Cat. No.: HY-N0726

Dracorhodin perchlorate

(Synonyms: Dracohodin perochlorate)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Dracorhodin perchlorate (Dracohodin perochlorate) is a natural product that can be obtained from the natural active molecule Dragon's blood. Dracorhodin perchlorate inhibits PI3K/Akt and NF-κB activation, upregulates p53 expression, activates caspase, produces ROS, and promotes Apoptosis. Dracorhodin perchlorate regulates the TLR4. Dracorhodin perchlorate promotes wound healing, improves diabetes. Dracorhodin perchlorate has anti-tumor activity against prostate cancer, breast cancer, cervical cancer and other cancers.

For research use only. We do not sell to patients.

Purity: 99.02%
CAS No.: 125536-25-6
Formula: C₁₇H₁₅ClO₇
Molecular Weight:366.75

Storage:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Dracorhodin perchlorate Chemical Structure

CAS No.: 125536-25-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]^[2]^[3]^[4]^[5]^[6]^[7]^[8]

TLR4

Caspase 3

All Akt Isoforms :

All PI3K Isoforms :

All NF-κB Isoforms :

All Caspase Isoforms :

All Toll-like Receptor (TLR) Isoforms :

All PARP Isoforms :

In Vitro

Dracorhodin perchlorate (0-80 μM; 12-48 h) inhibits the growth of human cervical cancer HeLa cells, human malignant melanoma A375-S2 cells, human breast cancer MCF-7 cells and human histiocytic lymphoma U937 cells in a dose-and time-dependent manner^[1].
Dracorhodin perchlorate (0-200 μM; 48 h) inhibits the growth of human gastric adenocarcinoma SGC-7901 cells in a dose-dependent manner^[2].
Dracorhodin perchlorate (0.625-40 μg/mL; 24 h) promotes the proliferation of NIH/3T3 fibroblasts at concentrations of 0.625-10 μg/mL and inhibits proliferation at concentrations >20 μg/mL^[3].
Dracorhodin perchlorate (10-80 μM；12-48 h) inhibits the growth of human prostate cancer PC-3 cells in a dose-and time-dependent manner, with an IC₅₀ of 40.18 μM at 24 h^[4].
Dracorhodin perchlorate (40-150 μM; 12-48 h) inhibits the growth of MCF-7 cells in a dose-and time-dependent manner^[5].
Dracorhodin perchlorate (10 μg/mL; 3-9 h) upregulates Pdx1 expression in INS-1 cells^[7].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[2]

Cell Line:

SGC-7901
Concentration:

60, 80, 100 μM
Incubation Time:

48 h
Result:

Induced G1/S or G1 phase arrest and apoptosis, as shown by changes in cell cycle distribution, nuclear morphology, and apoptotic markers.
Regulated the expression of proteins involved in cell cycle and apoptosis pathways, such as p53, p21^waf1, Bcl-2 family proteins, and phosphorylated Akt and PI3K.
Affected caspase-3 activation, leading to PARP cleavage.

In Vivo

Dracorhodin perchlorate (2.5-10 μg/mL；applied as an ointment；twice daily；0-14 days) promotes wound healing in rats, as evidenced by increased wound healing rate, enhanced fibroblast proliferation in wound tissue, and up -regulation of phosphorylated-ERK in wound tissue^[3].
Dracorhodin perchlorate (200 μg/mL; topical application) promotes skin wound healing, collagen deposition, and microvascular formation in diabetic rats by regulating the TLR4 pathway and related inflammatory factors^[6].
Dracorhodin perchlorate (5-20 mg/kg; i.p.; every other day; 30 d) lowers blood glucose, raises insulin levels, enhances Pdx1 expression, increases islet size and number, and shows protective effects on islets and β-cells in diabetic mice^[7].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male Sprague-Dawley rats (170-220 g, clean grade, 7-week-old approximately)+diabetes mellitus model induced by Streptozotocin (HY-13753) injection and high-fat diet^[6]
Dosage:

200 μg/mL (dissolved in DMSO and made into ointment with Vaseline)
Administration:

Topical application
Result:

Accelerated the wound healing in diabetic rats.
Increased the wound healing rate.
Promoted collagen deposition and inhibited scar formation.
Increased the number of microvessels.
Reduced the activation of the TLR4 pathway, decreased the mRNA and protein expressions of inflammatory factors, increased eNOS protein expression and NO content in the later stage of wound healing.

