1. Protein Tyrosine Kinase/RTK
  2. c-Met/HGFR
    VEGFR
  3. SCR-1481B1

SCR-1481B1 (Synonyms: c-Met inhibitor 2)

Cat. No.: HY-18711A Purity: 99.99%
Handling Instructions

SCR-1481B1 (c-Met inhibitor 2) is a potent compound that has activity against cancers dependent upon Met activation and also has activity against cancers as a VEGFR inhibitor.

For research use only. We do not sell to patients.

SCR-1481B1 Chemical Structure

SCR-1481B1 Chemical Structure

CAS No. : 1174161-86-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 139 In-stock
Estimated Time of Arrival: December 31
5 mg USD 90 In-stock
Estimated Time of Arrival: December 31
10 mg USD 150 In-stock
Estimated Time of Arrival: December 31
50 mg USD 450 In-stock
Estimated Time of Arrival: December 31
100 mg USD 750 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
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Description

SCR-1481B1 (c-Met inhibitor 2) is a potent compound that has activity against cancers dependent upon Met activation and also has activity against cancers as a VEGFR inhibitor.

IC50 & Target[1]

VEGFR1

 

In Vitro

More details please refer to Patent WO 2009094417 A1.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

699.98

Formula

C₂₈H₂₉ClF₂N₅O₁₀P

CAS No.

1174161-86-4

SMILES

O=C(C1=CN(COP(O)(O)=O)C=C(C2=CC=C(F)C=C2)C1=O)NC3=CC=C(OC4=C(Cl)C(N)=NC=C4)C(F)=C3.OCC(CO)(N)CO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (142.86 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4286 mL 7.1431 mL 14.2861 mL
5 mM 0.2857 mL 1.4286 mL 2.8572 mL
10 mM 0.1429 mL 0.7143 mL 1.4286 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (3.57 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (3.57 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

SCR-1481B1c-Met inhibitor 2c-Met/HGFRVEGFRVascular endothelial growth factor receptorInhibitorinhibitorinhibit

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Product Name:
SCR-1481B1
Cat. No.:
HY-18711A
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