (extracted from patent WO2021203772A1, compound 51) .
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-
- HY-145070
-
|
Phosphodiesterase (PDE)
|
Infection
Cancer
|
Enpp-1-IN-9 is a potent inhibitor of ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1). The ENPP 1 has broad specificity and can cleave a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds nucleotides and nucleotide sugars. Enpp-1-IN-9 has the potential for the research of cancer and infectious diseases (extracted from patent WO2021203772A1, compound 51) .
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-
- HY-145027
-
|
ERK
|
Cancer
|
ERK1/2 inhibitor 5 is a potent inhibitor of ERK1/2. Mitogen-activated protein kinase (MAPK) plays an extremely important role in the signal transduction pathway, and extracellular signal regulated kinase (ERK) is a member of the MAPK family. ERK1/2 inhibitor 5 has the potential for the research or prevention of cancer, inflammation or other proliferative diseases (extracted from patent WO2020238776A1) .
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-
- HY-145035
-
|
MAP4K
|
Inflammation/Immunology
Cancer
|
HPK1-IN-9 is potent inhibitor of HPK1. HPK1 is a serine/threonine protein kinase cloned from hematopoietic progenitor cells and belongs to the MAP4K family of mammalian Ste-20-related protein kinases. HPK1-IN-9 has the potential for the research of HPK1 related diseases (extracted from patent WO2021213317A1, compound 112) .
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-
- HY-143587
-
|
CDK
|
Cancer
|
CDK7-IN-2 is a potent inhibitor of CDK7. CDK7 is implicated in both temporal control of the cell cycle and transcriptional activity. CDK7 is implicated in the transcriptional initiation process by phosphorylation of Rbpl subunit of RNA Polymerase II (RNAPII). CDK7 has the potential for the research of cancer disease, in particular aggressive and hard- to-treat cancers (extracted from patent WO2019099298A1, compound 1) .
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-
- HY-W181102
-
|
Calcineurin
|
Cardiovascular Disease
Neurological Disease
Inflammation/Immunology
|
NFAT Inhibitor-2 is a potent inhibitor of calcineurin NFAT signalling. Calcineurin is a serine/threonine protein phosphatase regulated by Ca2+ and calmodulin. NFAT Inhibitor-2 has the potential for the research of inflammatory disease, an autoimmune disorder, a cardiovascular disease, a neurodegenerative disease, a disease occurring with uncontrolled cell proliferation and/or differentiation, an angiogenesis-related disease, an allergy, anaphylaxis and alopecia (extracted from patent WO2016207212A1, compound 17) .
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-
- HY-145071
-
|
PROTACs
Estrogen Receptor/ERR
|
Cancer
|
PROTAC ERα Y537S degrader-1 comprises a ubiquitin E3 ligase binding group, a linker and a protein binding group. PROTAC ERα Y537S degrader-1 extracts from patent WO2021143822, example 12. PROTAC ERα Y537S degrader-1 is an estrogen receptor-alpha (ERα) Y537S degrader .
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- HY-144200
-
|
CCR
|
Neurological Disease
Cancer
|
CCR8 antagonist 2 is a potent antagonist of CCR8. CCR8 (C-C Motif Chemokine Receptor 8) is predominantly expressed on Treg cells and Th2 cells, but not on Th1 cells. CCR8 antagonist 2 inhibits CCR8 activity, which may be used in the research of diseases mediated by CCR8, such as cancer, and/or neuropathic pain (extracted from patent WO2022000443A1, compound 220) .
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-
- HY-B1290S
-
Phenylethyl alcohol-d4; Phenethyl alcohol-d4; Benzyl carbinol-d4
|
Bacterial
Virus Protease
Antibiotic
|
Infection
|
2-Phenylethanol-d4 is the deuterium labeled 2-Phenylethanol[1]. 2-Phenylethanol (Phenethyl alcohol), extracted from rose, carnation, hyacinth, Aleppo pine, orange blossom and other organisms, is a colourless liquid. It has a pleasant floral odor and also an autoantibiotic produced by the fungus Candida albicans[2]. It is used as an additive in cigarettes and also used as a preservative in soaps due to its stability in basic conditions.
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-
- HY-B1290S1
-
Phenylethyl alcohol-d9; Phenethyl alcohol-d9; Benzyl carbinol-d9
|
Bacterial
Virus Protease
Antibiotic
|
Infection
|
2-Phenylethanol-d9 is the deuterium labeled 2-Phenylethanol[1]. 2-Phenylethanol (Phenethyl alcohol), extracted from rose, carnation, hyacinth, Aleppo pine, orange blossom and other organisms, is a colourless liquid. It has a pleasant floral odor and also an autoantibiotic produced by the fungus Candida albicans[2]. It is used as an additive in cigarettes and also used as a preservative in soaps due to its stability in basic conditions.
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-
- HY-B1290S2
-
Phenylethyl alcohol-d5; Phenethyl alcohol-d5; Benzyl carbinol-d5
|
Bacterial
Virus Protease
Antibiotic
|
Infection
|
2-Phenylethanol-d5 is the deuterium labeled 2-Phenylethanol[1]. 2-Phenylethanol (Phenethyl alcohol), extracted from rose, carnation, hyacinth, Aleppo pine, orange blossom and other organisms, is a colourless liquid. It has a pleasant floral odor and also an autoantibiotic produced by the fungus Candida albicans[2]. It is used as an additive in cigarettes and also used as a preservative in soaps due to its stability in basic conditions.
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-
- HY-W145695
-
|
Biochemical Assay Reagents
|
Inflammation/Immunology
|
Chitoheptaose is a chitosan oligosaccharide. Chitoheptaose is capable of extracting exoskeletons from crustaceans, such as the shells of crabs, shrimp and lobsters. Chitoheptaose has antioxidant, anti-inflammatory and anti-apoptotic activities and can be used in the study of myocarditis. Chitoheptaose has cardioprotective effects and improves cardiac parameters (left ventricular internal size, end-systolic and end-diastolic, ejection fraction and shortening fraction), inflammatory cytokines (IL-1β) in vanishing models .
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-
- HY-107802
-
Breviscapinun
|
Others
|
Cardiovascular Disease
|
Breviscapine is a crude flavonoid extract of Breviscapine, which is more than 85% of the active ingredient, Breviscapine. Breviscapine has a wide range of cardiovascular pharmacological activities, such as increasing blood flow, improving microcirculation, dilating blood vessels, reducing blood viscosity, promoting fibrinolysis, inhibiting platelet aggregation and thrombosis. Breviscapine has been used in the study of cerebral infarction and its sequelae, cerebral thrombosis, coronary heart disease and angina pectoris .
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-
- HY-N11957
-
|
Others
|
Inflammation/Immunology
|
Angeloylbinankadsurin A (compound 7) is an anti-rheumatoid arthritis (RA) agent that can be isolated from EtOAc and CH2Cl2 extracts of Black Tiger Beard. Angeloylbinankadsurin A exhibits inhibitory activity on RA-FLS cells (IC50=11.70 μM). Angeloylbinankadsurin A is slightly toxic to human cancer cell lines (Hela and BGC-823) (IC50=19.9 μM, 21.93 μM) .
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-
- HY-B1021
-
|
Free Fatty Acid Receptor
|
Cardiovascular Disease
Metabolic Disease
|
Vincamine is a monoterpenoid indole alkaloid extracted from the Madagascar periwinkle. Vincamine is a peripheral vasodilator and exerts a selective vasoregulator action on the brain microcapilar circulation . Vincamine is a GPR40 agonist and acts as a β-cell protector by ameliorating β-cell dysfunction and promoting glucose-stimulated insulin secretion (GSIS). Vincamine improves glucose homeostasis in vivo, and has the potential for the type 2 diabetes mellitus (T2DM) research .
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-
- HY-N2025
-
|
PPAR
Glucosidase
|
Metabolic Disease
|
Oroxin A is the major component of an ethanol-water Oroxylum indicum (L.) Kurz (Bignoniaceae) seed extract (OISE). Oroxin A acts as a partial PPARγ agonist that can activate PPARγ transcriptional activation. Oroxin A activates PPARγ by docking into the PPARγ protein ligand-binding domain. Oroxin A also exhibits an inhibitory activity against α-glucosidase and an antioxidant capacity . Oroxin A exerts anti-breast cancer effects by inducing ER stress-mediated senescence .
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-
- HY-N6973
-
|
RANKL/RANK
Apoptosis
|
Inflammation/Immunology
|
Boldine is an apomorphine isoquinoline alkaloid extracted from the root of the pheasant pepper (Litsea cubeba). Boldine is an oral effective antioxidant, anti-inflammatory, antitumor agent, and can inhibit osteoclast formation. Boldine induces apoptosis of human bladder cancer cells by regulating ERK, AKT and GSK-3β. Boldine ameliorates bone destruction by down-regulating the OPG/RANKL/RANK signaling pathway. It can be used in rheumatoid arthritis research .
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-
- HY-N0401A
-
|
Bacterial
|
Infection
Metabolic Disease
|
(Z)-Ligustilide is extracted from Ligusticum chuanxiong Hort, has antimicrobial and antifungal activity, exhibits an average antifungal score of 5.6 . (Z)-Ligustilide inhibits the expression of FATP5 and DGAT, inhibits fatty acid uptake and esterification in mice and has potential as therapeutics for nonalcoholic fatty liver disease (NAFLD) . (Z)-Ligustilide is also able to reactivate ERα, has epigenetic regulation, and is used in the study of tamoxifen-resistant breast cancer .
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-
- HY-42488
-
|
ADC Linker
PROTAC Linkers
|
Cancer
|
Hydroxy-PEG2-(CH2)2-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG2-(CH2)2-Boc is extracted from patent WO2004008101A2 (compound 196) . Hydroxy-PEG2-(CH2)2-Boc is also a PROTAC linker that can be used in the synthesis of PROTACs.
|
-
- HY-W039178
-
|
ADC Linker
PROTAC Linkers
|
Cancer
|
Hydroxy-PEG4-(CH2)2-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG4-(CH2)2-Boc is extracted from patent WO2004008101A2 (compound 191). Hydroxy-PEG4-(CH2)2-Boc is also a PROTAC linker that can be used in the synthesis of PROTACs.
|
-
- HY-W067061
-
|
ADC Linker
PROTAC Linkers
|
Cancer
|
Hydroxy-PEG2-(CH2)2-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG2-(CH2)2-Boc is extracted from patent WO2004008101A2 (compound 196) . Hydroxy-PEG2-(CH2)2-Boc is also a PROTAC linker that can be used in the synthesis of PROTACs.
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-
- HY-132137
-
|
DNA/RNA Synthesis
|
Others
|
5-Propargylamino-3'-azidomethyl-dUTP is a nucleoside molecule extracted from patent WO2004018497A2, compound 5. 5-Propargylamino-3'-azidomethyl-dUTP can be used in DNA synthesis and DNA sequencing . 5-Propargylamino-3'-azidomethyl-dUTP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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-
- HY-139643
-
|
CXCR
|
Inflammation/Immunology
Cancer
|
CXCR7 antagonist-1 is a CXCR7 antagonist that inhibits the binding of the SDF-1 chemokine (also known as the CXCL12 chemokine) or I-TAC (also known as CXCL11) to the chemokine receptor CXCR7. CXCR7 antagonist-1 is useful in preventing tumor cell proliferation, tumor formation, inflammatory diseases, and many other diseases (extracted from patent WO2014085490A1, compound 1.128) .
|
-
- HY-145240
-
|
Eukaryotic Initiation Factor (eIF)
|
Infection
Cancer
|
eIF4E-IN-1 is a potent inhibitor of eIF4E. eIF4E-IN-1 inhibits immunosuppression components such as immune checkpoint proteins PD-1, PD-L1, LAG3, TIM3, and/or IDO, in order to inhibit or release immune suppression in certain diseases, such as cancer and infectious disease (extracted from patent WO2021003194A1, compound Y) .
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-
- HY-143208
-
|
DNA/RNA Synthesis
|
Cancer
|
HOE 33187-O-CONH-PEG4-phenol-thiophenone-NHPh-COOEt has inhibitory activity against pre-miR-21 RNA. HOE 33187-O-CONH-PEG4-phenol-thiophenone-NHPh-COOEt has the potential for the research of neoplastic disease such as cancer and especially cancers expressing miR-21 (extracted from patent WO2021087084A1, compound 25) .
|
-
- HY-115627
-
GPX4-Activator-1d4
|
Glutathione Peroxidase
|
Inflammation/Immunology
|
PKUMDL-LC-101-D04 (GPX4-Activator-1d4) is a potent ferroptosis regulator glutathione peroxidase 4 (GPX4) allosteric activator (pEC50=4.7). PKUMDL-LC-101-D04 increases GPX4 activity to 150% at 20 μM in the cell-free assay and 61 μM in cell extracts .
|
-
- HY-145025
-
|
ERK
|
Inflammation/Immunology
Cancer
|
ERK1/2 inhibitor 3 is a potent inhibitor of ERK1/2. Mitogen-activated protein kinase (MAPK) plays an extremely important role in the signal transduction pathway, and extracellular signal regulated kinase (ERK) is a member of the MAPK family. ERK1/2 inhibitor 3 has the potential for the research or prevention of cancer, inflammation or other proliferative diseases (extracted from patent WO2021218912A1, compound 1) .
|
-
- HY-145028
-
|
ERK
|
Inflammation/Immunology
Cancer
|
ERK1/2 inhibitor 6 is a potent inhibitor of ERK1/2. Mitogen-activated protein kinase (MAPK) plays an extremely important role in the signal transduction pathway, and extracellular signal regulated kinase (ERK) is a member of the MAPK family. ERK1/2 inhibitor 6 has the potential for the research or prevention of cancer, inflammation or other proliferative diseases (extracted from patent WO2021063335A1, compound 1) .
|
-
- HY-145041
-
|
MAP4K
|
Inflammation/Immunology
Cancer
|
HPK1-IN-15 is a potent and selective inhibitor of HPK1. Hematopoietic progenitor kinase 1 (HPKl) originally cloned from hematopoietic progenitor cells is a member of MAP kinase kinase kinase kinases (MAP4Ks) family. HPK1-IN-15 is useful in researching, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer (extracted from patent WO2018049200A1, compound 50) .
|
-
- HY-145042
-
|
MAP4K
|
Inflammation/Immunology
Cancer
|
HPK1-IN-16 is a potent and selective inhibitor of HPK1. Hematopoietic progenitor kinase 1 (HPKl) originally cloned from hematopoietic progenitor cells is a member of MAP kinase kinase kinase kinases (MAP4Ks) family. HPK1-IN-16 is useful in researching, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer (extracted from patent WO2019051199A1, compound 39) .
|
-
- HY-145044
-
|
MAP4K
|
Inflammation/Immunology
Cancer
|
HPK1-IN-17 is a potent and selective inhibitor of HPK1. Hematopoietic progenitor kinase 1 (HPKl) originally cloned from hematopoietic progenitor cells is a member of MAP kinase kinase kinase kinases (MAP4Ks) family. HPK1-IN-17 is useful in researching, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer (extracted from patent WO2019238067A1, compound 73) .
|
-
- HY-145045
-
|
MAP4K
|
Inflammation/Immunology
Cancer
|
HPK1-IN-18 is a potent and selective inhibitor of HPK1. Hematopoietic progenitor kinase 1 (HPKl) originally cloned from hematopoietic progenitor cells is a member of MAP kinase kinase kinase kinases (MAP4Ks) family. HPK1-IN-18 is useful in researching, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer (extracted from patent WO2019238067A1, compound 1) .
|
-
- HY-145048
-
|
Ras
|
Cancer
|
SOS1-IN-5 is a potent inhibitor of SOS1. SOS1-IN-5 is a pyrimidobicyclic derivative. SOS1-IN-5 blocks the activation of KRAS by interfering with RAS-SOS1 interaction, and achieves the purpose of broad-spectrum inhibition of KRAS activity. SOS1-IN-5 has the potential for the research of cancer diseases (extracted from patent WO2021203768A1, compound 4) .
