2. Epigenetics
  3. Epigenetic Reader Domain
  4. Amredobresib

Amredobresib 

Cat. No.: HY-145550 Purity: 98.99%
COA Handling Instructions

Amredobresib is a potent inhibitor of BET. Amredobresib inhibits the binding of bromodomains to acetylated lysines on histone H3 and H4 and thus acts as important regulators of gene transcription. Amredobresib is useful for the research of acute myeloid leukemia (AML) and cancer (extracted from patent WO2019145410A1 and WO2021175824A1).

For research use only. We do not sell to patients.

Amredobresib Chemical Structure

Amredobresib Chemical Structure

CAS No. : 1610044-98-8

Size Price Stock Quantity
5 mg USD 510 In-stock
Estimated Time of Arrival: December 31
10 mg USD 820 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1680 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 4200 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Amredobresib is a potent inhibitor of BET. Amredobresib inhibits the binding of bromodomains to acetylated lysines on histone H3 and H4 and thus acts as important regulators of gene transcription. Amredobresib is useful for the research of acute myeloid leukemia (AML) and cancer (extracted from patent WO2019145410A1 and WO2021175824A1)[1].

IC50 & Target

BET[1]
Molecular Weight

467.57

Appearance

Solid

Formula

C26H29N9
CAS No.
SMILES

CNC1=NC(C2=NC3=C(N2CC4=CC=CC=C4)C=C(N5CCN(CC5)C)C=C3)=CN6C(C)=NN=C16
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

Amredobresib1610044-98-8Epigenetic Reader DomainBETbromodomainacetylated lysinehistone H3histone H4gene transcriptionacute myeloid leukemiaAMLcancerInhibitorinhibitorinhibit

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