1. PI3K/Akt/mTOR
    Stem Cell/Wnt
  2. GSK-3
  3. (R)-BRD3731

(R)-BRD3731 

Cat. No.: HY-124607 Purity: 98.22% ee.: 98.64%
Handling Instructions

(R)-BRD3731 is a GSK3 inhibitor extracted from patent US20160375006A1, compound example 273, has IC50s of 1.05 and 6.7 μM for GSK3β and GSK3α, respectively.

For research use only. We do not sell to patients.

(R)-BRD3731 Chemical Structure

(R)-BRD3731 Chemical Structure

CAS No. : 2056262-08-7

Size Price Stock Quantity
5 mg USD 550 In-stock
Estimated Time of Arrival: December 31
10 mg USD 880 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1950 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2950 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

(R)-BRD3731 is a GSK3 inhibitor extracted from patent US20160375006A1, compound example 273, has IC50s of 1.05 and 6.7 μM for GSK3β and GSK3α, respectively[1].

IC50 & Target[1]

GSK3β

1.05 μM (IC50)

GSK3α

6.7 μM (IC50)

Molecular Weight

377.52

Formula

C₂₄H₃₁N₃O

CAS No.

2056262-08-7

SMILES

O=C1C2=C(N=C3C([[email protected]@]2(C)C4=CC=CC=C4)=C(CC(C)(C)C)NN3)CC(C)(C)C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (529.77 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6489 mL 13.2443 mL 26.4887 mL
5 mM 0.5298 mL 2.6489 mL 5.2977 mL
10 mM 0.2649 mL 1.3244 mL 2.6489 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 5 mg/mL (13.24 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 5 mg/mL (13.24 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

(R)-BRD3731GSK-3Glycogen synthase kinase-3Glycogen synthase kinase 3GSK3βGSK3αInhibitorinhibitorinhibit

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Product Name:
(R)-BRD3731
Cat. No.:
HY-124607
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