|
-
- HY-143744
-
|
Influenza Virus
|
Infection
|
Cap-dependent endonuclease-IN-3 is a potent inhibitor of cap-dependent endonuclease (CEN). Not only can Cap-dependent endonuclease-IN-3 inhibit influenza virus well, but also has lower cytotoxicity, better in vivo agent kinetic properties and in vivo pharmacodynamic properties. Cap-dependent endonuclease-IN-3 has the potential for the research of influenza A and influenza B infection (extracted from patent WO2019141179A1, compound VI-1) .
|
-
- HY-143743
-
|
Influenza Virus
|
Infection
|
Cap-dependent endonuclease-IN-2 is a potent inhibitor of cap-dependent endonuclease (CEN). Not only can Cap-dependent endonuclease-IN-2 inhibit influenza virus well, but also has lower cytotoxicity, better in vivo agent kinetic properties and in vivo pharmacodynamic properties. Cap-dependent endonuclease-IN-2 has strong inhibitory effect on RNA polymerase activity of A virus (extracted from patent WO2019052565A1, compound 28) .
|
-
- HY-143755
-
|
Influenza Virus
|
Infection
|
Cap-dependent endonuclease-IN-9 is a potent inhibitor of cap-dependent endonuclease (CEN). Not only can Cap-dependent endonuclease-IN-9 inhibit influenza virus well, but also has lower cytotoxicity, better in vivo agent kinetic properties and in vivo pharmacodynamic properties. Cap-dependent endonuclease-IN-9 has strong inhibitory effect on RNA polymerase activity of A virus (extracted from patent CN112521386A, compound VI-1) .
|
-
- HY-143546
-
|
RET
|
Cancer
|
RET-IN-9 is a potent inhibitor of RET. RET kinase is a single-pass transmembrane receptor tyrosine kinase that plays an important role in the development of the kidney and enteric nervous system, and the maintenance of homeostasis in the nervous, endocrine, hematopoietic, and male reproductive systems. RET-IN-9 has the potential for the research of RET-related disease including non-small cell lung cancer and medullary thyroid cancer (extracted from patent WO2021115457A1, compound 29) .
|
-
- HY-142700
-
|
Somatostatin Receptor
|
Neurological Disease
|
SSTR4 agonist 3 is a potent agonist of SSTR4. SSTR4 is expressed at relatively high levels in the hippocampus and neocortex, memory and learning regions, and Alzheimer's disease pathology. SSTR4 agonists are potent in rodent models of pain associated with acute and chronic associated anti-peripheral nociceptive and anti-inflammatory activity. SSTR4 agonist 3 has the potential for the research of pain (extracted from patent WO2021233427A1, compound 14) .
|
-
- HY-142701
-
|
Somatostatin Receptor
|
Neurological Disease
|
SSTR4 agonist 4 is a potent agonist of SSTR4. SSTR4 is expressed at relatively high levels in the hippocampus and neocortex, memory and learning regions, and Alzheimer's disease pathology. SSTR4 agonists are potent in rodent models of pain associated with acute and chronic associated anti-peripheral nociceptive and anti-inflammatory activity. SSTR4 agonist 4 has the potential for the research of pain (extracted from patent WO2021233428A1, compound 14) .
|
-
- HY-144039
-
|
DNA-PK
|
Cancer
|
DNA-PK-IN-6 is a potent inhibitor of DNA-PK. DNA-PK-IN-6 inhibits DNA-PKcs activity, thus greatly reducing tumor DNA repair and inducing cells to enter the apoptotic program. DNA-PK-IN-6 enhances the sensitivity of tumor tissues to radiotherapy, overcomes the problem of agent resistance, and enhances the inhibitory effect on a variety of solid tumors and hematological tumors (extracted from patent WO2021197159A1, compound 6) .
|
-
- HY-144038
-
|
DNA-PK
|
Cancer
|
DNA-PK-IN-5 is a potent inhibitor of DNA-PK. DNA-PK-IN-5 inhibits DNA-PKcs activity, thus greatly reducing tumor DNA repair and inducing cells to enter the apoptotic program. DNA-PK-IN-5 enhances the sensitivity of tumor tissues to radiotherapy, overcomes the problem of agent resistance, and enhances the inhibitory effect on a variety of solid tumors and hematological tumors (extracted from patent WO2021204111A1, compound 2) .
|
-
- HY-142932
-
|
Btk
|
Neurological Disease
Inflammation/Immunology
Cancer
|
BTK-IN-6 is a potent inhibitor of Bruton's Tyrosine Kinase (BTK). BTK is a member of the Tec family of tyrosine kinases and plays an important role in the regulation of early B-cell development and mature B-cell activation and survival. BTK-IN-6 has the potential for the research of immune disorders, cancer, cardiovascular diseases, viral infections, inflammation, metabolism/endocrine function disorders, and neurological disorders (extracted from patent WO2021136219A1, compound 8) .
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-
- HY-143869
-
|
MAP4K
|
Cancer
|
HPK1-IN-28 is a potent inhibitor of HPK1. Hematopoietic progenitor kinase 1 (HPK1) is a negative regulator of the activation response of dendritic cells (DCs), T cells and B cells. HPK1-IN-28 enhances the body's anti-tumor immunity. HPK1-IN-28 has the potential for the research of immune-related diseases, especially tumor (extracted from patent WO2021175270A1, compound 1) .
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-
- HY-143870
-
|
MAP4K
|
Cancer
|
HPK1-IN-29 is a potent inhibitor of HPK1. Hematopoietic progenitor kinase 1 (HPK1) is a negative regulator of the activation response of dendritic cells (DCs), T cells and B cells. HPK1-IN-29 enhances the body's anti-tumor immunity. HPK1-IN-29 has the potential for the research of immune-related diseases, especially tumor (extracted from patent WO2021175270A1, compound 38) .
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-
- HY-144181
-
|
Methionine Adenosyltransferase (MAT)
|
Cancer
|
MAT2A-IN-5 is a potent inhibitor of MAT2A. The expression level of MAT2A is abnormally elevated in several types of tumors, including gastric, colon, liver and pancreatic cancers. MAT2A-IN-5 reduces the proliferative activity of MTAP-deficient cancer cells. MAT2A-IN-5 has the potential for the potential for the research of cancer diseases (extracted from patent WO2021254529A1, compound 1) .
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-
- HY-144184
-
|
Methionine Adenosyltransferase (MAT)
|
Cancer
|
MAT2A-IN-6 is a potent inhibitor of MAT2A. The expression level of MAT2A is abnormally elevated in several types of tumors, including gastric, colon, liver and pancreatic cancers. MAT2A-IN-6 reduces the proliferative activity of MTAP-deficient cancer cells. MAT2A-IN-6 has the potential for the potential for the research of cancer diseases (extracted from patent WO2021254529A1, compound 18) .
|
-
- HY-144185
-
|
Methionine Adenosyltransferase (MAT)
|
Cancer
|
MAT2A-IN-7 is a potent inhibitor of MAT2A. The expression level of MAT2A is abnormally elevated in several types of tumors, including gastric, colon, liver and pancreatic cancers. MAT2A-IN-7 reduces the proliferative activity of MTAP-deficient cancer cells. MAT2A-IN-7 has the potential for the potential for the research of cancer diseases (extracted from patent WO2021254529A1, compound 24) .
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-
- HY-143864
-
|
LPL Receptor
|
Inflammation/Immunology
|
S1PR1 agonist 1 is a potent agonist of S1PR1. Sphingosine-1-phosphate (S1P) is a cell membrane-derived lysophospholipid signalling molecule that exerts its physiological functions mainly by stimulating some members of the G protein-coupled receptor family. S1PR1 agonist 1 has the potential for the research of autoimmune diseases (extracted from patent WO2021175223A1, compound 22) .
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-
- HY-143865
-
|
LPL Receptor
|
Inflammation/Immunology
|
S1PR1 agonist 2 is a potent agonist of S1PR1. Sphingosine-1-phosphate (S1P) is a cell membrane-derived lysophospholipid signalling molecule that exerts its physiological functions mainly by stimulating some members of the G protein-coupled receptor family. S1PR1 agonist 2 has the potential for the research of autoimmune diseases (extracted from patent WO2021175225A1, compound 1) .
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-
- HY-143717
-
|
JAK
Btk
|
Inflammation/Immunology
|
JAK3/BTK-IN-2 is a potent inhibitor of JAK3/BTK. BTK and JAK3 are two important targets for autoimmune diseases. Simultaneous inhibition of the BTK/JAK3 signalling pathway exhibits synergistic effects. JAK3/BTK-IN-2 has the potential for the research of JAK3 kinase and/or BTK-related diseases (extracted from patent WO2021147952A1, compound 004)
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-
- HY-143720
-
|
JAK
Btk
|
Inflammation/Immunology
|
JAK3/BTK-IN-5 is a potent inhibitor of JAK3/BTK. BTK and JAK3 are two important targets for autoimmune diseases. Simultaneous inhibition of the BTK/JAK3 signalling pathway exhibits synergistic effects. JAK3/BTK-IN-5 has the potential for the research of JAK3 kinase and/or BTK-related diseases (extracted from patent WO2021147953A1, compound 35)
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-
- HY-143716
-
|
JAK
Btk
|
Inflammation/Immunology
|
JAK3/BTK-IN-1 is a potent inhibitor of JAK3/BTK. BTK and JAK3 are two important targets for autoimmune diseases. Simultaneous inhibition of the BTK/JAK3 signalling pathway exhibits synergistic effects. JAK3/BTK-IN-1 has the potential for the research of JAK3 kinase and/or BTK-related diseases (extracted from patent WO2021147952A1, compound 002) .
|
-
- HY-143718
-
|
JAK
Btk
|
Inflammation/Immunology
|
JAK3/BTK-IN-3 is a potent inhibitor of JAK3/BTK. BTK and JAK3 are two important targets for autoimmune diseases. Simultaneous inhibition of the BTK/JAK3 signalling pathway exhibits synergistic effects. JAK3/BTK-IN-3 has the potential for the research of JAK3 kinase and/or BTK-related diseases (extracted from patent WO2021147952A1, compound 009)
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-
- HY-143719
-
|
JAK
Btk
|
Inflammation/Immunology
|
JAK3/BTK-IN-4 is a potent inhibitor of JAK3/BTK. BTK and JAK3 are two important targets for autoimmune diseases. Simultaneous inhibition of the BTK/JAK3 signalling pathway exhibits synergistic effects. JAK3/BTK-IN-4 has the potential for the research of JAK3 kinase and/or BTK-related diseases (extracted from patent WO2021147953A1, compound 003)
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-
- HY-142930
-
|
Somatostatin Receptor
|
Cancer
|
MAT2A-IN-3 is a potent inhibitor of MAT2A. The expression level of MAT2A is abnormally high in several types of tumors, including gastric, colon, liver and pancreatic cancers. MAT2A-IN-3 reduces the proliferative activity of MTAP-deficient cancer cells. MAT2A-IN-3 has the potential for the research of cancer diseases (extracted from patent WO2019191470A1, compound 265) .
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-
- HY-142929
-
|
Somatostatin Receptor
|
Cancer
|
MAT2A-IN-2 is a potent inhibitor of MAT2A. The expression level of MAT2A is abnormally high in several types of tumors, including gastric, colon, liver and pancreatic cancers. MAT2A-IN-2 reduces the proliferative activity of MTAP-deficient cancer cells. MAT2A-IN-2 has the potential for the research of cancer diseases (extracted from patent WO2020243376A1, compound 172) .
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-
- HY-142928
-
|
Somatostatin Receptor
|
Cancer
|
MAT2A-IN-1 is a potent inhibitor of MAT2A. The expression level of MAT2A is abnormally high in several types of tumors, including gastric, colon, liver and pancreatic cancers. MAT2A-IN-1 reduces the proliferative activity of MTAP-deficient cancer cells. MAT2A-IN-1 has the potential for the research of cancer diseases (extracted from patent WO2021139775A1, compound 64) .
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-
- HY-147593
-
|
CD73
|
Cancer
|
CD73-IN-12 is a potent inhibitor of CD73. CD73 is closely associated with tumor growth, angiogenesis and metastasis. CD73-IN-12 be used for preparing a medicament for tumor-related diseases (extracted from patent CN114437038A, compound 9) . CD73-IN-12 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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-
- HY-147615
-
|
c-Fms
|
Cancer
|
CSF1R-IN-12 is a potent inhibitor of CSF1R. Colony stimulating factor 1 (CSF-1, also known as macrophage colony stimulating factor, M-CSF) is an important growth factor that controls bone marrow progenitor cells, monocytes, macrophages, and giants. CSF1R-IN-12 has the potential for the research of cancer diseases (extracted from patent WO2019134661A1, compound 1) .
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-
- HY-147619
-
|
FGFR
|
Cancer
|
FGFR-IN-4 is a potent inhibitor of FGFR. Fibroblast growth factor receptor (FGFR) is a tyrosine kinase receptor that binds to fibroblast growth factor ligands. FGFR-IN-4 has the potential for the research of cancer diseases (extracted from patent WO2022033532A1, compound 20) . FGFR-IN-4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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-
- HY-147616
-
|
c-Fms
|
Cancer
|
CSF1R-IN-13 is a potent inhibitor of CSF1R. Colony stimulating factor 1 (CSF-1, also known as macrophage colony stimulating factor, M-CSF) is an important growth factor that controls bone marrow progenitor cells, monocytes, macrophages, and giants. CSF1R-IN-13 has the potential for the research of cancer diseases (extracted from patent WO2019134661A1, compound 32) .
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-
- HY-147620
-
|
FGFR
|
Cancer
|
FGFR-IN-5 is a potent inhibitor of FGFR. Fibroblast growth factor receptor (FGFR) is a tyrosine kinase receptor that binds to fibroblast growth factor ligands. FGFR-IN-5 has the potential for the research of cancer diseases (extracted from patent WO2022042612A1, compound 3) . FGFR-IN-5 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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-
- HY-139643A
-
|
CXCR
|
Inflammation/Immunology
Cancer
|
CXCR7 antagonist-1 hydrochloride is a CXCR7 antagonist that inhibits the binding of the SDF-1 chemokine (also known as the CXCL12 chemokine) or I-TAC (also known as CXCL11) to the chemokine receptor CXCR7. CXCR7 antagonist-1 hydrochloride is useful in preventing tumor cell proliferation, tumor formation, inflammatory diseases, and many other diseases (extracted from patent WO2014085490A1, compound 1.128) .
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-
- HY-D0007
-
Tetrazolium blue
|
Fluorescent Dye
|
Others
|
Blue Tetrazolium (Tetrazolium blue), as a blue dye for microbial research, can be reduced into blue tetrazolium formazan (BTF). Blue Tetrazolium can be used to determine the activity of succinate dehydrogenase (SDH) in yeast strains, which has been reduced as a substrate. Use DMSO to extract BTF from cells, and test absorption spectrum of BTF. The BTF shows a wide wavelength range of 480-600 nm with maximal absorbance seen at 540 nm. Blue Tetrazolium, combines with succinate dehydrogenase (SDH) .
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- HY-N0041R
-
Gypenoside IV (Standard)
|
NF-κB
COX
NO Synthase
|
Inflammation/Immunology
Cancer
|
Ginsenoside Rb3 (Standard) is the analytical standard of Ginsenoside Rb3. This product is intended for research and analytical applications. Ginsenoside Rb3 is extracted from steamed Panax ginseng C. A. Meyer. Ginsenoside Rb3 exhibits inhibitory effect on TNFα-induced NF-κB transcriptional activity with an IC50 of 8.2 μM in 293T cell lines. Ginsenoside Rb3 also inhibits the induction of COX-2 and iNOS mRNA.
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-
- HY-N0142
-
NSC 407292; RJC 02792
|
SGLT
Endogenous Metabolite
GLUT
|
Metabolic Disease
Cancer
|
Phloretin (NSC 407292; RJC 02792) is a flavonoid extracted from Malus pumila Mill., has anti-inflammatory activities. Phloridzin is a specific, competitive and orally active inhibitor of sodium/glucose cotransporters in the intestine (SGLT1) and kidney (SGLT2). Phloretin inhibits Yeast-made GLUT1 as well as Human erythrocyte GLUT1 with IC50values of 49 μM and 61 μM, respectively .Phloretin has the potential for the treatment of rheumatoid arthritis (RA) and allergic airway inflammation .