Chemical Information

CAS No. 125536-25-6
Appearance Solid
Molecular Weight 366.75
Formula C₁₇H₁₅ClO₇
Color Yellow to orange
SMILES

CC1=C(OC)C2=CC=C(C3=CC=CC=C3)[O+]=C2C=C1O.O=Cl(=O)([O-])=O
Synonyms

Dracohodin perochlorate
Structure Classification
- Flavonoids
- Anthocyans
Initial Source
- Plants
- other families
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (1)

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Int Immunopharmacol

Dracorhodin perochlorate sensitizes colorectal cancer to ferroptosis by activating HMOX1 and inhibiting the SLC7A11/GPX4 axis. [Abstract]

2025 Jun 17:158:114827. PMID: 40359890

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (272.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.7267 mL

13.6333 mL

27.2665 mL

5 mM

0.5453 mL

2.7267 mL

5.4533 mL

10 mM

0.2727 mL

1.3633 mL

2.7267 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (280 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Rasul A, et al. Dracorhodin perchlorate inhibits PI3K/Akt and NF-κB activation, up-regulates the expression of p53, and enhances apoptosis. Apoptosis. 2012 Oct;17(10):1104-19. [Content Brief]

[2]. Xia M, et al. Dracorhodin perchlorate induces apoptosis via activation of caspases and generation of reactive oxygen species. J Pharmacol Sci. 2004 Jun;95(2):273-83. [Content Brief]

[3]. Jiang X, et al. Dracorhodin perchlorate regulates fibroblast proliferation to promote rat's wound healing. J Pharmacol Sci. 2018 Feb;136(2):66-72. [Content Brief]

[4]. He Y, et al. Dracorhodin perchlorate suppresses proliferation and induces apoptosis in human prostate cancer cell line PC-3. J Huazhong Univ Sci Technolog Med Sci. 2011 Apr;31(2):215. [Content Brief]

[5]. Yu JH, et al. Dracorhodin perchlorate induced human breast cancer MCF-7 apoptosis through mitochondrial pathways. Int J Med Sci. 2013 Jul 7;10(9):1149-56. [Content Brief]

[6]. Xiong Z, et al. Dracorhodin Perchlorate Regulates the Expression of Inflammatory Cytokines through the TLR4 Pathway and Improves Skin Wound Healing in Diabetic Rats. Evid Based Complement Alternat Med. 2022 Apr 14;2022:9050686. [Content Brief]

[7]. Liu L, et al. Dracorhodin perchlorate protects pancreatic β-cells against glucotoxicity- or lipotoxicity-induced dysfunction and apoptosis in vitro and in vivo. FEBS J. 2019 Sep;286(18):3718-3736. [Content Brief]

[8]. Chen X, et al. Dracorhodin perchlorate induces the apoptosis of glioma cells. Oncol Rep. 2016 Apr;35(4):2364-72. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.7267 mL	13.6333 mL	27.2665 mL	68.1663 mL
	5 mM	0.5453 mL	2.7267 mL	5.4533 mL	13.6333 mL
	10 mM	0.2727 mL	1.3633 mL	2.7267 mL	6.8166 mL
	15 mM	0.1818 mL	0.9089 mL	1.8178 mL	4.5444 mL
	20 mM	0.1363 mL	0.6817 mL	1.3633 mL	3.4083 mL
	25 mM	0.1091 mL	0.5453 mL	1.0907 mL	2.7267 mL
	30 mM	0.0909 mL	0.4544 mL	0.9089 mL	2.2722 mL
	40 mM	0.0682 mL	0.3408 mL	0.6817 mL	1.7042 mL
	50 mM	0.0545 mL	0.2727 mL	0.5453 mL	1.3633 mL
	60 mM	0.0454 mL	0.2272 mL	0.4544 mL	1.1361 mL
	80 mM	0.0341 mL	0.1704 mL	0.3408 mL	0.8521 mL
	100 mM	0.0273 mL	0.1363 mL	0.2727 mL	0.6817 mL

Dracorhodin perchlorate

1 Cited Publications

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Dracorhodin perchlorate

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