2. Immunology/Inflammation
  3. Interleukin Related
  4. IL-17 modulator 1 disodium

IL-17 modulator 1 (disodium) is an orally active, highly efficacious IL-17 modulator extracted from patent WO 2020127685. IL-17 modulator 1 (disodium) can be used for the research of diseases including psoriasis, ankylosing spondylitis and psoriatic arthritis.

For research use only. We do not sell to patients.

IL-17 modulator 1 disodium Chemical Structure

IL-17 modulator 1 disodium Chemical Structure

CAS No. : 2446803-91-2

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5 mg USD 1280 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

IL-17 modulator 1 (disodium) is an orally active, highly efficacious IL-17 modulator extracted from patent WO 2020127685. IL-17 modulator 1 (disodium) can be used for the research of diseases including psoriasis, ankylosing spondylitis and psoriatic arthritis[1].

IC50 & Target[1]

IL-17

 

Molecular Weight

628.57

Formula

C28H35N6Na2O6P
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=NN1C(C)C)N[C@H](C(NC2=CC=C(C3=C(N(N=C3C)COP(O[Na])(O[Na])=O)C)C=C2)=O)C(C4CC4)C5CC5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (31.82 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5909 mL 7.9546 mL 15.9091 mL
5 mM 0.3182 mL 1.5909 mL 3.1818 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5909 mL 7.9546 mL 15.9091 mL 39.7728 mL
5 mM 0.3182 mL 1.5909 mL 3.1818 mL 7.9546 mL
10 mM 0.1591 mL 0.7955 mL 1.5909 mL 3.9773 mL
15 mM 0.1061 mL 0.5303 mL 1.0606 mL 2.6515 mL
20 mM 0.0795 mL 0.3977 mL 0.7955 mL 1.9886 mL
25 mM 0.0636 mL 0.3182 mL 0.6364 mL 1.5909 mL
30 mM 0.0530 mL 0.2652 mL 0.5303 mL 1.3258 mL
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IL-17 modulator 1 disodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IL-17 modulator 1 disodium2446803-91-2Interleukin RelatedILorallyefficacioussmall-moleculepsoriasisankylosingspondylitisarthritisInhibitorinhibitorinhibit

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