1. Protein Tyrosine Kinase/RTK
  2. RET
  3. cis-Pralsetinib

cis-Pralsetinib (Synonyms: cis-Blu667)

Cat. No.: HY-112301A
Handling Instructions

cis-Pralsetinib (cis-Blu667) is a highly potent and selective inhibitor of rearranged during transfection (RET), with IC50 values ranging from 0.3 to 0.4 nM for WT RET and four enzyme variants (V804L, V804M, M918T, CCDC6-RET), and with broad, robust and anti-tumor activity against multiple RET-driven solid tumor types.

For research use only. We do not sell to patients.

cis-Pralsetinib Chemical Structure

cis-Pralsetinib Chemical Structure

CAS No. : 2097132-93-7

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Description

cis-Pralsetinib (cis-Blu667) is a highly potent and selective inhibitor of rearranged during transfection (RET), with IC50 values ranging from 0.3 to 0.4 nM for WT RET and four enzyme variants (V804L, V804M, M918T, CCDC6-RET), and with broad, robust and anti-tumor activity against multiple RET-driven solid tumor types[1][2].

IC50 & Target

IC50: 0.4 nM (WT RET), 0.3 nM (RET V804L), 0.4 nM (RET V804M), 0.4 nM (RET M918T), 0.4 nM (CCDC6-RET)[2]

Clinical Trial
Molecular Weight

533.60

Formula

C₂₇H₃₂FN₉O₂

CAS No.

2097132-93-7

SMILES

O=C([[email protected]@]1(OC)CC[[email protected]@H](C2=NC(NC3=NNC(C)=C3)=CC(C)=N2)CC1)N[[email protected]](C4=CC=C(N5N=CC(F)=C5)N=C4)C

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Please store the product under the recommended conditions in the Certificate of Analysis.

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cis-Pralsetinib
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