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-
- HY-P1821
-
MHP4-14
|
PKC
|
Neurological Disease
|
Myelin Basic Protein (MHP4-14), a synthetic peptide comprising residues 4-14 of myelin basic protein, is a very selective PKC substrate (Km=7 μM). Myelin Basic Protein is not phosphorylated by cyclic AMP-dependent protein kinase, casein kinases I and II, Ca 2+/calmodulin-dependent protein kinase II, or phosphorylase kinase, and can be routinely used for the assay of protein kinase C with low background in the crude tissue extracts .
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-
- HY-N2447
-
|
AMPK
Apoptosis
|
Metabolic Disease
Cancer
|
Amarogentin is a secoiridoid glycoside that is mainly extracted from Swertia and Gentiana roots. Amarogentin exhibits many biological effects, including anti-oxidative, anti-tumour, and anti-diabetic activities. Amarogentin exerts hepatoprotective and immunomodulatory effects. Amarogentin promotes apoptosis, arrests G2/M cell cycle and downregulates of PI3K/Akt/mTOR signalling pathways. Amarogentin exerts beneficial vasculo-metabolic effect by activating AMPK .
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-
- HY-N0711
-
Cymophenol
|
Notch
Apoptosis
Fungal
Endogenous Metabolite
Bacterial
|
Infection
Inflammation/Immunology
Cancer
|
Carvacrol is an orally active monoterpenic phenol that can be extract from an abundant number of aromatic plants, including thyme and oregano, possessing antioxidant, antibacterial, antifungal, anticancer, anti-inflammatory, hepatoprotective, spasmolytic, and vasorelaxant properties. Carvacrol also causes cell cycle arrest in G0/G1, downregulates Notch-1, and Jagged-1, and induces apoptosis. Carvacrol is used in low concentrations as a food flavoring ingredient and preservative, as well as a fragrance ingredient in cosmetic formulations .
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-
- HY-N1346
-
Robinin
1 Publications Verification
|
Toll-like Receptor (TLR)
Apoptosis
|
Inflammation/Immunology
|
Robinin is a flavonoid that can be extracted from the leaves of purple cowpea, inhibiting TGF-β, TLR4/NF-κB and TLR2-PI3k-AKT signaling pathways. Robinin exerts anti-inflammatory and anti-tumor effects. The combination of Robinin and Methotrexate (HY-14519) reduces inflammation in experimental arthritis, Robinin can decrease the Doxorubicin (HY-15142A) induced cardiac toxicity effect .
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-
- HY-P1821A
-
MHP4-14 TFA
|
PKC
|
Neurological Disease
|
Myelin Basic Protein (MHP4-14) TFA, a synthetic peptide comprising residues 4-14 of myelin basic protein, is a very selective PKC substrate (Km=7 μM). Myelin Basic Protein TFA is not phosphorylated by cyclic AMP-dependent protein kinase, casein kinases I and II, Ca 2+/calmodulin-dependent protein kinase II, or phosphorylase kinase, and can be routinely used for the assay of protein kinase C with low background in the crude tissue extracts .
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-
- HY-145063
-
|
Phosphodiesterase (PDE)
|
Infection
Inflammation/Immunology
Cancer
|
Enpp-1-IN-5 is a potent inhibitor of ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1). The ENPP 1 has broad specificity and can cleave a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds nucleotides and nucleotide sugars. Enpp-1-IN-5 has the potential for the research of cancer and infectious diseases (extracted from patent WO2019046778A1/WO2021203772A1, compound 1) .
|
-
- HY-143757
-
|
Influenza Virus
|
Infection
|
Cap-dependent endonuclease-IN-10 is a potent inhibitor of cap-dependent endonuclease (CEN). Not only can Cap-dependent endonuclease-IN-10 inhibit influenza virus well, but also has lower cytotoxicity, better in vivo pharmacokinetic and in vivo pharmacodynamic properties, and better hepatic microsomal stability. Cap-dependent endonuclease-IN-10 has the potential for the research of viral infections (including influenza A, influenza B and influenza C) (extracted from patent WO2021129799A1, compound 1-1) .
|
-
- HY-144056
-
|
EGFR
|
Cancer
|
EGFR-IN-39 is a potent inhibitor of EGFR. EGFR-IN-39 is an anti-tumor agent with low toxic side effects. EGFR-IN-39 is an acrylamide derivative compound. Overexpression and mutation of the epidermal growth factor receptor (EGFR) has been clearly demonstrated to lead to uncontrollable cell growth and is associated with the progression of most cancer diseases, especially NSCLC. EGFR-IN-39 has the potential for the research of diseases associated with EGFR mutations (extracted from patent WO2021185348A1, compound 2) .
|
-
- HY-144055
-
|
EGFR
|
Cancer
|
EGFR-IN-38 is a potent inhibitor of EGFR. EGFR-IN-38 is an anti-tumor agent with low toxic side effects. EGFR-IN-33 is an acrylamide derivative compound. Overexpression and mutation of the epidermal growth factor receptor (EGFR) has been clearly demonstrated to lead to uncontrollable cell growth and is associated with the progression of most cancer diseases, especially NSCLC. EGFR-IN-38 has the potential for the research of diseases associated with EGFR mutations (extracted from patent WO2021185348A1, compound 4) .
|
-
- HY-144054
-
|
EGFR
|
Cancer
|
EGFR-IN-37 is a potent inhibitor of EGFR. EGFR-IN-37 is an anti-tumor agent with low toxic side effects. EGFR-IN-39 is an acrylamide derivative compound. Overexpression and mutation of the epidermal growth factor receptor (EGFR) has been clearly demonstrated to lead to uncontrollable cell growth and is associated with the progression of most cancer diseases, especially NSCLC. EGFR-IN-37 has the potential for the research of diseases associated with EGFR mutations (extracted from patent WO2021185348A1, compound 7) .
|
-
- HY-144052
-
|
EGFR
|
Cancer
|
EGFR-IN-35 is a potent inhibitor of EGFR. EGFR-IN-35 is an anti-tumor agent with low toxic side effects. EGFR-IN-35 is an acrylamide derivative compound. Overexpression and mutation of the epidermal growth factor receptor (EGFR) has been clearly demonstrated to lead to uncontrollable cell growth and is associated with the progression of most cancer diseases, especially NSCLC. EGFR-IN-35 has the potential for the research of diseases associated with EGFR mutations (extracted from patent WO2021185348A1, compound 11) .
|
-
- HY-144051
-
|
EGFR
|
Cancer
|
EGFR-IN-34 is a potent inhibitor of EGFR. EGFR-IN-34 is an anti-tumor agent with low toxic side effects. EGFR-IN-35 is an acrylamide derivative compound. Overexpression and mutation of the epidermal growth factor receptor (EGFR) has been clearly demonstrated to lead to uncontrollable cell growth and is associated with the progression of most cancer diseases, especially NSCLC. EGFR-IN-34 has the potential for the research of diseases associated with EGFR mutations (extracted from patent WO2021185348A1, compound 12) .
|
-
- HY-144050
-
|
EGFR
|
Cancer
|
EGFR-IN-33 is a potent inhibitor of EGFR. EGFR-IN-33 is an anti-tumor agent with low toxic side effects. EGFR-IN-33 is an acrylamide derivative compound. Overexpression and mutation of the epidermal growth factor receptor (EGFR) has been clearly demonstrated to lead to uncontrollable cell growth and is associated with the progression of most cancer diseases, especially NSCLC. EGFR-IN-33 has the potential for the research of diseases associated with EGFR mutations (extracted from patent WO2021185348A1, compound 13) .
|
-
- HY-144034
-
|
GCGR
|
Metabolic Disease
|
GLP-1R agonist 3 is a potent agonist of GLP-1R. GLP-1R agonist 3 is a thickened imidazole derivative compound. Glucagon-like peptide-1 (GLP-1) is an intestinal hypoglycemic hormone secreted by L-cells in the lower gastrointestinal tract. GLP-1R agonist 3 has the potential for the research of diabetes (extracted from patent WO2021197464A1, compound 1) .
|
-
- HY-144033
-
|
GCGR
|
Metabolic Disease
|
GLP-1R agonist 1 is a potent agonist of GLP-1R. GLP-1R agonist 1 is a thickened imidazole derivative compound. Glucagon-like peptide-1 (GLP-1) is an intestinal hypoglycemic hormone secreted by L-cells in the lower gastrointestinal tract. GLP-1R agonist 1 has the potential for the research of diabetes (extracted from patent WO2021197464A1, compound 4) .
|
-
- HY-146524
-
|
Trk Receptor
|
Cancer
|
TRK-IN-18 is a potent inhibitor of TRK. Tropomyosin-related kinases (Trks) are a family of receptor tyrosine kinases activated by neurotrophins, a group of soluble growth factors including Nerve Growth Factor (NGF), Brain-Derived Neurotrophic Factor (BDNF) and Neurotrophin-3 (NT-3) and Neurotrophin-4/5 (NT-4/5). TRK-IN-18 has the potential for the research of cancer diseases (extracted from patent WO2021148805A1, compound 7) .
|
-
- HY-146523
-
|
Trk Receptor
|
Cancer
|
TRK-IN-17 is a potent inhibitor of TRK. Tropomyosin-related kinases (Trks) are a family of receptor tyrosine kinases activated by neurotrophins, a group of soluble growth factors including Nerve Growth Factor (NGF), Brain-Derived Neurotrophic Factor (BDNF) and Neurotrophin-3 (NT-3) and Neurotrophin-4/5 (NT-4/5). TRK-IN-17 has the potential for the research of cancer diseases (extracted from patent WO2021148807A1, compound 3) .
|
-
- HY-147595
-
|
Ras
|
Cancer
|
KRAS G12D inhibitor 15 is a potent inhibitor of KRAS G12D. KRAS G12D inhibitor 15 has the potential for the research of various diseases or disorders, such as cancer or cancer metastasis (extracted from patent WO2022042630A1, compound 243) . KRAS G12D inhibitor 15 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-B0688S2
-
4,4′-Diaminodiphenyl sulfone-13C12; DDS-13C12
|
Isotope-Labeled Compounds
Antibiotic
Parasite
Bacterial
Reactive Oxygen Species
|
Infection
Inflammation/Immunology
|
Dapsone- 13C12 is the 13C12 labeled Dapsone (HY-B0688). Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al .
|
-
- HY-153567
-
|
Others
|
Inflammation/Immunology
|
Immune cell migration-IN-2 is a potent immune cell migration inhibitor with an EC50 of 13.5 nM in a T-cell adhesion assay. Immune cell migration-IN-2 is extracted from patent WO2019001171, example 11, can be used for dry-eye and other retinal diseases research . Immune cell migration-IN-2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-P3071
-
|
Potassium Channel
|
Inflammation/Immunology
|
ShK toxin blocks voltage-dependent potassium channel (Kv1.3 channel). ShK toxin can be isolated from the whole body extract of the Caribbean sea anemone (Stichodactylu helianthus). ShK toxin competes with dendrotoxin I and α-dendrotoxin for binding to synaptosomal membranes of rat brain, facilitates acetylcholine release. ShK toxin suppresses K+ currents in cultured rat dorsal root ganglion neurons. ShK toxin also inhibits T lymphocyte proliferation .
|
-
- HY-P5156
-
|
Potassium Channel
|
Neurological Disease
|
BDS-I known as blood depressing substance, is a marine toxin which can be extracted from Anemonia sulcata. BDS-I is a specific inhibitor of Potassium Channel, targeting to Kv3.4. BDS-I inhibits Aβ1-42-induced enhancement of KV3.4 activity, caspase-3 activation, and abnormal nuclear morphology of NGF-differentiated PC-12 cells. BDS-I reverts the Aβ peptide-induced cell death .
|
-
- HY-156519
-
|
NF-κB
|
Inflammation/Immunology
|
ALPK1-IN-3 is an inhibitor of ALPK1 extracted from patent WO2022063153A1 compound T007. ALPK1-IN-3 inhibits kidney proinflammatory gene expression and improves the survival rate of the animals in sepsis induced acute kidney injury animal model . ALPK1-IN-3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-N11997
-
|
Cholinesterase (ChE)
|
Neurological Disease
|
Feralolide is a dihydroisocoumarin isolated from the methanolic extract of aloe vera resin. Feralolide is also a dual inhibitor of AChE and BuChE, with IC50s of 55 μg/mL and 52 μg/mL respectively. Feralolide has antioxidant activity and inhibits 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2, 2′-azinobis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS). Feralolide could be used in research into cognitive disorders such as Alzheimer's disease, potentially restoring and enhancing memory .
|
-
- HY-106281A
-
PPD 10558 hemicalcium
|
HMG-CoA Reductase (HMGCR)
|
Cardiovascular Disease
Metabolic Disease
|
Bemfivastatin (PPD 10558) hemicalcium is an orally active lipid-lowering agent and HMG-CoA reductase inhibitor. Bemfivastatin hemicalcium enhances the activity of liver extracts. Bemfivastatin hemicalcium has no-observed adverse effect levels (NOAEL) with dosages of ≥320 mg/kg/d (rat developmental toxicity), ≥12.5 mg/kg/d (rabbit maternal toxicity), ≥25 mg/kg/d (rabbit developmental toxicity), respectively. Bemfivastatin hemicalcium can be used in the study of statin-related hypercholesterolemic myalgia in statin-intolerant patients.
|
-
- HY-19767A
-
|
|
|
GSK 3008348 hydrochloride is a small molecule integrin αvβ6 antagonist, extracted from patent WO/2014154725A1, example 1. The affinity (pIC50) for the human - a 6 protein in the Fluorescence Polarisation Assay for GSK 3008348 (hydrochloride) is 8.1, whereas its affinity in the cell Adhesion Assays was for: ανβ6 (pIC50 = 8.4); ανβ3 (pIC50 = 6); ανβ5 (pIC50 = 6.9); ανβ8 (pIC50 = 7.7).
|
-
- HY-N4314
-
4',5,6,7-Tetramethoxyflavone
|
Bacterial
|
Infection
Inflammation/Immunology
|
Scutellarein tetramethyl ether (4',5,6,7-Tetramethoxyflavone) is a bioactive component of Siam weed extract. Scutellarein tetramethyl ether (4',5,6,7-Tetramethoxyflavone) exhibits anti-inflammatory activity through NF-κB pathway . Scutellarein tetramethyl ether (4',5,6,7-Tetramethoxyflavone) modulats of bacterial agent resistance via efflux pump inhibition . Scutellarein tetramethyl ether (4',5,6,7-Tetramethoxyflavone) can enhance blood coagulation .
|
-
- HY-136857
-
|
PROTACs
Epigenetic Reader Domain
Ligands for Target Protein for PROTAC
|
Cancer
|
PROTAC BRD4 Degrader-7 is a potent bromodomain BRD4 degrader extracted from patent WO2020055976A1, example 1a, has IC50s of 15.5 and 12.3 nM for BRD4-BD1 and BRD4-BD2, respectively . PROTAC BRD4 Degrader-7 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-133487
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VH032-C8-NH2 dihydrochloride
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E3 Ligase Ligand-Linker Conjugates
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Inflammation/Immunology
Cancer
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(S,R,S)-AHPC-C8-NH2 dihydrochloride (VH032-C8-NH2 dihydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used for AKT PROTAC degrader. (S,R,S)-AHPC-C8-NH2 is XF038-164A, example 8, extracted from patent WO2019173516A1 .
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- HY-133487B
-
VH032-C8-NH2
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E3 Ligase Ligand-Linker Conjugates
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Inflammation/Immunology
Cancer
|
(S,R,S)-AHPC-C8-NH2 (VH032-C8-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used for AKT PROTAC degrader. (S,R,S)-AHPC-C8-NH2 is XF038-164A, example 8, extracted from patent WO2019173516A1 .
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- HY-136006A
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VH032-C6-NH2 hydrochloride
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E3 Ligase Ligand-Linker Conjugates
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Inflammation/Immunology
Cancer
|
(S,R,S)-AHPC-C6-NH2 hydrochloride (VH032-C6-NH2 hydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used for AKT PROTAC degrader. (S,R,S)-AHPC-C6-NH2 hydrochloride is XF038-161A, example 6, extracted from patent WO2019173516A1 .
