1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. Calcium Channel
  3. Cav 2.2 blocker 2

Cav 2.2 blocker 2 

Cat. No.: HY-132268 Purity: 98.45%
Handling Instructions

Cav 2.2 blocker 2 is a Cav2.2 calcium channel blocker extracted from patent WO2017046581A1, compound 1. Cav 2.2 blocker 2 can reverses hyperalgesia associated with an injury or inflammation in conjunction with the opioid.

For research use only. We do not sell to patients.

Cav 2.2 blocker 2 Chemical Structure

Cav 2.2 blocker 2 Chemical Structure

CAS No. : 1204535-44-3

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Description

Cav 2.2 blocker 2 is a Cav2.2 calcium channel blocker extracted from patent WO2017046581A1, compound 1. Cav 2.2 blocker 2 can reverses hyperalgesia associated with an injury or inflammation in conjunction with the opioid[1].

IC50 & Target[1]

N-Type Ca2+ Channel

 

In Vitro

Cav 2.2 blocker 2 (compound 1) (1-10 mg/kg; p.o.) in conjunction with Morphine (0.3 mg/kg) reverses the complete freunds adjuvant (CFA) induced hyperalgesia in rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

427.44

Formula

C₁₉H₂₀F₃N₃O₃S

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (233.95 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3395 mL 11.6975 mL 23.3951 mL
5 mM 0.4679 mL 2.3395 mL 4.6790 mL
10 mM 0.2340 mL 1.1698 mL 2.3395 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.85 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.85 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.85 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.45%

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Product Name:
Cav 2.2 blocker 2
Cat. No.:
HY-132268
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