886990-00-7
Chemical Structure
Neobritannilactone B
- CAS No.: 886990-00-7
- Formula:C15H20O3
- Molecular Weight:248.32
IUPAC Name: (3aR,4S,6E,10E,11aS)-4-hydroxy-6,10-dimethyl-3-methylene-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-2(3H)-one
InChIKey: PDEJECFRCJOMEN-RZPRNJIHSA-N
SMILES: C=C1C(O[C@H]2/C=C(CC/C=C(C[C@@H]([C@@H]12)O)\C)\C)=O
Biological Activity: Neobritannilactone B, a sesquiterpene, can be isolated from the chloroform fraction of the I. britannica. Neobritannilactone B is cytotoxic. Other extracts of I. britannica are also Dihydrofolate reductase (DHFR) inhibitors, which inhibit Shigella dysenteriae type 1[1][2].
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Neobritannilactone B | Neobritannilactone B, a sesquiterpene, can be isolated from the chloroform fraction of the I. britannica. Neobritannilactone B is cytotoxic. Other extracts of I. britannica are also Dihydrofolate reductase (DHFR) inhibitors, which inhibit Shigella dysenteriae type 1. | |||||||||||||||||||||
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- [1]. Choo SJ, et al. Hypo-pigmenting effect of sesquiterpenes from Inula britannica in B16 melanoma cells. Arch Pharm Res. 2014 May;37(5):567-74. [Content Brief]
- [2]. Jose S, et al. Phytochemical constituents of Inula britannica as potential inhibitors of dihydrofolate reductase: A strategic approach against shigellosis. J Biomol Struct Dyn. 2022;40(22):11932-11947. [Content Brief]
Keywords
