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AV-105 

Cat. No.: HY-120947 Purity: >98.0%
Handling Instructions

AV-105 is a Florbetapir (18F)-radiolabeled slyrylpyridine tosylate precursor extracted from patent WO2010078370A1, example 1.5. AV-105 can synthesize 18F-radiolabeled compounds, which are used for positron emission tomography (PET) imaging of neurodegenerative diseases of the brain.

For research use only. We do not sell to patients.

AV-105 Chemical Structure

AV-105 Chemical Structure

CAS No. : 1205550-99-7

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Description

AV-105 is a Florbetapir (18F)-radiolabeled slyrylpyridine tosylate precursor extracted from patent WO2010078370A1, example 1.5. AV-105 can synthesize 18F-radiolabeled compounds, which are used for positron emission tomography (PET) imaging of neurodegenerative diseases of the brain[1].

In Vitro

The AV-105 synthesis method utilizes a primary tosylate instead of a primary mesylate as an active leaving group. Use of the tosylate precursor for radiofluorination is beneficial, at least for the reason that the tosylate generated during the radiofluorination reaction is readily removed by chromatographic means from the 18F-radiolabeled imaging product[1].

Molecular Weight

612.73

Formula

C₃₂H₄₀N₂O₈S

CAS No.

1205550-99-7

SMILES

O=C(OC(C)(C)C)N(C)C1=CC=C(/C=C/C2=CC=C(OCCOCCOCCOS(=O)(C3=CC=C(C)C=C3)=O)N=C2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (102.00 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6320 mL 8.1602 mL 16.3204 mL
5 mM 0.3264 mL 1.6320 mL 3.2641 mL
10 mM 0.1632 mL 0.8160 mL 1.6320 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

AV-105AV105AV 105OthersFlorbetapirbrainimagingadiolabeledtosylateprecursorAlzheimer'sDiseaseInhibitorinhibitorinhibit

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AV-105
Cat. No.:
HY-120947
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