2. Protein Tyrosine Kinase/RTK
  3. c-Met/HGFR
    VEGFR
  4. SCR-1481B1

SCR-1481B1  (Synonyms: Metatinib anhydrous; c-Met inhibitor 2)

Cat. No.: HY-18711A Purity: 99.82%
COA Handling Instructions

SCR-1481B1 (Metatinib anhydrous) is a potent compound that has activity against cancers dependent upon Met activation and also has activity against cancers as a

For research use only. We do not sell to patients.

SCR-1481B1 Chemical Structure

SCR-1481B1 Chemical Structure

CAS No. : 1174161-86-4

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Based on 1 publication(s) in Google Scholar

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

  • Biological Activity

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  • References

  • Customer Review

Description

SCR-1481B1 (Metatinib anhydrous) is a potent compound that has activity against cancers dependent upon Met activation and also has activity against cancers as a VEGFR inhibitor.

IC50 & Target[1]

VEGFR1

 

In Vitro

More details please refer to Patent WO 2009094417 A1.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

821.12

Appearance

Solid

Formula

C32H40ClF2N6O13P
CAS No.
SMILES

O=C(C1=CN(COP(O)(O)=O)C=C(C2=CC=C(F)C=C2)C1=O)NC3=CC=C(C(F)=C3)OC4=C(Cl)C(N)=NC=C4.OCC(CO)(CO)N.OCC(CO)(CO)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (121.78 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2178 mL 6.0892 mL 12.1785 mL
5 mM 0.2436 mL 1.2178 mL 2.4357 mL
10 mM 0.1218 mL 0.6089 mL 1.2178 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (3.04 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (3.04 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

SCR-1481B11174161-86-4Metatinib c-Met inhibitor 2c-Met/HGFRVEGFRVascular endothelial growth factor receptorInhibitorinhibitorinhibit

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