AV-105
Based on 1 Customer Validation
AV-105 is a Florbetapir (18F)-radiolabeled slyrylpyridine tosylate precursor extracted from patent WO2010078370A1, example 1.5. AV-105 can synthesize 18F-radiolabeled compounds, which are used for positron emission tomography (PET) imaging of neurodegenerative diseases of the brain.
For research use only. We do not sell to patients.
- Purity: 99.70%
- CAS No.: 1205550-99-7
- Formula: C32H40N2O8S
- Molecular Weight:612.73
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
The AV-105 synthesis method utilizes a primary tosylate instead of a primary mesylate as an active leaving group. Use of the tosylate precursor for radiofluorination is beneficial, at least for the reason that the tosylate generated during the radiofluorination reaction is readily removed by chromatographic means from the 18F-radiolabeled imaging product[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1205550-99-7
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Appearance Solid
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Molecular Weight 612.73
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Formula C32H40N2O8S
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Color White to yellow
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SMILES
O=C(OC(C)(C)C)N(C)C1=CC=C(/C=C/C2=CC=C(OCCOCCOCCOS(=O)(C3=CC=C(C)C=C3)=O)N=C2)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
DMSO : 62.5 mg/mL (102.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6320 mL | 8.1602 mL | 16.3204 mL | 40.8010 mL |
| 5 mM | 0.3264 mL | 1.6320 mL | 3.2641 mL | 8.1602 mL | |
| 10 mM | 0.1632 mL | 0.8160 mL | 1.6320 mL | 4.0801 mL | |
| 15 mM | 0.1088 mL | 0.5440 mL | 1.0880 mL | 2.7201 mL | |
| 20 mM | 0.0816 mL | 0.4080 mL | 0.8160 mL | 2.0401 mL | |
| 25 mM | 0.0653 mL | 0.3264 mL | 0.6528 mL | 1.6320 mL | |
| 30 mM | 0.0544 mL | 0.2720 mL | 0.5440 mL | 1.3600 mL | |
| 40 mM | 0.0408 mL | 0.2040 mL | 0.4080 mL | 1.0200 mL | |
| 50 mM | 0.0326 mL | 0.1632 mL | 0.3264 mL | 0.8160 mL | |
| 60 mM | 0.0272 mL | 0.1360 mL | 0.2720 mL | 0.6800 mL | |
| 80 mM | 0.0204 mL | 0.1020 mL | 0.2040 mL | 0.5100 mL | |
| 100 mM | 0.0163 mL | 0.0816 mL | 0.1632 mL | 0.4080 mL |
AV-105 Related Classifications
HY-120947 Related Classifications
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