2. MAPK/ERK Pathway
  3. Raf
  4. B-Raf IN 2

B-Raf IN 2 

Cat. No.: HY-145120 Purity: 99.27%
COA Handling Instructions

B-Raf IN 2 is a potent and selective BRAF inhibitor extracted from patent WO2021116055A1, compound Ia. B-Raf IN 2 can be used for the research of cancer.

For research use only. We do not sell to patients.

B-Raf IN 2 Chemical Structure

B-Raf IN 2 Chemical Structure

CAS No. : 2649372-20-1

Size Price Stock Quantity
5 mg USD 260 In-stock
10 mg USD 420 In-stock
25 mg USD 840 In-stock
50 mg USD 1350 In-stock
100 mg USD 2200 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

B-Raf IN 2 Related Antibodies

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Description

B-Raf IN 2 is a potent and selective BRAF inhibitor extracted from patent WO2021116055A1, compound Ia. B-Raf IN 2 can be used for the research of cancer[1].

IC50 & Target

BRafV600E

 

In Vitro

B-Raf IN 2 shows considerably less paradoxial activation of the MAPK signaling pathway while retaining high potency[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

B-Raf IN 2 Related Antibodies
Molecular Weight

461.44

Appearance

Solid

Formula

C20H17F2N5O4S
CAS No.
SMILES

N#CC1=C(C(F)=CC=C1NS(=O)(N2C[C@@H](CC2)F)=O)OC3=CC=C(N=CN(C4=O)C)C4=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (216.71 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1671 mL 10.8356 mL 21.6713 mL
5 mM 0.4334 mL 2.1671 mL 4.3343 mL
10 mM 0.2167 mL 1.0836 mL 2.1671 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (5.42 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation
References
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B-Raf IN 2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

B-Raf IN 22649372-20-1RafRaf kinasesBRAFcancerInhibitorinhibitorinhibit

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