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-
- HY-136006
-
VH032-C6-NH2 dihydrochloride
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E3 Ligase Ligand-Linker Conjugates
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Inflammation/Immunology
Cancer
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(S,R,S)-AHPC-C6-NH2 dihydrochloride (VH032-C6-NH2 dihydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used for AKT PROTAC degrader. (S,R,S)-AHPC-C6-NH2 dihydrochloride is XF038-161A, example 6, extracted from patent WO2019173516A1 .
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- HY-46531
-
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Ligands for E3 Ligase
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Inflammation/Immunology
Cancer
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Thalidomide-5-NH2-CH2-COOH (compound 114) is a potent and selective inhibitor of tropomyosin receptor kinase (trk). Thalidomide-5-NH2-CH2-COOH is a ligand of E3 ligase. Thalidomide-5-NH2-CH2-COOH has the potential for researching one or more diseases (extracted from patent WO2021170109A1) .
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- HY-142669
-
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Phospholipase
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Neurological Disease
Metabolic Disease
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Lp-PLA2-IN-4 is a potent inhibitor of lipoprotein-associated phospholipase A2 (Lp-PLA2). Lp-PLA2 previously known as platelet- activating factor acetylhydrolase (PAF-AH), is a phospholipase A2 enzyme involved in hydrolysis of lipoprotein lipids or phospholipids. Lp-PLA2-IN-4 has the potential for the research of diseases associated with the activity of Lp-PLA2, for example atherosclerosis, Alzheimer's disease (extracted from patent WO2021228159A1, compound 38) .
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-
- HY-142670
-
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Phospholipase
|
Neurological Disease
Metabolic Disease
|
Lp-PLA2-IN-5 is a potent inhibitor of lipoprotein-associated phospholipase A2 (Lp-PLA2). Lp-PLA2 previously known as platelet- activating factor acetylhydrolase (PAF-AH), is a phospholipase A2 enzyme involved in hydrolysis of lipoprotein lipids or phospholipids. Lp-PLA2-IN-5 has the potential for the research of diseases associated with the activity of Lp-PLA2, for example atherosclerosis, Alzheimer's disease (extracted from patent WO2021228159A1, compound 32) .
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- HY-142677
-
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PI3K
|
Inflammation/Immunology
Cancer
|
PI3K-IN-27 is a potent inhibitor of PI3K. PI3K belongs to a large family of lipid signaling kinase that plays key role in cellular process including cell growth, differentiation, migration and apoptosis. PI3K-IN-27 has the potential for the research of hyper-proliferative diseases like cancer and inflammation, or immune and autoimmune diseases (extracted from patent WO2021233227A1, compound 1) .
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-
- HY-144043
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|
TGF-β Receptor
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Cancer
|
ALK5-IN-8 is a potent inhibitor of TGFβRI (ALK5). ALK5-IN-8 Inhibits the phosphorylation of ALK5 on its downstream signaling proteins (Smad2 or Smad3) by blocking the binding of TGFβRI to ligands, thereby affecting or blocking TGF-β signaling. ALK5-IN-8 has the potential for the research of various ALK5-mediated related diseases (extracted from patent WO2021190425A1, compound 1) .
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-
- HY-142949
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|
TGF-β Receptor
|
Inflammation/Immunology
Cancer
|
ALK5-IN-7 is a potent inhibitor of ALK5. Transforming growth factor beta (TGF-β) is a multifunctional cytokine that is involved in regulating cell proliferation, differentiation and apoptosis through complex receptor signaling pathways on the cell surface in an autocrine, paracrine and endocrine manner. ALK5-IN-7 has the potential for the research of TGF-β-related diseases and conditions, including but not limited to tumors, fibrotic diseases, inflammatory diseases, autoimmune diseases, etc (extracted from patent WO2021129621A1, compound 4) .
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-
- HY-142950
-
|
TGF-β Receptor
|
Inflammation/Immunology
Cancer
|
ALK5-IN-6 is a potent inhibitor of ALK5. Transforming growth factor beta (TGF-β) is a multifunctional cytokine that is involved in regulating cell proliferation, differentiation and apoptosis through complex receptor signaling pathways on the cell surface in an autocrine, paracrine and endocrine manner. ALK5-IN-6 has the potential for the research of TGF-β-related diseases and conditions, including but not limited to tumors, fibrotic diseases, inflammatory diseases, autoimmune diseases, etc (extracted from patent WO2021129621A1, compound 1) .
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-
- HY-146527
-
|
Bcr-Abl
|
Neurological Disease
Cancer
|
c-ABL-IN-2 is a potent inhibitor of c-Abl. Activation of c-Abl has been implicated in various diseases, notably cancer. c-ABL-IN-2 has the potential for the research of neurodegenerative diseases (amyotrophic lateral sclerosis (ALS) and Parkinson’s disease (PD) and cancer (extracted from patent WO2020260871A1, compound 25) . c-ABL-IN-2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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-
- HY-W007376S
-
3-Formylindole-13C3
|
Isotope-Labeled Compounds
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Others
|
Indole-3-carboxaldehyde- 13C (3-Formylindole- 13C) is a 13C labeled Indole-3-carboxaldehyde (HY-W007376). Indole-3-carboxaldehyde (3-Formylindole), a banlangen extract, is the product of the oxidative degradation of indole-3-acetic acid (IAA) by crude enzyme preparations from etiolated pea seedlings. Indole-3-carboxaldehyde (3-Formylindole) is a biochemical used to prepare analogs of the indole phytoalexin cyclobrassinin .
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-
- HY-113120
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6Z,9Z,12Z,15Z-Octadecatetraenoic acid
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Endogenous Metabolite
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Others
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Stearidonic acid (6Z,9Z,12Z,15Z-Octadecatetraenoic acid) is an intermediate fatty acid in the biosynthetic pathway from α-linolenic acid to VLC ω-3 PUFA. The conversion efficiency of stearidonic acid is higher than that of alpha-linolenic acid. Increasing the intake of stearidonic acid can increase the content of eicosapentaenoic acid (EPA) in red blood cells. Stearidonic acid can also be isolated from methanolic extracts of the brown alga Brachyphyllum gracilis .
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- HY-N0408
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NF-κB
Reactive Oxygen Species
Apoptosis
Influenza Virus
|
Infection
Neurological Disease
Inflammation/Immunology
Cancer
|
Picroside II, an iridoid compound extracted from Picrorhiza, exhibits anti-inflammatory and anti-apoptotic activities.
picroside II alleviates the inflammatory response in sepsis and enhances immune function by inhibiting the activation of NLRP3 inflammasome and NF-κB pathways .
Picroside II is an antioxidant, exhibits a significant neuroprotective effect through reducing ROS production and protects the blood-brain barrier (BBB) after cerebral ischemia-reperfusion (CI/R) injury. Picroside II has antioxidant, anti-inflammatory, immune regulatory, anti-virus and other pharmacological activities .
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- HY-N0103
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|
Autophagy
Apoptosis
PI3K
Akt
Influenza Virus
|
Infection
Inflammation/Immunology
Cancer
|
Sophocarpine is one of the significant alkaloid extracted from the traditional herb medicine Sophora flavescens which has many pharmacological properties such as anti-virus, anti-tumor, anti-inflammatory. Sophocarpine significantly inhibits the growth of gastric cancer (GC) cells through multiple mechanisms such as induction of autophagy, activation of cell apoptosis and down-regulation of cell survival PI3K/AKT signaling pathway. Sophocarpine has been demonstrated to have anti-tumor activity in various cancer cells, including hepatocellular carcinoma, prostate cancer and colorectal cancer .
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- HY-N0103A
-
|
Autophagy
Apoptosis
PI3K
Akt
Influenza Virus
|
Infection
Inflammation/Immunology
Cancer
|
Sophocarpine (monohydrate) is one of the significant alkaloid extracted from the traditional herb medicine Sophora flavescens which has many pharmacological properties such as anti-virus, anti-tumor, anti-inflammatory. Sophocarpine (monohydrate) significantly inhibits the growth of gastric cancer (GC) cells through multiple mechanisms such as induction of autophagy, activation of cell apoptosis and down-regulation of cell survival PI3K/AKT signaling pathway. Sophocarpine (monohydrate) has been demonstrated to have anti-tumor activity in various cancer cells, including hepatocellular carcinoma, prostate cancer and colorectal cancer .
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-
- HY-125990
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|
Sodium Channel
|
Cardiovascular Disease
Metabolic Disease
|
SLC13A5-IN-1 is a selective sodium-citrate co-transporter (SLC13A5) inhibitor. SLC13A5-IN-1 completely blocks the uptake of 14C-citrate with an IC50 value of 0.022 μM in HepG2 cells. SLC13A5-IN-1 has the potential for the treatment of metabolic and/or cardiovascular diseases. SLC13A5-IN-1 is extracted from patent WO2018104220A1, Compound I-5 .
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- HY-145429
-
|
Interleukin Related
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Neurological Disease
Inflammation/Immunology
Cancer
|
IL-17A modulator-2 is a IL-17A modulator, extracted from patent WO2021239743+A1, example 27. IL-17A modulator-2 inhibits the biological action of IL-17A with a pIC50 of 8.3. IL-17A modulator-2 can be used for the research of diseases or disorders associated with modulation of IL-17A activity including diseases with an immune component or autoimmune pathol, cancer and neurodegenerative disorders .
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-
- HY-145430
-
|
Interleukin Related
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Neurological Disease
Inflammation/Immunology
Cancer
|
IL-17A modulator-1 is a IL-17A modulator, extracted from patent WO2021239743+A1, example 9. IL-17A modulator-1 inhibits the biological action of IL-17A with a pIC50 of 8.2. IL-17A modulator-1 can be used for the research of diseases or disorders associated with modulation of IL-17A activity including diseases with an immune component or autoimmune pathol, cancer and neurodegenerative disorders .
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-
- HY-145262
-
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Eukaryotic Initiation Factor (eIF)
|
Cancer
|
eIF4E-IN-2 is a potent inhibitor of eukaryotic initiation factor 4e (eIF4e). eIF4E-IN-2 has the potential for researching eIF4e dependent diseases, including the research of cancer (extracted from patent WO2021003157A1, compound 1188) . eIF4E-IN-2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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-
- HY-127102
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DDD01305143
|
Parasite
Proteasome
|
Infection
|
GSK3494245 (DDD01305143) is a potent, orally active, and selective inhibitor of the chymotrypsin-like activity of the parasite proteasome binding in a site sandwiched between the β4 and β5 subunits (IC50=0.16 μM for WT L. donovani proteasomes). GSK3494245 moderately inhibits chymotrypsin-like activity of human proteasome (IC50: purified 26S=13 µM; enriched THP-1 extracts IC50=40µM). GSK3494245 exhibits attractive biological and biosafety properties .
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- HY-142779
-
|
Phospholipase
|
Neurological Disease
Metabolic Disease
|
Lp-PLA2-IN-11 is a potent inhibitor of lipoprotein-associated phospholipase A2 (Lp-PLA2). Lp-PLA2 previously known as platelet- activating factor acetylhydrolase (PAF-AH), is a phospholipase A2 enzyme involved in hydrolysis of lipoprotein lipids or phospholipids. Lp-PLA2-IN-11 has the potential for the research of diseases associated with the activity of Lp-PLA2, for example atherosclerosis, Alzheimer's disease (extracted from patent WO2014114249A1, compound E145) .
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-
- HY-144040
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|
c-Fms
|
Cancer
|
CSF1R-IN-4 is a potent inhibitor of CSF1R. CSF-1R is expressed in macrophages, and the survival and differentiation of macrophages depends on the CSF-1/CSF-1R signaling pathway. CSF1R-IN-4 affects the exchange of inflammatory factors between TAMs and glioma cells. CSF1R-IN-4 has the potential for the research of cancer disease (extracted from patent WO2021197276A1, compound 104) .
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-
- HY-144041
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|
c-Fms
|
Cancer
|
CSF1R-IN-5 is a potent inhibitor of CSF1R. CSF-1R is expressed in macrophages, and the survival and differentiation of macrophages depends on the CSF-1/CSF-1R signaling pathway. CSF1R-IN-5 affects the exchange of inflammatory factors between TAMs and glioma cells. CSF1R-IN-5 has the potential for the research of cancer disease (extracted from patent WO2021197276A1, compound 11) .
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-
- HY-144042
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|
c-Fms
|
Cancer
|
CSF1R-IN-6 is a potent inhibitor of CSF1R. CSF-1R is expressed in macrophages, and the survival and differentiation of macrophages depends on the CSF-1/CSF-1R signaling pathway. CSF1R-IN-6 affects the exchange of inflammatory factors between TAMs and glioma cells. CSF1R-IN-6 has the potential for the research of cancer disease (extracted from patent WO2021197276A1, compound 5) .
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- HY-143423A
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MALT1
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Inflammation/Immunology
Cancer
|
(S)-MALT1-IN-5 is a potent inhibitor of MALT1 protease. (S)-MALT1-IN-5 inhibits the activity of MALT1 is expected to be able to correct the enhancement of MALT1 activity due to abnormality of T cell receptor signal or B cell receptor signal, and cancer or inflammatory disease caused by MALT1 activity is expected. (S)-MALT1-IN-5 has the potential for the research of MALT1-related diseases (extracted from patent WO2020111087A1, compound 1) .
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- HY-144094
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|
Histone Methyltransferase
|
Cancer
|
EZH2-IN-9 is a potent inhibitor of EZH2. EZH2 overexpression or mutations in the SET region (Y641F, Y641N, A687V, A677G point mutations) all lead to abnormal elevation of H3K27me3 and promote the growth and development of many types of tumors, such as breast cancer, prostate cancer, leukemia, etc. EZH2-IN-9 has the potential for the research of cancer diseases (extracted from patent WO2021180235A1, compound 17) .
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- HY-143616
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|
Histone Methyltransferase
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Cancer
|
EZH2-IN-7 is a potent inhibitor of EZH2. EZH2 overexpression or mutations in the SET region (Y641F, Y641N, A687V, A677G point mutations) all lead to abnormal elevation of H3K27me3 and promote the growth and development of many types of tumors, such as breast cancer, prostate cancer, leukemia, etc. EZH2-IN-7 has the potential for the research of cancer diseases (extracted from patent WO2021129629A1, compound 259) .
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-
- HY-147617
-
|
c-Fms
|
Cancer
|
CSF1R-IN-14 is an isoindolinone derivative compound. CSF1R-IN-14 is a potent inhibitor of CSF1R. Colony stimulating factor 1 (CSF-1, also known as macrophage colony stimulating factor, M-CSF) is an important growth factor that controls bone marrow progenitor cells, monocytes, macrophages, and giants. CSF1R-IN-14 has the potential for the research of cancer diseases (extracted from patent WO2019134662A1, compound 1) .
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- HY-12946A
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BI 653048 phosphate is a selective and orally active nonsteroidal glucocorticoid (GC) agonist with an IC50 value of 55 nM . BI 653048 phosphate inhibits CP1A2, CYP2D6, CYP2C9, CYP2C19 and CYP3A4 isoforms’ activity and reduces affinity for the hERG ion channel (IC50>30 μM) . BI 653048 phosphate is extracted from patent WO2005028501A1 (Compound 103), is also a HCV NS3 protease inhibitor that can reduce viral loads infected with the hepatitis C virus .
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- HY-12946
-
|
|
|
BI 653048 is a selective and orally active nonsteroidal glucocorticoid (GC) agonist with an IC50 value of 55 nM . BI 653048 inhibits CP1A2, CYP2D6, CYP2C9, CYP2C19 and CYP3A4 isoforms’ activity and reduces affinity for the hERG ion channel (IC50>30 μM) . BI 653048 is extracted from patent WO2005028501A1 (Compound 103), is also a HCV NS3 protease inhibitor that can reduce viral loads infected with the hepatitis C virus .
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- HY-N7041
-
|
EBV
HSV
|
Infection
|
11-Oxomogroside IIa (11-oxomogroside II A1) is a cucurbitane glycoside extracted from the fruits of Siraitia grosVenorii.
11-Oxomogroside IIa has inhibitory effects against the Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), shows weak inhibitory effects on activation of (+/-)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexemide (NOR 1), a nitric oxide (NO) donor .
