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Cat. No.: HY-127067

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Yuanhuadin

Yuanhuadin, extracted from Genkwa Flos Daphne genkwa, has antitumor activity through inhibiting Akt/mTOR and EGFR pathways, induce cell-cycle arrest and abortion.

For research use only. We do not sell to patients.

CAS No.: 76402-66-9
Formula: C₃₂H₄₂O₁₀
Molecular Weight:586.67

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Yuanhuadin Chemical Structure

CAS No.: 76402-66-9

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Antibody-Drug Conjugates

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Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

Yuanhuadin, extracted from Genkwa Flos Daphne genkwa, has antitumor activity through inhibiting Akt/mTOR and EGFR pathways, induce cell-cycle arrest and abortion^[1].

All Akt Isoforms :

All mTOR Isoforms :

All EGFR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	>50 μM Compound: 9	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 23558238]
A549	IC₅₀	12 nM Compound: 1	Antiproliferative activity against human A549 cells after 3 days by SRB assay Antiproliferative activity against human A549 cells after 3 days by SRB assay	[PMID: 21916433]
B16	IC₅₀	0.06 μM Compound: 4	Inhibition of melanin production in alpha-MSH stimulated mouse B16 cells after 72 hrs by spectrophotometry Inhibition of melanin production in alpha-MSH stimulated mouse B16 cells after 72 hrs by spectrophotometry	[PMID: 23623417]
B16	IC₅₀	22 μM Compound: 4	Cytotoxicity against alpha-MSH stimulated mouse B16 cells after 72 hrs by MTT assay Cytotoxicity against alpha-MSH stimulated mouse B16 cells after 72 hrs by MTT assay	[PMID: 23623417]
HCT-116	IC₅₀	10.2 μM Compound: 1	Antiproliferative activity against human HCT116 cells after 3 days by SRB assay Antiproliferative activity against human HCT116 cells after 3 days by SRB assay	[PMID: 21916433]
HCT-116	IC₅₀	32.65 μM Compound: 9	Cytotoxicity against human HCT116 cells after 48 hrs by MTT assay Cytotoxicity against human HCT116 cells after 48 hrs by MTT assay	[PMID: 23558238]
HeLa	IC₅₀	17.06 μM Compound: 9	Cytotoxicity against human HeLa cells after 48 hrs by MTT assay Cytotoxicity against human HeLa cells after 48 hrs by MTT assay	[PMID: 23558238]
HepG2	IC₅₀	26.27 μM Compound: 9	Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 23558238]
HL-60	IC₅₀	30.05 μM Compound: 9	Cytotoxicity against human HL60 cells after 48 hrs by MTT assay Cytotoxicity against human HL60 cells after 48 hrs by MTT assay	[PMID: 23558238]
HT-1080	IC₅₀	<0.1 μM Compound: 9	Cytotoxicity against human HT1080 cells after 48 hrs by MTT assay Cytotoxicity against human HT1080 cells after 48 hrs by MTT assay	[PMID: 23558238]
K562	IC₅₀	22.16 μM Compound: 9	Cytotoxicity against human K562 cells after 48 hrs by MTT assay Cytotoxicity against human K562 cells after 48 hrs by MTT assay	[PMID: 23558238]
LoVo	IC₅₀	>10 μM Compound: 10	Cytotoxicity against human LoVo cells after 24 hrs by MTT assay Cytotoxicity against human LoVo cells after 24 hrs by MTT assay	[PMID: 32223193]
MCF7	IC₅₀	4.11 μM Compound: 9	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 23558238]
MT4	CC₅₀	>6.8 μM Compound: 14	Cytotoxicity against human MT4 cells incubated for 3 days by CellTiter-Glo luminescent assay Cytotoxicity against human MT4 cells incubated for 3 days by CellTiter-Glo luminescent assay	[PMID: 31860304]
NCI-H1299	IC₅₀	5.6 μM Compound: 1	Antiproliferative activity against human H1299 cells after 3 days by SRB assay Antiproliferative activity against human H1299 cells after 3 days by SRB assay	[PMID: 21916433]
