Neobritannilactone B
Neobritannilactone B, a sesquiterpene, can be isolated from the chloroform fraction of the I. britannica. Neobritannilactone B is cytotoxic. Other extracts of I. britannica are also Dihydrofolate reductase (DHFR) inhibitors, which inhibit Shigella dysenteriae type 1.
For research use only. We do not sell to patients.
- CAS No.: 886990-00-7
- Formula: C15H20O3
- Molecular Weight:248.32
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| AGS | IC50 |
21.4 μM
Compound: 3, neobritannilactone B
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Cytotoxicity against human AGS cells after 24 hrs by trypan blue exclusion assay
Cytotoxicity against human AGS cells after 24 hrs by trypan blue exclusion assay
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[PMID: 16643020] |
| COLO 205 | IC50 |
14.3 μM
Compound: 3, neobritannilactone B
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Cytotoxicity against human COLO205 cells after 24 hrs by trypan blue exclusion assay
Cytotoxicity against human COLO205 cells after 24 hrs by trypan blue exclusion assay
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[PMID: 16643020] |
| HL-60 | IC50 |
27.4 μM
Compound: 3, neobritannilactone B
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Cytotoxicity against human HL60 cells after 24 hrs by trypan blue exclusion assay
Cytotoxicity against human HL60 cells after 24 hrs by trypan blue exclusion assay
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[PMID: 16643020] |
| HT-29 | IC50 |
56.1 μM
Compound: 3, neobritannilactone B
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Cytotoxicity against human HT29 cells after 24 hrs by trypan blue exclusion assay
Cytotoxicity against human HT29 cells after 24 hrs by trypan blue exclusion assay
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[PMID: 16643020] |
Chemical Information
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CAS No. 886990-00-7
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Molecular Weight 248.32
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Formula C15H20O3
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SMILES
C=C1C(O[C@H]2/C=C(CC/C=C(C[C@@H]([C@@H]12)O)\C)\C)=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Choo SJ, et al. Hypo-pigmenting effect of sesquiterpenes from Inula britannica in B16 melanoma cells. Arch Pharm Res. 2014 May;37(5):567-74. [Content Brief]
[2]. Jose S, et al. Phytochemical constituents of Inula britannica as potential inhibitors of dihydrofolate reductase: A strategic approach against shigellosis. J Biomol Struct Dyn. 2022;40(22):11932-11947. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Neobritannilactone B Related Classifications
HY-N10791 Related Classifications
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