Sesquiterpene lactones from Inula britannica and their cytotoxic and apoptotic effects on human cancer cell lines

  • J Nat Prod. 2006 Apr;69(4):531-5. doi: 10.1021/np050437q.
Naisheng Bai  1 ,  Ching-Shu Lai ,  Kan He ,  Zhu Zhou ,  Li Zhang ,  Zheng Quan ,  Nanqun Zhu ,  Qun Yi Zheng ,  Min-Hsiung Pan ,  Chi-Tang Ho
Affiliations
  • 1. Department of Food Science, Rutgers University, 65 Dudley Road, New Brunswick, NJ 08901, USA.
PMID: 16643020 DOI: 10.1021/np050437q
Abstract

Three new Sesquiterpenes (1-3), together with four known sesquiterpene Lactones, were isolated from the flowers of Inula britannica var. chinensis. Structures were established on the basis of high-field 1D and 2D NMR methods supported by HRMS. All sesquiterpene Lactones were tested for cytotoxicity as well as apoptotic ratio in human COLO 205, HT 29, HL-60, and AGS Cancer cells. Compounds 3 and 4, two alpha-methylene gamma-lactone-bearing Sesquiterpenes, were modestly active in these assays.