NCI-H1993	IC₅₀	4.1 nM Compound: 1	Antiproliferative activity against gefitinib resistant human NCI-H1993 cells after 3 days by SRB assay Antiproliferative activity against gefitinib resistant human NCI-H1993 cells after 3 days by SRB assay	[PMID: 21916433]
NCI-H1993	IC₅₀	4.7 nM Compound: 1	Antiproliferative activity against human NCI-H1993 cells after 3 days by SRB assay Antiproliferative activity against human NCI-H1993 cells after 3 days by SRB assay	[PMID: 21916433]
NCI-H292	IC₅₀	<1 x 10^-6μM Compound: 1	Antiproliferative activity against gefitinib resistant human NCI-H292 cells after 3 days by SRB assay Antiproliferative activity against gefitinib resistant human NCI-H292 cells after 3 days by SRB assay	[PMID: 21916433]
NCI-H292	IC₅₀	<1 x 10^-6μM Compound: 1	Antiproliferative activity against human NCI-H292 cells after 3 days by SRB assay Antiproliferative activity against human NCI-H292 cells after 3 days by SRB assay	[PMID: 21916433]
NCI-H358	IC₅₀	9.1 μM Compound: 1	Antiproliferative activity against human NCI-H358 cells after 3 days by SRB assay Antiproliferative activity against human NCI-H358 cells after 3 days by SRB assay	[PMID: 21916433]
PC-3	IC₅₀	7.4 μM Compound: 1	Antiproliferative activity against human PC3 cells after 3 days by SRB assay Antiproliferative activity against human PC3 cells after 3 days by SRB assay	[PMID: 21916433]
RKO	IC₅₀	>10 μM Compound: 10	Cytotoxicity against human RKO cells after 24 hrs by MTT assay Cytotoxicity against human RKO cells after 24 hrs by MTT assay	[PMID: 32223193]
SK-HEP1	IC₅₀	12.9 μM Compound: 1	Antiproliferative activity against human SKHEP1 cells after 3 days by SRB assay Antiproliferative activity against human SKHEP1 cells after 3 days by SRB assay	[PMID: 21916433]
SK-MES-1	IC₅₀	<1 x 10^-6μM Compound: 1	Antiproliferative activity against human SK-MES cells after 3 days by SRB assay Antiproliferative activity against human SK-MES cells after 3 days by SRB assay	[PMID: 21916433]
SNU-638	IC₅₀	>20 μM Compound: 1	Antiproliferative activity against human SNU638 cells after 3 days by SRB assay Antiproliferative activity against human SNU638 cells after 3 days by SRB assay	[PMID: 21916433]
SW480	IC₅₀	11.8 μM Compound: 1	Antiproliferative activity against human SW480 cells after 3 days by SRB assay Antiproliferative activity against human SW480 cells after 3 days by SRB assay	[PMID: 21916433]
SW-620	IC₅₀	>10 μM Compound: 10	Cytotoxicity against human SW620 cells after 24 hrs by MTT assay Cytotoxicity against human SW620 cells after 24 hrs by MTT assay	[PMID: 32223193]
T47D	IC₅₀	12.7 μM Compound: 1	Antiproliferative activity against human T47D cells after 3 days by SRB assay Antiproliferative activity against human T47D cells after 3 days by SRB assay	[PMID: 21916433]
U-937	IC₅₀	14.66 μM Compound: 9	Cytotoxicity against human U937 cells after 48 hrs by MTT assay Cytotoxicity against human U937 cells after 48 hrs by MTT assay	[PMID: 23558238]

Chemical Information

CAS No. 76402-66-9
Molecular Weight 586.67
Formula C₃₂H₄₂O₁₀
SMILES

O=C1C(C)=C[C@@H]2[C@]3([C@H]4[C@H]5O[C@@]5([C@H]([C@@]12O)O)CO)O[C@]6(O[C@@]([C@@H](OC(C)=O)[C@H]3C)([C@H]4O6)C(C)=C)/C=C/C=C/CCCCC
Structure Classification
- Terpenoids
- Diterpenoids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Christian Bailly, et al. Yuanhuacin and Related Anti-Inflammatory and Anticancer Daphnane Diterpenes from Genkwa Flos—An Overview. Biomolecules. 2022 Feb; 12(2): 192.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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Yuanhuadin

All Akt Isoforms

All mTOR Isoforms

All EGFR Isoforms