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Cat. No.: HY-145761

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AMPA-IN-1

AMPA-IN-1 is an orally active AMPA receptor inhibitor with an IC₅₀ of 17.70 nM. AMPA-IN-1 inhibits AMPA-induced intracellular calcium influx in rat embryonic cerebral cortical neurons. AMPA-IN-1 exhibits anticonvulsant-related activity in the mouse 6 Hz psychomotor seizure model. AMPA-IN-1 can be used for research on AMPA-mediated diseases, such as epilepsy.

For research use only. We do not sell to patients.

CAS No.: 2097604-91-4
Formula: C₂₃H₁₂F₂N₄O₂
Molecular Weight:414.36

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (286 KB)

AMPA-IN-1 Chemical Structure

CAS No.: 2097604-91-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

AMPA Receptor

17.70 nM (IC₅₀)

All iGluR Isoforms :

In Vitro

AMPA-IN-1 (Example 17) inhibits AMPA-triggered intracellular calcium influx in cultured rat embryonic cerebral cortical neurons (IC₅₀ = 17.70 nM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

AMPA-IN-1 (Example 17) (p.o.; single administration) induces central nervous system-related motor impairment in the rotarod test, manifested as a shortened fall latency in test animals^[1].
AMPA-IN-1 (p.o.) produces anticonvulsant effects in the mouse 6 Hz psychomotor seizure model, with a therapeutic index (TD₅₀/ED₅₀) of 2.14^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 2097604-91-4
Molecular Weight 414.36
Formula C₂₃H₁₂F₂N₄O₂
SMILES

N#CC1=C(C2=CC3=C(N(C4=CC=CN=C4)C2=O)COC5=C3N=CC(F)=C5)C=CC=C1F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (286 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kurokawa T, et al. Pyranodipyridine compound. JPWO2017082288A1, 2017.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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