1. PROTAC
  2. Ligand for E3 Ligase
  3. CRBN modulator-1

CRBN modulator-1 

Cat. No.: HY-138040
Handling Instructions

CRBN modulator-1, a Thalidomide analog and a CRBN modulator extracted from WO2020006262A1, compound 10, has an IC50 of 3.5 μM and a Ki of 0.98 μM.

For research use only. We do not sell to patients.

CRBN modulator-1 Chemical Structure

CRBN modulator-1 Chemical Structure

CAS No. : 2407829-65-4

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Description

CRBN modulator-1, a Thalidomide analog and a CRBN modulator extracted from WO2020006262A1, compound 10, has an IC50 of 3.5 μM and a Ki of 0.98 μM[1].

IC50 & Target[1]

Cereblon

 

Molecular Weight

324.29

Formula

C₁₇H₁₂N₂O₅

CAS No.
SMILES

O=C1N(C(CC2)C(NC2=O)=O)C(C3=CC(O)=CC4=CC=CC1=C34)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (30.84 mM; ultrasonic and adjust pH to 2 with HCl)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0837 mL 15.4183 mL 30.8366 mL
5 mM 0.6167 mL 3.0837 mL 6.1673 mL
10 mM 0.3084 mL 1.5418 mL 3.0837 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

CRBN modulator-1CRBN modulator1CRBN modulator 1Ligand for E3 LigaseE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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CRBN modulator-1
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HY-138040
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