1. Metabolic Enzyme/Protease
  2. Indoleamine 2,3-Dioxygenase (IDO)
  3. IDO-IN-8

IDO-IN-8 (Synonyms: NLG-1487)

Cat. No.: HY-18770C Purity: 99.99%
Handling Instructions

IDO-IN-8 (NLG-1487) is an indoleamine 2,3-dioxygenase (IDO) inhibitor extracted from patent WO WO2012142237A1, compound 1487, has an IC50 of 1-10 μM.

For research use only. We do not sell to patients.

IDO-IN-8 Chemical Structure

IDO-IN-8 Chemical Structure

CAS No. : 1402837-77-7

Size Price Stock Quantity
10 mM * 1 mL in Ethanol USD 990 In-stock
Estimated Time of Arrival: December 31
5 mg USD 900 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1440 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

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Description

IDO-IN-8 (NLG-1487) is an indoleamine 2,3-dioxygenase (IDO) inhibitor extracted from patent WO WO2012142237A1, compound 1487, has an IC50 of 1-10 μM.

IC50 & Target[1]

IDO

1-10 μM (IC50)

In Vitro

IDO-IN-8 (Compound 1487) is an indoleamine 2,3-dioxygenase (IDO) inhibitor with an IC50 of 1-10 μM (this is the concentration of IDO-IN-8 at which inhibits 50% of enzymatic activity using recombinant human IDO)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

316.37

Formula

C₁₈H₂₁FN₂O₂

CAS No.

1402837-77-7

SMILES

O[[email protected]](CC1)CC[[email protected]]1([H])[[email protected]@H](O)C[[email protected]]2N3C(C4=C2C(F)=CC=C4)=CN=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

Ethanol : 100 mg/mL (316.09 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1609 mL 15.8043 mL 31.6086 mL
5 mM 0.6322 mL 3.1609 mL 6.3217 mL
10 mM 0.3161 mL 1.5804 mL 3.1609 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% EtOH    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.90 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% EtOH    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.90 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% EtOH    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.90 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

IDO-IN-8NLG-1487NLG1487NLG 1487Indoleamine 2,3-Dioxygenase (IDO)Inhibitorinhibitorinhibit

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IDO-IN-8
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HY-18770C
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