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-
- HY-132138
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|
DNA/RNA Synthesis
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Others
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5-Propargylamino-3'-azidomethyl-dCTP is a nucleoside molecule extracted from patent WO2004018497A2, compound 17. 5-Propargylamino-3'-azidomethyl-dCTP can be used in DNA synthesis and DNA sequencing . 5-Propargylamino-3'-azidomethyl-dCTP is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
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- HY-44809A
-
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HIF/HIF Prolyl-Hydroxylase
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Inflammation/Immunology
Cancer
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Izilendustat (hydrochloride) is a potent inhibitor of prolyl hydroxylase which stabilizes hypoxia inducible factor- 1 alpha (HIF- lα), as well as hypoxia inducible factor-2 (HIF-2). Izilendustat (hydrochloride) has the potential for the research of HIF- lα related diseases including Peripheral Vascular Disease (PVD), Coronary Artery Disease (CAD), heart failure, ischemia, anemia, colitis, and other inflammatory bowel diseases (extracted from patent WO2011057115A1/WO2011057112A1/WO2011057121A1) .
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- HY-138098
-
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Others
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Cancer
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Sartorypyrone B is a 2β-acetoxyl analogue of chevalone C. Sartorypyrone B is yielded from the ethyl acetate extract of the culture of the marine sponge-associated fungus Neosartorya tsunodae (KUFC 9213). Sartorypyrone B exhibits strong growth inhibitory activity, having GI50s of 17.8, 20.5, and 25.0 μM, respectively, for MCF-7, NCI-H460, and A375-C5. Sartorypyrone B has the potential for the research of breast adenocarcinoma, non-small cell lung cancer, and melanoma diseases .
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- HY-142778
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|
Phospholipase
|
Neurological Disease
Metabolic Disease
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Lp-PLA2-IN-10 is a potent inhibitor of lipoprotein-associated phospholipase A2 (Lp-PLA2). Lp-PLA2 previously known as platelet- activating factor acetylhydrolase (PAF-AH), is a phospholipase A2 enzyme involved in hydrolysis of lipoprotein lipids or phospholipids. Lp-PLA2-IN-10 has the potential for the research of neurodegenerative-related diseases such as Alzheimer's disease (AD), glaucoma, age-related macular degeneration (AMD), or cardiovascular diseases including atherosclerosis (extracted from patent WO2022001881A1, compound 4) .
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- HY-N8788
-
|
Others
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Inflammation/Immunology
Cancer
|
Baicalein 7-O-β-D-ethylglucuronide is a natural flavone glycoside that can be extracted from Scutellaria baicalensis Georgi. Baicalein 7-O-β-D-ethylglucuronide has antioxidant activity. Baicalein 7-O-β-D-ethylglucuronide inhibits FeSO4-Cys-induced lipid peroxidation of liver homogenate. Baicalein 7-O-β-D-ethylglucuronide also shows strong cytoprotective effect on H2O2-induced oxidative damage of human umbilical vein endothelial cells .
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- HY-N11507
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TKV
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PPAR
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Metabolic Disease
|
Tibesaikosaponin V (TKV) is a triterpene diglycoside, which can be isolated from the methanol extract of the roots of Bupleurum chinense DC.. Tibesaikosaponin V inhibits lipid accumulation and triacylglycerol content occurred without cytotoxicity to adipocytes. Tibesaikosaponin V suppresses the mRNA expression of nuclear transcription factors, such as peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer binding protein α (C/EBPα). Tibesaikosaponin V inhibits 3T3-L1 preadipocyte differentiation. Tibesaikosaponin V can be used fro research of obesity and its associated metabolic disorders .
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- HY-115407
-
|
Bacterial
|
Infection
Cancer
|
Cochliodone A is an active compound extracted from cultures of the deep-sea derived fungus Chaetomium sp. and has antibacterial and anticancer activity. Cochliodone A is toxic to a variety of bacteria, with MICs of 15.3 μg/mL (V. vulnificus), 32.7 μg/mL (V. rotiferianus), 15.9 μg/mL (S. aureus ATCC 43300), and 16.3 μg/mL (S . aureus CGMCC 1.12409). Cochliodone A also inhibits a variety of cancer cell lines, with IC50s of 28.1 μM (A549), 20.7 μM (HeLa), and 23.2 μM (Hep G2) .
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- HY-N0142R
-
NSC 407292 (Standard); RJC 02792 (Standard)
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SGLT
Endogenous Metabolite
GLUT
|
Metabolic Disease
Cancer
|
Phloretin (Standard) is the analytical standard of Phloretin. This product is intended for research and analytical applications. Phloretin (NSC 407292; RJC 02792) is a flavonoid extracted from Malus pumila Mill., has anti-inflammatory activities. Phloridzin is a specific, competitive and orally active inhibitor of sodium/glucose cotransporters in the intestine (SGLT1) and kidney (SGLT2). Phloretin inhibits Yeast-made GLUT1 as well as Human erythrocyte GLUT1 with IC50values of 49 μM and 61 μM, respectively .Phloretin has the potential for the treatment of rheumatoid arthritis (RA)?and allergic airway inflammation .
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- HY-128860
-
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EGFR
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Cancer
|
Mutated EGFR-IN-2 (compound 91) is a mutant-selective EGFR inhibitor extracted from patent WO2017036263A1, which potently inhibits single-mutant EGFR (T790M) and double-mutant EGFR (including L858R/T790M (IC50=<1nM) and ex19del/T790M), and can suppress activity of single gain-of-function mutant EGFR (including L858R and ex19del) as well. Mutated EGFR-IN-2 shows anti-tumor antivity .
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-
- HY-N0373
-
|
Amyloid-β
Apoptosis
NOD-like Receptor (NLR)
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Neurological Disease
|
Licochalcone B is an extract from the root of Glycyrrhiza uralensis. Licochalcone B inhibits amyloid β (42) self-aggregation (IC50=2.16 μM) and disaggregate pre-formed Aβ42 fibrils, reduce metal-induced Aβ42 aggregation through chelating metal ionsLicochalcone B inhibits phosphorylation of NF-κB p65 in LPS signaling pathway. Licochalcone B inhibits growth and induces apoptosis of NSCLC cells. Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7‐NLRP3 interaction .
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-
- HY-142444
-
|
AP-1
|
Metabolic Disease
|
SSAO/VAP-1 inhibitor 1 is a potent inhibitor of SSAO/VAP-1. SSAO/VAP-1 promotes the transfer of Glucose transport 4 (GLUT 4) from adipocytes to the cell membrane, thereby regulating glucose transport. In endothelial cells, SSAO/VAP-1 can mediate the adhesion and exudation of leukocytes and endothelial cells, and participate in inflammatory responses. SSAO/VAP-1 inhibitor 1 has the potential for the research of inflammation and/or inflammation-related disease or diabetes and/or diabetes-related disease (extracted from patent WO2021102774A1, compound E3) .
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- HY-N11009
-
|
EBV
|
Infection
|
11-Oxomogroside II A1 (compound 7) is an oxidized cucurbitin. It can be isolated from the ethanol extract of Rohanberry fruit. 11-Oxomogroside II A1 inhibits the activation of Epstein-Barr virus (EBV) early antigen (EBV-EA) induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). 11-Oxomogroside II A1 also weakly inhibits the activation of (±)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexemide (NOR 1), a nitric oxide (NO) donor .
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-
- HY-125139
-
ω-3 Arachidonic acid ethyl ester; (all-Z)-8,11,14,17-Eicosatetraenoic acid ethyl ester
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Biochemical Assay Reagents
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Others
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omega-3 Arachidonic Acid ethyl ester is a rare polyunsaturated fatty acid found in very small amounts in dietary sources. Omega-3 fatty acids are known to be essential for the growth and development of infants, and they protect against heart disease, blood clots, high blood pressure, and inflammatory and autoimmune diseases. In human platelet membranes, omega-3 arachidonic acid inhibits arachidonyl-CoA synthetase with a Ki of 14 μM. It also inhibits arachidonoyl-CoA synthetase in calf brain extract with an IC50 of approximately 5 μM. Omega-3 ethyl arachidonate is the more lipophilic form of the free acid.
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- HY-N6954
-
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ATM/ATR
STAT
CDK
|
Cancer
|
Garcinone C, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia that is used as an anti-inflammatory, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and 4E-BP1, while efficiently inhibiting the expression levels of cyclin B1, cyclin D1, cyclin E2, cdc2, Stat3 and CDK7. Garcinone C significantly inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time‑ and dose‑dependent manner .
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- HY-N9174
-
|
Others
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Cancer
|
5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone is a natural product that can be extracted from B. papyrifera. 5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone has potent anti-proliferation effects on ER-positive breast cancer cells, with an IC50 value of 4.41 μM for MCF-7 cells. 5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone also reduces the tumor growth in the BCAP-37 xenograft .
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-
- HY-N0926A
-
Columbamin chloride; Dehydroisocorypalmine chloride
|
Others
|
Others
|
Columbamine (Columbamin; Dehydroisocorypalmine) chloride is an alkaloid .
|
-
- HY-N10091
-
|
Apoptosis
|
Others
|
2,3-Dihydro-3α-methoxynimbolide is a limonoid compound isolated from the extracts of bark, leaves, roots, and seeds of Azadirachta indica A. Juss. var. siamensis Valeton. 2,3-Dihydro-3α-methoxynimbolide exhibits potent cyto-toxicities against one or more cell lines. 2,3-Dihydro-3α-methoxynimbolide activates caspases-3, -8, and -9, while increases the ratio of Bax/Bcl-2. 2,3-Dihydro-3α-methoxynimbolide induces apoptosis via both mitochondrial and death receptor pathways in AZ521 .
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-
- HY-N9790
-
|
Notch
|
Others
|
Procyanidin B2, 3,3'-di-O-gallate is an active constituent. Procyanidin B2, 3,3'-di-O-gallate can be isolated from grape seed extract (GSE) procyanidin mix. Procyanidin B2, 3,3' -di-o-gallate target cancer stem cells (CSCs) in prostate cancer (PCa). Procyanidin B2, 3,3'-di-O-gallate targets both unsorted and sorted CSCs at lower doses. Procyanidin B2, 3,3'-di-O-gallate strongly suppresses the constitutive as well as Jagged1 (Notch1 ligand)-induced activated Notch1 pathway .
|
-
- HY-108052
-
Delphinidin 3-O-glucoside chloride; Delphinidin 3-O-β-glucoside chloride
|
EGFR
Apoptosis
Akt
|
Cardiovascular Disease
Cancer
|
Delphinidin 3-glucoside chloride (Delphinidin 3-O-glucoside chloride) is an active anthocyanin found in Hibiscus sabdariffa extract. Delphinidin 3-glucoside chloride induces a pro-apoptotic effect in B cell chronic lymphocytic leukaemia (B CLL) . Delphinidin 3-glucoside chloride exerts phytoestrogen activity by binding to ERβ, with an IC50 of 9.7 μM . Delphinidin-3-O-glucoside chloride inhibits EGFR with an IC50 of 2.37 µM . Delphinidin 3-glucoside chloride exhibits antitumor effects through pAKT/IRF1/HOTAIR pathway. Delphinidin 3-glucoside chloride exhibits efficacy against oxidative stress, inhibits platelet activation and endothelial dysfunction .
|
-
- HY-103048
-
|
PD-1/PD-L1
|
Cancer
|
PD-1/PD-L1-IN 3, a macrocyclic peptide, is a potent and selective inhibitor of the PD-1/PD-L1 and CD80/PD-L1 interactions extracted from patent WO2014151634A1, compound No.1. PD-1/PD-L1-IN 3 interferes with PD-L1 binding to PD-1 and CD80 by binding to PD-L1, with IC50s of 5.60 nM and 7.04 nM, respectively. PD-1/PD-L1-IN 3 can be used for the research of various diseases, including cancer and infectious diseases .
|
-
- HY-103048A
-
|
PD-1/PD-L1
|
Cancer
|
PD-1/PD-L1-IN 3 TFA, a macrocyclic peptide, is a potent and selective inhibitor of the PD-1/PD-L1 and CD80/PD-L1 interactions extracted from patent WO2014151634A1, compound No.1. PD-1/PD-L1-IN 3 TFA interferes with PD-L1 binding to PD-1 and CD80 by binding to PD-L1, with IC50s of 5.60 nM and 7.04 nM, respectively. PD-1/PD-L1-IN 3 TFA can be used for the research of various diseases, including cancer and infectious diseases .
|
-
- HY-N2789
-
|
Bacterial
Fungal
|
Infection
|
(9Z)-9,17-Octadecadiene-12,14-diyne-1,11,16-triol is a nature product that could be isolated from the ethyl acetate extract of Cassonia barteri (Araliaceae) leaves. (9Z)-9,17-Octadecadiene-12,14-diyne-1,11,16-triol has antibacterial activity against Bacillus subtilis and Pseudomonas fluorescens, antifungal activity against Cladosporium cucumerinum, moiluscicidal activity against Biomphalaria glabrata . (9Z)-9,17-Octadecadiene-12,14-diyne-1,11,16-triol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-B1890
-
rel-Cianidanol; rel-Catechuic acid
|
COX
|
Infection
Cardiovascular Disease
Neurological Disease
Inflammation/Immunology
Cancer
|
(±)-Catechin (rel-Cianidanol) This is a green tea polyester. Catechin possesses anti-cancer activity, which has led to its demise. (±)-Catechin 具有两种forms (+)-Catechin and its reflection body (-)-Catechin. (+)-Catechin inhibitory environment-1 (COX-1) IC50 为 1.4 μM. (-)-Catechin has the effect of promoting hBM-MSC adipose cell differentiation, increasing adipose tissue, and PPARγ horizontal. (±)-Catechin has anti-diabetic, anti-hypertrophic, anti-diabetic, anti-cardiovascular, anti-infective, and liver-protecting effects.
|
-
-
-
HY-L912V
-
|
10,000,000 compounds
|
With MCE's 40,662 BBs, covering around 273 reaction types, more than 40 million molecules were generated. Compounds which comply with Ro5 criteria were selected. Inappropriate chemical structures, such as PAINS motifs and synthetically difficult accessible, were removed. Based on Morgan Fingerprint, molecular clustering analysis was carried out, and molecules close to each clustering center were extracted to form this drug-like and synthesizable diversity library. These selected molecules have 805,822 unique Bemis-Murcko Scaffolds (BMS) with diversified chemical space. This library is highly recommended for AI-based lead discovery, ultra-large virtual screening and novel lead discovery.
|
-
-
HY-L910V
-
|
50,000 compounds
|
MegaUni 50K Virtual Diversity Library consists of 50,000 novel, synthetically accessible, lead-like compounds. With MCE's 40,662 Building Blocks, covering around 273 reaction types, more than 40 million molecules were generated. Based on Morgan Fingerprint and Tanimoto Coefficient, molecular clustering analysis was carried out, and molecules closest to each clustering center were extracted to form a drug-like and synthesizable diversity library. The selected 50,000 drug-like molecules have 46,744 unique Bemis-Murcko Scaffolds (BMS), each containing only 1-3 compounds. This diverse library is highly recommended for virtual screening and novel lead discovery.
|
-
-
HY-L157
-
|
1062 compounds
|
Natural product have great diversity and structural complexity of scaffolds. And the number of their drugs represents a large number of sources of new pharmacological entities, so natural products are of great significance in drug discovery. The Dictionary of Natural Products (DNP) shows that natural products mainly come from plants, animals and microorganisms, and animal sources are the second important source of natural products. Animal derived natural products exist to varying degrees in almost all forms of animals, generally secondary metabolite extracted from organisms.
MCE provides a unique collection of 1062 animal-sourced natural products. MCE Animal-Sourced Natural Product Library is a useful tool for drug discovery that can be used for high throughput screening (HTS) and high content screening (HCS).
|
Cat. No. |
Product Name |
Type |
-
- HY-N0938
-
|
Dyes
|
Safflower yellow is extracted from the flowers of the plant safflower (Carthamus tinctorius) and as the traditional Chinese medicine it has been extensively used for the treatment of cardio cerebrovascular diseases.
|
-
- HY-113862
-
|
Dyes
|
PHOME is a fluorogenic substrate for sEH. sEH can hydrolyze the epoxy ring in the PHOME substrate. PHOME can be used for fluorescent epoxide hydrolase assay (extracted from patent CN113402447A) .
|
-
- HY-D1500
-
|
Fluorescent Dyes/Probes
|
Fluorescent NIR 885 is a cyanine near-infrared-absorbing dye. Fluorescent NIR 885 can be used as a photoprotective agent (extracted from patent WO2014006589 compound 1-35) .
|
Cat. No. |
Product Name |
Type |
-
- HY-W127744
-
-
- HY-156261
-
-
- HY-Y1888
-
|
Co-solvents
|
Corn oil, extracted from the germ of corn, can be used as a carrier for agent molecules.
|
-
- HY-N8332
-
Ox bile extract
|
Biochemical Assay Reagents
|
Bile extract is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-153126
-
|
Biochemical Assay Reagents
|
Yeast extract is a concentrate of the soluble part of yeast, especially Saccharomyces cerevisiae. The main nutritional components of yeast extract include partly hydrolyzed protein with 35-40% of free amino acid, and it also contain B vitamins and some trace elements. Yeast extract can be used as nutrients for bacterial culture media .
