2. PROTAC
  3. Ligands for E3 Ligase
  4. CRBN modulator-1

CRBN modulator-1, a Thalidomide analog and a CRBN modulator extracted from WO2020006262A1, compound 10, has an IC50 of 3.5 μM and a Ki of 0.98 μM.

For research use only. We do not sell to patients.

CRBN modulator-1 Chemical Structure

CRBN modulator-1 Chemical Structure

CAS No. : 2407829-65-4

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 165 In-stock
Solution
10 mM * 1 mL in DMSO USD 165 In-stock
Solid
1 mg USD 71 In-stock
5 mg USD 150 In-stock
10 mg USD 250 In-stock
25 mg USD 450 In-stock
50 mg USD 750 In-stock
100 mg USD 1250 In-stock
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500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

CRBN modulator-1 Related Antibodies

Top Publications Citing Use of Products

View All Ligands for E3 Ligase Isoform Specific Products:

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von Hippel-Lindau (VHL) MDM2 Cereblon IAP

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Description

CRBN modulator-1, a Thalidomide analog and a CRBN modulator extracted from WO2020006262A1, compound 10, has an IC50 of 3.5 μM and a Ki of 0.98 μM[1].

IC50 & Target[1]

Cereblon

 

Molecular Weight

324.29

Formula

C17H12N2O5
CAS No.
Appearance

Solid

Color

Light green to green

SMILES

O=C1N(C(CC2)C(NC2=O)=O)C(C3=CC(O)=CC4=CC=CC1=C34)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (30.84 mM; ultrasonic and adjust pH to 2 with HCl; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0837 mL 15.4183 mL 30.8366 mL
5 mM 0.6167 mL 3.0837 mL 6.1673 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0837 mL 15.4183 mL 30.8366 mL 77.0915 mL
5 mM 0.6167 mL 3.0837 mL 6.1673 mL 15.4183 mL
10 mM 0.3084 mL 1.5418 mL 3.0837 mL 7.7091 mL
15 mM 0.2056 mL 1.0279 mL 2.0558 mL 5.1394 mL
20 mM 0.1542 mL 0.7709 mL 1.5418 mL 3.8546 mL
25 mM 0.1233 mL 0.6167 mL 1.2335 mL 3.0837 mL
30 mM 0.1028 mL 0.5139 mL 1.0279 mL 2.5697 mL
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CRBN modulator-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CRBN modulator-12407829-65-4CRBN modulator1CRBN modulator 1Ligands for E3 LigaseE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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