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    Stem Cell/Wnt
  2. GSK-3
  3. BRD3731

BRD3731 

Cat. No.: HY-124607B
Handling Instructions

BRD3731 is a selective GSK3β inhibitor, with IC50s of 15 nM and 215 nM for GSK3β and GSK3α, respectively. BRD3731 can be used for the research of a mood disorder, post-traumatic stress disorder (PTSD), psychiatric disorder, diabetes, and neurodegenerative disorder.

For research use only. We do not sell to patients.

BRD3731 Chemical Structure

BRD3731 Chemical Structure

CAS No. : 2056262-07-6

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Description

BRD3731 is a selective GSK3β inhibitor, with IC50s of 15 nM and 215 nM for GSK3β and GSK3α, respectively. BRD3731 can be used for the research of a mood disorder, post-traumatic stress disorder (PTSD), psychiatric disorder, diabetes, and neurodegenerative disorder[1].

IC50 & Target[1]

GSK-3β

15 nM (IC50)

GSK-3α

215 nM (IC50)

In Vitro

BRD3731 is a GSK3β- selective inhibitor extracted from patent US20160375006A1, compound example 272[1].
BRD3731 (1-10 μM; 24 hours) inhibits the phosphorylation of CRMP2 in SH-SY5Y cells[1].
BRD3731 (20 μM; 24 hours) decreases β-catenin S33/37/T41 phosphorylation and induces β-catenin S675 phosphorylation inHL-60 cells[2].
BRD3731 (10-20 μM; 7-10 days) impairs colony formation in TF-1 and increases colony forming ability in the MV4–11 cell line[2]

In Vivo

BRD3731 (30 mg/kg; i.p.) reduces audiogenic seizures in Fmr1 KO mice[1].

Molecular Weight

377.52

Formula

C₂₄H₃₁N₃O

CAS No.

2056262-07-6

SMILES

O=C1C2=C(N=C3C([[email protected]]2(C)C4=CC=CC=C4)=C(CC(C)(C)C)NN3)CC(C)(C)C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (132.44 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6489 mL 13.2443 mL 26.4887 mL
5 mM 0.5298 mL 2.6489 mL 5.2977 mL
10 mM 0.2649 mL 1.3244 mL 2.6489 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 5 mg/mL (13.24 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 5 mg/mL (13.24 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References
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Keywords:

BRD3731BRD 3731BRD-3731GSK-3Glycogen synthase kinase-3Glycogen synthase kinase 3glycogensynthasekinaseGSK3mooddisorderpost-traumaticstressPTSDpsychiatricdiabetesneurodegenerativeInhibitorinhibitorinhibit

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BRD3731
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HY-124607B
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