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-
- HY-P0001
-
TFX-Jelfa
|
Native Proteins
|
Thymic factor X (TFX-Jelfa) is an aqueous extract from juvenile calf thymuses and a natural stimulator of lymphocyte function .
|
-
- HY-Y1887
-
|
Co-solvents
|
Cottonseed oil is a cooking oil extracted from the seeds of cotton plants and has been generally considered the most insecticidal of vegetable oils.
|
-
- HY-153186
-
|
Drug Delivery
|
LNP Lipid-3 is an ionizable lipid extracted from patent WO2021113777A, and can be used for the generation of Lipid nanoparticles (LNPs).
|
-
- HY-126389
-
|
Biochemical Assay Reagents
|
Chitin, from crab carapace (powder) is a variety of sugars extracted from the shells of marine crustaceans. In nature, chitin widely exists in shrimp, crabs, and worms.
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-
- HY-46760
-
|
Drug Delivery
|
CCD Lipid01 is a cationic lipid useful in the delivery of biologically active agents to cells and tissues (extracted from patent WO2015095340 A1) .
|
-
- HY-124433
-
iso-Tridecanoic methyl ester
|
Biochemical Assay Reagents
|
Methyl 11-Methyldodecanoate is a methylated fatty acid methyl ester that has been used as a standard for the quantitative analysis of 11-methyl lauric acid in vernix and M. oleifera extracts.
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-
- HY-101850
-
|
Biochemical Assay Reagents
|
MOPSO is a biological zwitterionic buffer with the useful pH range from 6.2 to 7.6. MOPSO has been employed as a buffer component of charcoal yeast extract medium .
|
-
- HY-148830
-
|
Drug Delivery
|
Piperazine-bis(ethyl octadeca-9,12-dienoate) is a cationic lipid extracted from patent WO2023036148A1, and can be used for the generation of Lipid nanoparticles (LNPs).
|
-
- HY-W127711
-
|
Biochemical Assay Reagents
|
Fast Blue B Salt is a coloring agent that dissolves fats and phenolic compounds extracted from rye, as well as diazonium. Fast Blue B Salt can be used for the semiquantification of alkylresorcinols in rye and produces a color precipitate in the presence of acetone .
|
-
- HY-156263
-
Luria-Bertani Base
|
Biochemical Assay Reagents
|
LB Broth Base, powder (Luria-Bertani Base) is generally used to maintain the growth of E. coli. The composition of 1 liter of LB medium is: 10 g peptone, 5 g yeast extract and 5 g NaCl .
|
-
- HY-157370
-
|
Microbial Culture
|
Blood Enrichment Medium can be used for enrichment culture of pathogenic bacteria in blood. Blood Enrichment Medium ingredients include peptone, beef extract powder, NaCl, glucose, sodium citrate, para-aminobenzoic acid, magnesium sulfate, phenol red .
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-
- HY-W250120
-
|
Biochemical Assay Reagents
|
Konjac glucomannan (Viscosity≥15000mPa.s) is an acetylated (1-4)-beta-D-glucomannan extracted from the tuber of konjac or konjac root. In Japan, it is a dietary supplement intended to reduce calorie intake because it swells in water.
|
-
- HY-W009048
-
DCH18C6; Perhydrodibenzo-18-crown-6
|
Biochemical Assay Reagents
|
Dicyclohexano-18-crown-6-ether selectively extracts lysine-rich cytochrome c proteins from other cationic proteins under weakly acidic and neutral conditions, demonstrating specificity in ligand-protein interactions .
|
-
- HY-157359
-
|
Microbial Culture
|
Bacterial Organophosphorus Medium can be used to determine the efficiency of phosphorus bacteria in decomposing organic phosphorus in phosphorus bacteria fertilizers. Bacterial Organophosphorus Medium ingredients include glucose, ammonium sulfate, yeast extract, sodium chloride, potassium chloride, magnesium sulfate, ferrous sulfate, manganese sulfate, lecithin, calcium carbonate, agar .
|
-
- HY-P3028
-
Ficin
|
Biochemical Assay Reagents
|
Ficain is an enzyme extract composed of several proteases that can be isolated from Ficus hispida L. and the latex of fig (Ficus carica). Ficain has different specificities in different proportions during fruit ripening. Ficain is widely used in protein hydrolysis, food, production of bioactive peptides and antibody fragments .
|
-
- HY-W036733
-
|
Biochemical Assay Reagents
|
4-Hydroxy-4-methylcyclohexanone is a useful synthetic reagent extracted from patent JP2009022162A. 4-Hydroxy-4-methylcyclohexanone can be used to synthesize trans-4-amino-1-methylcyclohexanol which is intermediate of pharmaceutical synthesis .
|
-
- HY-B2225B
-
Edible corn starch (from corn)
|
Biochemical Assay Reagents
|
Starch (from corn) is a carbohydrate extracted from the kernel of the corn plant. It contains two main components, namely amylose and amylopectin. Starches from corn have various applications in the food industry as thickeners, stabilizers and binders. It is commonly used in the production of products such as baked goods, snacks, sauces and soups. In addition, it can be used as a raw material for the production of biofuels and bioplastics.
|
-
- HY-132142
-
|
Gene Sequencing and Synthesis
|
5-Propargylamino-dCTP is a nucleoside molecule extracted from patent US9035035B2, compound dCTP-PA. 5-Propargylamino-dCTP can conjugate to molecular markers for use in nucleic acid labeling or sequence analysis . 5-Propargylamino-dCTP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-W145695
-
|
Biochemical Assay Reagents
|
Chitoheptaose is a chitosan oligosaccharide. Chitoheptaose is capable of extracting exoskeletons from crustaceans, such as the shells of crabs, shrimp and lobsters. Chitoheptaose has antioxidant, anti-inflammatory and anti-apoptotic activities and can be used in the study of myocarditis. Chitoheptaose has cardioprotective effects and improves cardiac parameters (left ventricular internal size, end-systolic and end-diastolic, ejection fraction and shortening fraction), inflammatory cytokines (IL-1β) in vanishing models .
|
-
- HY-132137
-
|
Gene Sequencing and Synthesis
|
5-Propargylamino-3'-azidomethyl-dUTP is a nucleoside molecule extracted from patent WO2004018497A2, compound 5. 5-Propargylamino-3'-azidomethyl-dUTP can be used in DNA synthesis and DNA sequencing . 5-Propargylamino-3'-azidomethyl-dUTP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-D0007
-
Tetrazolium blue
|
Biochemical Assay Reagents
|
Blue Tetrazolium (Tetrazolium blue), as a blue dye for microbial research, can be reduced into blue tetrazolium formazan (BTF). Blue Tetrazolium can be used to determine the activity of succinate dehydrogenase (SDH) in yeast strains, which has been reduced as a substrate. Use DMSO to extract BTF from cells, and test absorption spectrum of BTF. The BTF shows a wide wavelength range of 480-600 nm with maximal absorbance seen at 540 nm. Blue Tetrazolium, combines with succinate dehydrogenase (SDH) .
|
-
- HY-157356
-
|
Microbial Culture
|
Violet Red Bile Glucose Agar can be used for counting intestinal bacteria and identification of enterobacteriaceae. The composition of 1 liter of Violet Red Bile Glucose Agar contains: 7.0 g gelatin pancreatic enzyme hydrolysate, 3.0 g yeast extract powder, 1.5 g sodium deoxycholate, 10.0 g glucose, 5.0 g sodium chloride, 0.03 g neutral red, 0.002 g crystal violet, and 15.0 g agar in per liter .
|
-
- HY-132138
-
|
Gene Sequencing and Synthesis
|
5-Propargylamino-3'-azidomethyl-dCTP is a nucleoside molecule extracted from patent WO2004018497A2, compound 17. 5-Propargylamino-3'-azidomethyl-dCTP can be used in DNA synthesis and DNA sequencing . 5-Propargylamino-3'-azidomethyl-dCTP is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
|
-
- HY-125139
-
ω-3 Arachidonic acid ethyl ester; (all-Z)-8,11,14,17-Eicosatetraenoic acid ethyl ester
|
Biochemical Assay Reagents
|
omega-3 Arachidonic Acid ethyl ester is a rare polyunsaturated fatty acid found in very small amounts in dietary sources. Omega-3 fatty acids are known to be essential for the growth and development of infants, and they protect against heart disease, blood clots, high blood pressure, and inflammatory and autoimmune diseases. In human platelet membranes, omega-3 arachidonic acid inhibits arachidonyl-CoA synthetase with a Ki of 14 μM. It also inhibits arachidonoyl-CoA synthetase in calf brain extract with an IC50 of approximately 5 μM. Omega-3 ethyl arachidonate is the more lipophilic form of the free acid.
|
Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-105055
-
|
Peptides
|
Cancer
|
Didemnin B is a depsipeptide extracted from the marine tunicate Trididemnin cyanophorum. Didemnin B can be used for the research of cancer .
|
-
- HY-P1496
-
-
- HY-107989
-
|
Antibiotic
|
Endocrinology
|
Urofollitropin is a protein extract of human menopausal urine. Urofollitropin has the function of promoting follicle development and maturation, but contains very small amounts of urinary proteins .
|
-
- HY-123492
-
|
Peptides
|
Neurological Disease
Endocrinology
|
Kentsin, a contraceptive tetrapeptide, is originally extracted from hamster embryos. Kentsin prevents the maturation of Graafian follicles and consequently inhibits ovulation. Kentsin has opiate properties on gastrointestinal motility .
|
-
- HY-129271
-
Deltorphin A; Dermenkephalin
|
Opioid Receptor
|
Others
|
Deltorphin (Deltorphin A; Dermenkephalin) is a biological active peptide. (Deltorphin A peptide was isolated from skin extracts of the South American frog, Phyllomedusa sauvagei. Deltorphin A is a potent and selective agonist for the delta-opioid receptor.)
|
-
- HY-P1355
-
|
Calcineurin
|
Inflammation/Immunology
|
Cyclosporin A-Derivative 1 is a crystalline intermediate derived from the opening of cyclosporin A extracted from patent WO 2013167703 A1. Cyclosporin A is an immunosuppressive agent which can bind to the cyclophilin and inhibit calcineurin.
|
-
- HY-P3377
-
|
Peptides
|
Inflammation/Immunology
|
Rimtoregtide is a polypeptide compound which significantly reduces the increase in the levels of amylase and lipase in the blood caused by acute pancreatitis. Rimtoregtide has the potential for the research of pancreatitis and acute pancreatitis (extracted from patent WO2018205233A1).
|
-
- HY-103276
-
|
Peptides
|
Cardiovascular Disease
Neurological Disease
|
Alytesin, a bombesin-like peptide, is found in extracts of the skin of Alytes obstetricans. Alytesin reduces gastric acid secretion and induces hypertension. Alytesin also induces short-term anorexigenic effects in neonatal chicks
|
-
- HY-P1348
-
|
GCGR
|
Metabolic Disease
|
GLP-1 moiety from Dulaglutide is a 31-amino acid fragment of Dulaglutide which is a glucagon-like peptide 1 receptor (GLP-1) agonist, extracted from patent US 20160369010 A1.
|
-
- HY-P1355A
-
|
Calcineurin
|
Others
|
Cyclosporin A-Derivative 1 (Free base) is a crystalline intermediate derived from the opening of cyclosporin A extracted from patent WO 2013167703 A1. Cyclosporin A is an immunosuppressive agent which can bind to the cyclophilin and inhibit calcineurin.
|
-
- HY-P4835
-
|
Peptides
|
Others
|
pTH (2-34) (human) (80 μg/kg) slightly increases serum osteocalcin levels and alkaline phosphatase activity of bone extract (markers of bone formation) in mice. pTH (2-34) is not as effective as pTH (1-34) .
|
-
- HY-P2457
-
|
Bacterial
|
Infection
Inflammation/Immunology
|
rCRAMP (rat) is the rat cathelin-related antimicrobial peptide. rCRAMP (rat) contributes to the antibacterial activity in rat brain peptide/protein extracts. rCRAMP (rat) is a potential key player in the innate immune system of rat CNS .
|
-
- HY-P3685
-
|
CRFR
|
Endocrinology
|
[Met(O)21] Corticotropin Releasing Factor, ovine is a corticotropin releasing factor isolated from ovine hypothalamic extracts. Corticotropin releasing factor (CRF) is a hypothalamic hormone, which stimulates the secretion of adrenocorticotrophic hormone (ACTH) .
|
-
- HY-160429
-
|
Peptides
|
Others
|
PSAR18-COOH is a derivative of PSAR extracted from patent WO2009064913A1. PSAR is a highly hydrophilic, biodegradable, non-immunogenic and water-soluble polymer that has been employed in several delivery systems for drugs or diagnostics.
|
-
- HY-P3737
-
|
Peptides
|
Others
|
Osteocalcin (37-49), human is a peptide fragment of Osteocalcin. Osteocalcin (37-49), human has been used to detecte the intact human osteocalcin in HPLC purified plasma and peritoneal dialysate from patients with terminal renal insufficiency and in extracted human bone .
|
-
- HY-P3129
-
|
Peptides
|
Inflammation/Immunology
Cancer
|
KRAS G13D peptide, 25 mer, a KRAS activating oncogene mutation peptide, is an immune potentiator extracted from patent WO2018144775A1. KRAS G13D peptide, 25 mer can be used to prepare KRAS vaccine .
|
-
- HY-P3885
-
-
- HY-P2159
-
|
Opioid Receptor
Endogenous Metabolite
|
Neurological Disease
|
Dynorphin A (1-8) is the predominant opioid peptide identified in placental tissue extracts. Dynorphin A (1-8) is the most likely natural ligand of the kappa receptor. The binding of 3H-Bremazocine to the purified kappa receptor is inhibited by Dynorphin A (1-8) (IC50=303 nM) .
|
-
- HY-P3940
-
|
PKC
|
Others
|
Ac-MBP (4-14) Peptide is an acetylated MBP (4-14) peptide. MBP (4-14) Peptide is a very selective (protein kinase C) PKC substrate. Ac-MBP (4-14) Peptide can be used for PKC assay in extracts without prior purification to eliminate interfering protein kinases or phosphatases .
|
-
- HY-P5495
-
|
Peptides
|
Others
|
Uroguanylin-15 (Rat) is a biological active peptide. (Uroguanylin is a natriuretic peptide, a hormone that regulates sodium excretion by the kidney when excess NaCl is consumed. Uroguanylin and guanylin are related peptides that activate common guanylate cyclase signaling molecules in the intestine and kidney. Uroguanylin was isolated from urine and duodenum but was not detected in extracts from the colon of rats.)
|
-
- HY-P3869
-
|
Peptides
|
Neurological Disease
|
[D-Arg2]Dermorphin-(1-4) amide is a N-terminal shorter peptide amide of [D-Arg2]dermorphin with the hypothermic effect. [D-Arg2]Dermorphin-(1-4) amide shows analgesic activity and degradation in soluble mouse liver and brain extracts .
|
-
- HY-P1597
-
|
PKA
PKC
|
Cancer
|
Malantide is a synthetic dodecapeptide derived from the site phosphorylated by cAMP-dependent protein kinase (PKA) on the β-subunit of phosphorylase kinase. Malantide is a highly specific substrate for PKA with a Km of 15 μM and shows protein inhibitor (PKI) inhibition >90% substrate phosphorylation in various rat tissue extracts . Malantide is also an efficient substrate for PKC with a Km of 16 μM .
