2. Protein Tyrosine Kinase/RTK
  3. c-Met/HGFR
    VEGFR
  4. BMS-794833

BMS-794833 

Cat. No.: HY-10497 Purity: 99.78%
COA Handling Instructions

BMS-794833 is a VEGFR2 and Met inhibitor extracted from patent WO2009094417, compound example 1; has IC50s of 15 and 1.7 nM, respectively.

For research use only. We do not sell to patients.

BMS-794833 Chemical Structure

BMS-794833 Chemical Structure

CAS No. : 1174046-72-0

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Solution
10 mM * 1 mL in DMSO USD 131 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 131 In-stock
Solid
5 mg USD 119 In-stock
10 mg USD 210 In-stock
50 mg USD 810 In-stock
100 mg USD 1284 In-stock
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This product is a controlled substance and not for sale in your territory.

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  • Biological Activity

  • Protocol

  • Purity & Documentation

  • References

  • Customer Review

Description

BMS-794833 is a VEGFR2 and Met inhibitor extracted from patent WO2009094417, compound example 1; has IC50s of 15 and 1.7 nM, respectively.

IC50 & Target[1]

VEGFR2

15 nM (IC50)

Met

1.7 nM (IC50)

In Vitro

BMS794833 inhibits Met receptor activated gastric carcinoma cell line, GTL-16, with an IC50 of 39 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo

BMS-794833 is active by greater than 50% tumor growth inhibition for at least one tumor doubling time in the GTL-16 gastric carcinoma model. No toxicity is observed at any of the dose levels when administered once daily for a duration of 14 days[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

468.84

Appearance

Solid

Formula

C23H15ClF2N4O3
CAS No.
SMILES

ClC1=C(OC2=CC=C(NC(C3=CNC=C(C4=CC=C(F)C=C4)C3=O)=O)C=C2F)C=CN=C1N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (213.29 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1329 mL 10.6646 mL 21.3292 mL
5 mM 0.4266 mL 2.1329 mL 4.2658 mL
10 mM 0.2133 mL 1.0665 mL 2.1329 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.33 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.33 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
Cell Assay
[1]

GTL-16 cells are inoculated in to 96 well microtiter plates in 0.5% fetal calf serum and incubated at 37°C, 5% CO2, 95% air and 100% relative humidity for 24 h prior to addition of a compound. Cells are treated with BMS-794833 for an additional 72 h. Growth inhibition is calculated[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

BMS-7948331174046-72-0BMS794833BMS 794833c-Met/HGFRVEGFRVascular endothelial growth factor receptorInhibitorinhibitorinhibit

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