|
-
- HY-P1597A
-
|
PKA
PKC
|
Cancer
|
Malantide TFA is a synthetic dodecapeptide derived from the site phosphorylated by cAMP-dependent protein kinase (PKA) on the β-subunit of phosphorylase kinase. Malantide TFA is a highly specific substrate for PKA with a Km of 15 μM and shows protein inhibitor (PKI) inhibition >90% substrate phosphorylation in various rat tissue extracts . Malantide TFA is also an efficient substrate for PKC with a Km of 16 μM .
|
-
- HY-P3632
-
DADAD
|
Opioid Receptor
|
Neurological Disease
Metabolic Disease
|
[DAla2, DArg6] Dynorphin A, (1-13) (porcine) (DADAD) is an opioid peptide (dynorphinl-13, DYN) derivative found in porcine pituitary extracts. DYN is highly potent at the peripheral opioid receptors GPI and MVD, but is readily and rapidly degraded in vivo. [DAla2, DArg6] Dynorphin A, (1-13) (porcine) has some resistance to enzymatic cleavage and prevents peptide cleavage by enzymes .
|
-
- HY-P1821
-
MHP4-14
|
PKC
|
Neurological Disease
|
Myelin Basic Protein (MHP4-14), a synthetic peptide comprising residues 4-14 of myelin basic protein, is a very selective PKC substrate (Km=7 μM). Myelin Basic Protein is not phosphorylated by cyclic AMP-dependent protein kinase, casein kinases I and II, Ca 2+/calmodulin-dependent protein kinase II, or phosphorylase kinase, and can be routinely used for the assay of protein kinase C with low background in the crude tissue extracts .
|
-
- HY-P3071
-
|
Potassium Channel
|
Inflammation/Immunology
|
ShK toxin blocks voltage-dependent potassium channel (Kv1.3 channel). ShK toxin can be isolated from the whole body extract of the Caribbean sea anemone (Stichodactylu helianthus). ShK toxin competes with dendrotoxin I and α-dendrotoxin for binding to synaptosomal membranes of rat brain, facilitates acetylcholine release. ShK toxin suppresses K+ currents in cultured rat dorsal root ganglion neurons. ShK toxin also inhibits T lymphocyte proliferation .
|
-
- HY-P5156
-
|
Potassium Channel
|
Neurological Disease
|
BDS-I known as blood depressing substance, is a marine toxin which can be extracted from Anemonia sulcata. BDS-I is a specific inhibitor of Potassium Channel, targeting to Kv3.4. BDS-I inhibits Aβ1-42-induced enhancement of KV3.4 activity, caspase-3 activation, and abnormal nuclear morphology of NGF-differentiated PC-12 cells. BDS-I reverts the Aβ peptide-induced cell death .
|
-
- HY-103048A
-
|
PD-1/PD-L1
|
Cancer
|
PD-1/PD-L1-IN 3 TFA, a macrocyclic peptide, is a potent and selective inhibitor of the PD-1/PD-L1 and CD80/PD-L1 interactions extracted from patent WO2014151634A1, compound No.1. PD-1/PD-L1-IN 3 TFA interferes with PD-L1 binding to PD-1 and CD80 by binding to PD-L1, with IC50s of 5.60 nM and 7.04 nM, respectively. PD-1/PD-L1-IN 3 TFA can be used for the research of various diseases, including cancer and infectious diseases .
|
-
- HY-K0010
-
Maximum Cited Publications
978 Publications Verification
|
Protease inhibitor cocktail is used in cell lysates or tissue extracts to increase protein stability.
|
-
- HY-K0011
-
|
Protease inhibitor cocktail is used in cell lysates or tissue extracts to increase protein stability.
|
-
- HY-K6007
-
|
MCE Basement Membrane Matrix for Organoid Culture is primarily composed of natural basement membrane matrix extracted from mouse tumors. This product is mainly used for organoid culture.
|
-
- HY-K6006
-
|
MCE Basement Membrane Matrix IPSC-qualified is primarily composed of natural basement membrane matrix extracted from mouse tumors. This product is mainly used for stem cells culture.
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-
- HY-K0228
-
|
Oligo (dT)30 Magnetic Beads are designed for the rapid isolation of highly purified, intact mRNA from eukaryotic total RNA or directly from crude extracts of cells, plant and animal tissues.
|
-
- HY-K6002
-
1 Publications Verification
|
MCE Basement Membrane Matrix is primarily composed of natural basement membrane matrix extracted from mouse tumors.This product is mainly used for studies of tumor invasion, angiogenesis and organoids culture while avoiding color interference in subsequent experiments.
|
-
- HY-K6009
-
|
MCE Basement Membrane Matrix GFR&HC is primarily composed of natural basement membrane matrix extracted from mouse tumors, is suitable for cell cultures that need to reduce growth factor induction and studies related to growth factors, signaling pathways, etc.
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-
- HY-K6008
-
|
MCE Basement Membrane Matrix HC is primarily composed of natural basement membrane matrix extracted from mouse tumors, with higher content of various cytokines than the standard type.This product is mainly used for angiogenesis experiments, construction of animal models and 3D tumor models.
|
-
- HY-K6005
-
|
MCE Basement Membrane Matrix HC (Phenol Red) is primarily composed of natural basement membrane matrix extracted from mouse tumors, with higher content of various cytokines than the standard type.This product is mainly used for angiogenesis experiments, construction of animal models and 3D tumor models.
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Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
- HY-N0440
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- HY-117034
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- HY-N7341
-
-
- HY-N9451
-
-
- HY-N6572
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-
- HY-N3956
-
-
- HY-N10864
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-
- HY-N11900
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-
- HY-W194842
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-
- HY-N12370
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-
- HY-N12599
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-
- HY-W794998
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-
- HY-B0355
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-
- HY-N0890
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-
- HY-N2605
-
-
- HY-N5041
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-
- HY-N7662
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-
- HY-N4169
-
-
- HY-N10978
-
-
- HY-N3899
-
-
- HY-N3374
-
-
- HY-N11916
-
-
- HY-N3621
-
-
- HY-127029A
-
-
- HY-N3591
-
-
- HY-N12405
-
-
- HY-N3036
-
-
- HY-N3739
-
-
- HY-N0034
-
-
- HY-N1505
-
-
- HY-N0701
-
-
- HY-N6925
-
-
- HY-W017241
-
-
- HY-129208
-
-
- HY-N11025
-
-
- HY-N11100
-
-
- HY-N11543
-
-
- HY-N9909
-
-
- HY-N2975
-
-
- HY-N3290
-
-
- HY-N3882
-
-
- HY-N7927
-
-
- HY-N3440
-
-
- HY-N12190
-
-
- HY-N12239
-
-
- HY-N11921
-
-
- HY-N3309
-
-
- HY-N9125
-
-
- HY-N12515
-
-
- HY-N3613
-
-
- HY-N0659
-
-
- HY-N0258
-
-
- HY-42937
-
-
- HY-16502
-
-
- HY-N6249
-
-
- HY-N2376
-
-
- HY-N0687
-
-
- HY-N1089
-
-
- HY-N1340
-
-
- HY-N10884
-
-
- HY-W671746
-
-
- HY-N12251
-
-
- HY-N8452
-
-
- HY-N11985
-
-
- HY-126607
-
-
- HY-N11922
-
-
- HY-N12352
-
-
- HY-108170
-
-
- HY-N8482
-
-
- HY-N12596
-
-
- HY-N0841
-
-
- HY-N0145
-
-
- HY-N6584
-
-
- HY-N2623
-
-
- HY-N2401
-
-
- HY-N7657
-
-
- HY-113332
-
-
- HY-N5080
-
-
- HY-N9372
-
-
- HY-N8347
-
-
- HY-N9694
-
-
- HY-N11539
-
-
- HY-N3492
-
-
- HY-N3496
-
-
- HY-N1628
-
-
- HY-N8319
-
-
- HY-N12359
-
-
- HY-N9898
-
-
- HY-N12060
-
-
- HY-N0286
-
-
- HY-N4183
-
-
- HY-N0547
-
-
- HY-W002339
-
-
- HY-133865
-
-
- HY-N6255
-
-
- HY-105055
-
-
- HY-N11696
-
-
- HY-N9099
-
-
- HY-N11285
-
-
- HY-N7762
-
-
- HY-N8532
-
-
- HY-78036
-
-
- HY-N12580
-
-
- HY-N2954
-
-
- HY-N0098
-
-
- HY-122404
-
-
- HY-N3651
-
-
- HY-N0563
-
-
- HY-N3625
-
-
- HY-N0528
-
-
- HY-N1626
-
-
- HY-N10955
-
-
- HY-N3612A
-
-
- HY-N3652
-
-
- HY-N12014
-
-
- HY-119637
-
-
- HY-137583
-
-
- HY-N2087
-
-
- HY-N0009
-
-
- HY-111911
-
-
- HY-N6667
-
-
- HY-N0263
-
-
- HY-N2749
-
-
- HY-N10423
-
-
- HY-W009141
-
-
- HY-N9500
-
-
- HY-N10673
-
-
- HY-N3954
-
-
- HY-N8737
-
-
- HY-N4217
-
-
- HY-N12409
-
-
- HY-N9112
-
-
- HY-123080
-
-
- HY-N12579
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-
- HY-N0892
-
-
- HY-N0856
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-
- HY-B0923
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-
- HY-114336
-
-
- HY-N6008
-
-
- HY-N0398
-
-
- HY-N2628
-
-
- HY-15122
-
-
- HY-W004289
-
-
- HY-113427A
-
-
- HY-120333
-
-
- HY-32135
-
-
- HY-125115
-
-
- HY-125116
-
-
- HY-126389
-
-
- HY-133223
-
-
- HY-N3527
-
-
- HY-N0174
-
-
- HY-N0938
-
-
- HY-15122A
-
-
- HY-N2518
-
-
- HY-N6881
-
-
- HY-N0714
-
-
- HY-108277
-
-
- HY-N8377
-
-
- HY-N9454
-
-
- HY-N0975
-
-
- HY-N10672
-
-
- HY-N10694
-
-
- HY-N11702
-
-
- HY-N12175
-
-
- HY-N12367
-
-
- HY-N12439
-
-
- HY-N12575
-
-
- HY-N0706
-
-
- HY-N0546
-
-
- HY-125847
-
-
- HY-N5040
-
-
- HY-119580
-
-
- HY-N9524
-
-
- HY-N11021
-
-
- HY-N8617
-
-
- HY-N12343
-
-
- HY-N12471
-
-
- HY-N8520
-
-
- HY-N0858
-
-
- HY-N0776
-
-
- HY-N3386
-
-
- HY-N2558
-
-
- HY-N0564
-
-
- HY-N2417
-
-
- HY-N7494
-
-
- HY-N4232
-
-
- HY-N9381
-
-
- HY-N1160
-
-
- HY-N3866
-
-
- HY-N10133
-
-
- HY-127067
-
-
- HY-N12431
-
-
- HY-N12551
-
-
- HY-N12525
-
-
- HY-B0355R
-
-
- HY-N12566
-
-
- HY-N0040
-
-
- HY-N1516
-
-
- HY-N6942
-
-
- HY-N6945
-
-
- HY-N3075
-
-
- HY-W002110
-
-
- HY-N3977
-
-
- HY-N6606
-
-
- HY-N12001
-
-
- HY-N3007A
-
-
- HY-N8243
-
-
- HY-17388
-
-
- HY-N0332
-
-
- HY-N4095
-
-
- HY-N0726
-
-
- HY-N7029
-
-
- HY-N4309
-
-
- HY-N7439
-
-
- HY-N7542
-
-
- HY-N8914
-
-
- HY-121597
-
-
- HY-122949
-
-
- HY-N11993
-
-
- HY-N3411
-
-
- HY-W411439
-
-
- HY-N8761
-
-
- HY-32735
-
-
- HY-N0360
-
-
- HY-N6017
-
-
- HY-N4117
-
-
- HY-N3925
-
-
- HY-N9331
-
-
- HY-W012531
-
-
- HY-N8604
-
-
- HY-N12028
-
-
- HY-N0880
-
-
- HY-N2020
-
-
- HY-N2072
-
-
- HY-N6850
-
-
- HY-N6030
-
-
- HY-N6010
-
-
- HY-N4309A
-
-
- HY-N10603
-
Baihuaqianhuoside
|
Natural Products
Plants
Umbelliferae
Cunila spicata Benth.
|
Others
|
Praeroside (Baihuaqianhuoside), a coumarin glycoside. Praeroside can be extracted from the root of Peucedanum praeruptorum and Heracleum dissectum. Praeroside shows anti-inflammatory activity in vitro. Praeroside can be used for the research of inflammation .
|
-
- HY-N10685
-
-
- HY-N8589
-
-
- HY-N3642
-
-
- HY-N2809
-
-
- HY-N3872
-
-
- HY-N7324
-
-
- HY-N12552
-
-
- HY-N12710
-
-
- HY-N0044
-
-
- HY-N0800
-
-
- HY-N0770
-
-
- HY-N4084
-
-
- HY-N10356
-
-
- HY-N10890
-
-
- HY-N0098R
-
-
- HY-N3706
-
-
- HY-N2703
-
-
- HY-N2926
-
-
- HY-N7399
-
-
- HY-N7028
-
-
- HY-N2247A
-
-
- HY-N0730
-
-
- HY-12136
-
-
- HY-111588
-
-
- HY-N0746
-
-
- HY-N1098
-
-
- HY-N0676
-
-
- HY-N11667
-
-
- HY-N3048
-
-
- HY-N8730
-
-
- HY-N8859
-
-
- HY-N9966
-
-
- HY-131616
-
-
- HY-N0120A
-
-
- HY-N6845
-
-
- HY-N5106
-
-
- HY-N7699A
-
-
- HY-N7766
-
-
- HY-121381
-
-
- HY-N7486
-
-
- HY-N10791
-
-
- HY-N7321
-
-
- HY-N8225
-
-
- HY-135663
-
-
- HY-N0677
-
-
- HY-N4299
-
-
- HY-N4080
-
-
- HY-N6949
-
-
- HY-N2420
-
-
- HY-N7687
-
-
- HY-N9588
-
|
Flavonoids
Sesamum indicum Linn.
Pedaliaceae
Plants
Isoflavones
|
Others
|
Pedaliin is a bioactive component obtained from the ethanol extract of Sesame (Sesamum indicum L.) leaves (SLs). Pedaliin shows in vitro antioxidant and anti-colon cancer efficacy with radical scavenging activity and ferric reducing antioxidant power (FRAP) .
|
-
- HY-N10605
-
-
- HY-N7173
-
-
- HY-N8307
-
-
- HY-N10087
-
-
- HY-N9172
-
-
- HY-N12345
-
-
- HY-N12547
-
-
- HY-N6744
-
-
- HY-N6016
-
-
- HY-N10087A
-
-
- HY-N3283
-
-
- HY-N3974
-
-
- HY-N11970
-
-
- HY-N10079
-
-
- HY-N1504
-
-
- HY-N4193
-
-
- HY-N7206
-
-
- HY-N8110
-
-
- HY-N7330
-
-
- HY-N12032
-
-
- HY-N0776R
-
-
- HY-N6980
-
-
- HY-N2116
-
-
- HY-N6641
-
-
- HY-N7496
-
-
- HY-N0530
-
-
- HY-N0677A
-
-
- HY-N0484
-
-
- HY-N8228
-
-
- HY-N0611
-
-
- HY-N1778
-
-
- HY-N0406
-
-
- HY-137823
-
-
- HY-N3554
-
-
- HY-N3344
-
-
- HY-N12030
-
-
- HY-163113
-
-
- HY-N7140
-
-
- HY-N0479
-
-
- HY-119767
-
-
- HY-117616
-
-
- HY-N0712
-
-
- HY-126415
-
-
- HY-N9507
-
-
- HY-N8989
-
-
- HY-D0143A
-
-
- HY-N11137
-
-
- HY-N3240
-
-
- HY-N2438
-
-
- HY-N1620
-
-
- HY-N1671
-
-
- HY-W670700
-
-
- HY-125665
-
-
- HY-N7690
-
-
- HY-N8537
-
-
- HY-B0433B
-
-
- HY-N0120AR
-
-
- HY-W783267
-
-
- HY-N0044R
-
-
- HY-N0510
-
-
- HY-N0315
-
-
- HY-N6663
-
-
- HY-N0288
-
-
- HY-N0312
-
-
- HY-142074
-
-
- HY-N3824
-
-
- HY-N0041
-
-
- HY-N2022
-
-
- HY-N0392
-
-
- HY-N0047
-
-
- HY-N0261
-
-
- HY-N0284
-
-
- HY-N2203A
-
-
- HY-N9895
-
-
- HY-N2095
-
-
- HY-N6246
-
-
- HY-N2571
-
-
- HY-W017316
-
-
- HY-N7073
-
-
- HY-N7683
-
-
- HY-N9698
-
-
- HY-N7178
-
-
- HY-B2225B
-
-
- HY-W010668
-
|
Source classification
Plants
|
Flavivirus
Dengue virus
Parasite
Potassium Channel
|
Quinine sulfate hydrate (2:1:4) is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine sulfate hydrate (2:1:4) is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV with an IC50 of 169 μM .
|
-
- HY-N2939
-
-
- HY-N8029
-
-
- HY-N7165
-
-
- HY-111827
-
-
- HY-N2512
-
-
- HY-N7018
-
-
- HY-W001189
-
-
- HY-N7510
-
-
- HY-N9814
-
-
- HY-N9051
-
-
- HY-N9228
-
-
- HY-N12011
-
-
- HY-N7160
-
-
- HY-N12586
-
-
- HY-N2132
-
-
- HY-110028
-
-
- HY-N0485
-
-
- HY-N11020
-
-
- HY-N6973R
-
-
- HY-N0403
-
-
- HY-N3210
-
-
- HY-N7140R
-
-
- HY-N0551
-
-
- HY-N6018
-
-
- HY-N11844
-
-
- HY-N12349
-
-
- HY-W007376
-
-
- HY-107802
-
Breviscapinun
|
Structural Classification
Natural Products
Source classification
Plants
Compositae
Erigeron breviscapus (Vant.) Hand.-Mazz.
|
Others
|
Breviscapine is a crude flavonoid extract of Breviscapine, which is more than 85% of the active ingredient, Breviscapine. Breviscapine has a wide range of cardiovascular pharmacological activities, such as increasing blood flow, improving microcirculation, dilating blood vessels, reducing blood viscosity, promoting fibrinolysis, inhibiting platelet aggregation and thrombosis. Breviscapine has been used in the study of cerebral infarction and its sequelae, cerebral thrombosis, coronary heart disease and angina pectoris .
|
-
- HY-N11957
-
-
- HY-B1021
-
-
- HY-N2025
-
-
- HY-N6973
-
-
- HY-N0401A
-
-
- HY-N0041R
-
-
- HY-N0142
-
-
- HY-N2447
-
-
- HY-N0711
-
Cymophenol
|
Structural Classification
Monophenols
Preservatives
Classification of Application Fields
Labiatae
Phenols
Plants
Inflammation/Immunology
Disease Research Fields
Food Research
|
Notch
Apoptosis
Fungal
Endogenous Metabolite
Bacterial
|
Carvacrol is an orally active monoterpenic phenol that can be extract from an abundant number of aromatic plants, including thyme and oregano, possessing antioxidant, antibacterial, antifungal, anticancer, anti-inflammatory, hepatoprotective, spasmolytic, and vasorelaxant properties. Carvacrol also causes cell cycle arrest in G0/G1, downregulates Notch-1, and Jagged-1, and induces apoptosis. Carvacrol is used in low concentrations as a food flavoring ingredient and preservative, as well as a fragrance ingredient in cosmetic formulations .
|
-
- HY-N1346
-
-
- HY-N11997
-
-
- HY-N4314
-
4',5,6,7-Tetramethoxyflavone
|
Infection
Structural Classification
Flavonoids
Classification of Application Fields
Flavones
Plants
Compositae
Inflammation/Immunology
Disease Research Fields
Genista maderensis (Webb & Berthel.) Lowe
|
Bacterial
|
Scutellarein tetramethyl ether (4',5,6,7-Tetramethoxyflavone) is a bioactive component of Siam weed extract. Scutellarein tetramethyl ether (4',5,6,7-Tetramethoxyflavone) exhibits anti-inflammatory activity through NF-κB pathway . Scutellarein tetramethyl ether (4',5,6,7-Tetramethoxyflavone) modulats of bacterial agent resistance via efflux pump inhibition . Scutellarein tetramethyl ether (4',5,6,7-Tetramethoxyflavone) can enhance blood coagulation .
|
-
- HY-113120
-
-
- HY-N0408
-
-
- HY-N0103
-
-
- HY-N0103A
-
-
- HY-N7041
-
-
- HY-138098
-
-
- HY-N8788
-
-
- HY-N11507
-
TKV
|
Triterpenes
Structural Classification
Terpenoids
Source classification
Plants
Umbelliferae
|
PPAR
|
Tibesaikosaponin V (TKV) is a triterpene diglycoside, which can be isolated from the methanol extract of the roots of Bupleurum chinense DC.. Tibesaikosaponin V inhibits lipid accumulation and triacylglycerol content occurred without cytotoxicity to adipocytes. Tibesaikosaponin V suppresses the mRNA expression of nuclear transcription factors, such as peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer binding protein α (C/EBPα). Tibesaikosaponin V inhibits 3T3-L1 preadipocyte differentiation. Tibesaikosaponin V can be used fro research of obesity and its associated metabolic disorders .
|
-
- HY-115407
-
|
Structural Classification
Natural Products
Microorganisms
Source classification
|
Bacterial
|
Cochliodone A is an active compound extracted from cultures of the deep-sea derived fungus Chaetomium sp. and has antibacterial and anticancer activity. Cochliodone A is toxic to a variety of bacteria, with MICs of 15.3 μg/mL (V. vulnificus), 32.7 μg/mL (V. rotiferianus), 15.9 μg/mL (S. aureus ATCC 43300), and 16.3 μg/mL (S . aureus CGMCC 1.12409). Cochliodone A also inhibits a variety of cancer cell lines, with IC50s of 28.1 μM (A549), 20.7 μM (HeLa), and 23.2 μM (Hep G2) .
|
-
- HY-N0142R
-
-
- HY-N0373
-
-
- HY-N11009
-
-
- HY-N6954
-
|
Structural Classification
other families
Xanthones
Classification of Application Fields
Garcinia oblongifolia Champ. ex Benth.
Source classification
Guttiferae
Phenols
Polyphenols
Plants
Disease Research Fields
Cancer
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ATM/ATR
STAT
CDK
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Garcinone C, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia that is used as an anti-inflammatory, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and 4E-BP1, while efficiently inhibiting the expression levels of cyclin B1, cyclin D1, cyclin E2, cdc2, Stat3 and CDK7. Garcinone C significantly inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time‑ and dose‑dependent manner .
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- HY-N9174
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Structural Classification
Flavonoids
Flavones
Source classification
Plants
Moraceae
Broussonetia papyrifera (Linnaeus) L'Heritier ex Ventenat
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Others
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5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone is a natural product that can be extracted from B. papyrifera. 5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone has potent anti-proliferation effects on ER-positive breast cancer cells, with an IC50 value of 4.41 μM for MCF-7 cells. 5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone also reduces the tumor growth in the BCAP-37 xenograft .
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- HY-N0926A
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- HY-N9790
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Structural Classification
Source classification
Vitis vinifera cv. Zalema
Phenols
Polyphenols
Plants
Vitaceae
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Notch
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Procyanidin B2, 3,3'-di-O-gallate is an active constituent. Procyanidin B2, 3,3'-di-O-gallate can be isolated from grape seed extract (GSE) procyanidin mix. Procyanidin B2, 3,3' -di-o-gallate target cancer stem cells (CSCs) in prostate cancer (PCa). Procyanidin B2, 3,3'-di-O-gallate targets both unsorted and sorted CSCs at lower doses. Procyanidin B2, 3,3'-di-O-gallate strongly suppresses the constitutive as well as Jagged1 (Notch1 ligand)-induced activated Notch1 pathway .
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- HY-108052
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- HY-N2789
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Structural Classification
Natural Products
Source classification
Plants
Umbelliferae
Angelica apaensis R. H. Shan & C. Q. Yuan
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Bacterial
Fungal
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(9Z)-9,17-Octadecadiene-12,14-diyne-1,11,16-triol is a nature product that could be isolated from the ethyl acetate extract of Cassonia barteri (Araliaceae) leaves. (9Z)-9,17-Octadecadiene-12,14-diyne-1,11,16-triol has antibacterial activity against Bacillus subtilis and Pseudomonas fluorescens, antifungal activity against Cladosporium cucumerinum, moiluscicidal activity against Biomphalaria glabrata . (9Z)-9,17-Octadecadiene-12,14-diyne-1,11,16-triol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-B1890
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Cat. No. |
Product Name |
Chemical Structure |
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- HY-13749AS
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Sitagliptin-d4 (phosphate) is the deuterium labeled Sitagliptin phosphate. Sitagliptin phosphate (MK-0431 phosphate) is a potent inhibitor of DPP4 with an IC50 of 19 nM in Caco-2 cell extracts[1][2].
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- HY-13749S1
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Sitagliptin-d4 (hydrochloride) is the deuterium labeled Sitagliptin[1]. Sitagliptin (MK-0431) is a potent inhibitor of DPP4 with an IC50 of 19 nM in Caco-2 cell extracts[2].
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- HY-W700539S
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N1-Acetyl triethylenetetramine-d4 is deuterated N1-Acetyl triethylenetetramine and can be used as an internal standard in plasma extracts .
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- HY-139593S
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Polθ-IN-1-d3 (example 1) is a deuterated Polθ inhibitor used for cancer study (extracted from patent WO2021028670) .
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- HY-N0098S3
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Vanillin- 13C is the 13C labeled Vanillin[1]. Vanillin (p-Vanillin) is a single molecule extracted from vanilla beans and also a popular odor used widely in perfume, food and medicine[2][3].
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- HY-N0098S2
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Vanillin- 13C6 is the 13C labeled Vanillin[1]. Vanillin (p-Vanillin) is a single molecule extracted from vanilla beans and also a popular odor used widely in perfume, food and medicine[2][3].
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- HY-113427AS
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cis-Vaccenic acid-d13 is the deuterium labeled cis-Vaccenic acid. cis-Vaccenic acid, the antiviral extract from Rhodopseudomonas capsulate and the predominant active component of Rhodopseudomonas capsulate[1], acts a potential fetal hemoglobin inducer[2].
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- HY-N0098S1
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4- Hydroxy- 3- methoxy benzaldehyde- d3 is the deuterium labeled Vanillin[1]. Vanillin (p-Vanillin) is a single molecule extracted from vanilla beans and also a popular odor used widely in perfume, food and medicine[2][3].
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- HY-N7494S
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Pentacosane-d52 is the deuterium labeled Pentacosane[1]. Pentacosane is one of the major components in the acetone extract from Curcuma raktakanda and is also in the essential oil from the leaves of Malus domestica. Pentacosane exhibit anti-cancer activities[2].
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- HY-32735S
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Triptolide-d3 is the deuterium labeled Triptolide. Triptolide is a diterpenoid triepoxide extracted from the root of Tripterygium wilfordii with immunosuppressive, anti-inflammatory, antiproliferative and antitumour effects. Triptolide is a NF-κB activation inhibitor[1][2][3][4][5][6].
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- HY-N0098S
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Vanillin- 13C,d3 is the 13C and deuterium labeled Vanillin[1]. Vanillin (p-Vanillin) is a single molecule extracted from vanilla beans and also a popular odor used widely in perfume, food and medicine[2][3].
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- HY-79369S
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Succinic anhydride-d4 is the deuterium labeled Succinic anhydride. Succinic anhydride is a cyclic anhydride and a nonclaevable ADC linker extracted from patent WO2009064913A1. Succinic anhydride can react with compound 4 of the patent to link the proagent to an amine or hydroxy 1 group of a targeting polypeptide[1].
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- HY-79369S1
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Succinic anhydride- 13C2 is the 13C labeled Succinic anhydride[1]. Succinic anhydride is a cyclic anhydride and a nonclaevable ADC linker extracted from patent WO2009064913A1. Succinic anhydride can react with compound 4 of the patent to link the proagent to an amine or hydroxy 1 group of a targeting polypeptide[2].
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- HY-B0688S
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Dapsone-d8 is a deuterium labeled Dapsone. Dapsone is an orally active and blood-brain penetrant sulfonamide antibiotic with antibacterial, antigenic and anti-inflammatory activities[1]. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone can be used as an anticonvulsant and also in the research of skin and glioblastoma diseases[2][3][4][5].
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- HY-B0688S1
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Dapsone-d4 is the deuterium labeled Dapsone. Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities[1]. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al[2][3].
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- HY-B1290S
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2-Phenylethanol-d4 is the deuterium labeled 2-Phenylethanol[1]. 2-Phenylethanol (Phenethyl alcohol), extracted from rose, carnation, hyacinth, Aleppo pine, orange blossom and other organisms, is a colourless liquid. It has a pleasant floral odor and also an autoantibiotic produced by the fungus Candida albicans[2]. It is used as an additive in cigarettes and also used as a preservative in soaps due to its stability in basic conditions.
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- HY-B1290S1
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2-Phenylethanol-d9 is the deuterium labeled 2-Phenylethanol[1]. 2-Phenylethanol (Phenethyl alcohol), extracted from rose, carnation, hyacinth, Aleppo pine, orange blossom and other organisms, is a colourless liquid. It has a pleasant floral odor and also an autoantibiotic produced by the fungus Candida albicans[2]. It is used as an additive in cigarettes and also used as a preservative in soaps due to its stability in basic conditions.
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- HY-B1290S2
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2-Phenylethanol-d5 is the deuterium labeled 2-Phenylethanol[1]. 2-Phenylethanol (Phenethyl alcohol), extracted from rose, carnation, hyacinth, Aleppo pine, orange blossom and other organisms, is a colourless liquid. It has a pleasant floral odor and also an autoantibiotic produced by the fungus Candida albicans[2]. It is used as an additive in cigarettes and also used as a preservative in soaps due to its stability in basic conditions.
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- HY-B0688S2
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Dapsone- 13C12 is the 13C12 labeled Dapsone (HY-B0688). Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al .
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- HY-W007376S
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Indole-3-carboxaldehyde- 13C (3-Formylindole- 13C) is a 13C labeled Indole-3-carboxaldehyde (HY-W007376). Indole-3-carboxaldehyde (3-Formylindole), a banlangen extract, is the product of the oxidative degradation of indole-3-acetic acid (IAA) by crude enzyme preparations from etiolated pea seedlings. Indole-3-carboxaldehyde (3-Formylindole) is a biochemical used to prepare analogs of the indole phytoalexin cyclobrassinin .
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Cat. No. |
Product Name |
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Classification |
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- HY-U00318
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Alkynes
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JAK-IN-11 is a potent and selective JAK inhibitor extracted from patent WO2012122452A1, Compound II, has the potential for the skin disorders (such as cutaneous lupus) treatment . JAK-IN-11 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-156519
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Alkynes
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ALPK1-IN-3 is an inhibitor of ALPK1 extracted from patent WO2022063153A1 compound T007. ALPK1-IN-3 inhibits kidney proinflammatory gene expression and improves the survival rate of the animals in sepsis induced acute kidney injury animal model . ALPK1-IN-3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-132137
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Azide
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5-Propargylamino-3'-azidomethyl-dUTP is a nucleoside molecule extracted from patent WO2004018497A2, compound 5. 5-Propargylamino-3'-azidomethyl-dUTP can be used in DNA synthesis and DNA sequencing . 5-Propargylamino-3'-azidomethyl-dUTP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-147595
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Alkynes
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KRAS G12D inhibitor 15 is a potent inhibitor of KRAS G12D. KRAS G12D inhibitor 15 has the potential for the research of various diseases or disorders, such as cancer or cancer metastasis (extracted from patent WO2022042630A1, compound 243) . KRAS G12D inhibitor 15 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-132138
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Azide
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5-Propargylamino-3'-azidomethyl-dCTP is a nucleoside molecule extracted from patent WO2004018497A2, compound 17. 5-Propargylamino-3'-azidomethyl-dCTP can be used in DNA synthesis and DNA sequencing . 5-Propargylamino-3'-azidomethyl-dCTP is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
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